Page last updated: 2024-09-02

tanshinone and paclitaxel

tanshinone has been researched along with paclitaxel in 7 studies

Compound Research Comparison

Studies
(tanshinone)
Trials
(tanshinone)
Recent Studies (post-2010)
(tanshinone)
Studies
(paclitaxel)
Trials
(paclitaxel)
Recent Studies (post-2010) (paclitaxel)
1,445101,03331,8745,72915,395

Protein Interaction Comparison

ProteinTaxonomytanshinone (IC50)paclitaxel (IC50)
Integrin beta-3Homo sapiens (human)0.034
Integrin alpha-V Homo sapiens (human)0.034
ATP-dependent translocase ABCB1Homo sapiens (human)2.598
Botulinum neurotoxin type A Clostridium botulinum5.2
UDP-glucuronosyltransferase 2B7Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1-6Homo sapiens (human)4.9
Substance-K receptorHomo sapiens (human)6.125
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1A4Homo sapiens (human)4.9
UDP-glucuronosyltransferase 2B10 Homo sapiens (human)4.9
Delta-type opioid receptorHomo sapiens (human)4.202
Tyrosine-protein kinase MerHomo sapiens (human)4.9
Tubulin beta-3 chainHomo sapiens (human)0.0082
Beta-tubulin Leishmania donovani1
Nucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)7.9433
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)0.26
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.28

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (85.71)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Chang, DC; Feng, C; Le, XF; Luo, HW; Luo, KQ; Tian, HL; Xu, NN; Yu, T; Zhou, LY1
Huang, CH; Hung, YC; Pan, TL; Rau, KM; Wang, PW1
Gao, W; Huang, LQ; Zhou, YJ1
Lu, S; Zhang, L1
Chen, Z; Huang, N; Liu, Z; Qian, F; Sun, H; Zhang, L1
Cui, B; Li, S; Lin, H; Lin, Z; Xia, A; Xie, B; Zheng, L; Zhou, P1
Feng, N; Guo, T; Hou, X; Li, Z; Liu, W; Xia, Q; Zhang, Y; Zhu, C1

Reviews

2 review(s) available for tanshinone and paclitaxel

ArticleYear
[Application of synthetic biology to sustainable utilization of Chinese materia medica resources].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:1

    Topics: Abietanes; Artemisinins; Biosynthetic Pathways; Biotechnology; Drugs, Chinese Herbal; Escherichia coli; Ginsenosides; Metabolic Engineering; Paclitaxel; Saccharomyces cerevisiae; Salvia miltiorrhiza; Synthetic Biology

2014
Overview of Medicinally Important Diterpenoids Derived from Plastids.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:12

    Topics: Abietanes; Diterpenes; Diterpenes, Kaurane; Epoxy Compounds; Ginkgolides; Metabolic Engineering; Paclitaxel; Phenanthrenes; Plants; Plastids

2017

Other Studies

5 other study(ies) available for tanshinone and paclitaxel

ArticleYear
A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway.
    Cancer letters, 2010, Nov-01, Volume: 297, Issue:1

    Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Doxorubicin; Female; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasms; Paclitaxel; Phenanthrenes; Propyl Gallate; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptor, ErbB-2; Solubility; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

2010
Proteomic analysis reveals tanshinone IIA enhances apoptosis of advanced cervix carcinoma CaSki cells through mitochondria intrinsic and endoplasmic reticulum stress pathways.
    Proteomics, 2013, Volume: 13, Issue:23-24

    Topics: Abietanes; Adult; Aged; Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Female; Humans; Inhibitory Concentration 50; Middle Aged; Mitochondria; Molecular Sequence Data; Oxidative Stress; Paclitaxel; Proteome; Signal Transduction; Uterine Cervical Neoplasms

2013
Intermolecular Interactions between Coencapsulated Drugs Inhibit Drug Crystallization and Enhance Colloidal Stability of Polymeric Micelles.
    Molecular pharmaceutics, 2017, 10-02, Volume: 14, Issue:10

    Topics: Abietanes; Antineoplastic Agents; Chemistry, Pharmaceutical; Colloids; Crystallization; Drug Carriers; Drug Compounding; Drug Synergism; Enzyme Inhibitors; Humans; Micelles; Molecular Dynamics Simulation; NAD(P)H Dehydrogenase (Quinone); Nanoparticles; Naphthoquinones; Paclitaxel; Polyethylene Glycols

2017
Cytotoxicity of Tanshinone IIA combined with Taxol on drug-resist breast cancer cells MCF-7 through inhibition of Tau.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:4

    Topics: Abietanes; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Paclitaxel

2018
Folic acid modified lipid-bilayer coated mesoporous silica nanoparticles co-loading paclitaxel and tanshinone IIA for the treatment of acute promyelocytic leukemia.
    International journal of pharmaceutics, 2020, Aug-30, Volume: 586

    Topics: Abietanes; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Female; Folic Acid; Humans; Leukemia, Promyelocytic, Acute; Lipid Bilayers; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Paclitaxel; Silicon Dioxide; Xenograft Model Antitumor Assays

2020