Page last updated: 2024-09-04

tariquidar and acridines

tariquidar has been researched along with acridines in 21 studies

Compound Research Comparison

Studies
(tariquidar)
Trials
(tariquidar)
Recent Studies (post-2010)
(tariquidar)
Studies
(acridines)
Trials
(acridines)
Recent Studies (post-2010) (acridines)
210161386,987169856

Protein Interaction Comparison

ProteinTaxonomytariquidar (IC50)acridines (IC50)
AcetylcholinesteraseHomo sapiens (human)6.84

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (23.81)29.6817
2010's15 (71.43)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Berridge, G; Callaghan, R; Charlton, P; Higgins, CF; Martin, C; Mistry, P1
Bootle, D; Charlton, P; Dangerfield, W; Liddle, C; Mistry, P; Okiji, S; Plumb, JA; Stewart, AJ; Templeton, D1
Choo, EF; Glaeser, H; Higginbotham, JN; Kim, RB; Kurnik, D; Muszkat, M; Ohkubo, T; Shay, SD; Wilkinson, GR; Wood, AJ1
Bernhardt, G; Buschauer, A; Fellner, S; Höcherl, P; Hubensack, M; Müller, C; Spruss, T1
Azzariti, A; Berardi, F; Cantore, M; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Paradiso, A; Perrone, MG; Perrone, R; Porcelli, L; Simone, GM1
Bankstahl, JP; Bankstahl, M; Brauner, R; Ding, X; Karch, R; Kuntner, C; Langer, O; Löscher, W; Meier, M; Müller, M; Stanek, J; Stundner, G; Wanek, T1
Fukumura, T; Hatori, A; Kawamura, K; Konno, F; Nengaki, N; Ogawa, M; Wakizaka, H; Yamasaki, T; Yanamoto, K; Yoshida, Y; Yui, J; Zhang, MR1
Bankstahl, JP; Bankstahl, M; Erker, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Sauberer, M; Stanek, J; Strommer, S; Wacheck, V; Wanek, T1
Bankstahl, JP; Bankstahl, M; Erker, T; Fedrowitz, M; Kuntner, C; Langer, O; Löscher, W; Müller, M; Römermann, K; Stanek, J; Wanek, T; Windhorst, AD1
Bankstahl, JP; Bankstahl, M; Karch, R; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müllauer, J; Müller, M; Stanek, J; Wanek, T1
Bauer, M; Haslacher, H; Jäger, W; Karch, R; Langer, O; Mitterhauser, M; Müller, M; Philippe, C; Stanek, J; Wadsak, W; Zeitlinger, M1
Christlieb, M; Marighetti, F; Pajeva, IK; Steggemann, K; Sterz, K; Wiese, M1
Beduneau, A; Gromand, J; Lamprecht, A; Montesinos, RN; Moulari, B; Pellequer, Y1
Béduneau, A; Lamprecht, A; Nieto Montesinos, R; Pellequer, Y1
Ambudkar, SV; Chufan, EE; Kapoor, K1
Bauer, M; Hacker, M; Haslacher, H; Jäger, W; Jungbauer, C; Karch, R; Langer, O; Löscher, W; Maier-Salamon, A; Philippe, C; Römermann, K; Stanek, J; Wadsak, W; Wulkersdorfer, B; Zeitlinger, M1
Bauer, M; Blaickner, M; Hacker, M; Langer, O; Philippe, C; Wadsak, W; Zeitlinger, M1
Abel, B; Ambudkar, SV; Chufan, EE; Shukla, S1
Arabzadeh, S; Behravan, J; Hadizadeh, F; Mollazadeh, S; Sahebkar, A1
Bakos, É; Kucsma, N; Német, O; Özvegy-Laczka, C; Patik, I; Szakács, G; Várady, G1
Ambudkar, SV; Lusvarghi, S1

Reviews

1 review(s) available for tariquidar and acridines

ArticleYear
Structural and functional aspects of P-glycoprotein and its inhibitors.
    Life sciences, 2018, Dec-01, Volume: 214

    Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Products; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lipid Bilayers; Molecular Targeted Therapy; Piperidines; Protein Conformation; Quinolines; Tetrahydroisoquinolines

2018

Trials

2 trial(s) available for tariquidar and acridines

ArticleYear
Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:8

    Topics: Acridines; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Carbon Radioisotopes; Humans; Male; Neoplasm Proteins; Positron-Emission Tomography; Protein Binding; Quinolines; Tetrahydroisoquinolines

2013
Whole-Body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:8

    Topics: Acridines; Adult; Carbon Radioisotopes; Humans; Metabolic Clearance Rate; Organ Specificity; Positron-Emission Tomography; Quinolines; Radiation Dosage; Radiopharmaceuticals; Tetrahydroisoquinolines; Tissue Distribution; Whole-Body Counting

2016

Other Studies

18 other study(ies) available for tariquidar and acridines

ArticleYear
Communication between multiple drug binding sites on P-glycoprotein.
    Molecular pharmacology, 2000, Volume: 58, Issue:3

    Topics: Acridines; Allosteric Regulation; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Benzylidene Compounds; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Drug Interactions; Isoquinolines; Kinetics; Nicardipine; Paclitaxel; Quinolines; Radioligand Assay; Radiopharmaceuticals; Rhodamine 123; Tetrahydroisoquinolines; Tritium; Vinblastine

2000
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
    Cancer research, 2001, Jan-15, Volume: 61, Issue:2

    Topics: Acridines; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Division; Cyclosporins; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Isoquinolines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Quinolines; Tetrahydroisoquinolines; Time Factors; Treatment Outcome; Tritium; Xenograft Model Antitumor Assays

2001
Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:3

    Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Dose-Response Relationship, Drug; Loperamide; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Pain; Quinolines; T-Lymphocytes; Testis; Tetrahydroisoquinolines; Tissue Distribution

2006
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.
    Journal of cancer research and clinical oncology, 2008, Volume: 134, Issue:5

    Topics: Acridines; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Flow Cytometry; Mice; Mice, Nude; Paclitaxel; Quinolines; Tetrahydroisoquinolines

2008
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
    Bioorganic & medicinal chemistry, 2008, Jan-01, Volume: 16, Issue:1

    Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Female; Humans; Isoquinolines; Ligands; Quinolines; Structure-Activity Relationship; Tetrahydroisoquinolines

2008
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:5

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood Proteins; Blood-Brain Barrier; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tetrahydroisoquinolines; Verapamil

2010
Synthesis and in vivo evaluation of ¹⁸F-fluoroethyl GF120918 and XR9576 as positron emission tomography probes for assessing the function of drug efflux transporters.
    Bioorganic & medicinal chemistry, 2011, Jan-15, Volume: 19, Issue:2

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; Fluorine Radioisotopes; Humans; Mice; Molecular Probes; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Tetrahydroisoquinolines; Tissue Distribution

2011
A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
    European journal of nuclear medicine and molecular imaging, 2012, Volume: 39, Issue:1

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Mice; Phenotype; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Verapamil

2012
Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Cell Line, Transformed; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Functional Neuroimaging; Mice; Mice, Knockout; Quinolines; Radionuclide Imaging; Tetrahydroisoquinolines

2013
Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats.
    Nuclear medicine and biology, 2013, Volume: 40, Issue:6

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Carbon Radioisotopes; Female; Gene Expression Regulation; Kinetics; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Verapamil

2013
Interactions of the multidrug resistance modulators tariquidar and elacridar and their analogues with P-glycoprotein.
    ChemMedChem, 2013, Volume: 8, Issue:10

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Cell Line, Tumor; Drug Resistance, Multiple; Humans; Mice; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Quinolines; Rhodamine 123; Structure-Activity Relationship; Substrate Specificity; Tetrahydroisoquinolines

2013
Coadministration of P-glycoprotein modulators on loperamide pharmacokinetics and brain distribution.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:4

    Topics: Acridines; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Loperamide; Male; Mass Spectrometry; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tetrahydroisoquinolines; Tissue Distribution

2014
Liposomes Coloaded with Elacridar and Tariquidar To Modulate the P-Glycoprotein at the Blood-Brain Barrier.
    Molecular pharmaceutics, 2015, Nov-02, Volume: 12, Issue:11

    Topics: Acridines; Animals; Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gene Expression Regulation; Liposomes; Loperamide; Male; Quinolines; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydroisoquinolines; Tissue Distribution

2015
Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
    Biochemical pharmacology, 2016, Feb-01, Volume: 101

    Topics: Acridines; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biocatalysis; Dibenzocycloheptenes; HeLa Cells; Humans; Hydrogen Bonding; Hydrolysis; Lepidoptera; Ligands; Membrane Transport Modulators; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Mutant Proteins; Quinolines; Recombinant Proteins; Tetrahydroisoquinolines

2016
Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier.
    Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:2

    Topics: Acridines; Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Female; Humans; Male; Neoplasm Proteins; Pilot Projects; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Quinolines; Tetrahydroisoquinolines; Tissue Distribution; Verapamil; Young Adult

2016
Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.
    The Journal of biological chemistry, 2017, 04-28, Volume: 292, Issue:17

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Baculoviridae; Binding Sites; Detergents; Dibenzocycloheptenes; Drug Delivery Systems; Drug Evaluation, Preclinical; Glucosides; Humans; Hydrolysis; Inhibitory Concentration 50; Insecta; Ligands; Mice; Micelles; Peptides, Cyclic; Protein Binding; Quinolines; Tetrahydroisoquinolines; Verapamil

2017
A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2.
    The FEBS journal, 2020, Volume: 287, Issue:12

    Topics: Acridines; Cell Line; Dibenzocycloheptenes; Fluorescent Dyes; Humans; Organic Anion Transporters; Quinolines; Tetrahydroisoquinolines

2020
ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.
    The Biochemical journal, 2019, 12-19, Volume: 476, Issue:24

    Topics: Acridines; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Line; Dibenzocycloheptenes; Gene Expression Regulation; Humans; Insecta; Protein Binding; Protein Conformation; Protein Stability; Quinolines; Temperature; Tetrahydroisoquinolines; Verapamil

2019