talotrexin has been researched along with aminopterin in 5 studies
| Studies (talotrexin) | Trials (talotrexin) | Recent Studies (post-2010) (talotrexin) | Studies (aminopterin) | Trials (aminopterin) | Recent Studies (post-2010) (aminopterin) |
|---|---|---|---|---|---|
| 27 | 0 | 4 | 1,389 | 73 | 109 |
| Protein | Taxonomy | talotrexin (IC50) | aminopterin (IC50) |
|---|---|---|---|
| Dihydrofolate reductase | Homo sapiens (human) | 0.0201 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0253 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.005 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.011 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bader, H; Keyomarsi, K; Matherly, LH; Rosowsky, A; Wright, JE | 1 |
| Rosowsky, A | 1 |
| Forsch, RA; Rosowsky, A; Vaidya, CM; Wright, JE | 1 |
| Chen, YN; Rosowsky, A; Wright, JE; Yurasek, GK | 1 |
| Adamson, PC; Norris, RE | 1 |
1 review(s) available for talotrexin and aminopterin
| Article | Year |
|---|---|
PT523 and other aminopterin analogs with a hemiphthaloyl-L-ornithine side chain: exceptionally tight-binding inhibitors of dihydrofolate reductase which are transported by the reduced folate carrier but cannot form polyglutamates.
Topics: Aminopterin; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA Damage; Folic Acid Antagonists; Humans; Ornithine; Polyglutamic Acid; Pterins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tissue Distribution | 1999 |
4 other study(ies) available for talotrexin and aminopterin
| Article | Year |
|---|---|
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Folic Acid Antagonists; Humans; Methotrexate; Mice; Ornithine; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta
Topics: 4-Aminobenzoic Acid; Aminopterin; Antineoplastic Agents; Binding Sites; Cell Division; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Humans; Ornithine; Pterins; Reducing Agents; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2000 |
Further studies on the interaction of nonpolyglutamatable aminopterin analogs with dihydrofolate reductase and the reduced folate carrier as determinants of in vitro antitumor activity.
Topics: Amino Acids; Aminopterin; Antineoplastic Agents; Carboxylic Acids; Carrier Proteins; Humans; Membrane Transport Proteins; Ornithine; Pterins; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2003 |
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias.
Topics: Aminopterin; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Jurkat Cells; Leukemia; Lymphoma; Methotrexate; Molecular Structure; Ornithine; Pemetrexed; Pterins | 2010 |