tanshinone has been researched along with cryptotanshinone in 125 studies
| Studies (tanshinone) | Trials (tanshinone) | Recent Studies (post-2010) (tanshinone) | Studies (cryptotanshinone) | Trials (cryptotanshinone) | Recent Studies (post-2010) (cryptotanshinone) |
|---|---|---|---|---|---|
| 1,445 | 10 | 1,033 | 370 | 0 | 268 |
| Protein | Taxonomy | tanshinone (IC50) | cryptotanshinone (IC50) |
|---|---|---|---|
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | 90.06 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 9.02 | |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | 0.8 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 3.722 | |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | 10 | |
| Signal transducer and activator of transcription 3 | Homo sapiens (human) | 4.6 | |
| Tryptophan 2,3-dioxygenase | Homo sapiens (human) | 9.8 | |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | 1.47 | |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | 1.47 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (2.40) | 18.7374 |
| 1990's | 3 (2.40) | 18.2507 |
| 2000's | 43 (34.40) | 29.6817 |
| 2010's | 57 (45.60) | 24.3611 |
| 2020's | 19 (15.20) | 2.80 |
| Authors | Studies |
|---|---|
| Bastow, KF; Don, MJ; Lee, KH; Lin, YL; Nakamura, S; Sun, CM; Wang, X; Wu, TS; Yu, HJ | 1 |
| Dat, NT; Hong, YS; Jin, X; Kim, YH; Lee, D; Lee, JH; Lee, JJ; Lee, K | 1 |
| Cheung, CC; Fung, KP; Lai, PB; Lee, WY; Liu, KW; Wong, J; Yeung, JH | 1 |
| Adams, M; Fronza, M; Hamburger, M; Heinzmann, B; Laufer, S; Merfort, I; Murillo, R; Ślusarczyk, S | 1 |
| Jarstfer, MB; Keppler, BR; Lee, KH; Soares, J; Wang, X | 1 |
| Jeong, HJ; Kim, DW; Kim, JH; Kim, YM; Kwon, HJ; Lee, WS; Park, JY; Park, KH; Park, SJ; Ryu, YB | 1 |
| Edwards, CC; Hatfield, MJ; Hyatt, JL; Jeffries, C; Lemoff, A; Potter, PM; Tsurkan, LG; Yan, B | 1 |
| Liu, W; Loh, ML; Qu, CK; Tang, LD; Xu, G; Xu, WR; Yu, B | 1 |
| Fu, DJ; Li, J; Yu, B | 1 |
| Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW | 1 |
| Hu, Y; Jadhav, P; Tan, B; Tan, H; Wang, J | 1 |
| Liu, Y; Wang, B; Xie, P | 1 |
| Tao, LL; Xu, JT; Yuan, JM | 1 |
| Chen, GF | 1 |
| Bao, XS; Chen, JZ; Guan, DP; Ni, XB; Wu, PJ; Yuan, JX | 1 |
| Bai, DL; Sun, CJ | 1 |
| Chen, F; Chen, H; Song, JY; Yuan, JP; Zhang, YL | 1 |
| Bagherzadeh, K; Budnik, BA; Christensen, J; Jaroszewski, JW; Kharazmi, A; Sairafianpour, M; Staerk, D | 1 |
| Wen, ZM; Xu, LX | 1 |
| Jin, XS; Li, YC; Liu, LM; Zeng, JQ | 1 |
| Wang, F; Yang, P; Zhang, LW | 1 |
| Dong, C; Li, JF; Shuang, SM; Wei, YX; Xu, ZC | 1 |
| Gu, M; Ouyang, F; Su, Z; Zhang, G | 1 |
| Ge, X; Wu, J | 1 |
| Chang, W; He, J; Shi, Z; Yao, T; Zhao, M | 1 |
| Hur, JM; Jung, HJ; Kwon, HJ; Shim, JS | 1 |
| Hao, H; Li, J; Li, P; Wang, G | 1 |
| Ding, Z; Hao, H; Li, J; Li, P; Wang, G | 1 |
| Choi, DY; Lee, SY; Woo, ER | 1 |
| Chen, J; Du, R; Hang, TJ; Song, M; Zhang, ZhX | 1 |
| Guo, DA; Guo, H; Lin, YH; Liu, AH; Sun, JH; Yang, M | 1 |
| Hiroshi, K; Jiang, T; Xu, JK; Yao, XS; Zheng, JJ | 1 |
| Cai, P; Wang, NS; Xu, YH | 1 |
| He, Y; Li, Y; Liu, Y; Luo, XJ | 1 |
| Cui, GH; Huang, LQ; Qiu, DY; Wang, XY | 1 |
| Hang, TJ; Song, M; Zhang, ZX | 1 |
| Li, P; Li, SP; Wang, YT; Yang, FQ | 1 |
| Li, X; Li, Y; Wang, L; Xu, Y; Xue, M | 1 |
| Chiou, WF; Don, MJ | 1 |
| Cheong, JH; Jeon, SJ; Jung, JW; Kang, SS; Kim, DH; Kim, YS; Ko, KH; Lee, S; Ryu, JH; Shin, BY; Son, KH; Yoon, BH | 1 |
| Chiu, LC; Lee, WY; Yeung, JH | 1 |
| Chen, HY; Hang, TJ; Song, M; Zhang, Z | 1 |
| Ji, HY; Kim, NJ; Kim, YC; Kim, YH; Lee, HS; Park, EJ; Sohn, DH; Song, WY | 1 |
| Chen, KL; Huang, C | 1 |
| Chen, X; Tang, XQ; Wang, KC; Yu, BY | 1 |
| Bi, HC; Chen, X; Gu, LQ; Huang, M; Huang, ZY; Liu, PQ; Pan, Y; Zhao, LZ; Zhong, GP; Zhou, SF; Zuo, Z | 1 |
| Agrawal, DC; Chen, JJ; Lee, CY; Tsay, HS; Wang, CS; Yu, SM | 1 |
| Choi, YH; Jeon, SJ; Kim, HP; Kim, YS; Son, KH | 1 |
| Chae, HJ; Chae, SW; Choi, JY; Jung, YK; Kim, HK; Kim, HN; Kim, HR; Lee, HW; Park, HR; Woo, ER | 1 |
| Chan, KM; Lam, FF; Or, PM; Yeung, JH | 1 |
| Chen, S; Gao, L; Liu, Y; Shen, C; Sun, H; Ye, S; Yu, C; Zeng, S | 1 |
| Leung, SW; Man, RY; Wan, AK; Zhu, DY | 1 |
| Li, CG; Marriott, P; May, B; Pang, EC; Sheng, SJ; Story, D; Xue, CC; Zhou, S | 1 |
| Li, CG; Pang, EC; Sheng, SJ; Xue, CC | 1 |
| Lee, WY; Liu, KW; Yeung, JH | 1 |
| Li, CG; May, B; Pang, EC; Sheng, SJ; Xue, CC | 2 |
| Kim, YC; Park, EJ; Sohn, DH; Zhao, YZ | 1 |
| Liu, Q; Long, Y; Tang, F; Wu, K; Yao, S; Zhang, Q | 1 |
| Li, X; Li, Y; Liu, Y; Wang, L; Xue, M | 1 |
| Bi, YF; Liu, HM; Liu, XQ; Wang, ZJ; Xu, HW; Zhang, XJ | 1 |
| Abdolmaleky, H; Blackburn, GL; Gong, Y; Li, L; Li, Y; Lu, Y; Zhou, JR | 1 |
| Gao, C; Jiang, J; Ma, Y; Qiu, F; Sun, J; Wang, G; Zhang, R | 1 |
| Bi, W; Row, KH; Tian, M | 2 |
| Wang, X; Yeung, JH | 1 |
| Hu, P; Ignatova, S; Liang, Q; Luo, G; Sutherland, I; Wang, Y; Wu Jun, F; Zhang, M | 1 |
| Du, S; Li, X; Wu, Q; Yan, H; Yang, Y; Zhou, L | 1 |
| Hang, TJ; Lu, JG; Song, M; Zhang, SY | 1 |
| Kwan, YW; Lee, WY; Or, PM; Yeung, JH; Zhou, X | 1 |
| Jeong, SJ; Jiang, C; Kim, SH; Lee, EO; Lee, HJ; Lü, J; Won, SH; Ye, M; Zhang, J; Zhang, Y | 1 |
| Li, XB; Li, Y; Wang, W; Xie, XM; Zhou, GJ; Zhou, TS | 1 |
| Chu, T; Fu, HM; Jia, YQ; Li, H; Mao, SJ; Meng, WT; Shi, HY; Song, XR; Zhang, Q | 1 |
| Jia, X; Li, P; Ma, W; Peng, Y; Shu, L; Wang, B; Wang, C; Wei, Y | 1 |
| Choi, I; Jung, H; Kim, DO; Kim, MJ; Kim, TD; Kim, WS; Kwon, BM; Park, YJ; Yoon, SJ; Yoon, SR | 1 |
| Choi, HK; Kim, YG; Nepal, PR; Subedi, RK; Yu, H | 1 |
| Bai, L; Dai, H; Li, X; Li, Y; Xue, M | 1 |
| Jin, HJ; Li, CG; Xie, XL; Ye, JM | 1 |
| Chau, BT; Jaramillo, MC; Lantz, RC; Lau, A; Tao, S; Wondrak, GT; Wong, PK; Zhang, DD; Zheng, Y | 1 |
| Guo, M; Liang, J; Meng, J; Wu, S; Yang, Z | 1 |
| Chang, CC; Ho, TF; Huang, LR; Lai, JS; Liao, EC; Lin, JY; Lu, CH; Ma, SW; Tsai, CS | 1 |
| Huang, K; Pan, Y; Ren, Y; Wang, X; Xiang, Z; Xu, Y; Yan, P | 1 |
| Ding, C; Jiang, Y; Wang, L; Wang, T; Wang, X; Yang, R; Zhang, H; Zhang, L; Zhou, Y | 1 |
| Chu, ZY; Tian, L; Wu, LH | 1 |
| Huang, D; Liu, SQ; Song, L; Wu, Z | 1 |
| Chen, M; Chen, ML; Li, PY; Li, XM; Wang, X; Yang, G | 1 |
| Liu, SM; Sun, XB; Yang, ZH | 1 |
| Li, B; Liang, Z; Peng, L; Ru, M; Wang, K; Wang, Y; Xia, P | 1 |
| Chan, RL; Cho, CH; Hu, T; Li, M; Lu, L; Shen, J; To, KK; Wang, L; Yeung, JH; Zhang, L | 1 |
| Cao, J; Cao, W; Hu, SS; Ye, LH | 1 |
| Bifulco, G; Cantone, V; Chini, MG; De Feo, V; Maione, F; Mascolo, N | 1 |
| Cao, B; Qiu, F; Wang, Z; Yu, A; Zhang, H | 1 |
| Cho, CH; Hu, T; Kwan, YW; Or, PM; Wang, L; Yeung, JH; Zhou, X | 1 |
| Hao, H; Ji, H; Jiang, L; Ju, W; Li, P; Long, F; Peng, Y; Sun, B; Wang, G; Wei, Y; Xu, M | 1 |
| Chan, RL; Cho, CH; Hu, T; Li, M; Lu, L; Shen, J; To, KK; Wang, L; Wu, WK; Zhang, L | 1 |
| Cao, J; Ding, Y; Gao, W; Li, P; Qi, LW; Yang, H | 1 |
| Duan, J; Guan, H; Qian, D; Ren, H; Shang, E; Su, S; Zhang, W | 1 |
| Adams, M; Domaradzki, K; Hamburger, M; Matkowski, A; Slusarczyk, S; Topolski, J | 1 |
| Cai, Y; Chen, M; Chen, Z; He, C; Shi, Z; Zhang, W | 1 |
| Bi, W; Chen, Dda Y; Wang, J; Wang, M; Xia, Q; Yang, X; Zhang, Y | 1 |
| Cui, X; Luo, G; Qiao, Y; Shi, X; Xu, B; Xue, Z; Yang, C | 1 |
| Cerón-Carrasco, JP; den-Haan, H; Domaradzki, K; Girón-Rodríguez, F; Matkowski, A; Orhan, IE; Peña-García, J; Pérez-Garrido, A; Pérez-Sánchez, H; Senol, FS; Ślusarczyk, S | 1 |
| Cao, Y; Chai, Y; Chen, X; Ding, X; Gong, Z; Hong, Z; Jia, D; Liu, Y; Lv, L; Wang, D; Yuan, Y; Zhang, G; Zhao, L; Zhu, Z | 1 |
| Chen, J; Cui, G; Huang, L; Li, B; Qi, X; Shen, G; Zhan, Z | 1 |
| Cao, YF; Fang, ZZ; Wang, LX; Yuan, XL; Zhang, XX | 1 |
| Xu, M; Yu, HB; Zhang, LT; Zheng, XT; Zhong, ZF; Zhou, CH | 1 |
| Ding, F; Feng, J; Feng, Y; Gao, H; Huang, L; Tang, H; Xu, QM; Yang, K; Yang, S | 1 |
| Fu, J; Han, S; Jia, Q; Lin, Y; Lv, Y | 1 |
| Chang, YX; Chen, S; Ding, M; Gao, XM; Li, J; Li, Y; Ma, W; Mao, H; Wang, H; Wang, Q; Wang, X; Wei, J; Yang, X; Yang, Y; Zou, S | 1 |
| Chen, S; Chen, T; Cui, S; Li, S; Wu, Q | 1 |
| Cao, L; Huang, M; Jin, J; Tan, G; Wang, D; Xu, C; Yu, W; Zhao, Z | 1 |
| Chen, J; Hou, Z; Li, Y; Liang, Z; Su, F; Xu, L; Yang, D; Zhang, X | 1 |
| Cao, F; Gao, J; Hu, B; Li, B; Li, J; Luo, L; Peng, L; Yan, Y; Yang, B; Zhang, G | 1 |
| Cai, X; Dong, J; Li, X; Lu, Z; Ma, P; Ou Yang, Q; Zhang, B | 1 |
| Li, SP; Liu, MT; Zhao, J | 1 |
| Choi, JS; Fauzi, FM; Jung, HA; Park, SE; Paudel, P; Prajapati, R; Seong, SH | 1 |
| Campagnari, R; Cardile, A; Cerulli, A; Masullo, M; Menegazzi, M; Piacente, S; Zanrè, V | 1 |
| Chen, W; Hong, B; Liu, J; Peng, D; Shi, Y; Wang, G; Wang, L; Wu, C; Yu, N | 1 |
| Fang, Y; Guo, J; Han, Q; He, M; Huang, D; Jiang, H; Li, X; Liu, J; Wang, F; Xin, L | 1 |
| Diel, P; Guigas, C; Kulling, SE; Roth, A; Soukup, ST; Stärke, J; Zhao, P | 1 |
| Balcerczak, E; Jeleń, A; Kuźma, Ł; Majewska, M; Szymczyk, P | 1 |
| Chen, ML; Kang, LP; Wang, YL; Zheng, LL; Zhou, XT | 1 |
| Jin, J; Li, Y; Qiu, F; Ren, J; Song, G; Tan, B; Wang, Q; Weng, F; Yan, D; Zou, B | 1 |
| Liu, Q; Wang, J; Wei, F; Xie, X; Yu, Y; Zhang, M | 1 |
| Calabriso, N; Carluccio, MA; Carpi, S; Cecchini, M; Doccini, S; Maione, F; Marigliano, N; Massaro, M; Nieri, P; Polini, B; Quarta, S; Santorelli, FM; Saviano, A; Scoditti, E; Wabitsch, M | 1 |
3 review(s) available for tanshinone and cryptotanshinone
| Article | Year |
|---|---|
Annual review of LSD1/KDM1A inhibitors in 2020.
Topics: Antineoplastic Agents, Phytogenic; Enzyme Inhibitors; Histone Demethylases; Humans; Molecular Structure; Neoplasms | 2021 |
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
Topics: Antiviral Agents; Coronavirus Papain-Like Proteases; COVID-19 Drug Treatment; Humans; Pandemics; Protease Inhibitors; SARS-CoV-2 | 2022 |
Recent insights into the biological activities and drug delivery systems of tanshinones.
Topics: Abietanes; Cyclodextrins; Drug Carriers; Drug Delivery Systems; Drugs, Chinese Herbal; Emulsions; Humans; Liposomes; Nanoparticles; Phenanthrenes; Salvia miltiorrhiza; Solubility | 2016 |
122 other study(ies) available for tanshinone and cryptotanshinone
| Article | Year |
|---|---|
Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Furans; Humans; Pyrones; Receptor, ErbB-2; Receptors, Estrogen; Salvia miltiorrhiza | 2004 |
Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1; Korea; Plants, Medicinal; Salvia miltiorrhiza; Tumor Cells, Cultured | 2007 |
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxorubicin; Drug Resistance, Neoplasm; Humans; Models, Biological; Molecular Structure; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2010 |
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Humans; Lamiaceae; Phytotherapy; Plant Extracts; Plant Roots; Salvia; Structure-Activity Relationship | 2011 |
ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.
Topics: Abietanes; Benzoquinones; Catalase; Cell Line, Tumor; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Oxidation-Reduction; Telomerase | 2011 |
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
Topics: Abietanes; Cysteine Proteinase Inhibitors; Humans; Kinetics; Protein Binding; Salvia miltiorrhiza; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Ubiquitination | 2012 |
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
Topics: Abietanes; Algorithms; Camptothecin; Carboxylesterase; Clinical Trials, Phase I as Topic; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Irinotecan; Medicine, Chinese Traditional; Molecular Structure; Phenanthrolines; Plant Roots; Salvia miltiorrhiza | 2013 |
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
Topics: Animals; Catalytic Domain; Cell Line, Tumor; Computer-Aided Design; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Humans; Mice; Models, Molecular; Mutation; Phenanthrenes; Protein Tyrosine Phosphatase, Non-Receptor Type 11 | 2013 |
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors | 2021 |
[Evaluation of radix Salviae Miltiorrhizae and its preparation].
Topics: Abietanes; Benzaldehydes; Catechols; Chromatography, Thin Layer; Densitometry; Drug Combinations; Drugs, Chinese Herbal; Lactates; Phenanthrenes; Phenanthrolines; Plant Extracts; Salvia miltiorrhiza; Tablets | 1990 |
Immobilization of callus tissue cells of Salvia miltiorrhiza and the characteristics of their products.
Topics: Abietanes; Alginates; Cell Differentiation; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Culture Media; Drugs, Chinese Herbal; Kinetics; Phenanthrenes | 1990 |
[High performance liquid chromotographic determination of two tanshinones and the chromotographic profiles of 15 danshens].
Topics: Abietanes; Anti-Infective Agents; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Phenanthrenes; Phenanthrolines; Plant Extracts; Plants, Medicinal; Salvia miltiorrhiza; Species Specificity | 1987 |
[Quality evaluation of cultivated Salvia miltiorrhiza Bge. in Chongming, a suburb of Shanghai].
Topics: Abietanes; Benzaldehydes; Catechols; Drug Combinations; Drugs, Chinese Herbal; Pharmacognosy; Phenanthrenes; Phenanthrolines; Plant Extracts; Plants, Medicinal; Salvia miltiorrhiza | 1988 |
[Synthesis of some compounds related to tanshinquinone].
Topics: Abietanes; Anti-Bacterial Agents; Cardiovascular Agents; Diterpenes; Drug Resistance, Microbial; Phenanthrenes; Quinones; Staphylococcus aureus | 1985 |
Tanshinone production in Ti-transformed Salvia miltiorrhiza cell suspension cultures.
Topics: Abietanes; Agrobacterium tumefaciens; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Drugs, Chinese Herbal; Glucose; Light; Phenanthrenes; Plant Extracts; Salvia miltiorrhiza; Transformation, Genetic | 1997 |
Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones.
Topics: Abietanes; Animals; Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Antiprotozoal Agents; Chromatography, Thin Layer; Diterpenes; Drug Resistance; Humans; Iran; Lamiaceae; Leishmania major; Lymphocytes; Nuclear Magnetic Resonance, Biomolecular; Phenanthrenes; Phytohemagglutinins; Plant Lectins; Plant Roots; Plants, Medicinal; Plasmodium falciparum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured | 2001 |
[Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)].
Topics: Abietanes; Crataegus; Drug Combinations; Drugs, Chinese Herbal; Hypolipidemic Agents; Paeonia; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza; Sitosterols; Triterpenes; Ursolic Acid | 2001 |
[Extraction of three tanshinones from the root of Salvia miltiorrhiza Bunge by supercritical carbon dioxide fluid and their analysis with high performance liquid chromatography].
Topics: Abietanes; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2002 |
[Spectroscopic studies on the binding of effective component of Chinese herbs with human serum albumin].
Topics: Abietanes; Binding Sites; Cyclodextrins; Energy Transfer; Humans; Phenanthrenes; Protein Binding; Protein Conformation; Salvia miltiorrhiza; Serum Albumin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan | 2001 |
Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I.
Topics: Abietanes; Hydrogen-Ion Concentration; Models, Chemical; Phenanthrenes; Spectrometry, Fluorescence; Spectrophotometry; Temperature; Time Factors; Ultraviolet Rays | 2004 |
Identification of major active constituents in the fingerprint of Salvia miltiorrhiza Bunge developed by high-speed counter-current chromatography.
Topics: Abietanes; Countercurrent Distribution; Phenanthrenes; Reference Standards; Salvia; Spectrophotometry, Ultraviolet | 2004 |
Induction and potentiation of diterpenoid tanshinone accumulation in Salvia miltiorrhiza hairy roots by beta-aminobutyric acid.
Topics: Abietanes; Aminobutyrates; Diterpenes; Dose-Response Relationship, Drug; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Time Factors | 2005 |
Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix salvia miltiorrhiza by HPLC.
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2005 |
Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro.
Topics: Abietanes; Angiogenesis Inhibitors; Animals; Cattle; Cell Movement; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Endothelial Cells; Fibroblast Growth Factor 2; Humans; Neovascularization, Physiologic; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2005 |
Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Simultaneous quantification of cryptotanshinone and its active metabolite tanshinone IIA in plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS).
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge.
Topics: Abietanes; Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Furans; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Phenanthrenes; Plant Extracts; Plant Roots; Quinones; Salvia miltiorrhiza | 2005 |
Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Abietanes; Animals; Chromatography, Liquid; Drug Stability; Female; Male; Mass Spectrometry; Phenanthrenes; Rats; Reproducibility of Results; Sensitivity and Specificity | 2005 |
High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional chinese medicinal preparations.
Topics: Abietanes; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Spectrophotometry, Ultraviolet | 2006 |
[Protective effect of tanshinones against liver injury in mice loaded with restraint stress].
Topics: Abietanes; Alanine Transaminase; Animals; Antioxidants; Ascorbic Acid; Drugs, Chinese Herbal; Glutathione; Liver; Liver Diseases; Male; Malondialdehyde; Mice; Phenanthrenes; Plants, Medicinal; Protective Agents; Reactive Oxygen Species; Restraint, Physical; Salvia miltiorrhiza; Stress, Physiological | 2006 |
[Effect of micronization on the quality of Salvia miltiorrhiza Bge].
Topics: Abietanes; Biological Availability; Drug Stability; Drugs, Chinese Herbal; Particle Size; Phenanthrenes; Plant Roots; Plants, Medicinal; Powders; Quality Control; Salvia miltiorrhiza; Solubility; Technology, Pharmaceutical | 2006 |
[Study on uniform-design for optimizing supercritical-CO2 fluid extraction technique of tanshinones in radix salviae].
Topics: Abietanes; Carbon Dioxide; Chromatography, Supercritical Fluid; Phenanthrenes; Plant Roots; Plants, Medicinal; Reproducibility of Results; Salvia miltiorrhiza | 2006 |
[Effects of methyl jasmonat on accumulation and release of tanshinones in suspension cultures of Salvia miltiorrhiza hairy root].
Topics: Abietanes; Acetates; Culture Techniques; Cyclopentanes; Oxylipins; Phenanthrenes; Plant Growth Regulators; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza | 2007 |
[Pharmacokinetic interactions between the main components in the extracts of Salvia miltiorrhiza Bge. in rat].
Topics: Abietanes; Animals; Area Under Curve; Benzaldehydes; Benzofurans; Catechols; Drug Interactions; Female; Male; Metabolic Clearance Rate; Molecular Structure; Phenanthrenes; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2007 |
Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography.
Topics: Abietanes; Capillary Electrochromatography; Drugs, Chinese Herbal; Furans; Molecular Structure; Phenanthrenes; Plant Extracts; Quinones; Reproducibility of Results; Salvia miltiorrhiza; Solid Phase Extraction | 2007 |
Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Coumaric Acids; Drug Interactions; Drugs, Chinese Herbal; Lactates; Male; Medicine, Chinese Traditional; Molecular Structure; Phenanthrenes; Rabbits; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2007 |
Cryptotanshinone inhibits macrophage migration by impeding F-actin polymerization and filopodia extension.
Topics: Abietanes; Actins; Anti-Inflammatory Agents; Cell Movement; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemotactic Factors; Complement C5a; Cytoskeleton; Drugs, Chinese Herbal; Flow Cytometry; Fluorescent Dyes; Humans; Macrophage Inflammatory Proteins; Macrophages; Phenanthrenes; Pseudopodia | 2007 |
Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.
Topics: Abietanes; Animals; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Furans; Male; Memory Disorders; Mice; Mice, Inbred ICR; Phenanthrenes; Quinones; Receptors, GABA-A; Scopolamine | 2007 |
Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Flow Cytometry; Glutathione; Humans; Liver Neoplasms; Mass Spectrometry; Oxidative Stress; Phenanthrenes; Salvia miltiorrhiza | 2008 |
Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat.
Topics: Abietanes; Animals; Chromatography, Liquid; Diterpenes; Drugs, Chinese Herbal; Female; Male; Molecular Structure; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Tandem Mass Spectrometry; Time Factors; Tissue Distribution | 2007 |
Simultaneous determination of tanshinone I, dihydrotanshinone I, tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study of a standardized fraction of Salvia miltiorrhiza,
Topics: Abietanes; Animals; Chromatography, Liquid; Male; Molecular Structure; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salvia miltiorrhiza; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
[Contrast studies on content of hydrophobic components between Salvia yunnanensis roots and Salvia miltiorrhiza roots].
Topics: Abietanes; Chromatography, Thin Layer; Hydrophobic and Hydrophilic Interactions; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Solubility; Species Specificity | 2007 |
[Analysis on biomasses and contents of active components in roots of Salvia miltiorrhiza from different populations].
Topics: Abietanes; Benzofurans; Biomass; Caffeic Acids; China; Chromatography, High Pressure Liquid; Ecosystem; Lactates; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Spectrophotometry, Ultraviolet | 2007 |
Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza).
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Abietanes; Administration, Oral; Animals; beta-Cyclodextrins; Cardiovascular Agents; Dogs; Drugs, Chinese Herbal; Drugs, Investigational; Female; Male; Phenanthrenes; Phenanthrolines; Rats; Salvia miltiorrhiza; Tissue Distribution | 2008 |
T-DNA activation tagging as a tool to isolate Salvia miltiorrhiza transgenic lines for higher yields of tanshinones.
Topics: Abietanes; Chromatography, High Pressure Liquid; DNA, Bacterial; Mutagenesis, Insertional; Phenanthrenes; Phenotype; Plants, Medicinal; Rhizobium; Salvia miltiorrhiza; Transformation, Genetic | 2008 |
Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Edema; Electrophoretic Mobility Shift Assay; Furans; Lipopolysaccharides; Macrophages; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Plant Roots; Quinones; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2008 |
The correlation of Salvia miltiorrhiza extract-induced regulation of osteoclastogenesis with the amount of components tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone.
Topics: Abietanes; Animals; Antioxidants; Bone Density Conservation Agents; Cell Differentiation; Drugs, Chinese Herbal; Female; Humans; Immunosuppressive Agents; Male; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Osteoporosis, Postmenopausal; Phenanthrenes; Plant Extracts; Rats; Salvia miltiorrhiza | 2008 |
Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels.
Topics: Abietanes; Animals; Calcium; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Inhibitory Concentration 50; Male; Myocytes, Smooth Muscle; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Serotonin; Vasodilation | 2008 |
PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
Topics: Abietanes; Cell Line, Tumor; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Enzyme Induction; Genes, Reporter; Humans; Phenanthrenes; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; Recombinant Proteins; RNA, Messenger; Salvia miltiorrhiza; Transcription Factors; Transcriptional Activation | 2009 |
Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery.
Topics: Abietanes; Animals; Coronary Vessels; Diterpenes; Drugs, Chinese Herbal; Humans; Lipids; Medicine, Chinese Traditional; Molecular Structure; Phenanthrenes; Phenanthrolines; Plant Roots; Quinones; Salvia miltiorrhiza; Sus scrofa | 2008 |
Cultivar variations of Australian-grown Danshen (Salvia miltiorrhiza): bioactive markers and root yields.
Topics: Abietanes; Australia; Benzofurans; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2009 |
Seasonal variations in bioactive marker contents in Australian-grown Salvia miltiorrhiza roots.
Topics: Abietanes; Australia; Benzofurans; Biomarkers; Chromatography, High Pressure Liquid; Phenanthrenes; Plant Roots; Salvia miltiorrhiza; Seasons | 2009 |
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors | 2009 |
HPLC profiles and biomarker contents of Australian-grown Salvia miltiorrhiza f. alba roots.
Topics: Abietanes; Australia; Benzofurans; Biomarkers; Chromatography, High Pressure Liquid; Phenanthrenes; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza | 2009 |
Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo.
Topics: Abietanes; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatocytes; Male; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2009 |
Ionic liquid surfactant-mediated ultrasonic-assisted extraction coupled to HPLC: application to analysis of tanshinones in Salvia miltiorrhiza bunge.
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ionic Liquids; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza; Solvents; Surface-Active Agents; Ultrasonics | 2009 |
Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic-mass spectrometry and the application to pharmacokinetics in rats.
Topics: Abietanes; Animals; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Drug Stability; Lactates; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Rosmarinic Acid; Salvia miltiorrhiza; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2010 |
Synthesis and vasodilative activity of tanshinone IIA derivatives.
Topics: Abietanes; Animals; Aorta, Thoracic; Muscle, Smooth, Vascular; Norepinephrine; Phenanthrenes; Rats; Rats, Wistar; Salvia miltiorrhiza; Structure-Activity Relationship; Vasodilator Agents | 2010 |
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Aurora Kinase A; Aurora Kinases; Blotting, Western; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Humans; Immunoenzyme Techniques; In Vitro Techniques; Male; Mice; Mice, SCID; Phenanthrenes; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Salvia miltiorrhiza; Tumor Cells, Cultured | 2011 |
Activation of CYP3A-mediated testosterone 6β-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes.
Topics: Abietanes; Cytochrome P-450 CYP3A; Enzyme Activation; Humans; Hydroxylation; Hydroxytestosterones; Microsomes, Liver; Midazolam; Phenanthrenes; Testosterone | 2010 |
Molecular imprinting in ionic liquid-modified porous polymer for recognitive separation of three tanshinones from Salvia miltiorrhiza Bunge.
Topics: Abietanes; Adsorption; Chromatography, High Pressure Liquid; Imidazoles; Ionic Liquids; Molecular Imprinting; Phenanthrenes; Plant Extracts; Polymers; Porosity; Salvia miltiorrhiza; Solid Phase Extraction | 2011 |
Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship.
Topics: Abietanes; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P450 Family 2; Drugs, Chinese Herbal; Hydroxylation; Male; Membrane Proteins; Microsomes, Liver; Molecular Structure; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Steroid 16-alpha-Hydroxylase; Structure-Activity Relationship; Testosterone | 2011 |
Development of a strategy and process parameters for a green process in counter-current chromatography: purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study.
Topics: Abietanes; Countercurrent Distribution; Green Chemistry Technology; Phenanthrenes; Plant Extracts; Salvia miltiorrhiza | 2011 |
[Absorption mechanism of tanshinone II A, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo].
Topics: Abietanes; Absorption; Animals; Drugs, Chinese Herbal; Intestine, Small; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2010 |
[Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].
Topics: Abietanes; Administration, Oral; Animals; Area Under Curve; Dogs; Drug Combinations; Drugs, Chinese Herbal; Female; Ginsenosides; Lactates; Male; Panax notoginseng; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2010 |
Plant density-dependent variations in bioactive markers and root yield in Australian-grown Salvia miltiorrhiza Bunge.
Topics: Abietanes; Australia; Benzofurans; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2011 |
Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids.
Topics: Abietanes; Drugs, Chinese Herbal; Ionic Liquids; Phenanthrenes; Plant Proteins; Plants, Medicinal; Salvia miltiorrhiza; Ultrasonics | 2011 |
Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes.
Topics: Abietanes; Animals; Benzofurans; Cell Survival; Cytochrome P-450 CYP1A2; Cytochromes; Drugs, Chinese Herbal; Enzyme Activation; Enzyme Induction; Ethanol; Hepatocytes; Male; Phenacetin; Phenanthrenes; Phenanthrolines; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; RNA, Messenger; Salvia miltiorrhiza; Tacrine | 2012 |
Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling.
Topics: Abietanes; Active Transport, Cell Nucleus; Androgen Antagonists; Anilides; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Phenanthrenes; Prostate-Specific Antigen; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Receptors, Androgen; RNA, Messenger; Salvia miltiorrhiza; Signal Transduction; Time Factors; Tosyl Compounds; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Production of salvianolic acid B in roots of Salvia miltiorrhiza (Danshen) during the post-harvest drying process.
Topics: Abietanes; Benzofurans; Chromatography, High Pressure Liquid; Desiccation; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Phenanthrenes; Plant Roots; Salvia miltiorrhiza | 2012 |
Growth-inhibitory and apoptosis-inducing effects of tanshinones on hematological malignancy cells and their structure-activity relationship.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Microscopy, Fluorescence; Phenanthrenes; Structure-Activity Relationship; Time Factors | 2012 |
Metabolism of tanshinone IIA, cryptotanshinone and tanshinone I from Radix Salvia miltiorrhiza in zebrafish.
Topics: Abietanes; Animals; Drugs, Chinese Herbal; Metabolic Networks and Pathways; Phenanthrenes; Salvia miltiorrhiza; Zebrafish | 2012 |
Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation.
Topics: Abietanes; Animals; Cell Differentiation; Drugs, Chinese Herbal; Imidazoles; Interleukin-15; Killer Cells, Natural; Lymphocyte Subsets; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Pyridines; Transcription Factors | 2012 |
Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone I and tanshinone IIA extracted from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Area Under Curve; Drug Carriers; Hydrogen-Ion Concentration; Male; Phenanthrenes; Plant Extracts; Poloxamer; Povidone; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Solubility; Solvents; Tablets | 2012 |
Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp.
Topics: Abietanes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Biological Transport; Dose-Response Relationship, Drug; Drug Synergism; Intestinal Absorption; Intestinal Mucosa; Intestines; Phenanthrenes; Plant Roots; Rats; Salvia; Salvia miltiorrhiza | 2012 |
TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells.
Topics: Abietanes; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Hypoxia; Cell Survival; Cyclosporine; Cytochromes c; Cytoprotection; Enzyme Activation; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Phenanthrenes; Protein Stability; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats | 2013 |
Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo.
Topics: Abietanes; Animals; Antioxidants; Arsenic; Mice; Mice, Knockout; NF-E2-Related Factor 2; Phenanthrenes; Pneumonia; Salvia miltiorrhiza | 2013 |
Conical coils counter-current chromatography for preparative isolation and purification of tanshinones from Salvia miltiorrhiza Bunge.
Topics: Abietanes; Chromatography, High Pressure Liquid; Countercurrent Distribution; Drugs, Chinese Herbal; Phenanthrenes; Phenanthrolines; Plant Extracts; Rhizome; Salvia miltiorrhiza | 2013 |
Proapoptotic and TRAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen).
Topics: Abietanes; Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Cell Division; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; Inhibitory Concentration 50; Neoplasms; Phenanthrenes; Phenanthrolines; Plant Extracts; Poly(ADP-ribose) Polymerases; Salvia miltiorrhiza; TNF-Related Apoptosis-Inducing Ligand | 2013 |
A rapid UFLC-MS/MS method for simultaneous determination of formononetin, cryptotanshinone, tanshinone IIA and emodin in rat plasma and its application to a pharmacokinetic study of Bu Shen Huo Xue formula.
Topics: Abietanes; Animals; Chromatography, Liquid; Drugs, Chinese Herbal; Emodin; Isoflavones; Limit of Detection; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2013 |
A simple and reliable method for distinguishing danshen in salvia: simultaneous quantification of six active compositions by HPLC.
Topics: Abietanes; Benzofurans; Caffeic Acids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lactates; Limit of Detection; Phenanthrenes; Reproducibility of Results; Salvia; Salvia miltiorrhiza | 2014 |
[Determination of five components in rongxin pills by HPLC].
Topics: Abietanes; Chromatography, High Pressure Liquid; Cyclooctanes; Drugs, Chinese Herbal; Lignans; Linear Models; Organic Chemicals; Phenanthrenes; Polycyclic Compounds; Quality Control; Reproducibility of Results | 2014 |
Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae.
Topics: Abietanes; Amino Acids; Dose-Response Relationship, Drug; Gene Deletion; Humans; Microbial Viability; Phenanthrenes; Phytochemicals; Plant Roots; Protein Kinases; Saccharomyces cerevisiae; Salvia; Superoxide Dismutase; Time Factors | 2014 |
[Effect of Glomus versiforme and Trichoderma harzianum on growth and quality of Salvia miltiorrhiza].
Topics: Abietanes; Antibiosis; Benzofurans; Glomeromycota; Host-Pathogen Interactions; Phenanthrenes; Plant Diseases; Plant Roots; Salvia miltiorrhiza; Trichoderma | 2014 |
[Simultaneous determination of six Salvia miltiorrhiza gradients in rat plasma and brain by LC-MS/MS].
Topics: Abietanes; Animals; Benzaldehydes; Benzofurans; Blood-Brain Barrier; Brain; Caffeic Acids; Catechols; Chromatography, Liquid; Hydroxybenzoates; Injections, Intravenous; Lactates; Phenanthrenes; Plant Preparations; Rats; Reproducibility of Results; Salvia miltiorrhiza; Tandem Mass Spectrometry | 2014 |
Spaceflight environment-induced variation in root yield and active constituents of Salvia miltiorrhiza.
Topics: Abietanes; Benzofurans; Biomass; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Environment; Humans; Phenanthrenes; Plant Extracts; Plant Roots; Principal Component Analysis; Rosmarinic Acid; Salvia miltiorrhiza; Space Flight | 2014 |
Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Camptothecin; Digoxin; Doxorubicin; Drugs, Chinese Herbal; Furans; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Phenanthrenes; Quinones; Salvia miltiorrhiza | 2014 |
Dispersive micro-solid-phase extraction using mesoporous hybrid materials for simultaneous determination of semivolatile compounds from plant tea by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectromet
Topics: Abietanes; Camellia sinensis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Food Analysis; Limit of Detection; Phenanthrenes; Salvia miltiorrhiza; Solid Phase Extraction; Solvents; Tandem Mass Spectrometry; Time Factors; Volatile Organic Compounds | 2014 |
Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis.
Topics: Abietanes; Animals; Blood Platelets; Drugs, Chinese Herbal; Male; Molecular Docking Simulation; Molecular Structure; Phenanthrenes; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Rats, Wistar | 2015 |
Ultrasound-assisted ionic liquid-based homogeneous liquid-liquid microextraction high-performance liquid chromatography for determination of tanshinones in Salvia miltiorrhiza Bge. root.
Topics: Abietanes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Liquid Phase Microextraction; Phenanthrenes; Plant Extracts; Plant Roots; Salvia miltiorrhiza; Ultrasonics | 2015 |
Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.
Topics: Abietanes; Catalytic Domain; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Drugs, Chinese Herbal; Ethanol; Herb-Drug Interactions; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Phenanthrenes; Salvia miltiorrhiza | 2015 |
In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase.
Topics: Abietanes; Alkenes; Drugs, Chinese Herbal; Epoxide Hydrolases; Ethanol; Humans; Phenanthrenes; Plant Extracts; Polyphenols; Salvia miltiorrhiza | 2015 |
Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity.
Topics: Abietanes; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Phenanthrenes; Tumor Suppressor Protein p53 | 2015 |
Efficient separation of tanshinones by polyvinylpyrrolidone-stabilized graphene-modified micellar electrokinetic chromatography.
Topics: 2-Propanol; Abietanes; Buffers; Chromatography, Micellar Electrokinetic Capillary; Drugs, Chinese Herbal; Furans; Graphite; Hydrogen-Ion Concentration; Phenanthrenes; Povidone; Quinones; Reproducibility of Results; Salvia miltiorrhiza | 2015 |
Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them.
Topics: Abietanes; Animals; Benzaldehydes; Benzofurans; Catechols; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Lactates; Limit of Detection; Liquid-Liquid Extraction; Male; Phenanthrenes; Polyphenols; Rats, Sprague-Dawley; Rosmarinic Acid; Tandem Mass Spectrometry | 2016 |
Isolation and Fast Selective Determination of Nor-abietanoid Diterpenoids from Perovskia atriplicifolia Roots Using LC-ESI-MS/MS with Multiple Reaction Monitoring.
Topics: Abietanes; Chromatography, Liquid; Cinnamates; Depsides; Diterpenes; Lamiaceae; Phenanthrenes; Plant Roots; Rosmarinic Acid; Spectrometry, Mass, Electrospray Ionization | 2015 |
Fast environment-friendly ball mill-assisted deep eutectic solvent-based extraction of natural products.
Topics: Abietanes; Biological Products; Chemistry Techniques, Analytical; Drugs, Chinese Herbal; Green Chemistry Technology; Phenanthrenes; Plant Extracts; Reproducibility of Results; Salvia miltiorrhiza | 2016 |
Overall uncertainty measurement for near infrared analysis of cryptotanshinone in tanshinone extract.
Topics: Abietanes; Analysis of Variance; Calibration; Chromatography, High Pressure Liquid; Phenanthrenes; Plant Extracts; Reproducibility of Results; Spectroscopy, Near-Infrared; Uncertainty | 2017 |
Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.
Topics: Abietanes; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Cinnamates; Depsides; Diterpenes; Drugs, Chinese Herbal; Lamiaceae; Phenanthrenes; Quantitative Structure-Activity Relationship; Rosmarinic Acid; Salvia | 2017 |
Development of APTES-Decorated HepG2 Cancer Stem Cell Membrane Chromatography for Screening Active Components from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Apoptosis; Binding Sites; Cell Membrane; Cell Proliferation; Chromatography, Affinity; Hep G2 Cells; Humans; Mice; Mice, Nude; Molecular Docking Simulation; Neoplastic Stem Cells; Phenanthrenes; Plant Extracts; Propylamines; Salvia miltiorrhiza; Silanes; Silica Gel; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Targeted mutagenesis in the medicinal plant Salvia miltiorrhiza.
Topics: Abietanes; Agrobacterium; Base Sequence; CRISPR-Cas Systems; Diterpenes; Gene Editing; Gene Expression Regulation, Plant; Gene Knockout Techniques; Genome, Plant; Hydroxybenzoates; Ligases; Mutagenesis; Phenanthrenes; Plant Proteins; Plant Roots; Plants, Medicinal; Salvia miltiorrhiza; Sequence Alignment | 2017 |
Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs).
Topics: Abietanes; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Glucuronosyltransferase; Herb-Drug Interactions; Inhibitory Concentration 50; Isoenzymes; Phenanthrenes; Rats; Salvia miltiorrhiza | 2017 |
Effects of Danshen capsules on the pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Topics: Abietanes; Area Under Curve; Blotting, Western; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 CYP3A; Enzyme Induction; Healthy Volunteers; Hep G2 Cells; Hepatocytes; Humans; Male; Phenanthrenes; Platelet Aggregation Inhibitors; Salvia miltiorrhiza; Tandem Mass Spectrometry; Ticlopidine | 2018 |
Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation.
Topics: Abietanes; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Kidney; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenanthrenes; RAW 264.7 Cells; Salvia miltiorrhiza; Sepsis | 2018 |
Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors.
Topics: Abietanes; Alkenes; Cell Proliferation; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; ErbB Receptors; Gefitinib; HEK293 Cells; Humans; Phenanthrenes; Polyphenols; Protein Kinase Inhibitors; Receptor, Fibroblast Growth Factor, Type 4; Salvia miltiorrhiza; Sorafenib; Spectrometry, Mass, Electrospray Ionization | 2019 |
A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease.
Topics: Abietanes; Administration, Oral; Animals; Chromatography, Liquid; Coronary Disease; Drugs, Chinese Herbal; Glucosides; Isoflavones; Male; Monoterpenes; Myocardium; Pharmacology; Phenanthrenes; Protein Interaction Maps; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2019 |
A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Humans; Inflammation; Lipopolysaccharides; Macrophage Activation; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Protein Interaction Mapping; Protein Interaction Maps; RAW 264.7 Cells; Salvia miltiorrhiza; Signal Transduction; Toll-Like Receptors | 2020 |
Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats.
Topics: Abietanes; Animals; Area Under Curve; Chromatography, Liquid; Half-Life; Lipids; Male; Molecular Structure; Phenanthrenes; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salvia miltiorrhiza; Tandem Mass Spectrometry | 2020 |
Quantitative Determination and Validation of Four Ketones in
Topics: Abietanes; China; Chromatography, High Pressure Liquid; Cluster Analysis; Furans; Ketones; Limit of Detection; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Phenanthrenes; Plant Extracts; Plant Roots; Protons; Pyridines; Quinones; Reproducibility of Results; Salvia miltiorrhiza | 2020 |
Increased phenolic acid and tanshinone production and transcriptional responses of biosynthetic genes in hairy root cultures of Salvia przewalskii Maxim. treated with methyl jasmonate and salicylic acid.
Topics: Abietanes; Acetates; Benzofurans; Caffeic Acids; Cinnamates; Cyclopentanes; Depsides; Dose-Response Relationship, Drug; Gene Expression Regulation, Plant; Hydroxybenzoates; Oxylipins; Phenanthrenes; Plant Growth Regulators; Plant Proteins; Plant Roots; Rosmarinic Acid; Salicylic Acid; Salvia; Time Factors | 2020 |
Lipopolysaccharide Enhances Tanshinone Biosynthesis via a Ca
Topics: Abietanes; Calcium; Calcium Signaling; Furans; Lipopolysaccharides; Phenanthrenes; Plant Proteins; Quinones; Salvia miltiorrhiza; Transcription Factors | 2020 |
Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza.
Topics: Abietanes; Benzofurans; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cinnamates; Depsides; Drugs, Chinese Herbal; Phenanthrenes; Quality Control; Rosmarinic Acid; Salvia miltiorrhiza; Smartphone | 2021 |
Monoamine Oxidase Inhibition by Major Tanshinones from
Topics: Abietanes; Animals; CHO Cells; Cricetulus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenanthrenes; Receptor, Muscarinic M4; Salvia miltiorrhiza | 2021 |
Salviolone from
Topics: Abietanes; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Diterpenes; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Melanoma; Phenanthrenes; Phosphorylation; Plant Extracts; Salvia miltiorrhiza; Signal Transduction; Up-Regulation | 2022 |
Comparison of Sweated and Non-Sweated Ethanol Extracts of
Topics: Abietanes; Animals; Ethanol; Glucuronosyltransferase; Herb-Drug Interactions; Humans; Phenanthrenes; Plant Extracts; PPAR alpha; Rats; Receptors, Cytoplasmic and Nuclear; Salvia miltiorrhiza; Uridine Diphosphate | 2022 |
Radix
Topics: Abietanes; Anti-Inflammatory Agents; Cyclooxygenase 2; Drugs, Chinese Herbal; Humans; Interleukin-6; Leukocytes, Mononuclear; Network Pharmacology; Phenanthrenes; Retrospective Studies; Salvia miltiorrhiza; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2022 |
Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems.
Topics: Abietanes; Chromatography, Liquid; Humans; Phenanthrenes | 2023 |
Isolation of
Topics: Salvia miltiorrhiza | 2022 |
[Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza].
Topics: Plant Growth Regulators; Plant Roots; Rosmarinic Acid; Salvia miltiorrhiza | 2023 |
15,16-dihydrotanshinone I in Danshen ethanol extract aggravated cholestasis by inhibiting Cyp3a11 mediated bile acids hydroxylation.
Topics: Animals; Bile Acids and Salts; Cholestasis; Cytochrome P-450 CYP3A; Ethanol; Hydroxylation; Lithocholic Acid; Membrane Proteins; Mice; Salvia miltiorrhiza | 2023 |
Integrated serum pharmacochemistry and serum pharmacology to investigate the active components and mechanism of Bushen Huoxue Prescription in the treatment of diabetic retinopathy.
Topics: Diabetes Mellitus; Diabetic Retinopathy; Humans; Vascular Endothelial Growth Factor A | 2023 |
Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes.
Topics: Adipocytes; Chemokine CCL5; Chemokine CXCL10; Humans; Inflammation; Interleukin-8; MicroRNAs; Tumor Necrosis Factor-alpha | 2023 |