tariquidar has been researched along with ly335979 in 9 studies
| Studies (tariquidar) | Trials (tariquidar) | Recent Studies (post-2010) (tariquidar) | Studies (ly335979) | Trials (ly335979) | Recent Studies (post-2010) (ly335979) |
|---|---|---|---|---|---|
| 210 | 16 | 138 | 112 | 12 | 54 |
| Protein | Taxonomy | tariquidar (IC50) | ly335979 (IC50) |
|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 0.0589 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U | 1 |
| Waghray, D; Zhang, Q | 1 |
| Cutler, M; Lau, JYN; Lee, G; Pitzonka, L; Smolinski, MP; Suh, KH; Urgaonkar, S | 1 |
| Bates, SF; Chen, C; Figg, WD; Fojo, T; Kang, M; Robey, R | 1 |
| Alcantara, LM; Ayong, LS; Franco, CH; Franzoi, KD; Freitas-Junior, LH; Kim, J; Lee, S; Moraes, CB | 1 |
| Ambudkar, SV; Chufan, EE; Kapoor, K | 1 |
| Abel, B; Ambudkar, SV; Chufan, EE; Shukla, S | 1 |
| Bakos, É; Kucsma, N; Német, O; Özvegy-Laczka, C; Patik, I; Szakács, G; Várady, G | 1 |
| Ambudkar, SV; Lusvarghi, S | 1 |
2 review(s) available for tariquidar and ly335979
| Article | Year |
|---|---|
Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Neoplasm; Humans; Protein Conformation | 2018 |
Reversal of multidrug resistance: lessons from clinical oncology.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Clinical Trials as Topic; Cyclosporins; Dibenzocycloheptenes; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Genes, MDR; Humans; Mice; Mice, Knockout; Neoplasm Proteins; Neoplasms; Piperidines; Pyridines; Quinolines; Radionuclide Imaging; Radiopharmaceuticals; Rhodamines; Technetium Tc 99m Sestamibi; Tissue Distribution; Tumor Cells, Cultured | 2002 |
7 other study(ies) available for tariquidar and ly335979
| Article | Year |
|---|---|
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2012 |
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Drug Discovery; Humans; Intestinal Mucosa; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Tetrazoles | 2021 |
Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites.
Topics: Antimalarials; Artemisinins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Boron Compounds; Chloroquine; Chlorpheniramine; Dibenzocycloheptenes; Drug Interactions; Drug Resistance, Multiple; Erythrocytes; Fluorescent Dyes; Gefitinib; Humans; Imatinib Mesylate; Mefloquine; Piperazines; Plasmodium falciparum; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Quinolines | 2013 |
Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
Topics: Acridines; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biocatalysis; Dibenzocycloheptenes; HeLa Cells; Humans; Hydrogen Bonding; Hydrolysis; Lepidoptera; Ligands; Membrane Transport Modulators; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Mutant Proteins; Quinolines; Recombinant Proteins; Tetrahydroisoquinolines | 2016 |
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Baculoviridae; Binding Sites; Detergents; Dibenzocycloheptenes; Drug Delivery Systems; Drug Evaluation, Preclinical; Glucosides; Humans; Hydrolysis; Inhibitory Concentration 50; Insecta; Ligands; Mice; Micelles; Peptides, Cyclic; Protein Binding; Quinolines; Tetrahydroisoquinolines; Verapamil | 2017 |
A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2.
Topics: Acridines; Cell Line; Dibenzocycloheptenes; Fluorescent Dyes; Humans; Organic Anion Transporters; Quinolines; Tetrahydroisoquinolines | 2020 |
ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line; Dibenzocycloheptenes; Gene Expression Regulation; Humans; Insecta; Protein Binding; Protein Conformation; Protein Stability; Quinolines; Temperature; Tetrahydroisoquinolines; Verapamil | 2019 |