tariquidar has been researched along with paclitaxel in 19 studies
| Studies (tariquidar) | Trials (tariquidar) | Recent Studies (post-2010) (tariquidar) | Studies (paclitaxel) | Trials (paclitaxel) | Recent Studies (post-2010) (paclitaxel) |
|---|---|---|---|---|---|
| 210 | 16 | 138 | 31,874 | 5,729 | 15,395 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Waghray, D; Zhang, Q | 1 |
| Bi, Y; Chen, X; Huang, W; Li, X; Liang, K; Liu, S; Ma, M; Wang, B; Wang, H; Zeng, W | 1 |
| Cutler, M; Lau, JYN; Lee, G; Pitzonka, L; Smolinski, MP; Suh, KH; Urgaonkar, S | 1 |
| Bi, Y; Cheng, H; Huang, W; Liu, S; Qiao, H; Tian, Q; Wang, H; Wang, L; Wang, R; Wang, Y; Xu, S | 1 |
| Cai, Z; Ghaleb, H; Huang, W; Jiang, Y; Liu, Y; Qian, H; Qiu, Q; Shi, W; Yin, Z; Zhang, P; Zhou, J; Zou, F | 1 |
| Berridge, G; Callaghan, R; Charlton, P; Higgins, C; Martin, C; Mistry, P | 1 |
| Berridge, G; Callaghan, R; Charlton, P; Higgins, CF; Martin, C; Mistry, P | 1 |
| Bootle, D; Charlton, P; Dangerfield, W; Liddle, C; Mistry, P; Okiji, S; Plumb, JA; Stewart, AJ; Templeton, D | 1 |
| Carson, RE; Eckelman, WC; Herscovitch, P; Kiesewetter, DO; Kurdziel, KA | 1 |
| Callaghan, R; Kerr, ID; McMahon, R; Rothnie, A; Storm, J; Taylor, A | 1 |
| Acharya, MR; Desai, N; Figg, WD; Smith, NF; Sparreboom, A | 1 |
| Bernhardt, G; Buschauer, A; Fellner, S; Höcherl, P; Hubensack, M; Müller, C; Spruss, T | 1 |
| Ambudkar, SV; Barnett, D; Bates, SE; Finley, EM; Fojo, T; Oldham, RK; Robey, RW; Shukla, S | 1 |
| Ma, L; Panyam, J; Patil, Y; Sadhukha, T | 1 |
| Mongayt, D; Patel, NR; Rathi, A; Torchilin, VP | 1 |
| Assaraf, YG; Bar-Zeev, M; Livney, YD | 1 |
| Sarisozen, C; Torchilin, VP; Zou, W | 1 |
| Garabadzhiu, A; Grigoreva, T; Novikova, D; Romanova, A; Sagaidak, A; Tribulovich, V | 1 |
2 review(s) available for tariquidar and paclitaxel
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Neoplasm; Humans; Protein Conformation | 2018 |
1 trial(s) available for tariquidar and paclitaxel
| Article | Year |
|---|---|
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Factors; Biological Transport; Cell Line; Cell Line, Tumor; Cyclosporins; Depsipeptides; Fluorescent Dyes; Fluorouracil; Humans; Insecta; Multidrug Resistance-Associated Proteins; Neoplasms; Paclitaxel; Prazosin; Quinolines; Rhodamine 123; Verapamil; Vinblastine | 2008 |
16 other study(ies) available for tariquidar and paclitaxel
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.
Topics: Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2021 |
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Drug Discovery; Humans; Intestinal Mucosa; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Tetrazoles | 2021 |
Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Mice, Nude; Nitrogen; Oleanolic Acid | 2022 |
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel | 2022 |
The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Membrane; CHO Cells; Cricetinae; Drug Resistance, Neoplasm; Kinetics; Paclitaxel; Protein Binding; Quinolines; Vinblastine | 1999 |
Communication between multiple drug binding sites on P-glycoprotein.
Topics: Acridines; Allosteric Regulation; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Benzylidene Compounds; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Drug Interactions; Isoquinolines; Kinetics; Nicardipine; Paclitaxel; Quinolines; Radioligand Assay; Radiopharmaceuticals; Rhodamine 123; Tetrahydroisoquinolines; Tritium; Vinblastine | 2000 |
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
Topics: Acridines; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Division; Cyclosporins; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Isoquinolines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Quinolines; Tetrahydroisoquinolines; Time Factors; Treatment Outcome; Tritium; Xenograft Model Antitumor Assays | 2001 |
Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Female; Humans; Isotope Labeling; Macaca mulatta; Male; Metabolic Clearance Rate; Organ Specificity; Paclitaxel; Primates; Quinolines; Radiation Dosage; Radiometry; Tissue Distribution; Whole-Body Counting | 2003 |
The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Baculoviridae; Binding Sites; Catalysis; Cell Line; Cell Membrane; Coumarins; Cysteine; Hydrolysis; Insecta; Kinetics; Linear Models; Mutagenesis, Site-Directed; Nicardipine; Paclitaxel; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Protein Transport; Quinolines; Recombinant Proteins; Sulfhydryl Compounds; Time Factors; Vinblastine | 2005 |
Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Hepatocytes; Humans; Ketoconazole; Liver; Liver-Specific Organic Anion Transporter 1; Mice; Mice, Inbred Strains; Oocytes; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Paclitaxel; Quinolines; Solute Carrier Organic Anion Transporter Family Member 1B3; Xenopus laevis | 2005 |
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.
Topics: Acridines; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Flow Cytometry; Mice; Mice, Nude; Paclitaxel; Quinolines; Tetrahydroisoquinolines | 2008 |
Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotin; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Lactic Acid; Leukemia, T-Cell; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasm Transplantation; Paclitaxel; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinolines | 2009 |
Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Liposomes; Molecular Targeted Therapy; Paclitaxel; Particle Size; Quinolines; Rhodamine 123; Surface Properties | 2011 |
β-casein nanovehicles for oral delivery of chemotherapeutic Drug combinations overcoming P-glycoprotein-mediated multidrug resistance in human gastric cancer cells.
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta Catenin; Cell Proliferation; Drug Carriers; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Micelles; Nanoparticles; Paclitaxel; Quinolines; Stomach Neoplasms; Tumor Cells, Cultured | 2016 |
The reversal of multidrug resistance in ovarian carcinoma cells by co-application of tariquidar and paclitaxel in transferrin-targeted polymeric micelles.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Multiple; Female; Humans; Micelles; Ovarian Neoplasms; Paclitaxel; Polymers; Quinolines | 2017 |
Establishment of drug-resistant cell lines under the treatment with chemicals acting through different mechanisms.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Resistance, Neoplasm; Enzyme Inhibitors; HCT116 Cells; Humans; Imidazoles; Paclitaxel; Piperazines; Proto-Oncogene Proteins c-mdm2; Quinolines; Vanadates | 2021 |