tariquidar has been researched along with loperamide in 13 studies
| Studies (tariquidar) | Trials (tariquidar) | Recent Studies (post-2010) (tariquidar) | Studies (loperamide) | Trials (loperamide) | Recent Studies (post-2010) (loperamide) |
|---|---|---|---|---|---|
| 210 | 16 | 138 | 1,358 | 196 | 488 |
| Protein | Taxonomy | tariquidar (IC50) | loperamide (IC50) |
|---|---|---|---|
| Cocaine esterase | Homo sapiens (human) | 5.7 | |
| Beta-2 adrenergic receptor | Homo sapiens (human) | 3.005 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 2.5 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 9.27 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Histamine H2 receptor | Homo sapiens (human) | 3.081 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 2.202 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0014 | |
| D(3) dopamine receptor | Homo sapiens (human) | 1.337 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.896 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 3.125 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 4.105 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.033 | |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | 0.239 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.628 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 11 (84.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Choo, EF; Glaeser, H; Higginbotham, JN; Kim, RB; Kurnik, D; Muszkat, M; Ohkubo, T; Shay, SD; Wilkinson, GR; Wood, AJ | 1 |
| Donahue, JP; Kurnik, D; Muszkat, M; Nair, UB; Sofowora, GG; Wilkinson, GR; Wood, AJ | 1 |
| Herscovitch, P; Innis, RB; Kimura, N; Kreisl, WC; Liow, JS; Morse, CL; Pike, VW; Seneca, N; Zoghbi, SS | 1 |
| Brimacombe, KR; Gottesman, MM; Hall, MD; Halldin, C; Innis, RB; Kannan, P; Kreisl, WC; Liow, JS; Pike, VW; Telu, S; Zhang, Y; Zoghbi, SS | 1 |
| Butelman, ER; Caspers, M; Kreek, MJ; Lovell, KM; Prisinzano, TE | 1 |
| Li, H; Shen, GL; Sun, HX; Yuan, M; Zhuang, XM | 1 |
| Amano, N; Hirabayashi, H; Moriwaki, T; Sugimoto, H | 1 |
| Bae, SA; Chong, DJ; Easwaramoorthy, B; Farwell, MD; Ichise, M; Iida, Y | 1 |
| Beduneau, A; Gromand, J; Lamprecht, A; Montesinos, RN; Moulari, B; Pellequer, Y | 1 |
| Bhatia, R; Innis, RB; Kreisl, WC; Morse, CL; Pike, VW; Shetty, HU; Woock, AE; Zoghbi, SS | 1 |
| Béduneau, A; Lamprecht, A; Nieto Montesinos, R; Pellequer, Y | 1 |
| Ahn, JH; Ahn, S; Bae, MA; Chae, JS; Im, SH; Kim, GR; Kim, HR; Kim, P; Kim, SS; Lee, BH; Lee, KR; Lee, YR; Shin, DS; Song, JS; Woo, JC; Yang, JY; Yun, CS | 1 |
1 review(s) available for tariquidar and loperamide
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
3 trial(s) available for tariquidar and loperamide
| Article | Year |
|---|---|
Tariquidar, a selective P-glycoprotein inhibitor, does not potentiate loperamide's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein.
Topics: Adult; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cross-Over Studies; Double-Blind Method; Drug Synergism; Female; Humans; Loperamide; Lymphocytes; Male; Pupil; Quinolines; Young Adult | 2008 |
P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Kinetics; Loperamide; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Quinolines; Radioactive Tracers | 2010 |
Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.
Topics: Administration, Intravenous; Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Dose-Response Relationship, Drug; Female; Humans; Loperamide; Male; Permeability; Positron-Emission Tomography; Quinolines; Safety | 2015 |
9 other study(ies) available for tariquidar and loperamide
| Article | Year |
|---|---|
Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.
Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Dose-Response Relationship, Drug; Loperamide; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Pain; Quinolines; T-Lymphocytes; Testis; Tetrahydroisoquinolines; Tissue Distribution | 2006 |
Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line, Tumor; Humans; Isotope Labeling; Loperamide; Lysosomes; Mice; Positron-Emission Tomography; Quinolines; Radiography; Tritium | 2011 |
Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Blepharoptosis; Blood-Brain Barrier; Central Nervous System; Discrimination, Psychological; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Facial Muscles; Female; Hallucinogens; Loperamide; Macaca mulatta; Male; Quinolines; Receptors, Opioid, kappa; Salvia | 2012 |
[Evaluation of P-glycoprotein mediated in vitro loperamide biliary excretion with sandwich-cultured rat hepatocytes model].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclosporine; Hepatocytes; Loperamide; Male; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Rhodamine 123; Tandem Mass Spectrometry | 2012 |
Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Drug Interactions; Humans; LLC-PK1 Cells; Loperamide; Quinolines; Swine; Verapamil | 2013 |
Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Cyclosporine; Kinetics; Loperamide; Male; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley | 2013 |
Coadministration of P-glycoprotein modulators on loperamide pharmacokinetics and brain distribution.
Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Loperamide; Male; Mass Spectrometry; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tetrahydroisoquinolines; Tissue Distribution | 2014 |
Liposomes Coloaded with Elacridar and Tariquidar To Modulate the P-Glycoprotein at the Blood-Brain Barrier.
Topics: Acridines; Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gene Expression Regulation; Liposomes; Loperamide; Male; Quinolines; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydroisoquinolines; Tissue Distribution | 2015 |
Zebrafish as a Screening Model for Testing the Permeability of Blood-Brain Barrier to Small Molecules.
Topics: Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Membrane Permeability; Drug Delivery Systems; High-Throughput Screening Assays; Loperamide; Male; Mice; Mice, Inbred ICR; Models, Animal; Quinolines; Zebrafish | 2017 |