tamibarotene has been researched along with tretinoin in 54 studies
| Studies (tamibarotene) | Trials (tamibarotene) | Recent Studies (post-2010) (tamibarotene) | Studies (tretinoin) | Trials (tretinoin) | Recent Studies (post-2010) (tretinoin) |
|---|---|---|---|---|---|
| 198 | 10 | 105 | 23,654 | 1,083 | 6,085 |
| Protein | Taxonomy | tamibarotene (IC50) | tretinoin (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.18 | |
| Adenosine receptor A3 | Homo sapiens (human) | 5.275 | |
| Retinoic acid receptor alpha | Homo sapiens (human) | 2.2542 | |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 5.3 | |
| Retinoic acid receptor beta | Homo sapiens (human) | 0.7537 | |
| Retinoic acid receptor alpha | Mus musculus (house mouse) | 0.0057 | |
| Retinoic acid receptor gamma | Homo sapiens (human) | 0.0064 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.275 | |
| Retinoic acid receptor gamma | Mus musculus (house mouse) | 0.004 | |
| Retinoic acid receptor beta | Mus musculus (house mouse) | 0.005 | |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | 0.576 | |
| Nuclear receptor ROR-alpha | Homo sapiens (human) | 0.1995 | |
| Alpha-synuclein | Homo sapiens (human) | 3 | |
| Cellular retinoic acid-binding protein 1 | Gallus gallus (chicken) | 0.5233 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.358 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.275 | |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | 0.35 | |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | 0.1995 | |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 5.3 | |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | 0.82 | |
| 60 kDa chaperonin | Escherichia coli | 6.7 | |
| 10 kDa chaperonin | Escherichia coli | 6.7 | |
| Nuclear receptor ROR-beta | Homo sapiens (human) | 0.1259 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.70) | 18.7374 |
| 1990's | 12 (22.22) | 18.2507 |
| 2000's | 15 (27.78) | 29.6817 |
| 2010's | 23 (42.59) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, Y; Kagechika, H; Kawachi, E; Shudo, K; Yamakawa, T | 1 |
| Himi, T; Kagechika, H; Kawachi, E; Shudo, K | 1 |
| Hashimoto, Y; Himi, T; Kagechika, H; Kawachi, E; Shudo, K | 1 |
| Chandraratna, RA; Davies, PJ; Fésüs, L; Heyman, RA; Lamph, W; Nagy, L; Shipley, GL; Thomázy, VA | 1 |
| Eyrolles, L; Fukasawa, H; Hashimoto, Y; Iijima, T; Kagechika, H; Kawachi, E; Matsushima, Y; Shudo, K | 1 |
| Ebisawa, M; Eisenmann, G; Eyrolles, L; Fukasawa, H; Gronemeyer, H; Hashimoto, Y; Kagechika, H; Kawachi, E; Shudo, K; Umemiya, H | 1 |
| Chandraratna, RA; Thacher, SM; Vasudevan, J | 1 |
| Endo, Y; Iijima, T; Inoue, N; Itai, A; Kagechika, H; Kawachi, E; Kubo, A; Yaguchi, K | 1 |
| Kagechika, H; Kansui, H; Kurihara, M; Miyata, N; Okuda, H; Rouf, AS | 1 |
| Amano, Y; Fukasawa, H; Muratake, H; Nakagomi, M; Noguchi, M; Shudo, K | 1 |
| Kamei, Y; Kawada, T; Mizukami, J; Sugimoto, E | 1 |
| Breitman, TR; Takahashi, N | 1 |
| Hashimoto, Y; Heersche, JN; Von Schroeder, HP | 1 |
| Chiba, H; Iba, K; Ishii, S; Mori, M; Nuka, S; Sawada, N | 1 |
| Harada, M; Kibata, M; Ohno, R; Omoto, E; Shudo, K; Takahashi, K; Takeuchi, M; Ueda, R; Yano, T | 2 |
| Hiraoka, A; Karasuno, T; Kitamura, K; Miyawaki, S; Naoe, T; Ohnishi, K; Ohno, R; Takeshita, A; Takeuchi, M; Tobita, T; Ueda, R; Yanagi, M | 1 |
| Ohno, R | 1 |
| Ata, K; Fukutani, H; Hiraoka, A; Miyawaki, S; Ohnishi, K; Ohno, R; Sakura, T; Shinjo, K; Takeshita, A; Takeuchi, M; Tomoyasu, S; Ueda, R; Wakita, H | 1 |
| Hara, M; Hashizume, K; Ichikawa, K; Kakizawa, T; Kumagai, M; Miyamoto, T; Mori, J; Sakuma, T; Suzuki, S; Takeda, T; Yamashita, K | 1 |
| Takeshita, A | 1 |
| Inoue, K; Ishida, S; Kagechika, H; Ohno, Y; Ozawa, S; Sawada, J; Shigemoto-Mogami, Y; Shinozaki, Y; Shudo, K | 1 |
| Gronemeyer, H; Kagechika, H; Lou, YR; Miettinen, S; Tuohimaa, P | 1 |
| Fukasawa, H; Kagechika, H; Shudo, K | 1 |
| Ohnishi, K | 2 |
| Hamaguchi, A; Igarashi, R; Ohta, Y; Okano, H; Shudo, K; Takenaga, M; Tokura, Y | 1 |
| Klemann, AK; Klemann, C; Oki, S; Ozawa, T; Raveney, BJ; Shudo, K; von Hörsten, S; Yamamura, T | 1 |
| Bianchi, MG; Bussolati, O; Cagnin, S; Gazzola, GC; Kagechika, H | 1 |
| Fukui, T; Kodera, Y; Koizumi, F; Masuda, N; Nishio, K; Tamura, T | 1 |
| Tallman, MS | 1 |
| Enjoji, M; Kitaoka, A; Nakashima, M; Shiohira, H; Shirasawa, H | 1 |
| Chikamatsu, Y; Harigae, H; Ito, S; Kagechika, H; Matsuda, K; Nata, K; Noguchi, N; Okamoto, H; Sugawara, A; Uruno, A; Yoshikawa, T | 1 |
| Anderson, LD; Collins, RH; Kirk, A; Levitt, D; Naina, HV; Scaglioni, PP; Vusirikala, M | 1 |
| Malavasi, F | 1 |
| Inoue, A; Kawakami, C; Takitani, K; Tamai, H | 1 |
| Hijioka, M; Hisatsune, A; Isohama, Y; Katsuki, H; Matsushita, H; Shudo, K | 1 |
| Asou, N; Fujita, H; Hyo, R; Inaguma, Y; Ishigatsubo, Y; Iwanaga, M; Izumi, T; Kiyoi, H; Matsuda, M; Miyawaki, S; Miyazaki, Y; Nakaseko, C; Naoe, T; Nomura, S; Ohnishi, K; Ohtake, S; Okada, M; Shinagawa, K; Takeshita, A; Yamauchi, T | 1 |
| Feng, J; Huang, BX; Jin, R; Qiu, LZ; Zhou, GP; Zhu, LH; Zhuang, LL | 1 |
| Harada, T; Keino, H; Kitaoka, Y; Okada, AA; Sato, Y; Shudo, K; Watanabe, T | 1 |
| Douer, D; Ganzel, C | 1 |
| Choe, J; Han, HJ; Jang, YS; Kang, SH; Kim, J; Kim, PH; Kim, WS; Lee, JM; Park, SR; Rhee, KJ; Seo, GY | 1 |
| Inamura, J; Kohgo, Y; Shindo, M | 1 |
| Fujita, H | 1 |
| Ishijima, N; Kanki, K; Shimizu, H; Shiota, G | 1 |
| Inomata, T; Sunami, K | 1 |
| Allen, SL; Altman, JK; Cortes, JE; Coutre, S; Di Bona, E; Kantarjian, H; Lo-Coco, F; Ravandi, F; Sanford, D; Sanz, MA; Wetzler, M | 1 |
| Blagburn, JM; Blanco, RE; Duprey-Díaz, MV | 1 |
| Li, B; Li, D; Tang, B; Wang, X; Wang, Y; Zhang, Y; Zuo, Q | 1 |
| Azuma, M; Fujiwara, K; Kikuchi, M; Maliza, R; Yashiro, T | 1 |
| de Haan, LHJ; Groten, JP; Houtman, R; Louisse, J; Melchers, D; Miro Estruch, I; Rietjens, IMCM | 1 |
| Bae, SH; Jung, J; Kwak, SH; Nam, GS | 1 |
| Fujii, S; Kagechika, H; Kawachi, E; Masuno, H; Mori, S; Oikawa, T | 1 |
| Kagechika, H; Katsuki, H; Kimura, Y; Kinoshita, K; Koyama, H; Kurauchi, Y; Nakanishi, S; Seki, T; Suzuki, K; Suzuki, M | 1 |
10 review(s) available for tamibarotene and tretinoin
| Article | Year |
|---|---|
Therapeutic applications for ligands of retinoid receptors.
Topics: Animals; Drug Design; Humans; Ligands; Receptors, Retinoic Acid; Retinoids; Structure-Activity Relationship | 2000 |
Relapsed acute promyelocytic leukemia previously treated with all-trans retinoic acid: clinical experience with a new synthetic retinoid, Am-80.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenicals; Benzoates; Biomarkers, Tumor; Cheilitis; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Leukemia, Promyelocytic, Acute; Leukocytosis; Male; Middle Aged; Neoplasm Proteins; Oncogene Proteins, Fusion; Pilot Projects; Recurrence; Remission Induction; Salvage Therapy; Tetrahydronaphthalenes; Treatment Outcome; Tretinoin; Tumor Cells, Cultured | 1998 |
[Development of anti-leukemic drugs and clinical studies in Japan].
Topics: Antineoplastic Agents; Benzoates; Clinical Trials as Topic; Humans; Informed Consent; International Cooperation; Japan; Leukemia; Tetrahydronaphthalenes; Tretinoin | 1999 |
[Recent advances in the treatment of acute myelogenous leukemia: a view of the new agents].
Topics: Alkyl and Aryl Transferases; Aminoglycosides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Benzoates; Cyclosporine; Cytarabine; Daunorubicin; Drug Design; Farnesyltranstransferase; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Neoplasm Recurrence, Local; Nucleosides; Oxides; Prognosis; Radioisotopes; Remission Induction; Tetrahydronaphthalenes; Topoisomerase Inhibitors; Tretinoin; Verapamil | 2003 |
[Retinoid therapy for autoimmune diseases].
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Benzoates; Humans; Leukemia, Promyelocytic, Acute; Receptors, Retinoic Acid; Retinoids; Skin Diseases; T-Lymphocytes; Tetrahydronaphthalenes; Tretinoin | 2006 |
[Therapeutic strategies for patients with relapsed acute promyelocytic leukemia].
Topics: Aminoglycosides; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzoates; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gemtuzumab; Hematopoietic Stem Cell Transplantation; Humans; Hydroxamic Acids; Leukemia, Promyelocytic, Acute; Oxides; Practice Guidelines as Topic; Recurrence; Remission Induction; Tetrahydronaphthalenes; Tretinoin | 2006 |
PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzoates; Humans; Leukemia, Promyelocytic, Acute; Oncogene Proteins, Fusion; Oxides; Tetrahydronaphthalenes; Tretinoin | 2007 |
Extramedullary disease in APL: a real phenomenon to contend with or not?
Topics: Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Benzoates; Cerebral Hemorrhage; Humans; Incidence; Leukemia, Promyelocytic, Acute; Leukemic Infiltration; Models, Biological; Multicenter Studies as Topic; Organ Specificity; Oxides; Prognosis; Randomized Controlled Trials as Topic; Remission Induction; Risk Factors; Tetrahydronaphthalenes; Tretinoin | 2014 |
[Molecular target drugs for AML--current state and prospects for the future].
Topics: Aminoglycosides; Antibodies, Monoclonal, Humanized; Benzoates; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Tetrahydronaphthalenes; Tretinoin | 2014 |
[Treatment for acute promyelocytic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Benzoates; Clinical Trials, Phase III as Topic; Consolidation Chemotherapy; Disseminated Intravascular Coagulation; Gene Fusion; Humans; Induction Chemotherapy; Leukemia, Promyelocytic, Acute; Maintenance Chemotherapy; Molecular Targeted Therapy; Nuclear Proteins; Oxides; Promyelocytic Leukemia Protein; Receptors, Retinoic Acid; Recurrence; Remission Induction; Retinoic Acid Receptor alpha; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Tumor Suppressor Proteins | 2014 |
4 trial(s) available for tamibarotene and tretinoin
| Article | Year |
|---|---|
Treatment with a new synthetic retinoid, Am80, of acute promyelocytic leukemia relapsed from complete remission induced by all-trans retinoic acid.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzoates; Cell Differentiation; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Female; Gastrointestinal Diseases; Humans; Leukemia, Promyelocytic, Acute; Leukocytosis; Male; Middle Aged; Pain; Prospective Studies; Receptors, Retinoic Acid; Recurrence; Remission Induction; Retinoic Acid Receptor gamma; Retinoids; Salvage Therapy; Tetrahydronaphthalenes; Treatment Outcome; Tretinoin | 1997 |
Relapsed acute promyelocytic leukemia previously treated with all-trans retinoic acid: clinical experience with a new synthetic retinoid, Am-80.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenicals; Benzoates; Biomarkers, Tumor; Cheilitis; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Leukemia, Promyelocytic, Acute; Leukocytosis; Male; Middle Aged; Neoplasm Proteins; Oncogene Proteins, Fusion; Pilot Projects; Recurrence; Remission Induction; Salvage Therapy; Tetrahydronaphthalenes; Treatment Outcome; Tretinoin; Tumor Cells, Cultured | 1998 |
Good prognosis of patients with acute promyelocytic leukemia who achieved second complete remission (CR) with a new retinoid, Am80, after relapse from CR induced by all-trans-retinoic acid.
Topics: Adult; Aged; Antineoplastic Agents; Benzoates; Female; Follow-Up Studies; Humans; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Prognosis; Recurrence; Remission Induction; Retinoids; Tetrahydronaphthalenes; Tretinoin | 2000 |
Tamibarotene in patients with acute promyelocytic leukaemia relapsing after treatment with all-trans retinoic acid and arsenic trioxide.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Benzoates; Biomarkers, Tumor; Cardiovascular Diseases; Cell Differentiation; Combined Modality Therapy; Consolidation Chemotherapy; Disease-Free Survival; Drug Resistance, Neoplasm; Febrile Neutropenia; Female; Hematopoietic Stem Cell Transplantation; Humans; Kaplan-Meier Estimate; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Oncogene Proteins, Fusion; Oxides; Recurrence; Remission Induction; Salvage Therapy; Tetrahydronaphthalenes; Tretinoin | 2015 |
41 other study(ies) available for tamibarotene and tretinoin
| Article | Year |
|---|---|
Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group(s) in human promyelocytic leukemia cells HL-60.
Topics: Antineoplastic Agents; Benzoates; Cell Differentiation; Chemical Phenomena; Chemistry; Humans; Leukemia, Prolymphocytic; Organometallic Compounds; Silicon; Structure-Activity Relationship; Trimethylsilyl Compounds; Tumor Cells, Cultured | 1990 |
Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity.
Topics: Amides; Benzoates; Cell Differentiation; Cell Line; Humans; Leukemia, Promyelocytic, Acute; Magnetic Resonance Spectroscopy; Molecular Structure; Retinoids; Structure-Activity Relationship | 1989 |
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
Topics: Amides; Binding Sites; Cell Differentiation; Humans; Leukemia, Promyelocytic, Acute; Methylation; Molecular Structure; Retinoids; Structure-Activity Relationship | 1988 |
Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
Topics: Apoptosis; Benzoates; Binding, Competitive; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Hematopoietic Stem Cells; Humans; Leukemia; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Signal Transduction; Structure-Activity Relationship; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1995 |
Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring.
Topics: Benzimidazoles; Benzoates; Benzodiazepines; Cell Differentiation; Cell Line; Drug Design; Humans; Receptors, Retinoic Acid; Retinoids; Structure-Activity Relationship; Tetrahydronaphthalenes; Tumor Cells, Cultured | 1994 |
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Topics: Azepines; Benzoates; Binding, Competitive; Cell Differentiation; Dibenzazepines; Dimerization; Drug Synergism; HL-60 Cells; Humans; Molecular Structure; Protein Binding; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; Tetrahydronaphthalenes; Transcription Factors | 1997 |
Structure-Activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal activity and conformation of two aromatic nuclei.
Topics: Animals; Benzoates; Boranes; Boron Neutron Capture Therapy; Cell Differentiation; COS Cells; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Models, Molecular; Molecular Conformation; Receptors, Retinoic Acid; Retinoids; Structure-Activity Relationship; Transcriptional Activation | 2001 |
Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity.
Topics: HL-60 Cells; Humans; Models, Molecular; Retinoids; Urea | 2004 |
Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures.
Topics: Cell Differentiation; Drug Design; HL-60 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Protein Binding; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids | 2013 |
The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha.
Topics: 3T3 Cells; Adipocytes; Animals; Benzoates; Cell Differentiation; Chalcone; Chalcones; Chromans; Mice; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoids; Tetrahydronaphthalenes; Tretinoin | 1994 |
Induction of differentiation and covalent binding to proteins by the synthetic retinoids Ch55 and Am80.
Topics: Benzoates; Cell Differentiation; Chalcone; Chalcones; Drug Synergism; Electrophoresis, Gel, Two-Dimensional; Humans; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Protein Binding; Tetrahydronaphthalenes; Tretinoin; Tumor Cells, Cultured | 1994 |
The effects of natural and synthetic retinoids on the differentiation of RCJ C5.18 chondrogenic cells.
Topics: Animals; Benzoates; Cartilage; Cell Differentiation; Cell Line; Chalcone; Chalcones; Dose-Response Relationship, Drug; Glycosaminoglycans; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Retinoid X Receptors; Retinoids; Teratogens; Tetrahydronaphthalenes; Transcription Factors; Tretinoin | 1994 |
All-trans retinoic acid inhibits dexamethasone-induced ALP activity and mineralization in human osteoblastic cell line SV HFO.
Topics: Alkaline Phosphatase; Benzoates; Biomarkers; Calcification, Physiologic; Cell Line; Dexamethasone; Enzyme Inhibitors; Humans; Naphthalenes; Osteoblasts; Osteocalcin; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Retinoids; Teratogens; Tetrahydronaphthalenes; Tretinoin | 1997 |
Re-induction of complete remission with a new synthetic retinoid, Am-80, for relapse of acute promyelocytic leukaemia previously treated with all-trans retinoic acid.
Topics: Adult; Benzoates; Female; Humans; Leukemia, Promyelocytic, Acute; Middle Aged; Recurrence; Remission Induction; Tetrahydronaphthalenes; Tretinoin | 1997 |
Thyroid hormone regulation of apoptosis induced by retinoic acid in promyeloleukemic HL-60 cells: studies with retinoic acid receptor-specific and retinoid x receptor-specific ligands.
Topics: Apoptosis; Benzoates; CD11 Antigens; Cell Division; Dibenzazepines; Drug Synergism; Flow Cytometry; Gene Expression; HL-60 Cells; Humans; Ligands; Proto-Oncogene Proteins c-bcl-2; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Tetrahydronaphthalenes; Transcription Factors; Tretinoin; Triiodothyronine | 2000 |
Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis.
Topics: Antineoplastic Agents; Benzoates; Carrier Proteins; Cell Differentiation; Gene Expression Profiling; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Tetrahydronaphthalenes; Tretinoin; Tumor Cells, Cultured | 2004 |
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Topics: Benzoates; Calcitriol; Cell Line; Cell Line, Tumor; Cells, Cultured; Dibenzazepines; Epithelial Cells; Gene Expression Regulation; Humans; Male; Prostate; Prostatic Neoplasms; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Retinoids; Steroid Hydroxylases; Tetrahydronaphthalenes; Transfection; Tretinoin; Vitamin D3 24-Hydroxylase | 2005 |
The effect of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats.
Topics: Animals; Benzoates; Biomarkers; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Female; Hindlimb; Humans; Keratolytic Agents; Locomotion; Movement Disorders; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Retinoids; Spinal Cord Injuries; Tetrahydronaphthalenes; Tretinoin | 2009 |
Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis.
Topics: Animals; Benzoates; Cell Differentiation; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Interleukin-17; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Tetrahydronaphthalenes; Tretinoin | 2009 |
The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.
Topics: Animals; Benzoates; Cell Line, Tumor; Dibenzazepines; Excitatory Amino Acid Transporter 3; Gene Silencing; Rats; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; RNA, Messenger; Tetrahydronaphthalenes; Tretinoin | 2009 |
Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cells.
Topics: Animals; Antineoplastic Agents; Benzoates; Cell Division; Cell Line, Tumor; Cell Survival; Drug Synergism; Female; Glucocorticoids; Humans; Mice; Mice, SCID; Multiple Myeloma; Retinoids; Tetrahydronaphthalenes; Tretinoin | 2009 |
Updates on the treatment of acute promyelocytic leukemia.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Benzoates; Cytarabine; Daunorubicin; Hemorrhage; Humans; Idarubicin; Leukemia, Promyelocytic, Acute; Tetrahydronaphthalenes; Tretinoin | 2010 |
Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line.
Topics: Antineoplastic Agents; Benzoates; Cell Differentiation; Cell Line, Tumor; GAP-43 Protein; Humans; Neuroblastoma; Neurons; Receptors, Retinoic Acid; Tetrahydronaphthalenes; Tretinoin | 2010 |
All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.
Topics: ADP-ribosyl Cyclase 1; Benzoates; Cell Adhesion; Endothelial Cells; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Leukemia; Protein Kinase C-delta; Retinoids; Tetrahydronaphthalenes; Tretinoin | 2011 |
Successful treatment of relapsed and refractory extramedullary acute promyelocytic leukemia with tamibarotene.
Topics: Adult; Aminoglycosides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Benzoates; Bone Marrow; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Resistance, Neoplasm; Gemtuzumab; Hematopoietic Stem Cell Transplantation; Humans; Idarubicin; Leukemia, Promyelocytic, Acute; Leukemic Infiltration; Male; Mercaptopurine; Methotrexate; Oxides; Radionuclide Imaging; Remission Induction; Salvage Therapy; Sarcoma, Myeloid; Soft Tissue Neoplasms; Tetrahydronaphthalenes; Tretinoin | 2011 |
Editorial: CD38 and retinoids: a step toward a cure.
Topics: ADP-ribosyl Cyclase 1; Benzoates; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Tetrahydronaphthalenes; Tretinoin | 2011 |
Sustained molecular remission after arsenic trioxide and gemutuzumab ozogamicin in a pediatric patient with relapsed acute promyelocytic leukemia.
Topics: Aminoglycosides; Antibodies, Monoclonal, Humanized; Arsenic Trioxide; Arsenicals; Benzoates; Child; Drug Administration Schedule; Gemtuzumab; Humans; Leukemia, Promyelocytic, Acute; Male; Oxides; Recurrence; Remission Induction; Tetrahydronaphthalenes; Tretinoin | 2012 |
Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice.
Topics: Animals; Bacterial Proteins; Benzoates; Brain; Cell Count; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Dose-Response Relationship, Drug; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Microbial Collagenase; Microglia; Neurons; Neuroprotective Agents; Psychomotor Disorders; Receptors, Retinoic Acid; Retinoids; Tetrahydronaphthalenes; Time Factors; Tretinoin | 2012 |
Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzoates; Combined Modality Therapy; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Japan; Kaplan-Meier Estimate; Leukemia, Promyelocytic, Acute; Male; Middle Aged; Oxides; Recurrence; Retrospective Studies; Salvage Therapy; Tetrahydronaphthalenes; Transplantation Conditioning; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome; Tretinoin; Young Adult | 2013 |
All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation.
Topics: 3' Untranslated Regions; Animals; Asthma; Benzoates; Cell Differentiation; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Epithelial Cells; Gene Expression Regulation; Humans; Introns; Membrane Proteins; Mice; NIH 3T3 Cells; Phosphorylation; Receptors, Retinoic Acid; Response Elements; Retinoic Acid Receptor alpha; Signal Transduction; Tetrahydronaphthalenes; Transcription, Genetic; Tretinoin | 2013 |
Retinoic acid receptor stimulation ameliorates experimental autoimmune optic neuritis.
Topics: Animals; Benzoates; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Injections, Intraperitoneal; Interferon-gamma; Interleukin-17; Mice; Mice, Inbred C57BL; Neuritis, Autoimmune, Experimental; Oligonucleotide Array Sequence Analysis; Optic Neuritis; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Superoxide Dismutase; Superoxide Dismutase-1; Tetrahydronaphthalenes; Tretinoin | 2015 |
Retinoic acid acts as a selective human IgA switch factor.
Topics: B-Lymphocytes; Benzoates; Dibenzazepines; Gene Expression Regulation; Humans; Immunoglobulin A; Immunoglobulin Class Switching; Immunoglobulin G; Immunoglobulin M; Palatine Tonsil; Primary Cell Culture; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; RNA, Messenger; Signal Transduction; Tetrahydronaphthalenes; Transforming Growth Factor beta1; Tretinoin | 2014 |
Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Benzoates; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Retinoids; Sorafenib; Tetrahydronaphthalenes; Tretinoin | 2015 |
[Antileukemic].
Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Benzoates; Humans; Leukemia; Oxides; Remission Induction; Tetrahydronaphthalenes; Tretinoin | 2015 |
Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury.
Topics: Animals; Anura; Benzoates; Chromans; Naphthols; Nerve Regeneration; Optic Nerve; Optic Nerve Injuries; Receptors, Retinoic Acid; Retinal Ganglion Cells; Tetrahydronaphthalenes; Tretinoin | 2016 |
Selection of the Inducer for the Differentiation of Chicken Embryonic Stem Cells into Male Germ Cells In Vitro.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzoates; Cell Differentiation; Chick Embryo; Chickens; Embryonic Stem Cells; Estradiol; Germ Cells; Immunohistochemistry; Integrins; Lewis X Antigen; Male; Microscopy, Fluorescence; Nanog Homeobox Protein; Proto-Oncogene Proteins c-kit; RNA-Binding Proteins; Tetrahydronaphthalenes; Tretinoin; Up-Regulation | 2016 |
Effect of retinoic acid on midkine gene expression in rat anterior pituitary cells.
Topics: 2-Naphthylamine; Aldehyde Dehydrogenase 1 Family; Animals; Benzoates; Cells, Cultured; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Kinetics; Male; Midkine; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Pituitary Gland, Anterior; Pyrimidines; Rats, Wistar; Receptors, Retinoic Acid; Retinal Dehydrogenase; Retinaldehyde; RNA, Messenger; Signal Transduction; Tetrahydronaphthalenes; Tretinoin; Up-Regulation | 2017 |
Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action.
Topics: Amino Acid Motifs; Anthracenes; Benzoates; Binding Sites; Chromans; Protein Array Analysis; Protein Binding; Protein Domains; Receptors, Retinoic Acid; Recombinant Proteins; Response Elements; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Retinoids; Structure-Activity Relationship; Tetrahydronaphthalenes; Thiophenes; Tretinoin | 2017 |
Effect of Specific Retinoic Acid Receptor Agonists on Noise-Induced Hearing Loss.
Topics: Animals; Benzoates; Hearing Loss, Noise-Induced; Mice, Inbred C57BL; Naphthols; Noise; Receptors, Retinoic Acid; Tetrahydronaphthalenes; Thiazoles; Tretinoin | 2019 |
Structural Development of Silicon-Containing Retinoids: Structure-Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities.
Topics: Benzoates; Retinoid X Receptors; Retinoids; Silicon; Structure-Activity Relationship; Tetrahydronaphthalenes; Tretinoin | 2022 |
Acyclic retinoid peretinoin reduces hemorrhage-associated brain injury in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Brain; Brain Injuries; Cerebral Hemorrhage; Mice; NF-kappa B; Rats; Thrombin; Tretinoin | 2023 |