tanshinone has been researched along with phenanthrenes in 436 studies
| Studies (tanshinone) | Trials (tanshinone) | Recent Studies (post-2010) (tanshinone) | Studies (phenanthrenes) | Trials (phenanthrenes) | Recent Studies (post-2010) (phenanthrenes) |
|---|---|---|---|---|---|
| 1,445 | 10 | 1,033 | 7,618 | 110 | 3,211 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (3.67) | 18.7374 |
| 1990's | 28 (6.42) | 18.2507 |
| 2000's | 273 (62.61) | 29.6817 |
| 2010's | 107 (24.54) | 24.3611 |
| 2020's | 12 (2.75) | 2.80 |
| Authors | Studies |
|---|---|
| Pan, LM; Zhan, S; Zhou, Y | 1 |
| Kito, H; Nagase, H; Ose, Y; Sakai, Y; Sato, M; Sato, T | 1 |
| Chang, HM; Choang, TF; Chui, KY; Hon, PM; Lee, CM; Wong, HN | 1 |
| Chang, WL; Chen, CF; Wu, WL | 1 |
| Li, XH; Tang, RY | 1 |
| Fujimoto, K; Niwa, T; Takeo, S; Tanonaka, K; Yagi, A | 1 |
| Liu, Y; Wang, B; Xie, P | 1 |
| Tao, LL; Xu, JT; Yuan, JM | 1 |
| Fujimoto, K; Hirai, K; Kawaguchi, K; Ogawa, M; Takeo, S; Tanonaka, K; Yagi, A | 1 |
| Ji, J; Luo, HW | 1 |
| Han, GR | 1 |
| Gao, JY | 1 |
| Shi, YD | 1 |
| Chen, GF | 1 |
| Bao, XS; Chen, JZ; Guan, DP; Ni, XB; Wu, PJ; Yuan, JX | 1 |
| Qiao, M; Shen, JX; Zhang, PZ | 1 |
| Chang, XL; Guan, YM | 1 |
| Chiou, GC; Lei, XL | 1 |
| Yao, MR | 1 |
| Bai, DL; Sun, CJ | 1 |
| Wang, DB | 1 |
| Gao, YG | 1 |
| Liu, AS; Wang, DB | 1 |
| Gao, YG; Tang, JX; Wang, LZ | 1 |
| Luo, HW; Sheng, LS; Wei, P; Xu, LF; Zhang, SQ | 1 |
| Liu, H; Song, J; Zhang, Y; Zhao, B | 1 |
| Huang, G; Wang, X; Yuan, S | 1 |
| Cao, EH; Liu, XQ; Wang, JJ; Xu, NF | 1 |
| Hou, JW; Jiang, W; Xin, WJ; Zhao, BL; Zhao, Y | 1 |
| Choi, SU; Lee, CO; Ryu, SY | 1 |
| Wang, C; Wang, X; Yuan, S | 1 |
| Huang, R; Song, Y; Wang, X; Yuan, S | 1 |
| Jia, Y; Sun, Y; Wang, S | 1 |
| Lu, G; Qi, J; Song, J; Zhang, Y | 1 |
| Chen, F; Chen, H; Song, JY; Yuan, JP; Zhang, YL | 1 |
| Du, Z; Xu, B; Xu, G | 1 |
| Xu, W; Zheng, J; Zhou, Z | 1 |
| Jeon, WK; Kim, YO; Park, HJ; Sung, HJ; Yoon, Y | 1 |
| An, KS; Choi, SM; Sung, HJ; Yoon, Y | 1 |
| Hou, JW; Ma, GE; Xin, WJ; Zhao, BL; Zhou, GY | 1 |
| Hirota, Y; Hoshiai, K; Ichimori, K; Li, M; Nakazawa, H; Niu, XL; Yang, X | 1 |
| Chung, SW; Kang, BY; Kim, SH; Kim, TS; Ryu, SY | 1 |
| Kong, L; Ni, J; Wang, H; Zou, H | 1 |
| Chen, X; Li, W; Liu, X; Luo, H; Xia, W | 1 |
| Ito, Y; Tian, G; Yang, F; Zhang, T; Zhang, Y | 1 |
| Liu, XJ; Wu, WT | 1 |
| Liu, H; Niu, G; Pan, X | 1 |
| Cheng, H; Luo, Q; Wang, K | 1 |
| Chen, H; Jiang, Y; Liu, Y | 2 |
| Bagherzadeh, K; Budnik, BA; Christensen, J; Jaroszewski, JW; Kharazmi, A; Sairafianpour, M; Staerk, D | 1 |
| Ji, ZN; Liu, GQ | 1 |
| Ito, Y; Tian, G; Zhang, T; Zhang, Y | 1 |
| Jia, Y; Liang, Y; Liu, T; Meng, W; Yang, Y; Yuan, S | 1 |
| Chung, MY; Kang, JS; Kim, YK; Kim, YS; Ko, JS; Lee, HS; Rho, MC; Ryu, SY | 1 |
| Pan, LQ; Wang, K; Zhao, HR; Zhao, Y | 1 |
| Chang, HW; Kang, SS; Kim, HP; Kim, SY; Moon, TC; Son, KH | 1 |
| Deng, C; Jia, Y; Liu, T; Meng, W; Yang, Y | 1 |
| Hou, A; Liang, X; Qian, Z; Ruan, Z | 1 |
| Jia, Y; Liang, Y; Liu, T; Niu, T; Qin, H; Qin, P; Xu, C; Yang, Y; Yuan, S | 1 |
| Chu, MQ; Gu, HC; Liu, GJ | 1 |
| Wen, ZM; Xu, LX | 1 |
| He, LN; He, SB; Jiang, Y; Liu, C; Wang, J; Yang, J | 1 |
| Jin, XS; Li, YC; Liu, LM; Zeng, JQ | 1 |
| Fu, J; Qi, JJ; Ren, CL; Song, JY; Zhang, YL | 1 |
| Guo, C; Huo, Y; Shao, Y; Zhang, C | 1 |
| Chen, B; Liu, LL; Wu, YT; Xing, WX; Zhu, M | 1 |
| Jia, Y; Li, Y; Liu, T; Meng, W; Wu, Y; Yang, Y | 1 |
| Chen, X; Song, Y; Wang, Y; Yang, Y; Yuan, S | 1 |
| Kim, JY; Kim, KM; Lee, SJ; Nan, JX; Park, PH; Sohn, DH; Zhao, YZ | 1 |
| Lesniak, W; Schacht, J; Sha, SH; Wang, AM | 1 |
| Feng, YX; Guo, BL; Zhao, YJ | 1 |
| Chung, SK; Lam, BY; Lo, AC; Luo, HW; Sucher, NJ; Sun, X | 1 |
| Fu, LB; Tang, Y; Tang, ZZ | 1 |
| Chen, TL; Jan, WC; Kuo, YH; Lin, YL; Peng, HC; Peter Guengerich, F; Ueng, YF | 1 |
| Cheng, Y; Deng, C; Jia, Y; Li, L; Liang, X; Liu, T; Meng, W; Yang, Y | 1 |
| Chu, MQ; Liu, GJ | 1 |
| Wang, F; Yang, P; Zhang, LW | 1 |
| Abliz, Z; Hou, PL; Li, YW; Qiao, JP | 1 |
| Fu, L; Tang, Y; Tang, Z | 1 |
| Liu, Y; Wang, X | 1 |
| Lu, WH; Wang, NP; Yang, XF; Zeng, FD | 1 |
| Chen, CF; Kuo, YH; Lin, YL; Ueng, YF; Wang, SY | 1 |
| Zhao, J | 1 |
| Wang, XJ; Wei, YQ; Yuan, SL | 1 |
| Jang, SI; Jeong, SI; Kim, HJ; Kim, HM; Kim, KJ; Park, R; You, YO; Yu, HH | 1 |
| Cheuk, WK; Wu, J; Yan, Q; Zhang, C | 1 |
| Dong, C; Li, JF; Shuang, SM; Wei, YX; Xu, ZC | 1 |
| Ha, H; Han, SH; Huang, H; Kim, HH; Kim, JH; Kwak, HB; Lee, SW; Lee, ZH; Woo, ER | 1 |
| Ai, CM; Chen, HQ; Cui, L; Deng, YF; Liu, YY; Wu, T | 1 |
| Liang, FL; Wu, GX; Yan, H; Zhou, JM | 1 |
| Len, SM; Ong, ES | 1 |
| Guo, YB; Huang, GQ; Lu, YR; Song, Y; Xiao, L; Yang, Y; Zhang, J | 1 |
| Dai, JP; Li, LX; Ru, LQ; Yin, GF; Zhao, B | 1 |
| Li, SF; Wang, XJ; Wei, YQ; Xiao, F; Yuan, SL; Zhang, J | 1 |
| Gu, M; Ouyang, F; Su, Z; Zhang, G | 1 |
| Chuan, D; Junfen, L; Yuexian, F | 1 |
| Huang, CL; Liu, ZG; Meng, WT; Yang, YM | 1 |
| Cho, DI; Choi, HK; Choi, HS; Im, SY; Kim, KM; Ryu, SY | 1 |
| Chen, YJ; Kuo, YH; Liao, HF; Shyu, SY; Yang, YC | 1 |
| Fan, Q; Li, BY; Lv, HY; Zhang, N | 1 |
| Fan, GJ; Fan, Q; Yang, PM; Zhao, JY | 1 |
| Ge, X; Wu, J | 1 |
| Deng, HS; Han, JP; Liang, ZS; Sun, Q; Wang, JM; Wei, XR | 1 |
| Du, JR; Li, X; Qian, ZM; Zhang, LF; Zhang, R | 1 |
| Han, JP; Liang, ZS; Liu, WT; Sun, Q; Wang, JM; Wang, WL; Wei, XR | 1 |
| Huang, GQ; Song, Y; Wang, XJ; Yang, YM; Yuan, SL | 1 |
| Chang, W; He, J; Shi, Z; Yao, T; Zhao, M | 1 |
| Chen, B; Kong, J; Shen, X | 1 |
| Du, JR; Li, X; Qian, ZM; Zhang, R | 1 |
| Gao, X; Wang, H; Zhang, B | 1 |
| Liu, G; Lu, Y; Wang, W; Wang, X; Wei, Y; Yuan, S; Zhang, J | 1 |
| Hur, JM; Jung, HJ; Kwon, HJ; Shim, JS | 1 |
| Chang, CC; Chau, GY; Chau, YP; Don, MJ; Jeng, CJ; Kung, HN; Wang, AG; Yang, LJ | 1 |
| Hu, Z; Tan, RX; Wu, J; Yan, Q | 1 |
| Gu, M; Ouyang, F; Su, ZG | 1 |
| Fu, R; Jing, LP; Liang, Y; Qu, W; Song, WX; Wang, J; Wu, XZ | 1 |
| Chen, LN; Zhu, XX | 1 |
| Baba, K; Taniguchi, M; Xiao, YQ; Zhang, C | 1 |
| Deng, H; Hu, H; Huang, F; Zhang, Y | 1 |
| Du, Z; Liu, J; Qin, B; Zhu, J | 1 |
| Chen, HX; Gao, WY; Guo, XH; Huang, LQ | 1 |
| Hao, H; Li, J; Li, P; Wang, G | 1 |
| Ding, Z; Hao, H; Li, J; Li, P; Wang, G | 1 |
| Choi, DY; Lee, SY; Woo, ER | 1 |
| Chen, J; Du, R; Hang, TJ; Song, M; Zhang, ZhX | 1 |
| Chan, WY; Chik, KW; Fok, TF; Fung, KP; Gu, GJ; Li, K; Ng, HK; Ng, PC; Wang, CC; Woo, KS; Xia, WJ; Yang, M | 1 |
| Chow, MS; Zhou, L; Zuo, Z | 1 |
| Hao, HP; Li, J; Li, P; Wang, GJ; Zheng, CN | 3 |
| Deng, CQ; Meng, WT; Yang, YM; Zhang, HL | 1 |
| Chen, H; Chen, Y; Liang, Y; Long, B; Zeng, Z | 1 |
| Cao, W; Liu, W; Qin, H; Suo, Z; Zheng, J | 1 |
| Hu, YJ; Li, HL; Zhang, SY; Zhang, ZY | 1 |
| Guan, S; Guo, D; Liu, A; Sun, J; Xu, M; Yang, M | 1 |
| Hu, ZD; Wu, JY; Yan, Q | 1 |
| Guan, XM; Meng, XF; Peng, B; Shi, J; Zhang, C; Zou, XJ | 1 |
| Du, JR; Li, X; Qian, ZM; Sun, W; Wang, WD; Zheng, H; Zheng, XY; Zong, X | 1 |
| Jang, SI; Jeong, SI; Kim, HJ; Kim, YJ; You, YO | 1 |
| Han, CJ; Lin, R; Liu, JT; Wang, WR; Yang, GD | 1 |
| Ha, H; Kim, HH; Kim, HN; Kwak, HB; Lee, JH; Lee, S; Lee, ZH; Woo, ER; Yang, D | 1 |
| Guo, DA; Guo, H; Lin, YH; Liu, AH; Sun, JH; Yang, M | 1 |
| Jiang, X; Wang, L; Yang, J; Zhou, J | 1 |
| Li, ZY; Liu, XL; Wang, HG | 1 |
| Han, SY; Kim, BT; Kim, MH; Kim, MS; Kim, SH; Lee, JS; Min, YK; Yu, CM | 1 |
| Lee, KH; Morris-Natschke, SL; Wang, X | 1 |
| Cheng, HM; Li, HL; Zhang, ZY | 1 |
| Jiang, S; Lin, P; Lu, Y; Ren, J; Wang, J; Wang, Q; Wang, X; Wu, Y; Xiong, Z; Yang, H; Yuan, S; Zhang, J | 1 |
| Huang, M; Huang, RW; Li, XD; Lin, DJ; Liu, JJ; Liu, PQ | 1 |
| Hiroshi, K; Jiang, T; Xu, JK; Yao, XS; Zheng, JJ | 1 |
| Kwok, KW; Shi, M; Wu, JY | 1 |
| Cui, N; Ding, Z; Hao, H; Li, J; Wang, G; Xie, L | 2 |
| Cai, P; Wang, NS; Xu, YH | 1 |
| Chen, HX; Chen, W; Gao, WY; Guo, XH; Huang, LQ; Xiao, PG | 1 |
| Guo, DA; Liu, AH; Sun, JH; Wang, XM; Xu, M; Yang, M | 1 |
| Guo, ZX; Shi, CX; Yang, YW; Zhu, GG | 1 |
| Liu, T; Yang, YM | 1 |
| Wang, SQ; Zhang, HS | 1 |
| Liu, YR; Maitz, MF; Qu, SX; Tan, R; Weng, J | 1 |
| Huang, KJ; Wang, H; Xie, WZ; Zhang, HS | 1 |
| Bao, L; Chen, S; Gao, J; Huang, H; Li, R; Liu, P; Tang, F; Wang, P; Wang, T; Wu, X; Zhang, H | 1 |
| Chen, WG; Li, QX; Liu, YH; Qiu, Y; Zhong, ZH | 1 |
| Bi, HC; Chen, X; Ding, L; Huang, M; Law, FC; Pan, Y; Xu, CS; Xu, Q; Zhao, LZ; Zhong, GP | 1 |
| He, Y; Li, Y; Liu, Y; Luo, XJ | 1 |
| Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Sheu, FS; Wen, JY; Yu, XQ; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Fang, CX; Li, XY; Tang, WK; Yang, Q; Zhang, JX; Zhang, XL; Zheng, CY | 1 |
| Chen, X; Duan, W; Li, XT; Liang, J; Lin, SG; Wen, JY; Yu, XQ; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Cui, GH; Huang, LQ; Qiu, DY; Wang, XY | 1 |
| Bi, Y; Hou, S; Jin, H; Li, H; Liang, Z; Mao, S | 1 |
| Jiang, X; Li, C; Wang, L; Xu, W | 1 |
| Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Liu, PQ; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Hang, TJ; Song, M; Zhang, ZX | 1 |
| Li, P; Li, SP; Wang, YT; Yang, FQ | 1 |
| Chen, J; Fu, J; Huang, H; Liu, J; Liu, P; Pi, R | 1 |
| Chen, YZ; Sha, M; Xu, W; Yin, LF | 1 |
| Kim, YC; Park, EJ; Sohn, DH; Zhao, YZ | 2 |
| Li, X; Li, Y; Wang, L; Xu, Y; Xue, M | 1 |
| Bai, A; Fan, X; Guo, Y; Lu, N | 1 |
| Chiou, WF; Don, MJ | 1 |
| Guo, D; Han, J; Liu, P; Ma, X; Sun, J; Wang, B; Xu, M; Yang, M | 1 |
| Bi, YQ; Chen, QX; Gan, LC; Hou, SX; Wang, CG; Wang, XC | 1 |
| Jing, J; Lin, P; Ren, JJ; Wang, J; Wang, XJ; Wu, YY; Xiong, ZJ; Yang, HL; Zhang, J; Zheng, H | 1 |
| Huang, L; Shi, XM; Xiong, SD; Zhong, XY | 1 |
| Chen, X; Li, XX; Xue, CC; Zhou, SF; Zhou, ZW | 1 |
| Tang, C; Wang, YJ; Wu, AH; Xue, HL | 1 |
| Duan, JA; Gu, XJ; Li, P; Li, YB; Qian, SH | 1 |
| Chen, XY; Li, HL; Ma, LL; Zhang, ZY | 1 |
| Chou, GX; Hu, ZB; Li, YG; Liu, M; Wang, ZT; Yang, L; Zhang, F | 1 |
| Chen, Q; Deng, L; Fu, H; Gong, T; Liu, J; Nie, Y; Wang, X; Zhang, ZR | 1 |
| Cai, Z; Liu, J; Wang, X; Wu, J | 1 |
| Jiang, S; Lin, P; Ren, JJ; Wang, J; Wang, X; Wu, Y; Xiong, Z; Yang, H; Zhang, J | 1 |
| Song, Y; Su, L; Zeng, Y; Zhang, Z | 1 |
| Cheong, JH; Jeon, SJ; Jung, JW; Kang, SS; Kim, DH; Kim, YS; Ko, KH; Lee, S; Ryu, JH; Shin, BY; Son, KH; Yoon, BH | 1 |
| Li, YS; Liang, QS; Wang, J | 1 |
| Jiang, X; Li, C; Ren, J; Wang, L | 1 |
| Ng, J; Shi, M; Wu, JY; Wu, SJ | 1 |
| Chiu, LC; Lee, WY; Yeung, JH | 1 |
| Chen, Y; Liang, L; Sun, M; Xiong, S; Zeng, Z; Zhang, H | 1 |
| Fragiorge, EJ; Graf, U; Rezende, AA; Spanó, MA | 1 |
| Hua, JX; Ling, W; Rui, LC | 1 |
| Huo, WZ; Jiang, HY; Xie, K; Zhao, LL; Zhu, SS | 1 |
| Chen, FY; Li, RZ; Liao, HW | 1 |
| Fang, ZY; Lin, R; Liu, Y; Yuan, BX; Zhang, H | 1 |
| Chen, HY; Hang, TJ; Song, M; Zhang, Z | 1 |
| Xin, N; Zhang, SP; Zhou, GL | 1 |
| Chen, HS; Chen, YC; Liang, YJ; Long, B; Zeng, Z | 1 |
| Chang, HW; Chang, YC; Jin, UH; Kim, CH; Lee, SH; Son, JK; Son, KH; Suh, SJ | 1 |
| Cao, L | 1 |
| Fang, ZY; Lin, R; Liu, Y; Yang, GD; Yuan, BX; Zhang, H | 1 |
| Li, M; Lü, XY; Weng, MW | 1 |
| Shi, M; Wu, JY | 1 |
| Cheng, Y; Liu, X; Song, Y; Wang, L | 1 |
| Bi, HC; Chen, X; Deng, Y; Gu, LQ; Huang, M; Huang, ZY; Liu, PQ; Pan, Y; Sun, HY; Wen, YY; Xu, CS; Zhao, LZ; Zhou, SF; Zuo, Z | 1 |
| Chen, S; Gao, J; Le, K; Li, R; Liu, P; Pi, R; Wang, P; Yang, G; Zhang, H | 1 |
| Ji, HY; Kim, NJ; Kim, YC; Kim, YH; Lee, HS; Park, EJ; Sohn, DH; Song, WY | 1 |
| Khlentzos, A; Li, J; Li, P; Liu, X; Roberts, MS; Wang, GJ; Zhang, Q | 1 |
| Dong, J; Dong, X; Peng, G | 1 |
| Chen, KL; Huang, C | 1 |
| Shi, M; Wu, JY; Wu, SJ | 1 |
| Chen, X; Tang, XQ; Wang, KC; Yu, BY | 1 |
| Bi, HC; Chen, X; Gu, LQ; Huang, M; Huang, ZY; Liu, PQ; Pan, Y; Zhao, LZ; Zhong, GP; Zhou, SF; Zuo, Z | 1 |
| Li, CG; Xue, CC; Yu, XQ; Zhou, SF; Zhou, ZW | 1 |
| Li, B; Li, WH; Liang, L; Wu, R; Xie, Q; Xiong, SB; Zeng, Z | 1 |
| Li, QF; Liang, Y; Liu, QR; Shi, SL; Song, J; Tang, J | 1 |
| Chen, P; Du, F; Gao, X; Huang, Y; Li, C; Liu, C; Lu, T; Shang, H; Sun, Y; Wan, R; Wang, F; Wang, Y; Xu, F; Yang, J; Zhang, B | 1 |
| Choi, YJ; Kim, YC; Kim, YS; Lee, BH; Ryu, SY; Sohn, DH; Yin, HQ | 1 |
| Agrawal, DC; Chen, JJ; Lee, CY; Tsay, HS; Wang, CS; Yu, SM | 1 |
| Cai, SS; Dong, HP; Wang, N; Wei, H | 1 |
| Choi, YH; Jeon, SJ; Kim, HP; Kim, YS; Son, KH | 1 |
| Chae, HJ; Chae, SW; Choi, JY; Jung, YK; Kim, HK; Kim, HN; Kim, HR; Lee, HW; Park, HR; Woo, ER | 1 |
| Dong, MQ; Jin, ZX; Li, GR; Li, ZC; Luo, Y; Sun, DD; Wang, HC; Wang, XB | 1 |
| Chang, KC; Cho, MK; Jeon, SJ; Kang, SS; Kim, HJ; Kim, YS; Lee, GW; Lee, JH; Lee, JS; Nizamutdinova, IT; Seo, HG; Son, KH | 1 |
| Kong, QY; Ran, R; Wang, T; Zhou, FQ | 1 |
| Chen, SB; Wang, YP; Zhang, XX | 1 |
| He, XX; Liang, QS; Zhan, CY; Zhou, DX | 1 |
| Chan, MH; Chen, GW; Kang, JC; Su, CC | 1 |
| Chen, YC; Liang, L; Zeng, Z; Zhang, HH | 1 |
| Cai, Z; Lee, FS; Liu, J; Wang, X | 1 |
| Ji, HS; Yang, J; Yu, F | 1 |
| Genovese, KJ; He, H; Kaiser, P; Kogut, MH | 1 |
| Guo, ZJ; Li, H; Sun, QS; Tang, X; Zhang, Y | 1 |
| Chan, KM; Lam, FF; Or, PM; Yeung, JH | 1 |
| Chang, KC; Jeon, SJ; Kang, SS; Kim, HJ; Kim, YS; Lee, GW; Lee, JH; Nizamutdinova, IT; Seo, HG; Son, KH | 1 |
| Lin, YH; Su, CC | 2 |
| Chan, WK; Chang, DC; Luo, H; Luo, KQ; Xiao, K; Xu, N; Zhou, L | 1 |
| Elmer, G; Leboeuf, RC; Li, YI | 1 |
| Qian, X; Song, T; Wang, Y; Zhang, J; Zhang, Z | 1 |
| Liu, Y; Liu, YF; Yan, FF; Zhao, YX | 1 |
| Du, W; Qin, HY; Wei, YH; Wu, XA; Zhao, G | 1 |
| Chen, S; Gao, L; Liu, Y; Shen, C; Sun, H; Ye, S; Yu, C; Zeng, S | 1 |
| Gong, Z; Huang, C; Li, Q; Peng, L; Sheng, X; Wang, MW; Zang, YQ; Zhang, Y | 1 |
| Li, YS; Wang, J; Wang, ZH | 1 |
| Chang, HW; Chang, YC; Jin, UH; Kang, YJ; Kim, CH; Lee, SH; Lee, YC; Son, JK; Son, KH | 1 |
| Chu, T; Jin, H; Li, H; Liang, Z; Mao, SJ; Yin, ZN | 1 |
| Dong, K; Qiao, H; Wu, L; Xu, W; Yang, J | 1 |
| Tang, J; Zhan, C; Zhou, J | 1 |
| Leung, SW; Man, RY; Wan, AK; Zhu, DY | 1 |
| Chen, JM; Li, MH; Peng, Y; Wu, Q; Xiao, PG | 1 |
| Chen, GW; Lin, JG; Su, CC | 1 |
| Ha, H; Kim, HH; Kim, HN; Kwak, HB; Lee, JH; Lee, ZH; Shin, HI; Sun, HM | 1 |
| Chen, X; Huang, L; Huang, S; Liu, Y; Shao, F; Wu, H; Yin, Y; Zhang, L; Zhao, Z; Zhuang, J | 1 |
| Ma, JH; Tu, DN; Yang, L; Zhang, PH; Zou, AR | 1 |
| Chen, CH; Chen, HW; Chen, JJ; Lee, CY; Lin, CS; Liu, CC; Sher, HF; Tsay, HS; Yang, PC | 1 |
| Fan, Z; Feng, N; Li, Q; Nan, Y; Sun, J; Wang, Y | 1 |
| Gao, J; Jin, L; Song, T; Wu, G; Zhang, J; Zhang, Z | 1 |
| Dai, JY; Guo, YQ; Liu, DH; Tan, XH; Wang, B; Wang, KC | 1 |
| Bai, B; Du, JR; Li, X; Yang, F; Yu, Y; Zheng, H; Zheng, XY | 1 |
| Du, GD; Liang, ZS; Lu, G; Wang, JR | 1 |
| Jung, KH; Kim, SK; Lee, BC | 1 |
| Jeon, SJ; Jung, SH; Lee, JR; Seol, HJ; Son, KH | 1 |
| Deng, M; Yang, H; Yi, H | 1 |
| Guo, L; Lei, CK; Shan, M | 1 |
| Li, CG; Marriott, P; May, B; Pang, EC; Sheng, SJ; Story, D; Xue, CC; Zhou, S | 1 |
| Row, KH; Tian, M; Yan, H | 1 |
| Cui, GH; Gao, W; Huang, LQ; Wang, XY; Yuan, Y | 1 |
| Lin, DJ; Liu, JJ; Xiao, RZ; Zhang, Y | 1 |
| Liang, Z; Liu, Y; Meng, X; Yang, D; Yang, S; Zhang, Y | 1 |
| Meng, WT; Yang, YM; Zhou, J | 1 |
| Du, R; Meng, WT; Qin, H; Wang, YP; Yuan, SL; Zheng, H | 1 |
| Cao, FL; Cui, Y; Dong, HY; Dong, MQ; Huang, YF; Li, ZC; Liu, ML; Liu, Y; Luo, Y; Niu, W; Wang, XB; Wang, YX; Xu, M; Zhang, B; Zhao, PT | 1 |
| Li, CG; Pang, EC; Sheng, SJ; Xue, CC | 1 |
| Chen, X; Liang, J; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Li, XX; Zhou, SF; Zhou, ZW | 1 |
| Guan, S; Guo, DA; Jiang, B; Li, M; Liu, X; Wang, J; Wang, Y; Wu, W; Yang, M; Zhang, L | 1 |
| Chen, JH; Han, M; He, SX; Hou, HL; Ren, MD; Wang, ZL; Zhai, XM | 1 |
| Li, XY; Pan, YJ; Yang, GT | 1 |
| He, YQ; Hu, Y; Li, W; Liu, HX; Liu, Y; Yang, L | 1 |
| Lee, WY; Or, PM; Wang, X; Yeung, JH | 1 |
| Kapoor, S | 1 |
| Fan, GW; Gao, XM; Hu, LM; Kang, LY; Su, YF; Wang, H; Zhang, BL; Zhang, J; Zhu, Y | 1 |
| Cai, SS; Wang, N; Wei, H; Wu, WH | 1 |
| Lü, Q; Zhang, PR | 1 |
| Lee, WY; Liu, KW; Yeung, JH | 1 |
| Wu, LM; Xu, W; Yang, J | 1 |
| Qing, DX; Wu, GB; Zhou, EX | 1 |
| Du, G; Gao, J; Song, T; Wang, Y; Wu, G; Zhang, J; Zhang, T; Zhang, Z | 1 |
| Huang, S; Li, S; Liang, Q; Wang, Z; Yang, G; Yang, L | 1 |
| Li, CG; May, B; Pang, EC; Sheng, SJ; Xue, CC | 2 |
| He, Y; Hou, S; Mao, S; Shen, Q; Yuan, J | 1 |
| Li, T; Liu, QS; Qin, XY; Tian, Y; Yan, L | 1 |
| Ma, Z; Song, Z; Zhang, M | 1 |
| Li, QF; Liang, Y; Liu, QR; Shi, SL; Tang, J; Xu, DH; Yang, LM; Zhao, ZL | 1 |
| Cheong, JH; Jeon, SJ; Kim, DH; Kim, S; Ko, KH; Lee, S; Ryu, JH; Son, KH; Yoon, BH | 1 |
| Cai, B; Chu, W; Li, B; Li, X; Lu, Y; Pan, Z; Qiao, G; Shan, H; Xu, C; Yang, B; Zhang, L; Zhang, Y | 1 |
| Can, R; Mao, C; Shao, H; Wang, A; Wang, L; Xu, Z; Zhang, Y; Zhu, L | 1 |
| Chen, Y; Ma, J; Ren, ZH; Tong, YH; Xu, W | 1 |
| Liang, QS; Tu, EY; Wang, ZH; Yang, GT; Zhou, YG | 1 |
| Chen, JC; Shan, YF; Shen, X; Shi, HQ; Song, QT; Xie, YK; Yu, ZP; Zhang, QY; Zhou, MT | 1 |
| Chen, J; Lu, Q; Zhang, P; Zhang, X | 1 |
| Chen, R; Gong, N; Hou, Y; Li, B; Lu, Y; Ma, L | 1 |
| Cui, G; Gao, W; Hillwig, ML; Huang, L; Kong, J; Peters, RJ; Wang, X; Yang, B | 1 |
| Che, XH; Kim, WH; Park, EJ; Sohn, DH; Zhao, YZ | 1 |
| Liu, Q; Long, Y; Tang, F; Wu, K; Yao, S; Zhang, Q | 1 |
| Jiang, X; Wu, D; Wu, S | 1 |
| Cao, L; Mao, C; Shao, H; Wang, L; Xu, Z; Zhang, Y; Zhu, L | 1 |
| Li, L; Zhang, ZH; Zhao, WD | 1 |
| Dong, J; Dong, X; Fan, L; Liu, L; Wu, G; Zhang, R | 1 |
| Chiu, TL; Su, CC | 1 |
| Cui, L; Du, W; Li, M; Liu, L; Wang, L; Yang, R; Zhang, X | 1 |
| Huang, HB; Tang, C; Wang, XG; Xue, HL | 1 |
| Chen, ST; Cheng, CS; Hsu, TK; Hung, YC; Lyu, PC; Pan, TL; Sintupisut, N; Wang, PW | 1 |
| Chen, WC; Mei, B; Sun, ZW; Zhang, L; Zhu, SJ | 1 |
| Wu, JY; Zhao, JL; Zhou, LG | 1 |
| Bai, H; Dong, CD; Gu, X; Liu, JP; Yang, RH; Zhang, WL | 1 |
| Kim, HJ; Kim, SH | 1 |
| Dai, H; Li, X; Li, Y; Wang, L; Wang, M; Xue, M | 1 |
| Bai, B; Du, JR; Li, X; Yu, Y; Zheng, XY | 1 |
| Cao, F; Du, J; Gao, H; Li, Y; Sun, D; Wang, H; Wei, L; Zhang, Y; Zhao, L | 1 |
| Hao, H; Jiang, S; Lai, L; Liu, Y; Wang, G; Wang, Q; Wang, Y; Yu, G; Zhu, X | 1 |
| Cui, L; Du, W; Li, M; Liu, L; Wang, L; Wang, S; Yang, R; Zhang, X | 1 |
| Li, X; Li, Y; Liu, Y; Wang, L; Xue, M | 1 |
| Cheung, CC; Fung, KP; Lai, PB; Lee, WY; Liu, KW; Wong, J; Yeung, JH | 1 |
| Dong, MQ; Gao, YQ; Li, ZC; Liu, LL; Liu, ML; Luo, Y; Wang, J; Xu, DQ; Xu, M; Zhang, B; Zhao, PT | 1 |
| Chang, DC; Feng, C; Le, XF; Luo, HW; Luo, KQ; Tian, HL; Xu, NN; Yu, T; Zhou, LY | 1 |
| Fang, ZG; He, Y; Hu, Y; Huang, RW; Li, XD; Lin, DJ; Liu, JJ; Liu, PQ; Liu, WD; Wang, CZ; Xiao, RZ; Yang, HZ; Zhang, Y | 1 |
| Bai, C; Fu, R; Tang, C; Wu, A; Xue, H | 1 |
| Cui, G; Dai, Z; Huang, L; Zhang, X; Zhou, SF | 1 |
| Bi, YF; Liu, HM; Liu, XQ; Wang, ZJ; Xu, HW; Zhang, XJ | 1 |
| Cheung, CM; Lee, WY; Or, PM; Wang, X; Yeung, JH | 1 |
| Cheng, CY; Su, CC | 1 |
| Wang, JW; Wu, JY | 1 |
| Lv, G; Ma, X; Wang, S; Wang, Y; Xie, W; Yang, R; Zhao, S | 1 |
| Chae, SJ; Jeon, SJ; Joh, EH; Kim, DH; Son, KH; Trinh, HT | 1 |
| Hu, HT; Jin, H; Liu, T; Sun, QR; Xu, JH | 1 |
| Row, KH; Wang, Y; Zhu, T | 1 |
| Cui, Y; Guan, S; Guo, DA; Jiang, B; Liu, X; Wang, Y; Wu, W; Yang, M; Yin, Y | 1 |
| Feng, J; Li, CH; Liu, HL; Lou, JN; Peng, L; Ye, LY; Zhang, WJ; Zhou, R | 1 |
| Liu, M; Xia, XH | 1 |
| Abdolmaleky, H; Blackburn, GL; Gong, Y; Li, L; Li, Y; Lu, Y; Zhou, JR | 1 |
| Cao, Y; Guo, J; Huang, HQ; Liu, PQ; Liu, WH; Tang, FT; Wang, LJ; Wang, TQ; Xu, SW; Zhou, XS | 1 |
| Fong, YC; Hsu, CJ; Tang, CH | 1 |
| Chen, W; Chen, X; Du, S; Wu, H; Wu, Q | 1 |
| He, Z; Lu, W; Pan, Z | 1 |
| Gao, C; Jiang, J; Ma, Y; Qiu, F; Sun, J; Wang, G; Zhang, R | 1 |
| Li, J; Meng, W; Xing, H; Yang, Y; Zhang, K | 1 |
| Ahn, SY; Ahn, YM; Chung, JH; Kang, SW; Kim, SD; Kim, SK; Lee, BC; Lee, SH | 1 |
| Chen, J; Chen, X; He, Z; Ma, Y; Wan, D; Wang, J; Yan, Z | 1 |
| CHAN, P; CHENG, TH; HONG, HJ; LIU, JC | 1 |
| Feng, Z; He, T; Zhang, Z; Zou, Q | 1 |
| Bi, W; Row, KH; Tian, M | 2 |
| Dong, Y; Lee, KH; Morris-Natschke, SL | 1 |
| Wang, X; Yeung, JH | 1 |
| Hu, P; Ignatova, S; Liang, Q; Luo, G; Sutherland, I; Wang, Y; Wu Jun, F; Zhang, M | 1 |
| Jia, YH; Li, J; Li, LJ; Yang, P; Zhou, FH | 1 |
| Du, S; Li, X; Wu, Q; Yan, H; Yang, Y; Zhou, L | 1 |
| Gao, Y; Liu, Y; Zhou, Y | 1 |
| Hang, TJ; Lu, JG; Song, M; Zhang, SY | 1 |
| Kwan, YW; Lee, WY; Or, PM; Yeung, JH; Zhou, X | 1 |
| Jeong, SJ; Jiang, C; Kim, SH; Lee, EO; Lee, HJ; Lü, J; Won, SH; Ye, M; Zhang, J; Zhang, Y | 1 |
| Li, XB; Li, Y; Wang, W; Xie, XM; Zhou, GJ; Zhou, TS | 1 |
| Chu, T; Fu, HM; Jia, YQ; Li, H; Mao, SJ; Meng, WT; Shi, HY; Song, XR; Zhang, Q | 1 |
| Jia, X; Li, P; Ma, W; Peng, Y; Shu, L; Wang, B; Wang, C; Wei, Y | 1 |
| Choi, I; Jung, H; Kim, DO; Kim, MJ; Kim, TD; Kim, WS; Kwon, BM; Park, YJ; Yoon, SJ; Yoon, SR | 1 |
| Choi, HK; Kim, YG; Nepal, PR; Subedi, RK; Yu, H | 1 |
| Bai, L; Dai, H; Li, X; Li, Y; Xue, M | 1 |
| Jin, HJ; Li, CG; Xie, XL; Ye, JM | 1 |
| Chau, BT; Jaramillo, MC; Lantz, RC; Lau, A; Tao, S; Wondrak, GT; Wong, PK; Zhang, DD; Zheng, Y | 1 |
| Guo, M; Liang, J; Meng, J; Wu, S; Yang, Z | 1 |
| Chang, CC; Ho, TF; Huang, LR; Lai, JS; Liao, EC; Lin, JY; Lu, CH; Ma, SW; Tsai, CS | 1 |
| Huang, K; Pan, Y; Ren, Y; Wang, X; Xiang, Z; Xu, Y; Yan, P | 1 |
| Ding, C; Jiang, Y; Wang, L; Wang, T; Wang, X; Yang, R; Zhang, H; Zhang, L; Zhou, Y | 1 |
| Guan, CW; Huang, ZY; Jin, J; Li, J; Zhao, ZX | 1 |
| Chu, ZY; Tian, L; Wu, LH | 1 |
| Huang, D; Liu, SQ; Song, L; Wu, Z | 1 |
| Fischer, W; Kaiser, M; Nörenberg, W; Schaefer, M; Sobottka, H | 1 |
| Chen, M; Chen, ML; Li, PY; Li, XM; Wang, X; Yang, G | 1 |
| Liu, SM; Sun, XB; Yang, ZH | 1 |
| Li, B; Liang, Z; Peng, L; Ru, M; Wang, K; Wang, Y; Xia, P | 1 |
| Chan, RL; Cho, CH; Hu, T; Li, M; Lu, L; Shen, J; To, KK; Wang, L; Yeung, JH; Zhang, L | 1 |
| Cao, J; Cao, W; Hu, SS; Ye, LH | 1 |
| Bifulco, G; Cantone, V; Chini, MG; De Feo, V; Maione, F; Mascolo, N | 1 |
| Cao, B; Qiu, F; Wang, Z; Yu, A; Zhang, H | 1 |
| Cho, CH; Hu, T; Kwan, YW; Or, PM; Wang, L; Yeung, JH; Zhou, X | 1 |
| Hao, H; Ji, H; Jiang, L; Ju, W; Li, P; Long, F; Peng, Y; Sun, B; Wang, G; Wei, Y; Xu, M | 1 |
| Chan, RL; Cho, CH; Hu, T; Li, M; Lu, L; Shen, J; To, KK; Wang, L; Wu, WK; Zhang, L | 1 |
| Cao, J; Ding, Y; Gao, W; Li, P; Qi, LW; Yang, H | 1 |
| Duan, J; Guan, H; Qian, D; Ren, H; Shang, E; Su, S; Zhang, W | 1 |
| Adams, M; Domaradzki, K; Hamburger, M; Matkowski, A; Slusarczyk, S; Topolski, J | 1 |
| Cai, Y; Chen, M; Chen, Z; He, C; Shi, Z; Zhang, W | 1 |
| Akaberi, M; Iranshahi, M; Mehri, S | 1 |
| Bi, W; Chen, Dda Y; Wang, J; Wang, M; Xia, Q; Yang, X; Zhang, Y | 1 |
| Lu, S; Zhang, L | 1 |
| Cui, X; Luo, G; Qiao, Y; Shi, X; Xu, B; Xue, Z; Yang, C | 1 |
| Ahmed, T; Budzyńska, B; Daglia, M; Javed, S; Nabavi, SF; Nabavi, SM; Sobarzo-Sánchez, E; Tariq, A; Tejada, S | 1 |
| Cerón-Carrasco, JP; den-Haan, H; Domaradzki, K; Girón-Rodríguez, F; Matkowski, A; Orhan, IE; Peña-García, J; Pérez-Garrido, A; Pérez-Sánchez, H; Senol, FS; Ślusarczyk, S | 1 |
| He, S; Hu, J; Li, Q; Ma, S; Wang, Z; Zhang, H; Zhang, Q | 1 |
| Cao, Y; Chai, Y; Chen, X; Ding, X; Gong, Z; Hong, Z; Jia, D; Liu, Y; Lv, L; Wang, D; Yuan, Y; Zhang, G; Zhao, L; Zhu, Z | 1 |
| Chen, J; Cui, G; Huang, L; Li, B; Qi, X; Shen, G; Zhan, Z | 1 |
| Jin, H; Ma, WC; Mao, SJ; Wu, N; Wu, Y | 1 |
| Cao, YF; Fang, ZZ; Wang, LX; Yuan, XL; Zhang, XX | 1 |
| Bai, Z; Jiao, J; Liang, Z; Liu, J; Ru, M; Wang, R; Xia, P | 1 |
| Xu, M; Yu, HB; Zhang, LT; Zheng, XT; Zhong, ZF; Zhou, CH | 1 |
| Binder, RJ; Chi, L; Hatfield, MJ; Potter, PM | 1 |
| Ding, F; Feng, J; Feng, Y; Gao, H; Huang, L; Tang, H; Xu, QM; Yang, K; Yang, S | 1 |
| Fu, J; Han, S; Jia, Q; Lin, Y; Lv, Y | 1 |
| Deng, H; Han, M; Lan, Z; Li, W; Luan, S; Luo, X; Mleczko, L; Ni, L; Wu, Z; Zhang, F; Zhang, L | 1 |
| Gao, G; Gong, B; Li, Q; Luo, S; Ma, L; Mei, W; Qi, W; Xu, L; Yang, X; Yang, Z; Zhao, Z; Zhou, L; Zhou, T | 1 |
| Chang, YX; Chen, S; Ding, M; Gao, XM; Li, J; Li, Y; Ma, W; Mao, H; Wang, H; Wang, Q; Wang, X; Wei, J; Yang, X; Yang, Y; Zou, S | 1 |
| Chen, S; Chen, T; Cui, S; Li, S; Wu, Q | 1 |
| Cao, L; Huang, M; Jin, J; Tan, G; Wang, D; Xu, C; Yu, W; Zhao, Z | 1 |
| Chen, J; Hou, Z; Li, Y; Liang, Z; Su, F; Xu, L; Yang, D; Zhang, X | 1 |
| Cao, F; Gao, J; Hu, B; Li, B; Li, J; Luo, L; Peng, L; Yan, Y; Yang, B; Zhang, G | 1 |
| Cai, X; Dong, J; Li, X; Lu, Z; Ma, P; Ou Yang, Q; Zhang, B | 1 |
| Li, SP; Liu, MT; Zhao, J | 1 |
| Chen, H; Deng, W; Hu, W; Hua, L; Liang, S; Ou, Y; Sun, P; Yang, Z; Yue, H; Zhang, C | 1 |
| Choi, JS; Fauzi, FM; Jung, HA; Park, SE; Paudel, P; Prajapati, R; Seong, SH | 1 |
| Campagnari, R; Cardile, A; Cerulli, A; Masullo, M; Menegazzi, M; Piacente, S; Zanrè, V | 1 |
| Chen, W; Hong, B; Liu, J; Peng, D; Shi, Y; Wang, G; Wang, L; Wu, C; Yu, N | 1 |
| Fang, Y; Guo, J; Han, Q; He, M; Huang, D; Jiang, H; Li, X; Liu, J; Wang, F; Xin, L | 1 |
| Diel, P; Guigas, C; Kulling, SE; Roth, A; Soukup, ST; Stärke, J; Zhao, P | 1 |
13 review(s) available for tanshinone and phenanthrenes
| Article | Year |
|---|---|
[Review of germplasm resources studies on Salvia miltiorrhiza].
Topics: Abietanes; Conservation of Natural Resources; Culture Techniques; Drugs, Chinese Herbal; Ecology; Phenanthrenes; Plants, Medicinal; Quality Control; Salvia; Salvia miltiorrhiza; Soil | 2002 |
[Study of Salvia przewalskii and evaluation of its uses].
Topics: Abietanes; Animals; Anti-Infective Agents; Anticoagulants; Coronary Disease; Drugs, Chinese Herbal; History, 17th Century; History, 19th Century; Humans; Pharmacognosy; Phenanthrenes; Phytotherapy; Plants, Medicinal; Salvia | 2003 |
[Anticancer effect of tanshinone and its mechanisms].
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; DNA; Gene Expression; Humans; Phenanthrenes; Salvia miltiorrhiza; Telomerase | 2003 |
[Advances in study of the pharmacological effects of danshen on hemorheology].
Topics: Abietanes; Animals; Benzofurans; Drugs, Chinese Herbal; Hemorheology; Hemostasis; Lactates; Phenanthrenes; Plant Roots; Plants, Medicinal; Platelet Aggregation; Salvia miltiorrhiza | 2005 |
Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.
Topics: Abietanes; Angina Pectoris; Animals; Benzofurans; Drugs, Chinese Herbal; Fibrinolytic Agents; Herb-Drug Interactions; Humans; Hyperlipidemias; Lactates; Phenanthrenes; Phenanthrolines; Plant Extracts; Randomized Controlled Trials as Topic; Salvia miltiorrhiza; Stroke | 2005 |
New developments in the chemistry and biology of the bioactive constituents of Tanshen.
Topics: Abietanes; Animals; Anti-Infective Agents; Anticoagulants; Antihypertensive Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Drugs, Chinese Herbal; Humans; Hydroxybenzoates; Phenanthrenes; Salvia miltiorrhiza | 2007 |
[Advance of study on apoptosis inducer of several types of natural drug].
Topics: Abietanes; Antineoplastic Agents; Apoptosis; Emodin; Flavones; Humans; Neoplasms; Phenanthrenes; Saponins | 2007 |
Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures.
Topics: Abietanes; Bioreactors; Biotechnology; Culture Media; Diterpenes; Drugs, Chinese Herbal; Humans; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Tissue Culture Techniques | 2010 |
Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Molecular Structure; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2011 |
Recent insights into the biological activities and drug delivery systems of tanshinones.
Topics: Abietanes; Cyclodextrins; Drug Carriers; Drug Delivery Systems; Drugs, Chinese Herbal; Emulsions; Humans; Liposomes; Nanoparticles; Phenanthrenes; Salvia miltiorrhiza; Solubility | 2016 |
Molecular Signaling Pathways Behind the Biological Effects of Salvia Species Diterpenes in Neuropharmacology and Cardiology.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Biological Products; Diterpenes; Neuropharmacology; Phenanthrenes; Salvia; Signal Transduction | 2016 |
Overview of Medicinally Important Diterpenoids Derived from Plastids.
Topics: Abietanes; Diterpenes; Diterpenes, Kaurane; Epoxy Compounds; Ginkgolides; Metabolic Engineering; Paclitaxel; Phenanthrenes; Plants; Plastids | 2017 |
Tanshinones and mental diseases: from chemistry to medicine.
Topics: Abietanes; Animals; Antioxidants; Humans; Medicine, Chinese Traditional; Mental Disorders; Phenanthrenes; Plant Extracts | 2016 |
1 trial(s) available for tanshinone and phenanthrenes
| Article | Year |
|---|---|
Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris.
Topics: Abietanes; Angina, Unstable; Anticoagulants; Aspirin; Dimerization; Drugs, Chinese Herbal; Female; Fibrinogen; Fibrinolytic Agents; Humans; Male; Middle Aged; Phenanthrenes; Salvia miltiorrhiza | 2009 |
422 other study(ies) available for tanshinone and phenanthrenes
| Article | Year |
|---|---|
[Studies and preparations of fufang danshen granules].
Topics: Abietanes; beta-Cyclodextrins; Chromatography, Thin Layer; Cyclodextrins; Drug Combinations; Drugs, Chinese Herbal; Excipients; Phenanthrenes; Phenanthrolines; Plant Extracts; Quality Control; Salvia miltiorrhiza; Spectrophotometry, Ultraviolet; Technology, Pharmaceutical | 1992 |
Modulating effect of tanshinones on mutagenic activity of Trp-P-1 and benzo[a]pyrene in Salmonella typhimurium.
Topics: Abietanes; Benzo(a)pyrene; Carbolines; Chromatography, High Pressure Liquid; Drug Interactions; Drugs, Chinese Herbal; Molecular Structure; Mutagenicity Tests; Mutagens; Phenanthrenes; Salmonella typhimurium | 1992 |
Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza.
Topics: Abietanes; Diazepam; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Phenanthrenes; Plants, Medicinal; Receptors, GABA-A | 1991 |
Cytotoxic activities of tanshinones against human carcinoma cell lines.
Topics: Abietanes; Anti-Infective Agents; Carcinoma; Colonic Neoplasms; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; Laryngeal Neoplasms; Lethal Dose 50; Phenanthrenes; Tumor Cells, Cultured | 1991 |
[Relationship between inhibitory action of tanshinone on neutrophil function and its prophylactic effects on myocardial infarction].
Topics: Abietanes; Acid Phosphatase; Adhesiveness; Animals; Dose-Response Relationship, Drug; Female; Male; Myocardial Infarction; Myocardium; Neutrophils; Phagocytosis; Phenanthrenes; Rabbits | 1991 |
Effect of abietane- type pigments from Salvia miltiorrhiza on post-hypoxic recovery of cardiac contractile force in rats.
Topics: Abietanes; Animals; Drugs, Chinese Herbal; Myocardial Contraction; Phenanthrenes; Pigments, Biological; Rats | 1991 |
[Evaluation of radix Salviae Miltiorrhizae and its preparation].
Topics: Abietanes; Benzaldehydes; Catechols; Chromatography, Thin Layer; Densitometry; Drug Combinations; Drugs, Chinese Herbal; Lactates; Phenanthrenes; Phenanthrolines; Plant Extracts; Salvia miltiorrhiza; Tablets | 1990 |
Immobilization of callus tissue cells of Salvia miltiorrhiza and the characteristics of their products.
Topics: Abietanes; Alginates; Cell Differentiation; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Culture Media; Drugs, Chinese Herbal; Kinetics; Phenanthrenes | 1990 |
Beneficial effect of tan-shen, an extract from the root of Salvia, on post-hypoxic recovery of cardiac contractile force.
Topics: Abietanes; Adenosine Triphosphate; Animals; Calcium; Cardiovascular Agents; Creatine Kinase; Hypoxia; Male; Myocardial Contraction; Myocardial Reperfusion; Phenanthrenes; Phosphates; Rats; Rats, Inbred Strains | 1990 |
[Identification of tanshinones with related compounds by high performance thin layer chromatography and mass spectrometric analysis].
Topics: Abietanes; Anticoagulants; Chromatography, High Pressure Liquid; Diterpenes; Drug Combinations; Drugs, Chinese Herbal; Mass Spectrometry; Phenanthrenes; Phenanthrolines; Plant Extracts; Salvia miltiorrhiza | 1989 |
[Water soluble constituents from radix Salvia miltiorrhiza before and after slicing].
Topics: Abietanes; Benzaldehydes; Catechols; Drug Combinations; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Phenanthrenes; Phenanthrolines; Phenols; Plant Extracts; Plants, Medicinal; Salvia miltiorrhiza; Solubility; Technology, Pharmaceutical; Water | 1985 |
[Inhibitory actions of tanshinone leukocyte chemotaxis].
Topics: Abietanes; Anti-Inflammatory Agents; Chemotaxis, Leukocyte; Humans; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Phenanthrenes; Plants, Medicinal | 1985 |
[Anti-coagulation effect in vitro of danshan and its three chemical extracts].
Topics: Abietanes; Anticoagulants; Benzaldehydes; Blood Viscosity; Catechols; Drug Combinations; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Phenanthrenes; Phenanthrolines; Plant Extracts; Plants, Medicinal; Salvia miltiorrhiza | 1986 |
[High performance liquid chromotographic determination of two tanshinones and the chromotographic profiles of 15 danshens].
Topics: Abietanes; Anti-Infective Agents; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Phenanthrenes; Phenanthrolines; Plant Extracts; Plants, Medicinal; Salvia miltiorrhiza; Species Specificity | 1987 |
[Quality evaluation of cultivated Salvia miltiorrhiza Bge. in Chongming, a suburb of Shanghai].
Topics: Abietanes; Benzaldehydes; Catechols; Drug Combinations; Drugs, Chinese Herbal; Pharmacognosy; Phenanthrenes; Phenanthrolines; Plant Extracts; Plants, Medicinal; Salvia miltiorrhiza | 1988 |
[A novel synthesis of Tanshinone IIA--an active component of Salvia miltiorrhiza bunge].
Topics: Abietanes; Anticoagulants; Phenanthrenes | 1988 |
[Research on the quality of cultivated Salvia miltiorrhiza Bge. in Shandong Province].
Topics: Abietanes; Anti-Infective Agents; Anticoagulants; Benzaldehydes; Catechols; Drugs, Chinese Herbal; Microbial Sensitivity Tests; Phenanthrenes; Trace Elements | 1988 |
Cardiovascular pharmacology of Panax notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza.
Topics: Abietanes; Animals; Arteries; Blood Pressure; Coronary Circulation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Panax; Phenanthrenes; Phytotherapy; Plant Extracts; Plants, Medicinal; Rabbits; Rats; Salvia miltiorrhiza | 1986 |
[Evaluation of antimyocardial ischemia drugs].
Topics: Abietanes; Animals; Calcium Channel Blockers; Coronary Disease; Hydroxybenzoates; Phenanthrenes; Plant Extracts; Plants, Medicinal | 1985 |
[Synthesis of some compounds related to tanshinquinone].
Topics: Abietanes; Anti-Bacterial Agents; Cardiovascular Agents; Diterpenes; Drug Resistance, Microbial; Phenanthrenes; Quinones; Staphylococcus aureus | 1985 |
Tanshinone in the treatment of acne.
Topics: Abietanes; Acne Vulgaris; Anti-Infective Agents; Humans; Phenanthrenes | 1983 |
[Anti-inflammatory actions of tanshinone].
Topics: Abietanes; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Capillary Permeability; Cell Movement; Edema; Female; Leukocytes; Male; Mice; Phenanthrenes; Rats | 1983 |
[Tanshinone in the treatment of acne (a primary report of 20 cases (author's transl)].
Topics: Abietanes; Acne Vulgaris; China; Furans; Humans; Phenanthrenes | 1980 |
[Sex hormone-like activity of Tanshinone (author's transl)].
Topics: Abietanes; Acne Vulgaris; Animals; China; Female; Furans; Gonadal Steroid Hormones; Male; Mice; Organ Size; Phenanthrenes; Rats | 1980 |
[Tanshinones: antimycobacterial agents--its bile excretion and biotransformation in rat liver].
Topics: Abietanes; Animals; Bile; Biotransformation; Chromatography, Liquid; Liver; Male; Mycobacterium; Phenanthrenes; Rats | 1983 |
Crown gall culture and production of tanshinone in Salvia miltiorrhiza.
Topics: Abietanes; Agrobacterium tumefaciens; Anti-Bacterial Agents; Arginine; Cells, Cultured; Drugs, Chinese Herbal; Phenanthrenes; Plant Tumors; Plasmids; Spectrophotometry; Transformation, Genetic; Ultraviolet Rays | 1995 |
[The differentiation-inducing effect of tanshinone and retinoic acid on human cervical carcinoma cell line in vitro].
Topics: Abietanes; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Transformation, Neoplastic; Female; Humans; Mice; Mice, Nude; Phenanthrenes; Tretinoin; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1995 |
Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells.
Topics: Abietanes; Animals; Antioxidants; Butylated Hydroxytoluene; Cell Survival; DNA Adducts; DNA Damage; Drugs, Chinese Herbal; Guanine; Iron Chelating Agents; Lipid Peroxidation; Liver; Male; Malondialdehyde; Pentetic Acid; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Superoxide Dismutase; Vitamin E | 1996 |
Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury.
Topics: Abietanes; Animals; Antioxidants; Drugs, Chinese Herbal; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Intracellular Membranes; Lactates; Lipid Metabolism; Lipid Peroxidation; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenanthrenes; Plant Extracts; Rabbits; Salvia miltiorrhiza; Spin Trapping; Superoxides; Thiobarbituric Acid Reactive Substances | 1996 |
In vitro cytotoxicity of tanshinones from Salvia miltiorrhiza.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Humans; Medicine, Chinese Traditional; Molecular Structure; Phenanthrenes; Plants, Medicinal; Tumor Cells, Cultured | 1997 |
[A preliminary study of the anti-cancer effect of tanshinone on hepatic carcinoma and its mechanism of action in mice].
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Female; Liver Neoplasms, Experimental; Male; Mice; Phenanthrenes; Proliferating Cell Nuclear Antigen | 1996 |
[An observation of the effect of tanshinone on cancer cell proliferation by Brdu and PCNA labeling].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Division; DNA, Neoplasm; Drugs, Chinese Herbal; HL-60 Cells; Humans; Liver Neoplasms; Phenanthrenes; Proliferating Cell Nuclear Antigen; Tumor Cells, Cultured | 1996 |
[The technique for extracting liposoluble components of Salvia miltiorrniza].
Topics: Abietanes; Drugs, Chinese Herbal; Ethanol; Phenanthrenes; Plant Extracts; Salvia miltiorrhiza; Technology, Pharmaceutical; Vasodilator Agents | 1996 |
Selection of a high tanshinone-producing crown gall strain and production of tanshinone in the strain.
Topics: Abietanes; Drugs, Chinese Herbal; Phenanthrenes; Plant Tumors | 1997 |
Tanshinone production in Ti-transformed Salvia miltiorrhiza cell suspension cultures.
Topics: Abietanes; Agrobacterium tumefaciens; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Drugs, Chinese Herbal; Glucose; Light; Phenanthrenes; Plant Extracts; Salvia miltiorrhiza; Transformation, Genetic | 1997 |
[Stability of jingu tongxial pills].
Topics: Abietanes; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Drug Stability; Drugs, Chinese Herbal; Phenanthrenes | 1996 |
[Study on the effect of ofloxacin and tanshinone II A on human leukocyte chemotactic migration in vitro].
Topics: Abietanes; Anti-Infective Agents; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Ofloxacin; Phenanthrenes | 1997 |
Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspases; Coloring Agents; DNA Fragmentation; Drugs, Chinese Herbal; Flow Cytometry; Humans; In Vitro Techniques; Leukemia, Myeloid; Phenanthrenes; Plant Extracts; Poly(ADP-ribose) Polymerases; Propidium; Time Factors; Tumor Cells, Cultured | 1999 |
Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspases; Cell Cycle; DNA Fragmentation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; HL-60 Cells; Humans; Lamiaceae; Leukemia; Leukemia, Erythroblastic, Acute; Phenanthrenes; Tumor Cells, Cultured | 1999 |
Protective effects of sodium tanshinone IIA sulphonate against adriamycin-induced lipid peroxidation in mice hearts in vivo and in vitro.
Topics: Abietanes; Animals; Antioxidants; Doxorubicin; Drugs, Chinese Herbal; Free Radical Scavengers; Free Radicals; Heart; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; Mitochondrial Swelling; Phenanthrenes | 1999 |
Tanshinone II-A inhibits low density lipoprotein oxidation in vitro.
Topics: Abietanes; Copper; Drugs, Chinese Herbal; Free Radical Scavengers; Humans; Lipoproteins, LDL; Macrophages; Nitrates; Oxidation-Reduction; Peroxides; Phenanthrenes; Superoxides; Thiobarbituric Acid Reactive Substances | 2000 |
Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Cell Line; Cells, Cultured; Drugs, Chinese Herbal; Female; Immunosuppressive Agents; Interferon-gamma; Interleukin-12; Lymph Nodes; Lymphocyte Activation; Macrophage Activation; Macrophages; Mice; Mice, Inbred DBA; Phenanthrenes; Plant Extracts; Salvia miltiorrhiza | 2000 |
Analysis of bioactive components in traditional Chinese medicines by molecular biochromatography with alpha1-acid glycoprotein stationary phase.
Topics: Abietanes; Acetonitriles; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Medicine, Chinese Traditional; Orosomucoid; Osmolar Concentration; Phenanthrenes; Temperature | 2000 |
[A comparative study on the chemical components of Salvia miltiorrhiza Bge. collected from Zhongjiang of Sichuan and from other habitats].
Topics: Abietanes; China; Chromatography, Thin Layer; Drugs, Chinese Herbal; Lamiaceae; Phenanthrenes; Plant Extracts; Plants, Medicinal; Salvia miltiorrhiza; Sodium | 1997 |
Separation of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography using stepwise elution.
Topics: Abietanes; Chromatography, High Pressure Liquid; Magnoliopsida; Phenanthrenes; Spectrophotometry, Ultraviolet | 2000 |
Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance.
Topics: Abietanes; Animals; Anticoagulants; Benzoquinones; Female; Fibrinolytic Agents; Male; Maze Learning; Mice; Phenanthrenes; Pyrazines; Ubiquinone | 1999 |
Microwave-assisted extraction of tanshinones from Salvia miltiorrhiza bunge with analysis by high-performance liquid chromatography.
Topics: Abietanes; Chromatography, High Pressure Liquid; Microwaves; Phenanthrenes; Plant Roots; Salvia; Solvents | 2001 |
[Production of allochtonic formations in callus cells of Salvia miltiorrhiza Bge].
Topics: Abietanes; Cinnamates; Culture Techniques; Depsides; Drugs, Chinese Herbal; Lamiaceae; Phenanthrenes; Plant Extracts; Plant Growth Regulators; Plants, Medicinal; Rosmarinic Acid; Salvia miltiorrhiza | 1998 |
[Protective effect of tanshinone IIA on acute hepatic injury in mice].
Topics: Abietanes; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Male; Mice; Phenanthrenes; Phytotherapy | 2001 |
Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones.
Topics: Abietanes; Animals; Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Antiprotozoal Agents; Chromatography, Thin Layer; Diterpenes; Drug Resistance; Humans; Iran; Lamiaceae; Leishmania major; Lymphocytes; Nuclear Magnetic Resonance, Biomolecular; Phenanthrenes; Phytohemagglutinins; Plant Lectins; Plant Roots; Plants, Medicinal; Plasmodium falciparum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured | 2001 |
Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone II A.
Topics: Abietanes; Animals; Apoptosis; Culture Media, Serum-Free; DNA Fragmentation; Neuroprotective Agents; PC12 Cells; Phenanthrenes; Rats | 2001 |
Separation of tanshinones from Salvia miltiorrhiza bunge by multidimensional counter-current chromatography.
Topics: Abietanes; Chromatography, High Pressure Liquid; Countercurrent Distribution; Phenanthrenes; Salvia | 2002 |
[Acute promyelocytic leukemia cell differentiation induced by tanshinone II A and its molecular mechanism].
Topics: Abietanes; Cell Differentiation; Cell Division; Genes, p53; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes | 2000 |
Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza.
Topics: Abietanes; Acyltransferases; Animals; Diacylglycerol O-Acyltransferase; Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Phenanthrenes; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia; Taiwan | 2002 |
Novel sustained-release implant of herb extract using chitosan.
Topics: Abietanes; Animals; Biocompatible Materials; Biodegradation, Environmental; Chitin; Chitosan; Chromatography, High Pressure Liquid; Delayed-Action Preparations; In Vitro Techniques; Male; Phenanthrenes; Plant Extracts; Plant Preparations; Plants, Medicinal; Polymers; Rats; Rats, Wistar; Salvia miltiorrhiza; Time Factors; Wound Healing | 2002 |
Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Blotting, Western; Carrageenan; Cyclooxygenase 2; Dose-Response Relationship, Drug; Edema; Humans; Inhibitory Concentration 50; Isoenzymes; Male; Mast Cells; Membrane Proteins; Mice; Phenanthrenes; Phytotherapy; Plant Extracts; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rabbits; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2002 |
Study on the relationship between NB4 cell apoptosis induced by tanshinone IIA and the cell mitochondrial transmembrane potential.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; DNA; Humans; Membrane Potentials; Mitochondria; Phenanthrenes; Tumor Cells, Cultured | 2002 |
[Medicinal resources of Salvia yunnanensis].
Topics: Abietanes; Benzaldehydes; Catechols; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza; Spectrophotometry, Ultraviolet | 2002 |
[Terminal differentiation of human acute promyelocytic leukemia (APL) cells induced by Tanshinone II A in primary culture].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Cell Differentiation; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Tumor Cells, Cultured | 2000 |
[Study on improving the dissolution rate of tanshinone in vitro by solvent deposition method].
Topics: Abietanes; Drug Carriers; Phenanthrenes; Powders; Solubility; Starch | 2001 |
[Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)].
Topics: Abietanes; Crataegus; Drug Combinations; Drugs, Chinese Herbal; Hypolipidemic Agents; Paeonia; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza; Sitosterols; Triterpenes; Ursolic Acid | 2001 |
[Protective effect of tanshinone on injured cultured PC12 cells in vitro].
Topics: Abietanes; Animals; Cell Division; Free Radical Scavengers; L-Lactate Dehydrogenase; Neuroprotective Agents; PC12 Cells; Phenanthrenes; Rats | 2001 |
[Extraction of three tanshinones from the root of Salvia miltiorrhiza Bunge by supercritical carbon dioxide fluid and their analysis with high performance liquid chromatography].
Topics: Abietanes; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2002 |
[Dynamics of growth and total tanshinones accumulation in crown gall cultures of salvia miltiorrhiza].
Topics: Abietanes; Culture Media; Culture Techniques; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2000 |
[Studies on extracting procedure for huoxue jiangzhi capsules by orthogonal analysis].
Topics: Abietanes; Anthraquinones; Benzaldehydes; Capsules; Catechols; Drug Combinations; Drugs, Chinese Herbal; Hypolipidemic Agents; Phenanthrenes; Plants, Medicinal; Polygonum; Powders; Salvia miltiorrhiza; Technology, Pharmaceutical | 1999 |
[SFE-CGC determination of tanshinone in Salvia miltiorrhiza Bunge].
Topics: Abietanes; Chromatography, Gas; Chromatography, Supercritical Fluid; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2001 |
[Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats].
Topics: Abietanes; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Drugs, Chinese Herbal; Female; Liver; Liver Cirrhosis, Experimental; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2002 |
[Study on the differentiation of K562 cell-line induced by Tanshinone II A].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Differentiation; Cell Division; Humans; K562 Cells; Phenanthrenes; Proto-Oncogene Proteins c-myc | 2002 |
[A study on apoptosis of nasopharyngeal carcinoma cell line induced by Tanshinone II A and its molecular mechanism].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Humans; Nasopharyngeal Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Survival; Cell Transformation, Viral; Cells, Cultured; Cytochrome c Group; DNA Fragmentation; Drugs, Chinese Herbal; Enzyme Activation; Enzyme Precursors; Flow Cytometry; Liver; Membrane Potentials; Mitochondria, Liver; Phenanthrenes; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Simian virus 40 | 2003 |
Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo.
Topics: Abietanes; Animals; Anti-Bacterial Agents; Auditory Threshold; Cochlea; Drug Interactions; Drugs, Chinese Herbal; Evoked Potentials, Auditory, Brain Stem; Free Radical Scavengers; Gentamicins; Hearing Loss; Hydroxyl Radical; Kanamycin; Lipid Peroxidation; Male; Mice; Mice, Inbred CBA; Oxidants; Phenanthrenes; Superoxides | 2003 |
Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice.
Topics: Abietanes; Animals; Anticoagulants; Brain Ischemia; Drugs, Chinese Herbal; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Phenanthrenes; Phytotherapy; Plant Extracts; Plant Roots; Salvia miltiorrhiza | 2003 |
[Effect of tanshinone IIA on the growth behavior of human hepatoma cell line BEL-7402 in vitro and its mechanism].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Humans; Liver Neoplasms; Microscopy, Electron; Phenanthrenes | 2003 |
Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.
Topics: Abietanes; Algorithms; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Diterpenes; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidation-Reduction; Phenanthrenes; Salvia | 2003 |
[The variation of Caspase3 activity in tanshinone induced NB4 cells apoptosis].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspases; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Tumor Cells, Cultured | 2003 |
[Kinetic model for extraction process of Chinese traditional medicine].
Topics: Abietanes; Drugs, Chinese Herbal; Glycyrrhiza uralensis; Kinetics; Mathematics; Models, Chemical; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza; Schisandra; Technology, Pharmaceutical | 2002 |
[Spectroscopic studies on the binding of effective component of Chinese herbs with human serum albumin].
Topics: Abietanes; Binding Sites; Cyclodextrins; Energy Transfer; Humans; Phenanthrenes; Protein Binding; Protein Conformation; Salvia miltiorrhiza; Serum Albumin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan | 2001 |
[Determination of tanshinone IIA in rat plasma and the pharmacokinetics by RP-HPLC method].
Topics: Abietanes; Animals; Anti-Infective Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Stability; Male; Phenanthrenes; Random Allocation; Rats; Rats, Sprague-Dawley | 2003 |
Growth inhibition and apoptosis induction in human hepatoma cells by tanshinone II A.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Drugs, Chinese Herbal; Flow Cytometry; Humans; Liver Neoplasms; Phenanthrenes | 2003 |
[Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4].
Topics: Abietanes; Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Hepatocytes; Liver; Male; Phenanthrenes; Plants, Medicinal; Protective Agents; Rats; Rats, Wistar; Salvia miltiorrhiza | 2003 |
Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.
Topics: Abietanes; Animals; Antioxidants; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Ginkgo biloba; Glutathione Transferase; Isoenzymes; Kidney; Male; Malondialdehyde; Microsomes; Microsomes, Liver; Nitric Oxide; Phenanthrenes; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley | 2003 |
Induction of CYP1A by a diterpene quinone tanshinone IIA isolated from a medicinal herb Salvia miltiorrhiza in C57BL/6J but not in DBA/2J mice.
Topics: Abietanes; Administration, Oral; Animals; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Glutathione Transferase; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Microsomes, Liver; Phenanthrenes; RNA, Messenger; Salvia miltiorrhiza; Species Specificity | 2004 |
Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Interleukin-1; Interleukin-6; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenanthrenes; Phytotherapy; Plant Extracts; Plant Roots; Salvia miltiorrhiza; Tumor Necrosis Factor-alpha | 2003 |
Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag+ elicitation and nutrient feeding.
Topics: Abietanes; Culture Techniques; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Phenanthrenes; Phytotherapy; Plant Roots; Salvia miltiorrhiza; Sucrose; Thiosulfates | 2004 |
Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I.
Topics: Abietanes; Hydrogen-Ion Concentration; Models, Chemical; Phenanthrenes; Spectrometry, Fluorescence; Spectrophotometry; Temperature; Time Factors; Ultraviolet Rays | 2004 |
Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge.
Topics: Abietanes; Actins; Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Fusion; Cells, Cultured; Gene Expression; Glycoproteins; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoclasts; Osteoprotegerin; Phenanthrenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Salvia miltiorrhiza; Signal Transduction | 2004 |
Tanshinone prevents cancellous bone loss induced by ovariectomy in rats.
Topics: Abietanes; Animals; Body Weight; Bone Density; Bone Resorption; Drugs, Chinese Herbal; Ethinyl Estradiol; Female; Lumbar Vertebrae; Organ Size; Osteoclasts; Ovariectomy; Phenanthrenes; Rats; Rats, Sprague-Dawley; Tibia; Uterus | 2004 |
[Studies on the extraction of ingredients from Chinese traditional medicine with CO2 supercritical fluid].
Topics: Abietanes; Carbon Dioxide; Chromatography, Supercritical Fluid; Drugs, Chinese Herbal; Emodin; Phenanthrenes; Plants, Medicinal; Polygonum; Pressure; Salvia miltiorrhiza; Temperature | 2003 |
Evaluation of pressurized liquid extraction and pressurized hot water extraction for tanshinone I and IIA in Salvia miltiorrhiza using LC and LC-ESI-MS.
Topics: Abietanes; Chromatography, Liquid; Hot Temperature; Phenanthrenes; Pressure; Reference Standards; Salvia; Spectrometry, Mass, Electrospray Ionization; Water | 2004 |
[Enhancement of the bystander effect by tanshinone IIA in HSV-tK/GCV system is related to expression of connexin 43 mRNA].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Bystander Effect; Cell Line, Tumor; Cell Survival; Connexin 43; Female; Ganciclovir; Genetic Therapy; Humans; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; Simplexvirus; Thymidine Kinase; Uterine Cervical Neoplasms | 2004 |
Effects of tanshinone on neuropathological changes induced by amyloid beta-peptide(1-40) injection in rat hippocampus.
Topics: Abietanes; Acetylcholinesterase; Amyloid beta-Peptides; Animals; Hippocampus; Injections; Male; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peptide Fragments; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2004 |
Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Phenanthrenes | 2004 |
Identification of major active constituents in the fingerprint of Salvia miltiorrhiza Bunge developed by high-speed counter-current chromatography.
Topics: Abietanes; Countercurrent Distribution; Phenanthrenes; Reference Standards; Salvia; Spectrophotometry, Ultraviolet | 2004 |
Preparation and study on the inclusion complexes of two tanshinone compounds with beta-cyclodextrin.
Topics: Abietanes; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemical Precipitation; Magnetic Resonance Spectroscopy; Molecular Structure; Phenanthrenes; Spectroscopy, Fourier Transform Infrared; Temperature; Thermodynamics | 2005 |
[Differentiation and apoptosis of NB4 cells synergistically induced by Tanshinone II A and all-trans retinoic acid].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Differentiation; Cell Line, Tumor; Drug Synergism; Drugs, Chinese Herbal; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Tretinoin | 2004 |
Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells.
Topics: Abietanes; Animals; Cell Line; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Synthase; Phenanthrenes; Salvia miltiorrhiza | 2004 |
Compound 278E, structurally modified from tanshinone, induces monocytic differentiation and regulates proto-oncogene expression in human leukemic HL-60 cells.
Topics: Abietanes; Antineoplastic Agents; Benzofurans; Cell Differentiation; Cell Proliferation; Drugs, Chinese Herbal; Esterases; HL-60 Cells; Humans; Isoenzymes; Monocytes; Phenanthrenes; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins; Salvia miltiorrhiza; Superoxides | 2005 |
[Studies on HPLC fingerprints of tanshinone microemulsion].
Topics: Abietanes; Chromatography, High Pressure Liquid; Emulsions; Phenanthrenes; Plants, Medicinal; Quality Control; Salvia miltiorrhiza | 2004 |
[Effect of tanshinone microemulsion on reversing MDR in human tumor cells].
Topics: Abietanes; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Proliferation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Emulsions; Humans; K562 Cells; Phenanthrenes | 2004 |
Induction and potentiation of diterpenoid tanshinone accumulation in Salvia miltiorrhiza hairy roots by beta-aminobutyric acid.
Topics: Abietanes; Aminobutyrates; Diterpenes; Dose-Response Relationship, Drug; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Time Factors | 2005 |
[Study on the characteristic of assimilating nitrogenous phosphorous fertilizer and the accumulation disciplinarian of total tanshinons of Salvia miltiorrhiza].
Topics: Abietanes; Fertilizers; Nitrogen; Phenanthrenes; Phosphorus; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza | 2004 |
[The experimental study of the effect of tanshinone on artery restenosis in mouse].
Topics: Abietanes; Animals; Anticoagulants; Carotid Arteries; Carotid Stenosis; Dose-Response Relationship, Drug; Female; Hyperplasia; Ligation; Mice; Phenanthrenes; Plants, Medicinal; Proliferating Cell Nuclear Antigen; Random Allocation; Recurrence; Salvia miltiorrhiza; Tunica Intima | 2004 |
[The growth of Salvia miltiorrhiza seedling and root system following transplantation].
Topics: Abietanes; Agriculture; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Seedlings | 2005 |
[Alteration of activities of telomerase in tanshinone IIA inducing apoptosis of the leukemia cells].
Topics: Abietanes; Apoptosis; Cell Proliferation; HL-60 Cells; Humans; K562 Cells; Phenanthrenes; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Salvia miltiorrhiza; Telomerase; Tumor Suppressor Protein p53 | 2005 |
Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC.
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2005 |
Determining the purity of samples from natural products by coupling HPLC and CCD spectrometry.
Topics: Abietanes; Animals; Annelida; Biological Products; Chromatography, High Pressure Liquid; Drug Contamination; Molecular Structure; Phenanthrenes; Reproducibility of Results; Spectrophotometry | 2005 |
Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice.
Topics: Abietanes; Animals; Anticoagulants; Carotid Arteries; Female; Hyperplasia; Mice; Muscle, Smooth, Vascular; Phenanthrenes; Proliferating Cell Nuclear Antigen; Tunica Intima | 2005 |
Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells.
Topics: Abietanes; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Flow Cytometry; Male; Muscle, Smooth, Vascular; Phenanthrenes; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Tetrazolium Salts; Thiazoles | 2005 |
Potential anticancer activity of tanshinone IIA against human breast cancer.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Caspase 3; Caspases; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Transplantation; Phenanthrenes; Transplantation, Heterologous | 2005 |
Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro.
Topics: Abietanes; Angiogenesis Inhibitors; Animals; Cattle; Cell Movement; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Endothelial Cells; Fibroblast Growth Factor 2; Humans; Neovascularization, Physiologic; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2005 |
Tanshinone IIA isolated from Salvia miltiorrhiza elicits the cell death of human endothelial cells.
Topics: Abietanes; Acridine Orange; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Calcium; Caspase Inhibitors; Caspases; Cell Cycle; Cell Death; Cytochromes c; Dicumarol; Drugs, Chinese Herbal; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Membrane Potentials; Mitochondria; Models, Biological; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Phenanthrenes; Plant Extracts; Reactive Oxygen Species; Salvia miltiorrhiza; Time Factors | 2005 |
Efficient production and recovery of diterpenoid tanshinones in Salvia miltiorrhiza hairy root cultures with in situ adsorption, elicitation and semi-continuous operation.
Topics: Abietanes; Adsorption; Bioreactors; Cell Culture Techniques; Diterpenes; Drugs, Chinese Herbal; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2005 |
[Purification and fingerprinting development of Salvia miltiorrhiza Bunge by high-speed counter-current chromatography].
Topics: Abietanes; Chromatography, High Pressure Liquid; Countercurrent Distribution; Molecular Structure; Phenanthrenes; Reference Standards; Salvia miltiorrhiza | 2003 |
[A study on the cell differentiation induced by tanshinone IIA and its molecular mechanism in retinoic acid: resistant acute promyelocytic leukemia].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Tretinoin | 2005 |
[Studies on chemical constituents in roots of Peucedanum praeruptorum].
Topics: Abietanes; Apiaceae; Coumarins; Drugs, Chinese Herbal; Phenanthrenes; Plant Roots; Plants, Medicinal | 2005 |
[Inhibition of proliferation and induction of apoptosis by tanshinone II A in NCI-H460 cell].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Phenanthrenes; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; RNA, Messenger; Salvia miltiorrhiza | 2005 |
Preparation and pharmacokinetic evaluation of Tashinone IIA solid lipid nanoparticles.
Topics: Abietanes; Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Diffusion; Drug Compounding; Drug Evaluation, Preclinical; Half-Life; Injections, Intravenous; Light; Lipids; Microscopy, Electron, Transmission; Nanostructures; Particle Size; Phenanthrenes; Plant Extracts; Rabbits; Salvia; Scattering, Radiation | 2005 |
[Effects of mineral cations on the accumulation of tanshinone II A and protocatechuic aldehyde in the adventitious root culture of Salvia niltiorrhiza].
Topics: Abietanes; Benzaldehydes; Catechols; Copper; Iron; Magnesium; Manganese; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Tissue Culture Techniques; Zinc | 2005 |
Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Simultaneous quantification of cryptotanshinone and its active metabolite tanshinone IIA in plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS).
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge.
Topics: Abietanes; Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Furans; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Phenanthrenes; Plant Extracts; Plant Roots; Quinones; Salvia miltiorrhiza | 2005 |
Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Abietanes; Animals; Chromatography, Liquid; Drug Stability; Female; Male; Mass Spectrometry; Phenanthrenes; Rats; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Body Temperature; Brain; Brain Diseases; Cell Survival; Dose-Response Relationship, Drug; Free Radicals; Hypoxia; Hypoxia-Ischemia, Brain; In Vitro Techniques; Ischemia; Mitochondria; Models, Chemical; Neurons; Organ Size; Oxygen; Phenanthrenes; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography-tandem mass spectrometry.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Microsomes, Liver; Phenanthrenes; Rats; Spectrometry, Mass, Electrospray Ionization | 2006 |
[Effects of Tanshinone IIA on procoagulant activity of human ECV304 cell line induced by NB4 cells].
Topics: Abietanes; Anticoagulants; Cell Differentiation; Cell Line; Cell Line, Tumor; Culture Media, Conditioned; Drugs, Chinese Herbal; Endothelial Cells; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Thromboplastin; Tretinoin; Umbilical Veins | 2006 |
Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Male; Microsomes, Liver; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
[Inhibitive effect to collagen fiber of tanshinone II A in iliac artery following balloon injury in rabbit].
Topics: Abietanes; Animals; Catheterization; Collagen; Coronary Restenosis; Disease Models, Animal; Iliac Artery; Male; Muscle, Smooth, Vascular; Phenanthrenes; Plants, Medicinal; Rabbits; Salvia; Tunica Intima; Tunica Media | 2005 |
[Analysis of four components in Fufang Danshen Tablets by high performance liquid chromatography with electrochemical and ultraviolet detections].
Topics: Abietanes; Benzaldehydes; Caffeic Acids; Catechols; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydroxybenzoates; Methanol; Phenanthrenes; Phosphoric Acids; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tablets | 2005 |
[Preparation of tanshinone transfersome and its deformability].
Topics: Abietanes; Drug Compounding; Lecithins; Liposomes; Microscopy, Electron, Transmission; Particle Size; Phenanthrenes; Sodium Cholate; Technology, Pharmaceutical; Temperature | 2006 |
Characterization of tanshinones in the roots of Salvia miltiorrhiza (Dan-shen) by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
Topics: Abietanes; Chromatography, High Pressure Liquid; Indicators and Reagents; Isomerism; Naphthoquinones; Phenanthrenes; Plant Extracts; Plant Roots; Reference Standards; Salvia miltiorrhiza; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2006 |
[Synergistic effects of biotic and abiotic elicitors on the production of tanshinones in Salvia miltiorrhiza hairy root culture].
Topics: Abietanes; Aminoisobutyric Acids; Bioreactors; Cobalt; Culture Media; Culture Techniques; Drug Synergism; Phenanthrenes; Plant Roots; Plants, Medicinal; Saccharomyces cerevisiae; Salvia miltiorrhiza; Silver | 2006 |
Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry.
Topics: Abietanes; Animals; Anti-Infective Agents; Bile; Chromatography, Liquid; Drugs, Chinese Herbal; Feces; Glucuronides; Hydroxylation; Injections, Intravenous; Phenanthrenes; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization | 2006 |
Inhibition of ethanol-induced toxicity by tanshinone IIA in PC12 cells.
Topics: Abietanes; Animals; Apoptosis; Cell Survival; Ethanol; L-Lactate Dehydrogenase; Neuroprotective Agents; PC12 Cells; Phenanthrenes; Plants, Medicinal; Rats; Reactive Oxygen Species; Salvia miltiorrhiza; Tumor Suppressor Protein p53 | 2006 |
[Experimental study of effect of tanshinone on artery restenosis in rat carotid injury model].
Topics: Abietanes; Angioplasty, Balloon, Coronary; Animals; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis; Male; NF-kappa B; Nitric Oxide Synthase Type II; Phenanthrenes; Plants, Medicinal; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tunica Intima | 2006 |
Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways.
Topics: Abietanes; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; I-kappa B Kinase; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Structure; NF-kappa B; NF-kappaB-Inducing Kinase; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction | 2006 |
Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism.
Topics: Abietanes; Anti-Inflammatory Agents; Antioxidants; Apoptosis; CD40 Antigens; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Flow Cytometry; Humans; Hydrogen Peroxide; Methanol; Nitric Oxide; Phenanthrenes; Plant Extracts; Plant Roots; Salvia miltiorrhiza; Superoxide Dismutase; Time Factors; Umbilical Veins; Water | 2006 |
Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1.
Topics: Abietanes; Animals; Bone Marrow Cells; Carrier Proteins; Cell Differentiation; Cells, Cultured; Down-Regulation; Gene Expression; Immunoblotting; Macrophage Colony-Stimulating Factor; Male; Membrane Glycoproteins; Mice; Mice, Inbred ICR; NFATC Transcription Factors; Osteoclasts; Phenanthrenes; Proto-Oncogene Proteins c-fos; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional chinese medicinal preparations.
Topics: Abietanes; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Spectrophotometry, Ultraviolet | 2006 |
[Studies on absorptive mechanism of lipophilic components of danshen from its hydroxypropyl-beta-cyclodextrin inclusion complex].
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Abietanes; beta-Cyclodextrins; Biological Transport; Chromatography, High Pressure Liquid; Intestinal Absorption; Phenanthrenes; Salvia miltiorrhiza | 2006 |
Addition of tanshinone IIA to UW solution decreases skeletal muscle ischemia-reperfusion injury.
Topics: Abietanes; Adenosine; Adenosine Triphosphatases; Allopurinol; Animals; Apoptosis; Aspartate Aminotransferases; Creatine Kinase; Dose-Response Relationship, Drug; Glutathione; Hindlimb; Insulin; Intercellular Adhesion Molecule-1; L-Lactate Dehydrogenase; Male; Malondialdehyde; Muscle, Skeletal; Organ Preservation Solutions; Phenanthrenes; Raffinose; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2006 |
Synthesis of novel chemical probes for the study of tanshinone binding proteins.
Topics: Abietanes; Acid Phosphatase; Animals; Carrier Proteins; Cell Line; Cell Proliferation; Hydrogen; Isoenzymes; Membrane Glycoproteins; Mice; Molecular Structure; Osteoclasts; Osteogenesis; Phenanthrenes; Proteins; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Tartrate-Resistant Acid Phosphatase | 2006 |
[Initial studies of microemulsion formulation for the delivery of a combination of Tanshiones and Salvianolic acids].
Topics: Abietanes; Caffeic Acids; Drug Carriers; Emulsions; Oleic Acids; Particle Size; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza; Solvents; Technology, Pharmaceutical; Viscosity; Water | 2006 |
Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells.
Topics: Abietanes; Analysis of Variance; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Cell Differentiation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glial Fibrillary Acidic Protein; Glioma; Humans; Intermediate Filament Proteins; Nerve Tissue Proteins; Nestin; Phenanthrenes; RNA, Messenger; Statistics, Nonparametric; Tumor Cells, Cultured | 2007 |
Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro.
Topics: Abietanes; Apoptosis; Caspase 3; Cell Adhesion; Cell Line, Tumor; Humans; Leukemia, Promyelocytic, Acute; Neoplasm Invasiveness; Phenanthrenes | 2006 |
[Protective effect of tanshinones against liver injury in mice loaded with restraint stress].
Topics: Abietanes; Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Drugs, Chinese Herbal; Glutathione; Liver; Liver Diseases; Male; Malondialdehyde; Mice; Phenanthrenes; Plants, Medicinal; Protective Agents; Reactive Oxygen Species; Restraint, Physical; Salvia miltiorrhiza; Stress, Physiological | 2006 |
Enhancement of tanshinone production in Salvia miltiorrhiza Bunge (red or Chinese sage) hairy-root culture by hyperosmotic stress and yeast elicitor.
Topics: Abietanes; Biotechnology; Catalase; Cell Extracts; Drugs, Chinese Herbal; Osmotic Pressure; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Sorbitol; Superoxide Dismutase; Yeasts | 2007 |
Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion.
Topics: Abietanes; Administration, Oral; Animals; Area Under Curve; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Drugs, Chinese Herbal; Humans; Infusions, Intravenous; Liver; Lung; Phenanthrenes; Phytotherapy; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tissue Distribution | 2006 |
[Effect of micronization on the quality of Salvia miltiorrhiza Bge].
Topics: Abietanes; Biological Availability; Drug Stability; Drugs, Chinese Herbal; Particle Size; Phenanthrenes; Plant Roots; Plants, Medicinal; Powders; Quality Control; Salvia miltiorrhiza; Solubility; Technology, Pharmaceutical | 2006 |
[Studies on in vitro culture of adventitious root in Salvia miltiorrhiza].
Topics: Abietanes; Benzaldehydes; Catechols; Culture Media; Hydrogen-Ion Concentration; Phenanthrenes; Plant Growth Regulators; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Sucrose; Tissue Culture Techniques | 2006 |
Identification of tanshinones and their metabolites in rat bile after oral administration of TTE-50, a standardized extract of Salvia miltiorrhiza by HPLC-ESI-DAD-MSn.
Topics: Abietanes; Administration, Oral; Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Male; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Salvia; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2007 |
[Quantitative analysis on Radix Salviae miltiorrhizae by NIR].
Topics: Abietanes; Benzofurans; Electronic Data Processing; Least-Squares Analysis; Models, Theoretical; Phenanthrenes; Plant Roots; Plants, Medicinal; Quality Control; Reproducibility of Results; Salvia miltiorrhiza; Spectroscopy, Near-Infrared | 2006 |
[Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A].
Topics: Abietanes; Adult; Drug Resistance, Neoplasm; Humans; Leukemia, Promyelocytic, Acute; Male; Phenanthrenes; Remission Induction; Tretinoin | 2006 |
Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells.
Topics: Abietanes; Acyltransferases; Angiotensin II; Aorta; Humans; Hydrogen Peroxide; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Oxidation-Reduction; Phenanthrenes; Reactive Oxygen Species; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2007 |
The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells.
Topics: Abietanes; Alkaline Phosphatase; Animals; Benzaldehydes; Benzofurans; Bone Marrow Cells; Catechols; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Male; Mesenchymal Stem Cells; Osteoblasts; Osteogenesis; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2007 |
Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation.
Topics: Abietanes; Animals; Dicumarol; Drugs, Chinese Herbal; Glucuronides; Intestinal Mucosa; Intestines; Liver; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Phenanthrenes; Quinones; Rats; Rats, Sprague-Dawley | 2007 |
Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging.
Topics: Abietanes; Boron Compounds; Cells, Cultured; Endothelial Cells; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Nitric Oxide; Phenanthrenes; Reproducibility of Results; Time Factors | 2007 |
Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.
Topics: Abietanes; Animals; Antioxidants; Aorta, Thoracic; Atherosclerosis; Calcinosis; Calcium; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Ergocalciferols; Lipoproteins, LDL; Male; Malondialdehyde; Oxidative Stress; Phenanthrenes; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Superoxides; Time Factors | 2007 |
[Inhibition of cell growth and induction of apoptosis in human hepatoma cell line HepG2 by tanshione IIA].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flow Cytometry; Humans; Liver Neoplasms; Microscopy, Fluorescence; Phenanthrenes; Time Factors | 2007 |
Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution | 2007 |
[Study on uniform-design for optimizing supercritical-CO2 fluid extraction technique of tanshinones in radix salviae].
Topics: Abietanes; Carbon Dioxide; Chromatography, Supercritical Fluid; Phenanthrenes; Plant Roots; Plants, Medicinal; Reproducibility of Results; Salvia miltiorrhiza | 2006 |
Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain; Brain Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Stroke; Treatment Outcome | 2007 |
Coupling continuous ultrasound-assisted extraction with ultrasonic probe, solid-phase extraction and high-performance liquid chromatography for the determination of sodium Danshensu and four tanshinones in Salvia miltiorrhiza bunge.
Topics: Abietanes; Chromatography, High Pressure Liquid; Lactates; Phenanthrenes; Salvia miltiorrhiza; Sensitivity and Specificity; Ultrasonics | 2007 |
Role of ATP-binding cassette drug transporters in the intestinal absorption of tanshinone IIB, one of the major active diterpenoids from the root of Salvia miltiorrhiza.
Topics: Abietanes; Animals; Anticoagulants; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Diterpenes; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Mice; Mice, Knockout; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2007 |
[Effects of methyl jasmonat on accumulation and release of tanshinones in suspension cultures of Salvia miltiorrhiza hairy root].
Topics: Abietanes; Acetates; Culture Techniques; Cyclopentanes; Oxylipins; Phenanthrenes; Plant Growth Regulators; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza | 2007 |
Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.
Topics: Abietanes; Animals; Area Under Curve; Calibration; Cardiotonic Agents; Chromatography, High Pressure Liquid; Half-Life; Injections, Intravenous; Male; Mice; Phenanthrenes; Quality Control; Reproducibility of Results; Tissue Distribution | 2007 |
Complexation of tanshinone IIA with 2-hydroxypropyl-beta-cyclodextrin: effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Abietanes; Animals; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Carriers; Drug Compounding; Drugs, Chinese Herbal; Duodenum; Ileum; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Jejunum; Kinetics; Male; Permeability; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical; Water | 2007 |
Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.
Topics: Abietanes; Adenosine Triphosphate; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Digoxin; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Microsomes, Liver; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Probenecid; Propionates; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Temperature; Transfection; Verapamil | 2007 |
[Pharmacokinetic interactions between the main components in the extracts of Salvia miltiorrhiza Bge. in rat].
Topics: Abietanes; Animals; Area Under Curve; Benzaldehydes; Benzofurans; Catechols; Drug Interactions; Female; Male; Metabolic Clearance Rate; Molecular Structure; Phenanthrenes; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2007 |
Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography.
Topics: Abietanes; Capillary Electrochromatography; Drugs, Chinese Herbal; Furans; Molecular Structure; Phenanthrenes; Plant Extracts; Quinones; Reproducibility of Results; Salvia miltiorrhiza; Solid Phase Extraction | 2007 |
Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis.
Topics: Abietanes; Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Cell Survival; Cells, Cultured; DNA Fragmentation; Drugs, Chinese Herbal; Hydrogen Peroxide; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxidative Stress; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2007 |
[Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel].
Topics: Abietanes; Administration, Cutaneous; Animals; Dioxolanes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Gels; In Vitro Techniques; Male; Mice; Phenanthrenes; Reproducibility of Results; Salvia miltiorrhiza; Skin; Skin Absorption | 2007 |
PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation.
Topics: Abietanes; Animals; Apoptosis; Bile Acids and Salts; Blotting, Western; Caspases; Cells, Cultured; Cholagogues and Choleretics; Chromatography, High Pressure Liquid; Colorimetry; DNA Fragmentation; Enzyme Activation; Glycochenodeoxycholic Acid; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Oxidative Stress; Phenanthrenes; Phosphorylation; Plant Extracts; Rats; Reactive Oxygen Species; Salvia | 2007 |
Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Coumaric Acids; Drug Interactions; Drugs, Chinese Herbal; Lactates; Male; Medicine, Chinese Traditional; Molecular Structure; Phenanthrenes; Rabbits; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2007 |
Tanshinone IIA ameliorates trinitrobenzene sulfonic acid (TNBS)-induced murine colitis.
Topics: Abietanes; Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Colitis; Colon; Dose-Response Relationship, Drug; Glutathione; Immunohistochemistry; Interleukin-1beta; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Peroxidase; Phenanthrenes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Cryptotanshinone inhibits macrophage migration by impeding F-actin polymerization and filopodia extension.
Topics: Abietanes; Actins; Anti-Inflammatory Agents; Cell Movement; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemotactic Factors; Complement C5a; Cytoskeleton; Drugs, Chinese Herbal; Flow Cytometry; Fluorescent Dyes; Humans; Macrophage Inflammatory Proteins; Macrophages; Phenanthrenes; Pseudopodia | 2007 |
Profiling the metabolic difference of seven tanshinones using high-performance liquid chromatography/multi-stage mass spectrometry with data-dependent acquisition.
Topics: Abietanes; Animals; Bile; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Information Storage and Retrieval; Injections, Intravenous; Mass Spectrometry; Metabolic Clearance Rate; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2007 |
[Comparison of two preparation methods applied in tanshinone II(A)-loaded PLGA nanoparticles].
Topics: Abietanes; Chemical Precipitation; Crystallization; Emulsions; Lactic Acid; Nanoparticles; Particle Size; Phenanthrenes; Plant Roots; Plants, Medicinal; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Quality Control; Salvia miltiorrhiza; Technology, Pharmaceutical; Volatilization | 2007 |
[Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative].
Topics: Abietanes; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Phenanthrenes; Receptors, Estrogen | 2007 |
Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats.
Topics: Abietanes; Animals; Blood Coagulation; CD18 Antigens; Drugs, Chinese Herbal; Female; Lipopolysaccharides; Lung; Male; Malondialdehyde; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2007 |
Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier.
Topics: Abietanes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cells, Cultured; Endothelial Cells; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Quinidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Verapamil | 2007 |
Tanshinone IIA inhibits endothelin-1 production in TNF-alpha-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis.
Topics: Abietanes; Animals; Aspartic Acid Endopeptidases; Brain; Cell Survival; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelin-Converting Enzymes; Metalloendopeptidases; Phenanthrenes; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
[Studies on chemical constituents of Prunella vulgaris].
Topics: Abietanes; Amides; Anthraquinones; Chromatography, High Pressure Liquid; Flowers; Lactates; Magnetic Resonance Spectroscopy; Phenanthrenes; Plants, Medicinal; Prunella | 2007 |
[Preparation of tanshinone microemulsion and its absorption in rat intestine in situ].
Topics: Abietanes; Animals; Emulsions; Intestinal Absorption; Intestine, Small; Male; Particle Size; Phenanthrenes; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Technology, Pharmaceutical | 2007 |
Chromatographic fingerprinting analysis of Danshen root (Salvia miltiorrhiza Radix et Rhizoma) and its preparations using high performance liquid chromatography with diode array detection and electrospray mass spectrometry (HPLC-DAD-ESI/MS).
Topics: Abietanes; Benzofurans; Caffeic Acids; Chromatography, High Pressure Liquid; Cinnamates; Diterpenes; Drugs, Chinese Herbal; Lactates; Molecular Structure; Phenanthrenes; Phenylpropionates; Plant Extracts; Plant Roots; Reference Standards; Salvia miltiorrhiza; Spectrometry, Mass, Electrospray Ionization | 2007 |
Simultaneous determination and pharmacokinetic study of water-soluble and lipid-soluble components of danshen in rat plasma using HPLC-UV method.
Topics: Abietanes; Animals; Benzofurans; Calibration; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydrophobic and Hydrophilic Interactions; Lipids; Molecular Structure; Phenanthrenes; Phenanthrolines; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Salvia miltiorrhiza; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Water | 2007 |
Study of the phase I and phase II metabolism of a mixture containing multiple tanshinones using liquid chromatography/tandem mass spectrometry.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Complex Mixtures; Drugs, Chinese Herbal; Feces; Male; Metabolic Clearance Rate; Phase Transition; Phenanthrenes; Rats; Reproducibility of Results; Salvia miltiorrhiza; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Urinalysis | 2007 |
Establishment of a new human glioblastoma multiforme cell line (WJ1) and its partial characterization.
Topics: Abietanes; Adult; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Culture Techniques; Cell Division; Cell Line, Tumor; Cisplatin; Etoposide; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Intermediate Filament Proteins; Karyotyping; Male; Mice; Mice, Nude; Nerve Tissue Proteins; Nestin; Phenanthrenes; Xenograft Model Antitumor Assays | 2007 |
Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.
Topics: Abietanes; Animals; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Furans; Male; Memory Disorders; Mice; Mice, Inbred ICR; Phenanthrenes; Quinones; Receptors, GABA-A; Scopolamine | 2007 |
[Effect of tanshinone II A on angiotensin II induced nitric oxide production and endothelial nitric oxide synthase gene expression in cultured porcine aortic endothelial cells].
Topics: Abietanes; Angiotensin II; Animals; Aorta; Cells, Cultured; Drugs, Chinese Herbal; Endothelial Cells; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase Type III; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine | 2007 |
Investigation of the improved effects of 2-hydroxypropyl-beta-cyclodextrin on solubility, dissolution rate, and intestinal absorptive profile of tanshinone IIA in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Abietanes; Animals; beta-Cyclodextrins; Drug Stability; Drugs, Chinese Herbal; Excipients; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solubility | 2007 |
Enhanced secondary metabolite (tanshinone) production of Salvia miltiorrhiza hairy roots in a novel root-bacteria coculture process.
Topics: Abietanes; Bacillus cereus; Cell Culture Techniques; Coculture Techniques; Hydrogen Peroxide; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2007 |
Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Flow Cytometry; Glutathione; Humans; Liver Neoplasms; Mass Spectrometry; Oxidative Stress; Phenanthrenes; Salvia miltiorrhiza | 2008 |
[The inhibitive effect produced by local perfusion of tanshinone IIA nanoparticle on neointimal hyperplasia of rabbit carotid artery following intimal denudation].
Topics: Abietanes; Angioplasty, Balloon; Animals; Caprolactam; Carotid Arteries; Drug Carriers; Hyperplasia; Lactic Acid; Nanoparticles; Phenanthrenes; Polyesters; Polymers; Rabbits; Tunica Intima | 2007 |
Comparative genotoxicity evaluation of imidazolinone herbicides in somatic cells of Drosophila melanogaster.
Topics: Abietanes; Animals; Cell Line; Cell Survival; Comet Assay; Cricetinae; Cricetulus; DNA Damage; Hyptis; Micronucleus Tests; Mutagenicity Tests; Mutagens; Phenanthrenes; Plant Roots | 2008 |
In situ intestinal absorption behaviors of tanshinone IIA from its inclusion complex with hydroxypropyl-beta-cyclodextrin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Abietanes; Algorithms; Animals; beta-Cyclodextrins; Biological Availability; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Indicators and Reagents; Intestinal Absorption; Male; Models, Statistical; Permeability; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solutions; X-Ray Diffraction | 2007 |
[Quality analysis of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC].
Topics: Abietanes; China; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drugs, Chinese Herbal; Geography; Pharmacognosy; Phenanthrenes; Plants, Medicinal; Quality Control; Reproducibility of Results; Rhizome; Salvia miltiorrhiza | 2007 |
[Determination of tanshinone II A and deoxyschizandrin in danshenwuweizi tablet by RP-HPLC].
Topics: Abietanes; Chromatography, Thin Layer; Drug Combinations; Drugs, Chinese Herbal; Phenanthrenes; Plants, Medicinal; Polycyclic Compounds; Quality Control; Reproducibility of Results; Tablets | 2007 |
Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Coronary Artery Disease; Dietary Fats; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Female; Interleukin-1beta; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Molecular Structure; Phenanthrenes; Rabbits; Vascular Cell Adhesion Molecule-1 | 2007 |
Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat.
Topics: Abietanes; Animals; Chromatography, Liquid; Diterpenes; Drugs, Chinese Herbal; Female; Male; Molecular Structure; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tandem Mass Spectrometry; Time Factors; Tissue Distribution | 2007 |
[The influence of steaming processing on components in Chinese medicine by HPLC].
Topics: Abietanes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flowers; Hot Temperature; Lonicera; Pharmacognosy; Phenanthrenes; Plants, Medicinal; Reproducibility of Results; Rutin; Sophora; Steam; Technology, Pharmaceutical | 2007 |
[The inhibitive effect of sodium tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery ballon injury model].
Topics: Abietanes; Animals; Apoptosis; Catheterization; Disease Models, Animal; Drugs, Chinese Herbal; Hyperplasia; Iliac Artery; Injections, Intravenous; Male; Phenanthrenes; Plants, Medicinal; Rabbits; Sulfonic Acids; Tunica Intima; Tunica Media | 2007 |
Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway.
Topics: Abietanes; Aorta; Cell Movement; Drugs, Chinese Herbal; Humans; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Myocytes, Smooth Muscle; Phenanthrenes; Proto-Oncogene Proteins c-akt; Salvia miltiorrhiza; Signal Transduction | 2008 |
[In situ extraction effect of macroporous resins on tanshinones in Salvia miltiorrhiza hairy root culture].
Topics: Abietanes; Adsorption; Phenanthrenes; Plant Roots; Plants, Medicinal; Resins, Synthetic; Salvia miltiorrhiza; Tissue Culture Techniques | 2007 |
Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; CD40 Antigens; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Female; Male; Malondialdehyde; Matrix Metalloproteinase 2; Phenanthrenes; Plant Roots; Rabbits; Salvia miltiorrhiza; Superoxide Dismutase | 2008 |
[Inhibition effects of constituents of Radix Salviae Miltiorrhizae on proliferation and procollagen transcription of dermal fibroblasts in systemic sclerosis].
Topics: Abietanes; Benzaldehydes; Catechols; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type III; Drugs, Chinese Herbal; Female; Fibroblasts; Humans; Lactates; Male; Phenanthrenes; Plant Extracts; Procollagen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salvia miltiorrhiza; Scleroderma, Systemic; Transcription, Genetic | 2007 |
Ultrahigh diterpenoid tanshinone production through repeated osmotic stress and elicitor stimulation in fed-batch culture of Salvia miltiorrhiza hairy roots.
Topics: Abietanes; Biomass; Bioreactors; Culture Media; Diterpenes; Osmotic Pressure; Phenanthrenes; Plant Roots; Plants, Medicinal; Polysaccharides, Bacterial; Salvia miltiorrhiza; Tissue Culture Techniques | 2008 |
Orthogonal array design for the optimization of supercritical fluid extraction of tanshinones from Danshen.
Topics: Abietanes; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Phenanthrenes; Reference Standards; Salvia miltiorrhiza; Temperature | 2008 |
Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases.
Topics: Abietanes; Animals; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Male; Mass Spectrometry; Microsomes, Liver; Models, Animal; Myocardial Ischemia; Phenanthrenes; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Time Factors | 2008 |
Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis.
Topics: Abietanes; Animals; Animals, Newborn; Antineoplastic Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cell Nucleus; Cell Survival; Cells, Cultured; Chemoprevention; Cyclin D1; Dose-Response Relationship, Drug; Doxorubicin; Drugs, Chinese Herbal; Formazans; Myocytes, Cardiac; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetrazolium Salts | 2008 |
Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza,
Topics: Abietanes; Animals; Chromatography, Liquid; Male; Molecular Structure; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salvia miltiorrhiza; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; In Vitro Techniques; Injections, Intravenous; Liver; Mass Spectrometry; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; NAD; NADP; Phenanthrenes; Predictive Value of Tests; Rats; Reproducibility of Results; Subcellular Fractions; Uridine Diphosphate Glucuronic Acid | 2008 |
Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Humans; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Tumor Suppressor Protein p53 | 2007 |
[Contrast studies on content of hydrophobic components between Salvia yunnanensis roots and Salvia miltiorrhiza roots].
Topics: Abietanes; Chromatography, Thin Layer; Hydrophobic and Hydrophilic Interactions; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Solubility; Species Specificity | 2007 |
Cloning and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza (Chinese sage) hairy roots.
Topics: Abietanes; Aldose-Ketose Isomerases; Amino Acid Sequence; Cloning, Molecular; Diterpenes; Escherichia coli; Gene Expression Regulation, Plant; Gene Knockout Techniques; Metabolic Networks and Pathways; Molecular Sequence Data; Multienzyme Complexes; Oxidoreductases; Phenanthrenes; Phylogeny; Plant Roots; Salvia miltiorrhiza; Sequence Analysis, DNA; Stress, Physiological; Up-Regulation | 2009 |
[Analysis on biomasses and contents of active components in roots of Salvia miltiorrhiza from different populations].
Topics: Abietanes; Benzofurans; Biomass; Caffeic Acids; China; Chromatography, High Pressure Liquid; Ecosystem; Lactates; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Spectrophotometry, Ultraviolet | 2007 |
Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza).
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Abietanes; Administration, Oral; Animals; beta-Cyclodextrins; Cardiovascular Agents; Dogs; Drugs, Chinese Herbal; Drugs, Investigational; Female; Male; Phenanthrenes; Phenanthrolines; Rats; Salvia miltiorrhiza; Tissue Distribution | 2008 |
Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro.
Topics: Abietanes; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Female; In Situ Nick-End Labeling; Neurons; Phenanthrenes; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Staurosporine | 2008 |
[Inhibitive effect of local perfusion of tanshinone II A nanoparticles on MMP-2 secretion].
Topics: Abietanes; Animals; Carotid Arteries; Drugs, Chinese Herbal; Hyperplasia; Male; Matrix Metalloproteinase 2; Nanoparticles; Phenanthrenes; Rabbits | 2008 |
Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin.
Topics: Abietanes; Animals; Antineoplastic Agents; Blotting, Western; Cattle; Cell Differentiation; Cell Line, Tumor; Cinnamates; Cytoplasm; Databases, Factual; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Neoplastic; Ginsenosides; Mitochondria; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Nucleophosmin; Oncogenes; Phenanthrenes; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Suppressor Protein p53 | 2008 |
Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine.
Topics: Abietanes; Animals; Caco-2 Cells; Caffeic Acids; Cardiotonic Agents; Chromatography, Liquid; Dogs; Humans; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tandem Mass Spectrometry; Tissue Distribution | 2008 |
Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease.
Topics: Abietanes; Animals; Cell Death; Cell Line, Tumor; Cells, Cultured; Cytoprotection; Drugs, Chinese Herbal; Ethanol; Gene Expression Profiling; Hepatocytes; Lipid Metabolism; Lipopolysaccharides; Liver Diseases, Alcoholic; Mice; Phenanthrenes; Plant Extracts; Rats; Reactive Oxygen Species; Salvia miltiorrhiza | 2008 |
T-DNA activation tagging as a tool to isolate Salvia miltiorrhiza transgenic lines for higher yields of tanshinones.
Topics: Abietanes; Chromatography, High Pressure Liquid; DNA, Bacterial; Mutagenesis, Insertional; Phenanthrenes; Phenotype; Plants, Medicinal; Rhizobium; Salvia miltiorrhiza; Transformation, Genetic | 2008 |
[A new method for quick analysis of tanshinone II(A) and salvianolic acid in Fufang Danshen tablets by AOTF-near infrared spectroscopy].
Topics: Abietanes; Benzofurans; Drugs, Chinese Herbal; Phenanthrenes; Reproducibility of Results; Spectroscopy, Near-Infrared; Tablets | 2008 |
Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Edema; Electrophoretic Mobility Shift Assay; Furans; Lipopolysaccharides; Macrophages; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Plant Roots; Quinones; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2008 |
The correlation of Salvia miltiorrhiza extract-induced regulation of osteoclastogenesis with the amount of components tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone.
Topics: Abietanes; Animals; Antioxidants; Bone Density Conservation Agents; Cell Differentiation; Drugs, Chinese Herbal; Female; Humans; Immunosuppressive Agents; Male; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Osteoporosis, Postmenopausal; Phenanthrenes; Plant Extracts; Rats; Salvia miltiorrhiza | 2008 |
Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels.
Topics: Abietanes; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guanylate Cyclase; Heart; Humans; KCNQ1 Potassium Channel; Kv1.5 Potassium Channel; Nitric Oxide Donors; Oxadiazoles; Phenanthrenes; Potassium Channels, Voltage-Gated; Quinoxalines | 2008 |
Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules.
Topics: Abietanes; Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Adhesion; Cell Communication; Cell Proliferation; Endothelial Cells; Female; Humans; Intercellular Adhesion Molecule-1; Mice; Neoplasm Invasiveness; Phenanthrenes; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2008 |
[Comparison of tanshinone IIA in Radix Salviae Miltorrhizae from Shandong].
Topics: Abietanes; China; Chromatography, High Pressure Liquid; Phenanthrenes; Plant Roots; Plants, Medicinal; Rhizome; Salvia miltiorrhiza; Seasons | 2008 |
[Study on technical processes for extraction and purification of total tanshinones].
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ethanol; Phenanthrenes; Plant Roots; Plants, Medicinal; Reproducibility of Results; Salvia miltiorrhiza; Solvents; Technology, Pharmaceutical; Temperature; Time Factors | 2008 |
[Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A].
Topics: Abietanes; Angiotensin II; Animals; Cardiomegaly; Gene Expression Regulation; Genes, fos; Genes, jun; Myocytes, Cardiac; Phenanthrenes; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles; Valine; Valsartan | 2008 |
Growth inhibition and apoptosis induction by tanshinone IIA in human colon adenocarcinoma cells.
Topics: Abietanes; Adenocarcinoma; Animals; BALB 3T3 Cells; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Humans; Mice; Phenanthrenes | 2008 |
[Tanshinone II A inhibits in vitro cellular proliferation and migration of vascular smooth muscle cell of rabbit].
Topics: Abietanes; Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Cell Cycle; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Flow Cytometry; Immunohistochemistry; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenanthrenes; Rabbits | 2008 |
Effect of tanshinone IIA on the noncovalent interaction between warfarin and human serum albumin studied by electrospray ionization mass spectrometry.
Topics: Abietanes; Animals; Binding, Competitive; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Male; Phenanthrenes; Protein Binding; Rats; Rats, Sprague-Dawley; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Warfarin | 2008 |
[Comparative research on pharmacodynamics of Danshen co-microemulsion on hemorheology in rats with hyperlipidemia].
Topics: Abietanes; Animals; Blood Viscosity; Caffeic Acids; Cholesterol; Drug Carriers; Drug Synergism; Drugs, Chinese Herbal; Emulsions; Hyperlipidemias; Lactates; Male; Phenanthrenes; Platelet Aggregation; Random Allocation; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Triglycerides | 2008 |
Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways.
Topics: Abietanes; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chemokine CXCL2; Chickens; Flagellin; Flavonoids; Interleukin-6; Leukocytes; Lipopolysaccharides; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Neutrophils; NF-kappa B; Nitriles; Peptides; Phenanthrenes; Signal Transduction; Sulfones; Transcription Factor AP-1; Transcriptional Activation; Up-Regulation | 2008 |
Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats.
Topics: Abietanes; Animals; Area Under Curve; Caffeic Acids; Chromatography, High Pressure Liquid; Drug Interactions; Flavonoids; Half-Life; Injections, Intravenous; Lactates; Male; Phenanthrenes; Phenols; Plant Extracts; Polyphenols; Rats; Rats, Wistar; Salvia miltiorrhiza | 2008 |
Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels.
Topics: Abietanes; Animals; Calcium; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Inhibitory Concentration 50; Male; Myocytes, Smooth Muscle; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Serotonin; Vasodilation | 2008 |
Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Female; Flow Cytometry; Humans; In Situ Nick-End Labeling; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Receptors, Estrogen | 2008 |
Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios.
Topics: Abietanes; Actins; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Caspase 8; Cell Line, Tumor; Humans; Phenanthrenes | 2008 |
Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest.
Topics: Abietanes; Apoptosis; Blotting, Western; DNA; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Antibody Technique; Green Fluorescent Proteins; HeLa Cells; Humans; Interphase; Microtubules; Mitochondria, Muscle; Mitosis; Myeloid Cell Leukemia Sequence 1 Protein; Phenanthrenes; Plasmids; Proto-Oncogene Proteins c-bcl-2; Salvia miltiorrhiza; Subcellular Fractions; Transfection | 2008 |
Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase.
Topics: Abietanes; Animals; Caspases; Catalase; Cell Death; Cells, Cultured; Chromans; DNA Fragmentation; Glutathione Peroxidase; Hydrogen Peroxide; Macrophages; Membrane Potentials; Mice; Mitochondrial Membranes; Oxidants; Oxidative Stress; Phenanthrenes; Protective Agents; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2008 |
Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes.
Topics: Abietanes; Animals; Ataxia Telangiectasia Mutated Proteins; Cattle; Cell Cycle Proteins; Cell Line, Tumor; Chromatin; Circular Dichroism; DNA; DNA Damage; DNA Probes; DNA-Binding Proteins; Enzyme Activation; Humans; Intercalating Agents; Nucleic Acid Conformation; Phenanthrenes; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins | 2008 |
Determination of tanshinone I in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.
Topics: Abietanes; Animals; Calibration; Chromatography, High Pressure Liquid; Male; Phenanthrenes; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity | 2008 |
PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
Topics: Abietanes; Cell Line, Tumor; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Enzyme Induction; Genes, Reporter; Humans; Phenanthrenes; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; Recombinant Proteins; RNA, Messenger; Salvia miltiorrhiza; Transcription Factors; Transcriptional Activation | 2009 |
The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism.
Topics: 3T3 Cells; Abietanes; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; DNA, Complementary; Female; Flow Cytometry; Genes, Reporter; Glucose Tolerance Test; Lipids; Mice; Mice, Inbred C57BL; Obesity; Phenanthrenes; Polymerase Chain Reaction; PPAR gamma; RNA; Transfection | 2009 |
[Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading].
Topics: Abietanes; Animals; Blood Pressure; Calcium; Cardiomyopathy, Hypertrophic; Disease Models, Animal; Female; Humans; Male; Myocardium; Phenanthrenes; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 2008 |
Inhibition of microsomal triglyceride transfer protein expression and atherogenic risk factor apolipoprotein B100 secretion by tanshinone IIA in HepG2 cells.
Topics: Abietanes; Albumins; Apolipoprotein B-100; Carrier Proteins; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation; Hepatocytes; Humans; Molecular Structure; Phenanthrenes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Salvia miltiorrhiza; Sterol Regulatory Element Binding Protein 1; Substrate Specificity; Transcription, Genetic; Triglycerides | 2008 |
[Preparation and quality evaluation of intravenous tanshinone II (A) emulsion].
Topics: Abietanes; Centrifugation; Drug Stability; Drug Storage; Emulsions; Hydrogen-Ion Concentration; Injections, Intravenous; Particle Size; Phenanthrenes; Quality Control; Temperature | 2008 |
Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice.
Topics: Abietanes; Animals; Astrocytes; Brain; Brain Ischemia; Cells, Cultured; Cerebral Infarction; Drugs, Chinese Herbal; Hydrogen Peroxide; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phenanthrenes; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2009 |
Effects of tanshinone IIA on transforming growth factor beta1-Smads signal pathway in renal interstitial fibroblasts of rats.
Topics: Abietanes; Animals; Cells, Cultured; Fibroblasts; Fibronectins; Fibrosis; Kidney; Phenanthrenes; Rats; RNA, Messenger; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2008 |
Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery.
Topics: Abietanes; Animals; Coronary Vessels; Diterpenes; Drugs, Chinese Herbal; Humans; Lipids; Medicine, Chinese Traditional; Molecular Structure; Phenanthrenes; Phenanthrolines; Plant Roots; Quinones; Salvia miltiorrhiza; Sus scrofa | 2008 |
Investigation of Danshen and related medicinal plants in China.
Topics: Abietanes; China; Chromatography, High Pressure Liquid; Ethnopharmacology; Humans; Hydroxybenzoates; Interviews as Topic; Medicine, Chinese Traditional; Phenanthrenes; Phytotherapy; Plant Structures; Plants, Medicinal; Salvia; Salvia miltiorrhiza | 2008 |
Growth inhibition and apoptosis induction by tanshinone I in human colon cancer Colo 205 cells.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; G1 Phase; Humans; Phenanthrenes; Resting Phase, Cell Cycle; Salvia miltiorrhiza; Tumor Suppressor Protein p53 | 2008 |
Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Inflammation; Male; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Phenanthrenes | 2008 |
Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model.
Topics: Abietanes; Acetylcholinesterase; Alzheimer Disease; Animals; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hippocampus; Immunosuppressive Agents; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2008 |
Quercetin activates human Kv1.5 channels by a residue I502 in the S6 segment.
Topics: Abietanes; Action Potentials; Amino Acids, Neutral; Animals; Cloning, Molecular; Dose-Response Relationship, Drug; Electrophysiology; Female; Humans; Hydrogen Peroxide; Ion Channel Gating; Ion Transport; Kv1.5 Potassium Channel; Mutagenesis, Site-Directed; Mutation; Oocytes; Patch-Clamp Techniques; Phenanthrenes; Protein Binding; Quercetin; Time Factors; Xenopus laevis | 2009 |
Anticancer effects of tanshinone I in human non-small cell lung cancer.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Interleukin-8; Lung Neoplasms; Mice; Mice, SCID; Models, Biological; Neoplasm Metastasis; Phenanthrenes; RNA, Messenger | 2008 |
Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma.
Topics: Abietanes; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Mice; Nanoparticles; Phenanthrenes; Polymers; Tissue Distribution | 2008 |
Tanshinone IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon cancer cells in vitro and in vivo.
Topics: Abietanes; Actins; Animals; Antineoplastic Agents, Phytogenic; Caspase 3; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Down-Regulation; Humans; Male; Mice; Mice, SCID; Neoplasm Transplantation; Phenanthrenes; Receptor, ErbB-2; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Tanshinone IIA interacts with DNA by minor groove-binding.
Topics: Abietanes; Algorithms; Antineoplastic Agents, Phytogenic; Binding Sites; Cell Line; DNA; Fluorescent Antibody Technique; Furans; Humans; Intercalating Agents; Models, Molecular; Nucleic Acid Conformation; Phenanthrenes; Spectrometry, Fluorescence; Viscosity | 2008 |
[Mechanism of copper and zinc on tanshinones of cultivated Salvia miltiorrhiza].
Topics: Abietanes; Catechol Oxidase; Copper; Drugs, Chinese Herbal; Peroxidase; Phenanthrenes; Plant Proteins; Salvia miltiorrhiza; Zinc | 2008 |
[Inhibitory effects and mechanism of tanshinone IIA on proliferation of rat aortic smooth muscle cells].
Topics: Abietanes; Animals; Aorta; Cell Cycle; Cell Proliferation; Cells, Cultured; Down-Regulation; Gene Expression; Myocytes, Smooth Muscle; Phenanthrenes; Proto-Oncogene Proteins c-fos; Rats | 2008 |
[Optimization of enzymatic extraction of effective constituents from fibrous roots of Salvia miltiorrhiza by central composite design and response surface method].
Topics: Abietanes; Drugs, Chinese Herbal; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2008 |
Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy.
Topics: Abietanes; Angiotensin II; Animals; Blood Glucose; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Immunohistochemistry; Kidney; Macrophages; Monocytes; Neutrophil Infiltration; Phenanthrenes; Protective Agents; Proteinuria; Rats; Transforming Growth Factor beta1 | 2009 |
Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge.
Topics: 3T3-L1 Cells; Abietanes; Adipocytes; Animals; Cricetinae; Dose-Response Relationship, Drug; Female; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Mice; Phenanthrenes; Phosphorylation; Phosphotransferases; Plant Extracts; Plant Roots; Receptor, Insulin; Salvia miltiorrhiza; Tyrosine | 2009 |
[Experiment of extracting Salviae miltiorrhizae on using O/W microemulsion].
Topics: Abietanes; Benzofurans; Drugs, Chinese Herbal; Emulsions; Oils; Phenanthrenes; Reproducibility of Results; Salvia miltiorrhiza; Water | 2008 |
[Study of growth inhibitory effect and apoptosis induced by different matches of Tanshinone IIA and Salvianolic Acid B on Acute Promyelocytic Leukemia cells (HL-60)].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Benzofurans; Cell Proliferation; Drugs, Chinese Herbal; Flow Cytometry; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2008 |
Cultivar variations of Australian-grown Danshen (Salvia miltiorrhiza): bioactive markers and root yields.
Topics: Abietanes; Australia; Benzofurans; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2009 |
Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents.
Topics: Abietanes; Adsorption; Phenanthrenes; Plant Extracts; Salvia miltiorrhiza; Silicon Dioxide; Solid Phase Extraction | 2009 |
[A full length cDNA of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase cloning and analysis of introduced gene expression in Salvia miltiorrhiza].
Topics: Abietanes; Acetates; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Conserved Sequence; Cyclopentanes; DNA, Complementary; Gene Expression Regulation, Plant; Genes, Plant; Molecular Sequence Data; Open Reading Frames; Oxylipins; Phenanthrenes; Phosphotransferases (Alcohol Group Acceptor); Plant Proteins; Plant Roots; Plants, Medicinal; RNA, Messenger; Salvia miltiorrhiza; Sequence Homology, Amino Acid | 2008 |
Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Survivin | 2009 |
Metabolic profiles of three related Salvia species.
Topics: Abietanes; Chromatography, Liquid; Metabolome; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia; Salvia miltiorrhiza | 2009 |
[Effect of tanshinone II A on NB4 cell induced procoagulant activity in human umbilical vein endothelial cells].
Topics: Abietanes; Blood Coagulation Factors; Cell Line, Tumor; Endothelial Cells; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Thromboplastin; Tretinoin; Umbilical Veins | 2009 |
[Study of molecular mechanism of tanshinone II A inducing differentiation in acute promyelocytic leukemia NB4 cells].
Topics: Abietanes; Cell Differentiation; Cell Line, Tumor; Drugs, Chinese Herbal; Gene Expression Regulation, Leukemic; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes | 2008 |
Tanshinone IIA reduces lethality and acute lung injury in LPS-treated mice by inhibition of PLA2 activity.
Topics: Abietanes; Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epithelial Cells; Female; Lipopolysaccharides; Lung; Mice; NF-kappa B; Phenanthrenes; Phospholipase A2 Inhibitors; Survival Rate | 2009 |
Seasonal variations in bioactive marker contents in Australian-grown Salvia miltiorrhiza roots.
Topics: Abietanes; Australia; Benzofurans; Biomarkers; Chromatography, High Pressure Liquid; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Seasons | 2009 |
Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier.
Topics: Abietanes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Drugs, Chinese Herbal; Endothelial Cells; Mice; Mice, Knockout; Microcirculation; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tissue Distribution | 2007 |
Role of P-glycoprotein in the transport of tanshinone I, one active triterpenoid from Salvia miltiorrhiza.
Topics: Abietanes; Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Digoxin; Dogs; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Temperature | 2008 |
Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.
Topics: Abietanes; Animals; Antibiotics, Antineoplastic; Benzimidazoles; Cardiotonic Agents; Cell Line; Doxorubicin; Electrocardiography; Fibrillar Collagens; Fluorescent Dyes; Heart; Heart Diseases; Male; Mice; Myoblasts; Phenanthrenes; Rats; Tensile Strength | 2009 |
[Effect of Tanshinone II A on expression of EGF and EGFR in hepatocellular carcinoma cell line SMMC-7721].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Liver Neoplasms; Phenanthrenes | 2009 |
[Effect of tanshinone II A on the calcineurin activity in proliferating vascular smooth muscle cells of rats].
Topics: Abietanes; Angiotensin II; Animals; Calcineurin; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Male; Muscle, Smooth, Vascular; Phenanthrenes; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2009 |
Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6.
Topics: Abietanes; Aryl Hydrocarbon Hydroxylases; Catalysis; Drugs, Chinese Herbal; Humans; Hydroxylation; Microsomes, Liver; Phenanthrenes; Steroid Hydroxylases | 2009 |
Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates.
Topics: Abietanes; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Drugs, Chinese Herbal; Half-Life; Male; Metabolic Clearance Rate; Phenacetin; Phenanthrenes; Phenanthrolines; Plant Extracts; Plant Roots; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2009 |
Tanshinone IIA: a potent, natural anti-carcinogenic agent for the management of systemic malignancies.
Topics: Abietanes; Anticarcinogenic Agents; Humans; Medical Oncology; Medicine, Chinese Traditional; Neoplasm Metastasis; Neoplasms; Phenanthrenes | 2009 |
The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cytokines; Drugs, Chinese Herbal; Estrogen Receptor alpha; Estrogen Receptor beta; HeLa Cells; Humans; Lipopolysaccharides; Macrophages; Medicine, Chinese Traditional; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Salvia miltiorrhiza | 2009 |
[AOTF-near infrared spectroscopy for determining tanshinone II A in returning extraction process of Salvia miltiorrhiza].
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Least-Squares Analysis; Models, Theoretical; Phenanthrenes; Quality Control; Reproducibility of Results; Salvia miltiorrhiza; Spectroscopy, Near-Infrared | 2009 |
[A study on anticancer activity of tanshinone II A against human breast cancer].
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Proliferation; DNA, Neoplasm; Female; Humans; Phenanthrenes; Tumor Cells, Cultured | 2009 |
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors | 2009 |
Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats.
Topics: Abietanes; Animals; Antioxidants; Cardiotonic Agents; Heart; Hemodynamics; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Male; Myocardial Infarction; Myocardium; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Vascular Endothelial Growth Factor A | 2009 |
Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels.
Topics: Abietanes; Animals; Arterioles; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium; In Vitro Techniques; Male; Nitric Oxide; Phenanthrenes; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilation | 2009 |
Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Ascitic Fluid; Binding Sites; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Circular Dichroism; DNA; DNA Damage; Dose-Response Relationship, Drug; Flow Cytometry; Humans; In Situ Nick-End Labeling; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Neoplasm Transplantation; Nucleic Acid Conformation; Phenanthrenes; Phosphorylation; RNA Polymerase II; Tumor Suppressor Protein p53 | 2009 |
Tanshinone IIA selectively enhances hyperpolarization-activated cyclic nucleotide-modulated (HCN) channel instantaneous current.
Topics: Abietanes; Animals; Cyclic Nucleotide-Gated Cation Channels; Drugs, Chinese Herbal; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Oocytes; Phenanthrenes; Potassium Channels; Transfection; Xenopus laevis | 2009 |
HPLC profiles and biomarker contents of Australian-grown Salvia miltiorrhiza f. alba roots.
Topics: Abietanes; Australia; Benzofurans; Biomarkers; Chromatography, High Pressure Liquid; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza | 2009 |
[Influence of solid dispersion technique combination on dissolution of tanshinone IIA].
Topics: Abietanes; Phenanthrenes; Solubility; Temperature | 2009 |
Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines.
Topics: Abietanes; Alanine Transaminase; Animals; Aspartate Aminotransferases; Concanavalin A; Cytokines; Liver; Lymphocyte Activation; Male; Mice; Phenanthrenes; T-Lymphocyte Subsets | 2010 |
Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry.
Topics: Abietanes; Cell Line, Tumor; Chromatography, Liquid; Enzyme Activation; Glutathione; Humans; NAD(P)H Dehydrogenase (Quinone); Phenanthrenes; Plant Extracts; Salvia miltiorrhiza; Tandem Mass Spectrometry | 2009 |
Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo.
Topics: Abietanes; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatocytes; Male; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2009 |
Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT).
Topics: Abietanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biological Transport; Cell Line, Tumor; Cell Nucleus; Cinnamates; Cytoplasm; Gene Expression Regulation, Neoplastic; Ginsenosides; Humans; Oncogenes; Phenanthrenes; Prohibitins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Repressor Proteins; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 2009 |
Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway.
Topics: Abietanes; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Extracellular Signal-Regulated MAP Kinases; Learning; Male; Memory; Memory Disorders; Mice; Mice, Inbred ICR; Molecular Structure; Phenanthrenes; Phosphorylation | 2009 |
Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1.
Topics: Abietanes; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Down-Regulation; Drugs, Chinese Herbal; Electrocardiography; In Vitro Techniques; Male; MicroRNAs; Myocardial Infarction; Myocytes, Cardiac; Patch-Clamp Techniques; Phenanthrenes; Potassium Channels, Inwardly Rectifying; Quinidine; Rats; Rats, Wistar; Serum Response Factor | 2009 |
The effect of tanshinone IIA on renal and liver functions in ovine fetuses in utero.
Topics: Abietanes; Animals; Drugs, Chinese Herbal; Female; Fetus; KCNQ1 Potassium Channel; Kidney; Liver; Microsomes, Liver; Phenanthrenes; Phenanthrolines; Pregnancy; Pregnancy, Animal; Salvia miltiorrhiza; Sheep; Uterus | 2009 |
Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Coronary Vessels; Disease Models, Animal; Drugs, Chinese Herbal; Fibroblasts; Heart; Inflammation; Macrophages; Male; Myocardial Infarction; Myocardium; Myocytes, Cardiac; NF-kappa B; Phenanthrenes; Phytotherapy; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2010 |
Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats.
Topics: Abietanes; Animals; Cardiomegaly; Drugs, Chinese Herbal; Phenanthrenes; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2009 |
Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Dose-Response Relationship, Drug; HT29 Cells; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Phenanthrenes; Plant Extracts; Plant Roots; Salvia miltiorrhiza; Signal Transduction; Time Factors | 2009 |
Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Female; Histocytochemistry; Humans; Mice; Mice, Nude; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Receptor, ErbB-2; Statistics, Nonparametric; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2009 |
[A new identification and quautitation method for radix Salviae miltiorrhizae].
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Phenanthrenes; Salvia miltiorrhiza; X-Ray Diffraction | 2009 |
A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.
Topics: Abietanes; Biological Factors; Drugs, Chinese Herbal; Genomics; Molecular Structure; Phenanthrenes; Stereoisomerism | 2009 |
Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells.
Topics: Abietanes; Animals; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Hepatic Stellate Cells; Mitochondria, Liver; Mitogen-Activated Protein Kinases; Phenanthrenes; Rats; S Phase | 2010 |
Ionic liquid surfactant-mediated ultrasonic-assisted extraction coupled to HPLC: application to analysis of tanshinones in Salvia miltiorrhiza bunge.
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ionic Liquids; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza; Solvents; Surface-Active Agents; Ultrasonics | 2009 |
Direct purification of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography without presaturation of the two-phase solvent mixture.
Topics: Abietanes; Chromatography, High Pressure Liquid; Countercurrent Distribution; Drugs, Chinese Herbal; Humans; Molecular Structure; Phenanthrenes; Plant Extracts; Rhizome; Salvia miltiorrhiza; Solvents | 2010 |
The effect of tanshinone IIA on the cardiovascular system in ovine fetus in utero.
Topics: Abietanes; Animals; Blood Pressure; Cardiovascular Agents; Drugs, Chinese Herbal; Female; Fetal Heart; Fetus; Hematology; Models, Animal; Myocardium; Oxygen; Phenanthrenes; Pregnancy; Pregnancy Trimester, Third; Salvia miltiorrhiza; Sheep; Uterus | 2009 |
[Apoptosis of MR2 cells induced by Tanshinone II A combined with arsenic trioxide].
Topics: Abietanes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Arsenic Trioxide; Arsenicals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Humans; Leukemia, Promyelocytic, Acute; Oxides; Phenanthrenes; Tretinoin | 2009 |
Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cell Survival; Cells, Cultured; DNA Primers; Inflammation; Mice; Microglia; Phenanthrenes; Polymerase Chain Reaction; Radionuclide Imaging; Radiotherapy; RNA | 2009 |
Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium; Cell Line, Tumor; Cell Survival; Cytochromes c; DNA Fragmentation; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Phenanthrenes; Proto-Oncogene Mas; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53 | 2010 |
Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Capillary Permeability; Claudin-5; Down-Regulation; Endothelial Cells; Gene Expression; HMGB1 Protein; Male; Membrane Proteins; Microscopy, Confocal; Neuroprotective Agents; NF-kappa B; Phenanthrenes; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Toll-Like Receptor 4 | 2010 |
Tanshinone IIA inhibits constitutive STAT3 activation, suppresses proliferation, and induces apoptosis in rat C6 glioma cells.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; DNA Fragmentation; Dose-Response Relationship, Drug; Glioma; Phenanthrenes; Rats; STAT3 Transcription Factor; Time Factors | 2010 |
Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells.
Topics: Abietanes; Cell Death; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Fluorescent Antibody Technique; HeLa Cells; Humans; Inhibitory Concentration 50; Microtubules; Models, Molecular; Peptide Mapping; Phenanthrenes; Poly(ADP-ribose) Polymerases; Proteome; Proteomics; Reproducibility of Results; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Vimentin | 2010 |
Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.
Topics: Abietanes; Amino Acids; Antioxidants; Calcium; Cell Line, Tumor; Cell Survival; Cytosol; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glutathione; Humans; Indoles; L-Lactate Dehydrogenase; Malondialdehyde; Oxidative Stress; Phenanthrenes; Superoxide Dismutase; Time Factors; Xanthenes | 2010 |
Effects of biotic and abiotic elicitors on cell growth and tanshinone accumulation in Salvia miltiorrhiza cell cultures.
Topics: Abietanes; Acetates; Biomass; Cell Culture Techniques; Cells, Cultured; Culture Media; Cyclopentanes; Hydrogen-Ion Concentration; Metals, Heavy; Oxylipins; Phenanthrenes; Salicylic Acid; Salvia miltiorrhiza | 2010 |
Nanostructured lipid carriers constituted from high-density lipoprotein components for delivery of a lipophilic cardiovascular drug.
Topics: Abietanes; Cardiovascular Agents; Cell Line; Cell Survival; Drug Carriers; Drug Compounding; Lipoproteins, HDL; Nanoparticles; Particle Size; Phagocytosis; Phenanthrenes; Surface Properties | 2010 |
Tanshinone IIA enhances BMP-2-stimulated commitment of C2C12 cells into osteoblasts via p38 activation.
Topics: Abietanes; Animals; Bone Morphogenetic Protein 2; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Imidazoles; Mice; Molecular Structure; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Pyridines; Structure-Activity Relationship | 2010 |
Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC-ESI-MSn.
Topics: Abietanes; Animals; Biotransformation; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydroxylation; Male; Molecular Structure; Oxidation-Reduction; Phenanthrenes; Phenanthrolines; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Spectrometry, Mass, Electrospray Ionization | 2010 |
Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway.
Topics: Abietanes; Angioplasty, Balloon; Animals; Bromodeoxyuridine; Carotid Arteries; Carotid Artery Injuries; Cell Culture Techniques; Cell Cycle; Cell Proliferation; DNA; Extracellular Signal-Regulated MAP Kinases; Hyperplasia; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Phenanthrenes; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tunica Intima | 2010 |
Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.
Topics: Abietanes; Androstadienes; Animals; Anticoagulants; Apoptosis; Blotting, Western; Diabetes Mellitus, Experimental; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phenanthrenes; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Wortmannin | 2010 |
Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential.
Topics: Abietanes; Animals; Dogs; Glucuronides; Glucuronosyltransferase; Humans; Isoenzymes; Isomerism; Kinetics; Liver; Male; Mice; Mice, Inbred ICR; Mycophenolic Acid; NAD(P)H Dehydrogenase (Quinone); Phenanthrenes; Propofol; Rats; Rats, Sprague-Dawley; Species Specificity | 2010 |
The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.
Topics: Abietanes; Active Transport, Cell Nucleus; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Humans; Male; Neuroprotective Agents; Neuropsychological Tests; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stroke; Transcription Factors; Up-Regulation | 2010 |
Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic-mass spectrometry and the application to pharmacokinetics in rats.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Drug Stability; Lactates; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Rosmarinic Acid; Salvia miltiorrhiza; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2010 |
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxorubicin; Drug Resistance, Neoplasm; Humans; Models, Biological; Molecular Structure; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2010 |
Tanshinone IIA modulates pulmonary vascular response to agonist and hypoxia primarily via inhibiting Ca2+ influx and release in normal and hypoxic pulmonary hypertension rats.
Topics: Abietanes; Animals; Calcium; Carbon Monoxide; Endothelium, Vascular; Extracellular Space; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Intracellular Space; Male; Nitric Oxide; Phenanthrenes; Phenylephrine; Potassium; Potassium Channel Blockers; Prostaglandins; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2010 |
A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Doxorubicin; Female; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasms; Paclitaxel; Phenanthrenes; Propyl Gallate; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptor, ErbB-2; Solubility; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; DNA Fragmentation; Drugs, Chinese Herbal; Enzyme Activation; HL-60 Cells; Humans; K562 Cells; Leukemia, Myeloid; Membrane Potential, Mitochondrial; Molecular Structure; Phenanthrenes; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2010 |
The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats.
Topics: Abietanes; Animals; Blood-Brain Barrier; Brain; Edema; Evans Blue; Infarction, Middle Cerebral Artery; Intercellular Adhesion Molecule-1; Ischemic Attack, Transient; Matrix Metalloproteinase 9; Membrane Proteins; Occludin; Permeability; Phenanthrenes; Phytotherapy; Plant Extracts; Plant Roots; Rats; Reperfusion Injury; Salvia miltiorrhiza; Tight Junctions; Water | 2010 |
Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation.
Topics: Abietanes; Acyl Coenzyme A; Amino Acid Sequence; Computational Biology; Diterpenes; Molecular Sequence Data; Molecular Structure; Phenanthrenes; Phylogeny; Plant Roots; Polymerase Chain Reaction; Salvia miltiorrhiza; Sequence Homology, Amino Acid | 2011 |
Synthesis and vasodilative activity of tanshinone IIA derivatives.
Topics: Abietanes; Animals; Aorta, Thoracic; Muscle, Smooth, Vascular; Norepinephrine; Phenanthrenes; Rats; Rats, Wistar; Salvia miltiorrhiza; Structure-Activity Relationship; Vasodilator Agents | 2010 |
Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro.
Topics: Abietanes; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Liver; Microsomes, Liver; Phenanthrenes; Protein Isoforms; Salvia miltiorrhiza | 2010 |
Tanshinone IIA inhibits Hep-J5 cells by increasing calreticulin, caspase 12 and GADD153 protein expression.
Topics: Abietanes; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Calreticulin; Carcinoma, Hepatocellular; Caspase 12; Caspase Inhibitors; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cysteine Proteinase Inhibitors; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Male; Mitochondria; Phenanthrenes; Transcription Factor CHOP | 2010 |
[Self-microemulsifying drug delivery system increasing solubility and intestinal absorption in situ of tanshinones].
Topics: Abietanes; Animals; Drug Delivery Systems; Emulsions; Intestinal Absorption; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solubility | 2010 |
Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice.
Topics: Abietanes; Animals; Anti-Allergic Agents; Camphanes; Cell Line, Tumor; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Interleukin-4; Male; Mice; Mice, Inbred ICR; NF-kappa B; Panax notoginseng; Passive Cutaneous Anaphylaxis; Phenanthrenes; Proto-Oncogene Proteins c-jun; Rats; Rhizome; Salvia miltiorrhiza; Tumor Necrosis Factor-alpha | 2010 |
The neuroprotective effects of tanshinone IIA on β-amyloid-induced toxicity in rat cortical neurons.
Topics: Abietanes; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytochromes c; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neuroprotective Agents; Peptide Fragments; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2010 |
Preparation and evaluation of silica-based ionic liquid-modified stationary phase for HPLC.
Topics: Abietanes; Chromatography, High Pressure Liquid; Ionic Liquids; Nuclear Magnetic Resonance, Biomolecular; Phenanthrenes; Spectroscopy, Fourier Transform Infrared; Thermogravimetry | 2010 |
Tanshinone IIA increases mRNA expression of efflux transporters in cultured human intestinal cell.
Topics: Abietanes; Biological Availability; Caco-2 Cells; Cells, Cultured; Colon; Drugs, Chinese Herbal; Humans; Intestinal Absorption; Membrane Transport Proteins; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salvia miltiorrhiza; Up-Regulation | 2010 |
Tanshinone IIA protects the human blood-brain barrier model from leukocyte-associated hypoxia-reoxygenation injury.
Topics: Abietanes; Blood-Brain Barrier; Culture Media, Conditioned; Electric Impedance; Endothelial Cells; Humans; Hypoxia; Leukocytes; Oxygen; Permeability; Phenanthrenes; Reperfusion Injury | 2010 |
[Study on the chemical stability of tanshinone IIA].
Topics: Abietanes; Area Under Curve; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Kinetics; Light; Phenanthrenes; Quality Control; Salvia miltiorrhiza; Solutions; Technology, Pharmaceutical; Temperature | 2010 |
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Aurora Kinase A; Aurora Kinases; Blotting, Western; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Humans; Immunoenzyme Techniques; In Vitro Techniques; Male; Mice; Mice, SCID; Phenanthrenes; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Salvia miltiorrhiza; Tumor Cells, Cultured | 2011 |
Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression.
Topics: Abietanes; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta, Thoracic; Aortic Valve; Apolipoproteins E; Atherosclerosis; Biological Transport; Body Weight; CD36 Antigens; Cell Survival; Cholesterol; Down-Regulation; Humans; Lipid Metabolism; Lipoproteins, LDL; Liver; Macrophages; Male; Malondialdehyde; Mice; Phenanthrenes; PPAR gamma; RNA, Messenger; Scavenger Receptors, Class A | 2011 |
The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts.
Topics: Abietanes; Acetophenones; Benzopyrans; Cells, Cultured; Chemokine CCL5; CSK Tyrosine-Protein Kinase; Fibroblasts; Humans; Interleukin-6; Osteoarthritis; Phenanthrenes; Protein Kinase C-delta; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyrimidines; Receptors, CCR5; Signal Transduction; src-Family Kinases; Synovial Membrane; Transcription Factor AP-1 | 2010 |
[Dissolution of tanshinone IIA from xianling gubao capsule].
Topics: Abietanes; Capsules; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Phenanthrenes; Solubility | 2010 |
[Neuroprotective effects of tanshinone II A on vascular dementia in rats].
Topics: Abietanes; Animals; Dementia, Vascular; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Malondialdehyde; Maze Learning; Memory; Neuroprotective Agents; Phenanthrenes; Random Allocation; Rats; Rats, Sprague-Dawley | 2010 |
Activation of CYP3A-mediated testosterone 6β-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes.
Topics: Abietanes; Cytochrome P-450 CYP3A; Enzyme Activation; Humans; Hydroxylation; Hydroxytestosterones; Microsomes, Liver; Midazolam; Phenanthrenes; Testosterone | 2010 |
C/EBPβ and CHOP participate in tanshinone IIA-induced differentiation and apoptosis of acute promyelocytic leukemia cells in vitro.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Promyelocytic, Acute; Phenanthrenes; Transcription Factor CHOP | 2010 |
Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.
Topics: Abietanes; Administration, Oral; Angiotensin II; Animals; Collagen Type IV; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Kidney; Male; Phenanthrenes; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Salvia miltiorrhiza; Transforming Growth Factor beta1 | 2010 |
[Data distribution characteristics and deviation of tanshinone IIA content in Radix Salviae Miltiorrhizae].
Topics: Abietanes; Phenanthrenes; Salvia miltiorrhiza | 2010 |
Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes.
Topics: Abietanes; Angiotensin II; Animals; Animals, Newborn; Antioxidants; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Cytochromes c; Myocytes, Cardiac; Phenanthrenes; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Salvia miltiorrhiza | 2010 |
Study of sodium tanshinone II A sulfonate tissue distribution in rat by liquid chromatography/tandem mass spectrometry.
Topics: Abietanes; Animals; Blood-Brain Barrier; Calibration; Chromatography, High Pressure Liquid; Female; Indicators and Reagents; Male; Phenanthrenes; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution | 2010 |
Molecular imprinting in ionic liquid-modified porous polymer for recognitive separation of three tanshinones from Salvia miltiorrhiza Bunge.
Topics: Abietanes; Adsorption; Chromatography, High Pressure Liquid; Imidazoles; Ionic Liquids; Molecular Imprinting; Phenanthrenes; Plant Extracts; Polymers; Porosity; Salvia miltiorrhiza; Solid Phase Extraction | 2011 |
Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship.
Topics: Abietanes; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Hydroxylation; Male; Membrane Proteins; Microsomes, Liver; Molecular Structure; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Steroid 16-alpha-Hydroxylase; Structure-Activity Relationship; Testosterone | 2011 |
Development of a strategy and process parameters for a green process in counter-current chromatography: purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study.
Topics: Abietanes; Countercurrent Distribution; Green Chemistry Technology; Phenanthrenes; Plant Extracts; Salvia miltiorrhiza | 2011 |
Study of anti-myocardial cell oxidative stress action and effect of tanshinone IIA on prohibitin expression.
Topics: Abietanes; Animals; Apoptosis; Calcium; Cells, Cultured; Gene Expression; Hydrogen Peroxide; Male; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Oxidative Stress; Phenanthrenes; Prohibitins; Rats; Rats, Wistar; Repressor Proteins | 2010 |
[Absorption mechanism of tanshinone II A, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo].
Topics: Abietanes; Absorption; Animals; Drugs, Chinese Herbal; Intestine, Small; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2010 |
[Effect of tanshitone on prevention and treatment of retinoic acid induced osteoporosis in mice].
Topics: Abietanes; Alkaline Phosphatase; Animals; Bone Density; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Male; Mice; Osteoporosis; Phenanthrenes; Tretinoin | 2010 |
[Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].
Topics: Abietanes; Administration, Oral; Animals; Area Under Curve; Dogs; Drug Combinations; Drugs, Chinese Herbal; Female; Ginsenosides; Lactates; Male; Panax notoginseng; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2010 |
Plant density-dependent variations in bioactive markers and root yield in Australian-grown Salvia miltiorrhiza Bunge.
Topics: Abietanes; Australia; Benzofurans; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2011 |
Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids.
Topics: Abietanes; Drugs, Chinese Herbal; Ionic Liquids; Phenanthrenes; Plant Proteins; Plants, Medicinal; Salvia miltiorrhiza; Ultrasonics | 2011 |
Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes.
Topics: Abietanes; Animals; Benzofurans; Cell Survival; Cytochrome P-450 CYP1A2; Cytochromes; Drugs, Chinese Herbal; Enzyme Activation; Enzyme Induction; Ethanol; Hepatocytes; Male; Phenacetin; Phenanthrenes; Phenanthrolines; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; RNA, Messenger; Salvia miltiorrhiza; Tacrine | 2012 |
Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling.
Topics: Abietanes; Active Transport, Cell Nucleus; Androgen Antagonists; Anilides; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Phenanthrenes; Prostate-Specific Antigen; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Receptors, Androgen; RNA, Messenger; Salvia miltiorrhiza; Signal Transduction; Time Factors; Tosyl Compounds; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Production of salvianolic acid B in roots of Salvia miltiorrhiza (Danshen) during the post-harvest drying process.
Topics: Abietanes; Benzofurans; Chromatography, High Pressure Liquid; Desiccation; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2012 |
Growth-inhibitory and apoptosis-inducing effects of tanshinones on hematological malignancy cells and their structure-activity relationship.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microscopy, Fluorescence; Phenanthrenes; Structure-Activity Relationship; Time Factors | 2012 |
Metabolism of tanshinone IIA, cryptotanshinone and tanshinone I from Radix Salvia miltiorrhiza in zebrafish.
Topics: Abietanes; Animals; Drugs, Chinese Herbal; Metabolic Networks and Pathways; Phenanthrenes; Salvia miltiorrhiza; Zebrafish | 2012 |
Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation.
Topics: Abietanes; Animals; Cell Differentiation; Drugs, Chinese Herbal; Imidazoles; Interleukin-15; Killer Cells, Natural; Lymphocyte Subsets; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Pyridines; Transcription Factors | 2012 |
Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Area Under Curve; Drug Carriers; Hydrogen-Ion Concentration; Male; Phenanthrenes; Plant Extracts; Poloxamer; Povidone; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Solubility; Solvents; Tablets | 2012 |
Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp.
Topics: Abietanes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Dose-Response Relationship, Drug; Drug Synergism; Intestinal Absorption; Intestinal Mucosa; Intestines; Phenanthrenes; Plant Roots; Rats; Salvia; Salvia miltiorrhiza | 2012 |
TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells.
Topics: Abietanes; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Hypoxia; Cell Survival; Cyclosporine; Cytochromes c; Cytoprotection; Enzyme Activation; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Phenanthrenes; Protein Stability; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats | 2013 |
Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo.
Topics: Abietanes; Animals; Antioxidants; Arsenic; Mice; Mice, Knockout; NF-E2-Related Factor 2; Phenanthrenes; Pneumonia; Salvia miltiorrhiza | 2013 |
Conical coils counter-current chromatography for preparative isolation and purification of tanshinones from Salvia miltiorrhiza Bunge.
Topics: Abietanes; Chromatography, High Pressure Liquid; Countercurrent Distribution; Drugs, Chinese Herbal; Phenanthrenes; Phenanthrolines; Plant Extracts; Rhizome; Salvia miltiorrhiza | 2013 |
Proapoptotic and TRAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen).
Topics: Abietanes; Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Cell Division; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; Inhibitory Concentration 50; Neoplasms; Phenanthrenes; Phenanthrolines; Plant Extracts; Poly(ADP-ribose) Polymerases; Salvia miltiorrhiza; TNF-Related Apoptosis-Inducing Ligand | 2013 |
A rapid UFLC-MS/MS method for simultaneous determination of formononetin, cryptotanshinone, tanshinone IIA and emodin in rat plasma and its application to a pharmacokinetic study of Bu Shen Huo Xue formula.
Topics: Abietanes; Animals; Chromatography, Liquid; Drugs, Chinese Herbal; Emodin; Isoflavones; Limit of Detection; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2013 |
A simple and reliable method for distinguishing danshen in salvia: simultaneous quantification of six active compositions by HPLC.
Topics: Abietanes; Benzofurans; Caffeic Acids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lactates; Limit of Detection; Phenanthrenes; Reproducibility of Results; Salvia; Salvia miltiorrhiza | 2014 |
[Tanshinone IIA protects against triptolide-induced liver injury via Nrf2/ARE activation].
Topics: Abietanes; Animals; Antioxidant Response Elements; Chemical and Drug Induced Liver Injury; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Liver; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Phenanthrenes; RNA, Messenger; Signal Transduction | 2013 |
[Determination of five components in rongxin pills by HPLC].
Topics: Abietanes; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Linear Models; Organic Chemicals; Phenanthrenes; Polycyclic Compounds; Quality Control; Reproducibility of Results | 2014 |
Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae.
Topics: Abietanes; Amino Acids; Dose-Response Relationship, Drug; Gene Deletion; Humans; Microbial Viability; Phenanthrenes; Phytochemicals; Plant Roots; Protein Kinases; Saccharomyces cerevisiae; Salvia; Superoxide Dismutase; Time Factors | 2014 |
Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7.
Topics: Abietanes; Animals; Cell Survival; HEK293 Cells; Humans; Mice; Phenanthrenes; Purinergic P2X Receptor Antagonists; Rats; Receptors, Purinergic P2X7 | 2014 |
[Effect of Glomus versiforme and Trichoderma harzianum on growth and quality of Salvia miltiorrhiza].
Topics: Abietanes; Antibiosis; Benzofurans; Glomeromycota; Host-Pathogen Interactions; Phenanthrenes; Plant Diseases; Plant Roots; Salvia miltiorrhiza; Trichoderma | 2014 |
[Simultaneous determination of six Salvia miltiorrhiza gradients in rat plasma and brain by LC-MS/MS].
Topics: Abietanes; Animals; Benzaldehydes; Benzofurans; Blood-Brain Barrier; Brain; Caffeic Acids; Catechols; Chromatography, Liquid; Hydroxybenzoates; Injections, Intravenous; Lactates; Phenanthrenes; Plant Preparations; Rats; Reproducibility of Results; Salvia miltiorrhiza; Tandem Mass Spectrometry | 2014 |
Spaceflight environment-induced variation in root yield and active constituents of Salvia miltiorrhiza.
Topics: Abietanes; Benzofurans; Biomass; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Environment; Humans; Phenanthrenes; Plant Extracts; Plant Roots; Principal Component Analysis; Rosmarinic Acid; Salvia miltiorrhiza; Space Flight | 2014 |
Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Camptothecin; Digoxin; Doxorubicin; Drugs, Chinese Herbal; Furans; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Phenanthrenes; Quinones; Salvia miltiorrhiza | 2014 |
Dispersive micro-solid-phase extraction using mesoporous hybrid materials for simultaneous determination of semivolatile compounds from plant tea by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectromet
Topics: Abietanes; Camellia sinensis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Food Analysis; Limit of Detection; Phenanthrenes; Salvia miltiorrhiza; Solid Phase Extraction; Solvents; Tandem Mass Spectrometry; Time Factors; Volatile Organic Compounds | 2014 |
Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis.
Topics: Abietanes; Animals; Blood Platelets; Drugs, Chinese Herbal; Male; Molecular Docking Simulation; Molecular Structure; Phenanthrenes; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Rats, Wistar | 2015 |
Ultrasound-assisted ionic liquid-based homogeneous liquid-liquid microextraction high-performance liquid chromatography for determination of tanshinones in Salvia miltiorrhiza Bge. root.
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Liquid Phase Microextraction; Phenanthrenes; Plant Extracts; Plant Roots; Salvia miltiorrhiza; Ultrasonics | 2015 |
Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.
Topics: Abietanes; Catalytic Domain; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Drugs, Chinese Herbal; Ethanol; Herb-Drug Interactions; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Phenanthrenes; Salvia miltiorrhiza | 2015 |
In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase.
Topics: Abietanes; Alkenes; Drugs, Chinese Herbal; Epoxide Hydrolases; Ethanol; Humans; Phenanthrenes; Plant Extracts; Polyphenols; Salvia miltiorrhiza | 2015 |
Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity.
Topics: Abietanes; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Phenanthrenes; Tumor Suppressor Protein p53 | 2015 |
Efficient separation of tanshinones by polyvinylpyrrolidone-stabilized graphene-modified micellar electrokinetic chromatography.
Topics: 2-Propanol; Abietanes; Buffers; Chromatography, Micellar Electrokinetic Capillary; Drugs, Chinese Herbal; Furans; Graphite; Hydrogen-Ion Concentration; Phenanthrenes; Povidone; Quinones; Reproducibility of Results; Salvia miltiorrhiza | 2015 |
Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them.
Topics: Abietanes; Animals; Benzaldehydes; Benzofurans; Catechols; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Lactates; Limit of Detection; Liquid-Liquid Extraction; Male; Phenanthrenes; Polyphenols; Rats, Sprague-Dawley; Rosmarinic Acid; Tandem Mass Spectrometry | 2016 |
Isolation and Fast Selective Determination of Nor-abietanoid Diterpenoids from Perovskia atriplicifolia Roots Using LC-ESI-MS/MS with Multiple Reaction Monitoring.
Topics: Abietanes; Chromatography, Liquid; Cinnamates; Depsides; Diterpenes; Lamiaceae; Phenanthrenes; Plant Roots; Rosmarinic Acid; Spectrometry, Mass, Electrospray Ionization | 2015 |
Fast environment-friendly ball mill-assisted deep eutectic solvent-based extraction of natural products.
Topics: Abietanes; Biological Products; Chemistry Techniques, Analytical; Drugs, Chinese Herbal; Green Chemistry Technology; Phenanthrenes; Plant Extracts; Reproducibility of Results; Salvia miltiorrhiza | 2016 |
Overall uncertainty measurement for near infrared analysis of cryptotanshinone in tanshinone extract.
Topics: Abietanes; Analysis of Variance; Calibration; Chromatography, High Pressure Liquid; Phenanthrenes; Plant Extracts; Reproducibility of Results; Spectroscopy, Near-Infrared; Uncertainty | 2017 |
Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.
Topics: Abietanes; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Cinnamates; Depsides; Diterpenes; Drugs, Chinese Herbal; Lamiaceae; Phenanthrenes; Quantitative Structure-Activity Relationship; Rosmarinic Acid; Salvia | 2017 |
Matrix Solid-Phase Dispersion Coupled with High-Performance Liquid Chromatography Diode Array Detection for Simultaneous Determination of Four Lipophilic Constituents from Salvia miltiorrhiza Bunge.
Topics: Abietanes; Chromatography, High Pressure Liquid; Limit of Detection; Linear Models; Models, Statistical; Phenanthrenes; Plant Extracts; Reproducibility of Results; Salvia miltiorrhiza; Solid Phase Extraction | 2017 |
Development of APTES-Decorated HepG2 Cancer Stem Cell Membrane Chromatography for Screening Active Components from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Apoptosis; Binding Sites; Cell Membrane; Cell Proliferation; Chromatography, Affinity; Hep G2 Cells; Humans; Mice; Mice, Nude; Molecular Docking Simulation; Neoplastic Stem Cells; Phenanthrenes; Plant Extracts; Propylamines; Salvia miltiorrhiza; Silanes; Silica Gel; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Targeted mutagenesis in the medicinal plant Salvia miltiorrhiza.
Topics: Abietanes; Agrobacterium; Base Sequence; CRISPR-Cas Systems; Diterpenes; Gene Editing; Gene Expression Regulation, Plant; Gene Knockout Techniques; Genome, Plant; Hydroxybenzoates; Ligases; Mutagenesis; Phenanthrenes; Plant Proteins; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Sequence Alignment | 2017 |
Total Synthesis of Tanshinone I.
Topics: Abietanes; Cycloaddition Reaction; Molecular Structure; Phenanthrenes | 2017 |
Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs).
Topics: Abietanes; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Glucuronosyltransferase; Herb-Drug Interactions; Inhibitory Concentration 50; Isoenzymes; Phenanthrenes; Rats; Salvia miltiorrhiza | 2017 |
Molecular cloning and characterization of five SmGRAS genes associated with tanshinone biosynthesis in Salvia miltiorrhiza hairy roots.
Topics: Abietanes; Amino Acid Motifs; Amino Acid Sequence; Base Sequence; Biosynthetic Pathways; Cloning, Molecular; Conserved Sequence; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Gibberellins; Organ Specificity; Organophosphorus Compounds; Phenanthrenes; Phylogeny; Plant Proteins; Plant Roots; Salvia miltiorrhiza | 2017 |
Effects of Danshen capsules on the pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Topics: Abietanes; Area Under Curve; Blotting, Western; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 CYP3A; Enzyme Induction; Healthy Volunteers; Hep G2 Cells; Hepatocytes; Humans; Male; Phenanthrenes; Platelet Aggregation Inhibitors; Salvia miltiorrhiza; Tandem Mass Spectrometry; Ticlopidine | 2018 |
Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.
Topics: Abietanes; Carboxylesterase; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Humans; Methods; Naphthoquinones; Phenanthrenes; Structure-Activity Relationship | 2018 |
Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation.
Topics: Abietanes; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Kidney; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenanthrenes; RAW 264.7 Cells; Salvia miltiorrhiza; Sepsis | 2018 |
Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors.
Topics: Abietanes; Alkenes; Cell Proliferation; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; ErbB Receptors; Gefitinib; HEK293 Cells; Humans; Phenanthrenes; Polyphenols; Protein Kinase Inhibitors; Receptor, Fibroblast Growth Factor, Type 4; Salvia miltiorrhiza; Sorafenib; Spectrometry, Mass, Electrospray Ionization | 2019 |
Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS.
Topics: Abietanes; Azabicyclo Compounds; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyclooctanes; Drugs, Chinese Herbal; Evaluation Studies as Topic; Phenanthrenes; Piperidines; Plant Roots; Principal Component Analysis; Salvia; Salvia miltiorrhiza; Tandem Mass Spectrometry | 2019 |
TanshinoneⅡA phenanthroimidazole derivative polarizes macrophage to improve metabolic homeostasis.
Topics: Abietanes; Adipose Tissue; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Cell Differentiation; Cell Polarity; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fat; Fatty Acids, Nonesterified; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Macaca fascicularis; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; Obesity; Phenanthrenes; RAW 264.7 Cells | 2019 |
A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease.
Topics: Abietanes; Administration, Oral; Animals; Chromatography, Liquid; Coronary Disease; Drugs, Chinese Herbal; Glucosides; Isoflavones; Male; Monoterpenes; Myocardium; Pharmacology; Phenanthrenes; Protein Interaction Maps; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2019 |
A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Humans; Inflammation; Lipopolysaccharides; Macrophage Activation; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Protein Interaction Mapping; Protein Interaction Maps; RAW 264.7 Cells; Salvia miltiorrhiza; Signal Transduction; Toll-Like Receptors | 2020 |
Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats.
Topics: Abietanes; Animals; Area Under Curve; Chromatography, Liquid; Half-Life; Lipids; Male; Molecular Structure; Phenanthrenes; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salvia miltiorrhiza; Tandem Mass Spectrometry | 2020 |
Quantitative Determination and Validation of Four Ketones in
Topics: Abietanes; China; Chromatography, High Pressure Liquid; Cluster Analysis; Furans; Ketones; Limit of Detection; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Phenanthrenes; Plant Extracts; Plant Roots; Protons; Pyridines; Quinones; Reproducibility of Results; Salvia miltiorrhiza | 2020 |
Increased phenolic acid and tanshinone production and transcriptional responses of biosynthetic genes in hairy root cultures of Salvia przewalskii Maxim. treated with methyl jasmonate and salicylic acid.
Topics: Abietanes; Acetates; Benzofurans; Caffeic Acids; Cinnamates; Cyclopentanes; Depsides; Dose-Response Relationship, Drug; Gene Expression Regulation, Plant; Hydroxybenzoates; Oxylipins; Phenanthrenes; Plant Growth Regulators; Plant Proteins; Plant Roots; Rosmarinic Acid; Salicylic Acid; Salvia; Time Factors | 2020 |
Lipopolysaccharide Enhances Tanshinone Biosynthesis via a Ca
Topics: Abietanes; Calcium; Calcium Signaling; Furans; Lipopolysaccharides; Phenanthrenes; Plant Proteins; Quinones; Salvia miltiorrhiza; Transcription Factors | 2020 |
Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza.
Topics: Abietanes; Benzofurans; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cinnamates; Depsides; Drugs, Chinese Herbal; Phenanthrenes; Quality Control; Rosmarinic Acid; Salvia miltiorrhiza; Smartphone | 2021 |
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
Topics: Abietanes; AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Female; Furans; Gout; Humans; Inflammasomes; Inflammation; Male; Mice; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Phenanthrenes; Quinones; Rats; Reactive Oxygen Species; Shock, Septic; Uric Acid | 2021 |
Monoamine Oxidase Inhibition by Major Tanshinones from
Topics: Abietanes; Animals; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenanthrenes; Receptor, Muscarinic M4; Salvia miltiorrhiza | 2021 |
Salviolone from
Topics: Abietanes; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Diterpenes; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Melanoma; Phenanthrenes; Phosphorylation; Plant Extracts; Salvia miltiorrhiza; Signal Transduction; Up-Regulation | 2022 |
Comparison of Sweated and Non-Sweated Ethanol Extracts of
Topics: Abietanes; Animals; Ethanol; Glucuronosyltransferase; Herb-Drug Interactions; Humans; Phenanthrenes; Plant Extracts; PPAR alpha; Rats; Receptors, Cytoplasmic and Nuclear; Salvia miltiorrhiza; Uridine Diphosphate | 2022 |
Radix
Topics: Abietanes; Anti-Inflammatory Agents; Cyclooxygenase 2; Drugs, Chinese Herbal; Humans; Interleukin-6; Leukocytes, Mononuclear; Network Pharmacology; Phenanthrenes; Retrospective Studies; Salvia miltiorrhiza; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2022 |
Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems.
Topics: Abietanes; Chromatography, Liquid; Humans; Phenanthrenes | 2023 |