talotrexin has been researched along with pemetrexed in 7 studies
| Studies (talotrexin) | Trials (talotrexin) | Recent Studies (post-2010) (talotrexin) | Studies (pemetrexed) | Trials (pemetrexed) | Recent Studies (post-2010) (pemetrexed) |
|---|---|---|---|---|---|
| 27 | 0 | 4 | 2,469 | 657 | 1,695 |
| Protein | Taxonomy | talotrexin (IC50) | pemetrexed (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 1.1 | |
| Dihydrofolate reductase | Homo sapiens (human) | 4.0309 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 2.3 | |
| Thymidylate synthase | Homo sapiens (human) | 8.1787 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 2.3 | |
| Folate receptor beta | Homo sapiens (human) | 0.2585 | |
| Folate receptor alpha | Homo sapiens (human) | 0.2417 | |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.0342 | |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.07 | |
| Reduced folate transporter | Homo sapiens (human) | 0.0928 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 1.655 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.0229 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cherian, C; Deng, Y; Desmoulin, SK; Gangjee, A; Hou, Z; Kushner, J; Matherly, LH; Polin, L; Wang, L; White, K; Wu, J | 1 |
| Chang, MH; Cherian, C; Desmoulin, SK; Fulterer, A; Gangjee, A; Hou, Z; Kushner, J; Matherly, LH; Mitchell-Ryan, S; Polin, L; Romero, MF; Stout, M; Wang, L; White, K | 1 |
| Gangjee, A; Hou, Z; Karim, M; Kushner, J; Matherly, LH; O'Connor, C; Polin, L; Ravindra, M; Tong, N; Wallace-Povirk, A; White, K; Wilson, MR | 1 |
| Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
| Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhao, R | 1 |
| Adamson, PC; Norris, RE | 1 |
| Frühauf, J; Gangjee, A; Hou, Z; Matherly, LH; Ning, C; O'Connor, C; Tong, N; Wallace-Povirk, A | 1 |
7 other study(ies) available for talotrexin and pemetrexed
| Article | Year |
|---|---|
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduc
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Carrier Proteins; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Female; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Humans; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Mice, SCID; Ovarian Neoplasms; Proton-Coupled Folate Transporter; Purines; Pyrimidines; Receptors, Cell Surface; Reduced Folate Carrier Protein | 2010 |
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-gl
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Folate Receptor 1; Folate Receptor 2; Folic Acid Antagonists; Glutamates; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Oocytes; Patch-Clamp Techniques; Phosphoribosylglycinamide Formyltransferase; Proton-Coupled Folate Transporter; Pyrimidines; Pyrimidinones; Reduced Folate Carrier Protein; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Xenopus | 2011 |
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetulus; Fluorine; Folate Receptor 1; Folic Acid; Humans; Mice; Proton-Coupled Folate Transporter; Purine Nucleotides; Pyrimidines; Xenograft Model Antitumor Assays | 2018 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Division; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Membrane Transport Proteins; Ornithine; Pemetrexed; Polyglutamic Acid; Pterins; Quinazolines; Reduced Folate Carrier Protein; Thiophenes | 2004 |
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias.
Topics: Aminopterin; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Jurkat Cells; Leukemia; Lymphoma; Methotrexate; Molecular Structure; Ornithine; Pemetrexed; Pterins | 2010 |
Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.
Topics: Biological Transport; Cell Proliferation; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Methotrexate; Neoplasms; Ornithine; Pemetrexed; Proton-Coupled Folate Transporter; Pterins; Reduced Folate Carrier Protein | 2021 |