tanshinone has been researched along with Dihydrotanshinone I in 22 studies
| Studies (tanshinone) | Trials (tanshinone) | Recent Studies (post-2010) (tanshinone) | Studies (Dihydrotanshinone I) | Trials (Dihydrotanshinone I) | Recent Studies (post-2010) (Dihydrotanshinone I) |
|---|---|---|---|---|---|
| 1,445 | 10 | 1,033 | 88 | 0 | 74 |
| Protein | Taxonomy | tanshinone (IC50) | Dihydrotanshinone I (IC50) |
|---|---|---|---|
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | 3.05 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 0.59 | |
| Acetylcholinesterase | Homo sapiens (human) | 1 | |
| Tyrosine-protein phosphatase non-receptor type 6 | Homo sapiens (human) | 3.67 | |
| Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens (human) | 3.94 | |
| ELAV-like protein 1 | Homo sapiens (human) | 0.1085 | |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | 2.17 | |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | 2.17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 9 (40.91) | 2.80 |
| Authors | Studies |
|---|---|
| Dat, NT; Hong, YS; Jin, X; Kim, YH; Lee, D; Lee, JH; Lee, JJ; Lee, K | 1 |
| Cheung, CC; Fung, KP; Lai, PB; Lee, WY; Liu, KW; Wong, J; Yeung, JH | 1 |
| Jeong, HJ; Kim, DW; Kim, JH; Kim, YM; Kwon, HJ; Lee, WS; Park, JY; Park, KH; Park, SJ; Ryu, YB | 1 |
| Edwards, CC; Hatfield, MJ; Hyatt, JL; Jeffries, C; Lemoff, A; Potter, PM; Tsurkan, LG; Yan, B | 1 |
| Liu, W; Loh, ML; Qu, CK; Tang, LD; Xu, G; Xu, WR; Yu, B | 1 |
| Cheung, J; Gary, EN; Rosenberry, TL; Shiomi, K | 1 |
| Fu, DJ; Li, J; Yu, B | 1 |
| Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW | 1 |
| Bai, R; He, X; Wang, S; Xie, T; Ye, XY; Ye, Y; Zhang, H; Zhang, Y | 1 |
| Hu, Y; Jadhav, P; Tan, B; Tan, H; Wang, J | 1 |
| Choi, DY; Lee, SY; Woo, ER | 1 |
| Li, P; Li, SP; Wang, YT; Yang, FQ | 1 |
| Cheong, JH; Jeon, SJ; Jung, JW; Kang, SS; Kim, DH; Kim, YS; Ko, KH; Lee, S; Ryu, JH; Shin, BY; Son, KH; Yoon, BH | 1 |
| Choi, YH; Jeon, SJ; Kim, HP; Kim, YS; Son, KH | 1 |
| Lee, WY; Liu, KW; Yeung, JH | 1 |
| Chan, RL; Cho, CH; Hu, T; Li, M; Lu, L; Shen, J; To, KK; Wang, L; Yeung, JH; Zhang, L | 1 |
| Cao, J; Ding, Y; Gao, W; Li, P; Qi, LW; Yang, H | 1 |
| Chen, J; Hou, Z; Li, Y; Liang, Z; Su, F; Xu, L; Yang, D; Zhang, X | 1 |
| Cai, X; Dong, J; Li, X; Lu, Z; Ma, P; Ou Yang, Q; Zhang, B | 1 |
| Chen, H; Deng, W; Hu, W; Hua, L; Liang, S; Ou, Y; Sun, P; Yang, Z; Yue, H; Zhang, C | 1 |
| Jin, J; Li, Y; Qiu, F; Ren, J; Song, G; Tan, B; Wang, Q; Weng, F; Yan, D; Zou, B | 1 |
| Cui, J; Guo, HD; Li, XY; Shao, CL; Wang, H; Wang, YC | 1 |
3 review(s) available for tanshinone and Dihydrotanshinone I
| Article | Year |
|---|---|
Annual review of LSD1/KDM1A inhibitors in 2020.
Topics: Antineoplastic Agents, Phytogenic; Enzyme Inhibitors; Histone Demethylases; Humans; Molecular Structure; Neoplasms | 2021 |
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).
Topics: Drug Discovery; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Structure-Activity Relationship | 2022 |
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
Topics: Antiviral Agents; Coronavirus Papain-Like Proteases; COVID-19 Drug Treatment; Humans; Pandemics; Protease Inhibitors; SARS-CoV-2 | 2022 |
19 other study(ies) available for tanshinone and Dihydrotanshinone I
| Article | Year |
|---|---|
Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1; Korea; Plants, Medicinal; Salvia miltiorrhiza; Tumor Cells, Cultured | 2007 |
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxorubicin; Drug Resistance, Neoplasm; Humans; Models, Biological; Molecular Structure; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2010 |
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
Topics: Abietanes; Cysteine Proteinase Inhibitors; Humans; Kinetics; Protein Binding; Salvia miltiorrhiza; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Ubiquitination | 2012 |
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
Topics: Abietanes; Algorithms; Camptothecin; Carboxylesterase; Clinical Trials, Phase I as Topic; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Irinotecan; Medicine, Chinese Traditional; Molecular Structure; Phenanthrolines; Plant Roots; Salvia miltiorrhiza | 2013 |
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
Topics: Animals; Catalytic Domain; Cell Line, Tumor; Computer-Aided Design; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Humans; Mice; Models, Molecular; Mutation; Phenanthrenes; Protein Tyrosine Phosphatase, Non-Receptor Type 11 | 2013 |
Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.
Topics: | 2013 |
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors | 2021 |
Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge.
Topics: Abietanes; Animals; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Furans; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Phenanthrenes; Plant Extracts; Plant Roots; Quinones; Salvia miltiorrhiza | 2005 |
Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography.
Topics: Abietanes; Capillary Electrochromatography; Drugs, Chinese Herbal; Furans; Molecular Structure; Phenanthrenes; Plant Extracts; Quinones; Reproducibility of Results; Salvia miltiorrhiza; Solid Phase Extraction | 2007 |
Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.
Topics: Abietanes; Animals; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Furans; Male; Memory Disorders; Mice; Mice, Inbred ICR; Phenanthrenes; Quinones; Receptors, GABA-A; Scopolamine | 2007 |
Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Edema; Electrophoretic Mobility Shift Assay; Furans; Lipopolysaccharides; Macrophages; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Plant Roots; Quinones; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2008 |
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors | 2009 |
Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Camptothecin; Digoxin; Doxorubicin; Drugs, Chinese Herbal; Furans; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Phenanthrenes; Quinones; Salvia miltiorrhiza | 2014 |
Efficient separation of tanshinones by polyvinylpyrrolidone-stabilized graphene-modified micellar electrokinetic chromatography.
Topics: 2-Propanol; Abietanes; Buffers; Chromatography, Micellar Electrokinetic Capillary; Drugs, Chinese Herbal; Furans; Graphite; Hydrogen-Ion Concentration; Phenanthrenes; Povidone; Quinones; Reproducibility of Results; Salvia miltiorrhiza | 2015 |
Quantitative Determination and Validation of Four Ketones in
Topics: Abietanes; China; Chromatography, High Pressure Liquid; Cluster Analysis; Furans; Ketones; Limit of Detection; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Phenanthrenes; Plant Extracts; Plant Roots; Protons; Pyridines; Quinones; Reproducibility of Results; Salvia miltiorrhiza | 2020 |
Lipopolysaccharide Enhances Tanshinone Biosynthesis via a Ca
Topics: Abietanes; Calcium; Calcium Signaling; Furans; Lipopolysaccharides; Phenanthrenes; Plant Proteins; Quinones; Salvia miltiorrhiza; Transcription Factors | 2020 |
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
Topics: Abietanes; AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Female; Furans; Gout; Humans; Inflammasomes; Inflammation; Male; Mice; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Phenanthrenes; Quinones; Rats; Reactive Oxygen Species; Shock, Septic; Uric Acid | 2021 |
15,16-dihydrotanshinone I in Danshen ethanol extract aggravated cholestasis by inhibiting Cyp3a11 mediated bile acids hydroxylation.
Topics: Animals; Bile Acids and Salts; Cholestasis; Cytochrome P-450 CYP3A; Ethanol; Hydroxylation; Lithocholic Acid; Membrane Proteins; Mice; Salvia miltiorrhiza | 2023 |
Screening and identification of effective components from modified Taohong Siwu decoction for protecting H9c2 cells from damage.
Topics: Animals; Apoptosis; Hydrogen Peroxide; Proto-Oncogene Proteins c-akt; Signal Transduction; Superoxide Dismutase | 2023 |