Compounds > talotrexin
Page last updated: 2024-09-03

talotrexin and guanine

talotrexin has been researched along with guanine in 3 studies

Compound Research Comparison

Studies
(talotrexin)		Trials
(talotrexin)		Recent Studies (post-2010)
(talotrexin)		Studies
(guanine)		Trials
(guanine)		Recent Studies (post-2010) (guanine)
270416,2788224,809

Protein Interaction Comparison

ProteinTaxonomytalotrexin (IC50)guanine (IC50)
Purine nucleoside phosphorylaseHomo sapiens (human)5

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH1
Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhao, R1
Adamson, PC; Norris, RE1

Other Studies

3 other study(ies) available for talotrexin and guanine

ArticleYear
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
    Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2

    Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

2002
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
    Cancer research, 2004, May-01, Volume: 64, Issue:9

    Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Division; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Membrane Transport Proteins; Ornithine; Pemetrexed; Polyglutamic Acid; Pterins; Quinazolines; Reduced Folate Carrier Protein; Thiophenes

2004
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:6

    Topics: Aminopterin; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Jurkat Cells; Leukemia; Lymphoma; Methotrexate; Molecular Structure; Ornithine; Pemetrexed; Pterins

2010