Page last updated: 2024-09-04

tariquidar and ly335979

tariquidar has been researched along with ly335979 in 9 studies

Compound Research Comparison

Studies
(tariquidar)
Trials
(tariquidar)
Recent Studies (post-2010)
(tariquidar)
Studies
(ly335979)
Trials
(ly335979)
Recent Studies (post-2010) (ly335979)
210161381121254

Protein Interaction Comparison

ProteinTaxonomytariquidar (IC50)ly335979 (IC50)
ATP-dependent translocase ABCB1Homo sapiens (human)0.0589

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's6 (66.67)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U1
Waghray, D; Zhang, Q1
Cutler, M; Lau, JYN; Lee, G; Pitzonka, L; Smolinski, MP; Suh, KH; Urgaonkar, S1
Bates, SF; Chen, C; Figg, WD; Fojo, T; Kang, M; Robey, R1
Alcantara, LM; Ayong, LS; Franco, CH; Franzoi, KD; Freitas-Junior, LH; Kim, J; Lee, S; Moraes, CB1
Ambudkar, SV; Chufan, EE; Kapoor, K1
Abel, B; Ambudkar, SV; Chufan, EE; Shukla, S1
Bakos, É; Kucsma, N; Német, O; Özvegy-Laczka, C; Patik, I; Szakács, G; Várady, G1
Ambudkar, SV; Lusvarghi, S1

Reviews

2 review(s) available for tariquidar and ly335979

ArticleYear
Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment.
    Journal of medicinal chemistry, 2018, 06-28, Volume: 61, Issue:12

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Neoplasm; Humans; Protein Conformation

2018
Reversal of multidrug resistance: lessons from clinical oncology.
    Novartis Foundation symposium, 2002, Volume: 243

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Clinical Trials as Topic; Cyclosporins; Dibenzocycloheptenes; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Genes, MDR; Humans; Mice; Mice, Knockout; Neoplasm Proteins; Neoplasms; Piperidines; Pyridines; Quinolines; Radionuclide Imaging; Radiopharmaceuticals; Rhodamines; Technetium Tc 99m Sestamibi; Tissue Distribution; Tumor Cells, Cultured

2002

Other Studies

7 other study(ies) available for tariquidar and ly335979

ArticleYear
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship

2012
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
    Journal of medicinal chemistry, 2021, 04-08, Volume: 64, Issue:7

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Drug Discovery; Humans; Intestinal Mucosa; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Tetrazoles

2021
Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites.
    Experimental parasitology, 2013, Volume: 134, Issue:2

    Topics: Antimalarials; Artemisinins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Boron Compounds; Chloroquine; Chlorpheniramine; Dibenzocycloheptenes; Drug Interactions; Drug Resistance, Multiple; Erythrocytes; Fluorescent Dyes; Gefitinib; Humans; Imatinib Mesylate; Mefloquine; Piperazines; Plasmodium falciparum; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Quinolines

2013
Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
    Biochemical pharmacology, 2016, Feb-01, Volume: 101

    Topics: Acridines; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biocatalysis; Dibenzocycloheptenes; HeLa Cells; Humans; Hydrogen Bonding; Hydrolysis; Lepidoptera; Ligands; Membrane Transport Modulators; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Mutant Proteins; Quinolines; Recombinant Proteins; Tetrahydroisoquinolines

2016
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
    The Journal of biological chemistry, 2017, 04-28, Volume: 292, Issue:17

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Baculoviridae; Binding Sites; Detergents; Dibenzocycloheptenes; Drug Delivery Systems; Drug Evaluation, Preclinical; Glucosides; Humans; Hydrolysis; Inhibitory Concentration 50; Insecta; Ligands; Mice; Micelles; Peptides, Cyclic; Protein Binding; Quinolines; Tetrahydroisoquinolines; Verapamil

2017
A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2.
    The FEBS journal, 2020, Volume: 287, Issue:12

    Topics: Acridines; Cell Line; Dibenzocycloheptenes; Fluorescent Dyes; Humans; Organic Anion Transporters; Quinolines; Tetrahydroisoquinolines

2020
ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
    The Biochemical journal, 2019, 12-19, Volume: 476, Issue:24

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line; Dibenzocycloheptenes; Gene Expression Regulation; Humans; Insecta; Protein Binding; Protein Conformation; Protein Stability; Quinolines; Temperature; Tetrahydroisoquinolines; Verapamil

2019