Page last updated: 2024-09-02

tanshinone and tanshinone ii a

tanshinone has been researched along with tanshinone ii a in 13 studies

Compound Research Comparison

Studies (tanshinone)	Trials (tanshinone)	Recent Studies (post-2010) (tanshinone)	Studies (tanshinone ii a)	Trials (tanshinone ii a)	Recent Studies (post-2010) (tanshinone ii a)
1,445	10	1,033	61	0	41

Protein Interaction Comparison

Protein	Taxonomy	tanshinone ii a (IC50)
Chain A, RNA-directed RNA polymerase NS5	Dengue virus 2 16681-PDK53	100
Apoptotic peptidase activating factor 1	Homo sapiens (human)	4.82
Spike glycoprotein	Betacoronavirus England 1	0.8
Replicase polyprotein 1ab	Betacoronavirus England 1	0.8
caspase-9 isoform alpha precursor	Homo sapiens (human)	11.2
caspase-3 isoform a preproprotein	Homo sapiens (human)	11.2
Telomerase reverse transcriptase	Homo sapiens (human)	2.75
Transmembrane protease serine 2	Homo sapiens (human)	0.8
Procathepsin L	Homo sapiens (human)	0.8
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	1.14
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	1.2
Replicase polyprotein 1ab	Human coronavirus 229E	0.8
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	0.8
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	1.1855
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	8.69
Tyrosine-protein phosphatase non-receptor type 6	Homo sapiens (human)	2.14
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	0.8
Tyrosine-protein phosphatase non-receptor type 11	Homo sapiens (human)	2.59
Hypoxia-inducible factor 1-alpha	Homo sapiens (human)	6.855
Endothelial PAS domain-containing protein 1	Homo sapiens (human)	6.855
Angiotensin-converting enzyme 2	Homo sapiens (human)	0.8

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (15.38)	29.6817
2010's	8 (61.54)	24.3611
2020's	3 (23.08)	2.80

Authors

Authors	Studies
Bastow, KF; Don, MJ; Lee, KH; Lin, YL; Nakamura, S; Sun, CM; Wang, X; Wu, TS; Yu, HJ	1
Dat, NT; Hong, YS; Jin, X; Kim, YH; Lee, D; Lee, JH; Lee, JJ; Lee, K	1
Cheung, CC; Fung, KP; Lai, PB; Lee, WY; Liu, KW; Wong, J; Yeung, JH	1
Adams, M; Fronza, M; Hamburger, M; Heinzmann, B; Laufer, S; Merfort, I; Murillo, R; Ślusarczyk, S	1
Jarstfer, MB; Keppler, BR; Lee, KH; Soares, J; Wang, X	1
Jeong, HJ; Kim, DW; Kim, JH; Kim, YM; Kwon, HJ; Lee, WS; Park, JY; Park, KH; Park, SJ; Ryu, YB	1
Edwards, CC; Hatfield, MJ; Hyatt, JL; Jeffries, C; Lemoff, A; Potter, PM; Tsurkan, LG; Yan, B	1
Liu, W; Loh, ML; Qu, CK; Tang, LD; Xu, G; Xu, WR; Yu, B	1
Byun, BJ; Chae, CH; Cho, H; Choi, G; Kim, HY; Lee, JY; Park, WK; Ryu, SY; Woo, J	1
Cheung, J; Gary, EN; Rosenberry, TL; Shiomi, K	1
Banerjee, J; Biswas, N; Bural, S; Dey, A; Gain, C; Kar, GK; Rakshit, M; Saha, A; Sarkar, A	1
Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW	1
Hu, Y; Jadhav, P; Tan, B; Tan, H; Wang, J	1

Reviews

1 review(s) available for tanshinone and tanshinone ii a

Article	Year
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease. Journal of medicinal chemistry, 2022, 06-09, Volume: 65, Issue:11 Topics: Antiviral Agents; Coronavirus Papain-Like Proteases; COVID-19 Drug Treatment; Humans; Pandemics; Protease Inhibitors; SARS-CoV-2	2022

Other Studies

12 other study(ies) available for tanshinone and tanshinone ii a

Article	Year
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza. Journal of medicinal chemistry, 2004, Nov-04, Volume: 47, Issue:23 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Furans; Humans; Pyrones; Receptor, ErbB-2; Receptors, Estrogen; Salvia miltiorrhiza	2004
Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1. Journal of natural products, 2007, Volume: 70, Issue:7 Topics: Abietanes; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1; Korea; Plants, Medicinal; Salvia miltiorrhiza; Tumor Cells, Cultured	2007
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells. Journal of natural products, 2010, May-28, Volume: 73, Issue:5 Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxorubicin; Drug Resistance, Neoplasm; Humans; Models, Biological; Molecular Structure; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza	2010
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorganic & medicinal chemistry, 2011, Aug-15, Volume: 19, Issue:16 Topics: Abietanes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Humans; Lamiaceae; Phytotherapy; Plant Extracts; Plant Roots; Salvia; Structure-Activity Relationship	2011
ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide. Bioorganic & medicinal chemistry letters, 2011, Dec-15, Volume: 21, Issue:24 Topics: Abietanes; Benzoquinones; Catalase; Cell Line, Tumor; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Oxidation-Reduction; Telomerase	2011
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases. Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19 Topics: Abietanes; Cysteine Proteinase Inhibitors; Humans; Kinetics; Protein Binding; Salvia miltiorrhiza; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Ubiquitination	2012
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen"). Journal of natural products, 2013, Jan-25, Volume: 76, Issue:1 Topics: Abietanes; Algorithms; Camptothecin; Carboxylesterase; Clinical Trials, Phase I as Topic; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Irinotecan; Medicine, Chinese Traditional; Molecular Structure; Phenanthrolines; Plant Roots; Salvia miltiorrhiza	2013
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11). Journal of medicinal chemistry, 2013, Sep-26, Volume: 56, Issue:18 Topics: Animals; Catalytic Domain; Cell Line, Tumor; Computer-Aided Design; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Humans; Mice; Models, Molecular; Mutation; Phenanthrenes; Protein Tyrosine Phosphatase, Non-Receptor Type 11	2013
Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors. Bioorganic & medicinal chemistry letters, 2014, Jun-01, Volume: 24, Issue:11 Topics: Abietanes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Molecular Conformation; Polycomb Repressive Complex 2; Structure-Activity Relationship	2014
Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS medicinal chemistry letters, 2013, Nov-14, Volume: 4, Issue:11 Topics:	2013
Identification of two novel thiophene analogues as inducers of autophagy mediated cell death in breast cancer cells. Bioorganic & medicinal chemistry, 2021, 05-01, Volume: 37 Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Thiophenes; Unfolded Protein Response	2021
Perspectives on SARS-CoV-2 Main Protease Inhibitors. Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23 Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors	2021