tamandarin-b and plitidepsin

tamandarin-b has been researched along with plitidepsin* in 1 studies

Other Studies

1 other study(ies) available for tamandarin-b and plitidepsin

Article	Year
Synthesis and biological evaluation of tamandarin B analogues. Organic letters, 2006, Feb-02, Volume: 8, Issue:3 [structure: see text]. The synthesis of two tamandarin B analogues in which the N,O-Me2Tyr5 unit was replaced by N-Me-phenylalanine (N-MePhe5) and (S)-2-(methylamino)-3-(naphthalen-2-yl)propanoic acid (N-MeNaphth5) is described. The choice of the macrocyclization site was crucial to achieve satisfactory macrolactamization. Coupling between norstatine (Nst1) and threonine (Thr6) afforded only a 15% yield, while lactamization between proline (Pro4) and the aromatic moiety could be achieved in 65% yield. Topics: Antineoplastic Agents; Depsipeptides; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Peptides, Cyclic; Tumor Cells, Cultured	2006

Article

Year

Synthesis and biological evaluation of tamandarin B analogues.

Organic letters, 2006, Feb-02, Volume: 8, Issue:3

[structure: see text]. The synthesis of two tamandarin B analogues in which the N,O-Me2Tyr5 unit was replaced by N-Me-phenylalanine (N-MePhe5) and (S)-2-(methylamino)-3-(naphthalen-2-yl)propanoic acid (N-MeNaphth5) is described. The choice of the macrocyclization site was crucial to achieve satisfactory macrolactamization. Coupling between norstatine (Nst1) and threonine (Thr6) afforded only a 15% yield, while lactamization between proline (Pro4) and the aromatic moiety could be achieved in 65% yield.

Topics: Antineoplastic Agents; Depsipeptides; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Peptides, Cyclic; Tumor Cells, Cultured

2006