tariquidar has been researched along with elacridar in 29 studies
| Studies (tariquidar) | Trials (tariquidar) | Recent Studies (post-2010) (tariquidar) | Studies (elacridar) | Trials (elacridar) | Recent Studies (post-2010) (elacridar) |
|---|---|---|---|---|---|
| 210 | 16 | 138 | 284 | 8 | 119 |
| Protein | Taxonomy | tariquidar (IC50) | elacridar (IC50) |
|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 0.4427 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.2852 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 20 (68.97) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Bernhardt, G; Buschauer, A; Egger, M; Fricker, G; König, B; Kühnle, M; Mahringer, A; Müller, C | 1 |
| Müller, H; Pick, A; Wiese, M | 1 |
| Bankstahl, JP; Bankstahl, M; Bauer, F; Dörner, B; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Stanek, J; Wanek, T | 1 |
| Bauer, S; Bernhardt, G; Bürger, K; Buschauer, A; Höcherl, P; König, B; Kühnle, M; Puentes, CO | 1 |
| Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U | 1 |
| Bauer, S; Bernhardt, G; Buschauer, A; König, B; Kühnle, M; Ochoa-Puentes, C | 1 |
| Cutler, M; Lau, JYN; Lee, G; Pitzonka, L; Smolinski, MP; Suh, KH; Urgaonkar, S | 1 |
| Berridge, G; Callaghan, R; Charlton, P; Higgins, CF; Martin, C; Mistry, P | 1 |
| Bootle, D; Charlton, P; Dangerfield, W; Liddle, C; Mistry, P; Okiji, S; Plumb, JA; Stewart, AJ; Templeton, D | 1 |
| Choo, EF; Glaeser, H; Higginbotham, JN; Kim, RB; Kurnik, D; Muszkat, M; Ohkubo, T; Shay, SD; Wilkinson, GR; Wood, AJ | 1 |
| Bernhardt, G; Buschauer, A; Fellner, S; Höcherl, P; Hubensack, M; Müller, C; Spruss, T | 1 |
| Azzariti, A; Berardi, F; Cantore, M; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Paradiso, A; Perrone, MG; Perrone, R; Porcelli, L; Simone, GM | 1 |
| Bankstahl, JP; Bankstahl, M; Brauner, R; Ding, X; Karch, R; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Stundner, G; Wanek, T | 1 |
| Fukumura, T; Hatori, A; Kawamura, K; Konno, F; Nengaki, N; Ogawa, M; Wakizaka, H; Yamasaki, T; Yanamoto, K; Yoshida, Y; Yui, J; Zhang, MR | 1 |
| Bankstahl, JP; Bankstahl, M; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Sauberer, M; Stanek, J; Strommer, S; Wacheck, V; Wanek, T | 1 |
| Bankstahl, JP; Bankstahl, M; Erker, T; Fedrowitz, M; Kuntner, C; Langer, O; Löscher, W; Müller, M; Römermann, K; Stanek, J; Wanek, T; Windhorst, AD | 1 |
| Bankstahl, JP; Bankstahl, M; Karch, R; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müllauer, J; Müller, M; Stanek, J; Wanek, T | 1 |
| Bauer, M; Haslacher, H; Jäger, W; Karch, R; Langer, O; Mitterhauser, M; Müller, M; Philippe, C; Stanek, J; Wadsak, W; Zeitlinger, M | 1 |
| Christlieb, M; Marighetti, F; Pajeva, IK; Steggemann, K; Sterz, K; Wiese, M | 1 |
| Beduneau, A; Gromand, J; Lamprecht, A; Montesinos, RN; Moulari, B; Pellequer, Y | 1 |
| Béduneau, A; Lamprecht, A; Nieto Montesinos, R; Pellequer, Y | 1 |
| Ambudkar, SV; Chufan, EE; Kapoor, K | 1 |
| Bauer, M; Hacker, M; Haslacher, H; Jäger, W; Jungbauer, C; Karch, R; Langer, O; Löscher, W; Maier-Salamon, A; Philippe, C; Römermann, K; Stanek, J; Wadsak, W; Wulkersdorfer, B; Zeitlinger, M | 1 |
| Bauer, M; Blaickner, M; Hacker, M; Langer, O; Philippe, C; Wadsak, W; Zeitlinger, M | 1 |
| Abel, B; Ambudkar, SV; Chufan, EE; Shukla, S | 1 |
| Arabzadeh, S; Behravan, J; Hadizadeh, F; Mollazadeh, S; Sahebkar, A | 1 |
| Bakos, É; Kucsma, N; Német, O; Özvegy-Laczka, C; Patik, I; Szakács, G; Várady, G | 1 |
| Ambudkar, SV; Lusvarghi, S | 1 |
| Bartolucci, G; Braconi, L; Colabufo, NA; Contino, M; Dei, S; Guglielmo, S; Manetti, D; Perrone, MG; Riganti, C; Romanelli, MN; Teodori, E | 1 |
1 review(s) available for tariquidar and elacridar
| Article | Year |
|---|---|
Structural and functional aspects of P-glycoprotein and its inhibitors.
Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Products; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lipid Bilayers; Molecular Targeted Therapy; Piperidines; Protein Conformation; Quinolines; Tetrahydroisoquinolines | 2018 |
2 trial(s) available for tariquidar and elacridar
| Article | Year |
|---|---|
Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier.
Topics: Acridines; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Carbon Radioisotopes; Humans; Male; Neoplasm Proteins; Positron-Emission Tomography; Protein Binding; Quinolines; Tetrahydroisoquinolines | 2013 |
Whole-Body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans.
Topics: Acridines; Adult; Carbon Radioisotopes; Humans; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Quinolines; Radiation Dosage; Radiopharmaceuticals; Tetrahydroisoquinolines; Tissue Distribution; Whole-Body Counting | 2016 |
26 other study(ies) available for tariquidar and elacridar
| Article | Year |
|---|---|
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Female; Humans; Inhibitory Concentration 50; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Quinolines; Structure-Activity Relationship | 2009 |
Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line, Tumor; Chlorophyll; Humans; Molecular Conformation; Neoplasm Proteins; Phenylurea Compounds; Small Molecule Libraries | 2010 |
Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Autoradiography; Blood-Brain Barrier; Carbon Radioisotopes; Female; Mice; Mice, Knockout; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley | 2010 |
Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasm Proteins; Protein Transport; Quinolines | 2011 |
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2012 |
Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.
Topics: | 2013 |
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Drug Discovery; Humans; Intestinal Mucosa; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Tetrazoles | 2021 |
Communication between multiple drug binding sites on P-glycoprotein.
Topics: Acridines; Allosteric Regulation; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Benzylidene Compounds; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Drug Interactions; Isoquinolines; Kinetics; Nicardipine; Paclitaxel; Quinolines; Radioligand Assay; Radiopharmaceuticals; Rhodamine 123; Tetrahydroisoquinolines; Tritium; Vinblastine | 2000 |
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
Topics: Acridines; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Division; Cyclosporins; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Isoquinolines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Quinolines; Tetrahydroisoquinolines; Time Factors; Treatment Outcome; Tritium; Xenograft Model Antitumor Assays | 2001 |
Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.
Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Dose-Response Relationship, Drug; Loperamide; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Pain; Quinolines; T-Lymphocytes; Testis; Tetrahydroisoquinolines; Tissue Distribution | 2006 |
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.
Topics: Acridines; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Flow Cytometry; Mice; Mice, Nude; Paclitaxel; Quinolines; Tetrahydroisoquinolines | 2008 |
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Female; Humans; Isoquinolines; Ligands; Quinolines; Structure-Activity Relationship; Tetrahydroisoquinolines | 2008 |
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood Proteins; Blood-Brain Barrier; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tetrahydroisoquinolines; Verapamil | 2010 |
Synthesis and in vivo evaluation of ¹⁸F-fluoroethyl GF120918 and XR9576 as positron emission tomography probes for assessing the function of drug efflux transporters.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; Fluorine Radioisotopes; Humans; Mice; Molecular Probes; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Tetrahydroisoquinolines; Tissue Distribution | 2011 |
A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Mice; Phenotype; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Verapamil | 2012 |
Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Cell Line, Transformed; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Functional Neuroimaging; Mice; Mice, Knockout; Quinolines; Radionuclide Imaging; Tetrahydroisoquinolines | 2013 |
Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Carbon Radioisotopes; Female; Gene Expression Regulation; Kinetics; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Verapamil | 2013 |
Interactions of the multidrug resistance modulators tariquidar and elacridar and their analogues with P-glycoprotein.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Cell Line, Tumor; Drug Resistance, Multiple; Humans; Mice; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Quinolines; Rhodamine 123; Structure-Activity Relationship; Substrate Specificity; Tetrahydroisoquinolines | 2013 |
Coadministration of P-glycoprotein modulators on loperamide pharmacokinetics and brain distribution.
Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Loperamide; Male; Mass Spectrometry; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tetrahydroisoquinolines; Tissue Distribution | 2014 |
Liposomes Coloaded with Elacridar and Tariquidar To Modulate the P-Glycoprotein at the Blood-Brain Barrier.
Topics: Acridines; Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gene Expression Regulation; Liposomes; Loperamide; Male; Quinolines; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydroisoquinolines; Tissue Distribution | 2015 |
Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
Topics: Acridines; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biocatalysis; Dibenzocycloheptenes; HeLa Cells; Humans; Hydrogen Bonding; Hydrolysis; Lepidoptera; Ligands; Membrane Transport Modulators; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Mutant Proteins; Quinolines; Recombinant Proteins; Tetrahydroisoquinolines | 2016 |
Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier.
Topics: Acridines; Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Female; Humans; Male; Neoplasm Proteins; Pilot Projects; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Tissue Distribution; Verapamil; Young Adult | 2016 |
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Baculoviridae; Binding Sites; Detergents; Dibenzocycloheptenes; Drug Delivery Systems; Drug Evaluation, Preclinical; Glucosides; Humans; Hydrolysis; Inhibitory Concentration 50; Insecta; Ligands; Mice; Micelles; Peptides, Cyclic; Protein Binding; Quinolines; Tetrahydroisoquinolines; Verapamil | 2017 |
A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2.
Topics: Acridines; Cell Line; Dibenzocycloheptenes; Fluorescent Dyes; Humans; Organic Anion Transporters; Quinolines; Tetrahydroisoquinolines | 2020 |
ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line; Dibenzocycloheptenes; Gene Expression Regulation; Humans; Insecta; Protein Binding; Protein Conformation; Protein Stability; Quinolines; Temperature; Tetrahydroisoquinolines; Verapamil | 2019 |
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers.
Topics: Amides; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Neoplasm Proteins; Structure-Activity Relationship; Tetrazoles | 2023 |