talotrexin has been researched along with raltitrexed in 5 studies
| Studies (talotrexin) | Trials (talotrexin) | Recent Studies (post-2010) (talotrexin) | Studies (raltitrexed) | Trials (raltitrexed) | Recent Studies (post-2010) (raltitrexed) |
|---|---|---|---|---|---|
| 27 | 0 | 4 | 580 | 143 | 121 |
| Protein | Taxonomy | talotrexin (IC50) | raltitrexed (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 7.0667 | |
| Dihydrofolate reductase | Homo sapiens (human) | 1.8578 | |
| Thymidylate synthase | Lacticaseibacillus casei | 8.2667 | |
| Thymidylate synthase | Homo sapiens (human) | 1.208 | |
| Thymidylate synthase | Mus musculus (house mouse) | 0.67 | |
| Thymidylate synthase | Escherichia coli K-12 | 2.32 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 2.32 | |
| Folate receptor beta | Homo sapiens (human) | 0.384 | |
| Folate receptor alpha | Homo sapiens (human) | 0.015 | |
| Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (human) | 0.26 | |
| Reduced folate transporter | Homo sapiens (human) | 0.0063 | |
| Thymidylate synthase | Rattus norvegicus (Norway rat) | 0.9 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 1.7956 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.0995 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cherian, C; Deng, Y; Desmoulin, SK; Gangjee, A; Hou, Z; Kushner, J; Matherly, LH; Polin, L; Wang, L; White, K; Wu, J | 1 |
| Chang, MH; Cherian, C; Desmoulin, SK; Fulterer, A; Gangjee, A; Hou, Z; Kushner, J; Matherly, LH; Mitchell-Ryan, S; Polin, L; Romero, MF; Stout, M; Wang, L; White, K | 1 |
| Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
| Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhao, R | 1 |
| Assaraf, YG; Dijkmans, BA; Gerards, AH; Jansen, G; Lems, WF; Oerlemans, R; Scheper, RJ; van der Heijden, JW | 1 |
5 other study(ies) available for talotrexin and raltitrexed
| Article | Year |
|---|---|
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduc
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Carrier Proteins; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Female; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Humans; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Mice, SCID; Ovarian Neoplasms; Proton-Coupled Folate Transporter; Purines; Pyrimidines; Receptors, Cell Surface; Reduced Folate Carrier Protein | 2010 |
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-gl
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Folate Receptor 1; Folate Receptor 2; Folic Acid Antagonists; Glutamates; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Oocytes; Patch-Clamp Techniques; Phosphoribosylglycinamide Formyltransferase; Proton-Coupled Folate Transporter; Pyrimidines; Pyrimidinones; Reduced Folate Carrier Protein; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Xenopus | 2011 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Division; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Membrane Transport Proteins; Ornithine; Pemetrexed; Polyglutamic Acid; Pterins; Quinazolines; Reduced Folate Carrier Protein; Thiophenes | 2004 |
Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Ornithine; Pterins; Quinazolines; T-Lymphocytes; Thiophenes; Trimetrexate; Tumor Necrosis Factor-alpha | 2014 |