talatisamine and yunaconitine

To investigate the chemical constituents of the processed products of Aconitum Vilmorinian Radix.. The constituents were isolated by repeated column chromatography over silica gel, alumina and RP-C18 as well as recrystallization. The structures were elucidated on the basis of spectral analysis and physicochemical properties.. Ten compounds were obtained from the methanol extract, and they were identified as yunaconitine (1), 8-deacetyl-yunaconitine (2), geniculatine C (3), vilmorrianine B (4), vilmorrianine C(5), vilmorrianine D (6), talatisamine (7), β-sitosterol (8), β-daucosterol (9) and β-sitosterol acetate (10).. All compounds are obtained from the processed products of Aconitum Vilmoriniani Radix for the first time.

Topics: Aconitine; Aconitum; Phytochemicals; Plant Roots; Sitosterols

Seven new C19-diterpenoid alkaloids, circinasines A-G (1-7), together with six known compounds, talatisamine, yunaconitine, senbusine A, sachaconitine, hemsleyanisine, and isohemsleyanisine, were isolated from the roots of Aconitum hemsleyanum var. circinatum. The structures of 1-7 were determined by the interpretation of spectroscopic data and by the single-crystal X-ray crystallographic analysis of 6 and the acetonide derivative of 1. In addition, the structures of hemsleyanisine and isohemsleyanisine were revised from 8 and 9 to 10 and 11, respectively.

Topics: Aconitine; Aconitum; Alkaloids; Crystallography, X-Ray; Diterpenes; Drugs, Chinese Herbal; Molecular Conformation; Molecular Structure; Plant Roots

Two new C(19)-diterpenoid alkaloids, piepunensine A (1) and 18-acetylcammaconine (2), have been isolated from the roots of Aconitum piepunense together with five known alkaloids pengshenine B (3), talatisamine (4), aconosine (5), yunaconitine (6), and talatizidine (7). The structures of the new alkaloids were established on the basis of spectral data (1D- and 2D-NMR, HR-MS).

Topics: Aconitine; Aconitum; Alkaloids; Diterpenes; Drugs, Chinese Herbal; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Spectrometry, Mass, Electrospray Ionization

By means of HPLC method, yunaconitine and talatisamine contained in 10 samples of folk drug Caowu (aconite) have been analysed. The result shows that in 3 species both yunaconitine and talalisamine are present, and in 7 species only yunaconitine is found. The contents and HPLC chromatograms of these alkaloids vary with the samples.

Topics: Aconitine; Aconitum; Drugs, Chinese Herbal