tak 779 has been researched along with piperidines in 10 studies
| Studies (tak 779) | Trials (tak 779) | Recent Studies (post-2010) (tak 779) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 118 | 1 | 35 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adolfsen, W; Caldwell, CG; Castonguay, LA; Daugherty, BL; DeMartino, JA; Di Salvo, J; Finke, PE; Hale, JJ; Kilburn, R; Lynch, CL; MacCoss, M; Mills, SG; Springer, MS; Weng, Y | 1 |
| Clay, WC; Condreay, JP; Ferris, RG; Jenkinson, S; Kerner, SA; Lawrence, WK; McCoy, DC; Smith, CD | 1 |
| Fujisawa, J; Furuta, RA; Kanzaki, N; Nishi, T; Nishikawa, M; Takashima, K; Yamamoto, Y | 1 |
| Baroudy, BM; Clader, JW; Dragic, T; Gavrilov, S; Kuhmann, SE; McCombie, SW; Moore, JP; Palani, A; Sakmar, TP; Seibert, C; Smith, SO; Tagat, JR; Tsamis, F; Ying, W | 1 |
| Carnec, X; Dragic, T; Kajumo, F; Safarian, D; Tsamis, F | 1 |
| Coulton, L; Croucher, P; De Leenheer, E; De Raeve, H; Horuk, R; Imanishi, T; Menu, E; Miyashita, K; Van Camp, B; Van Riet, I; Van Valckenborgh, E; Vanderkerken, K | 1 |
| Kondo, M; Saita, Y; Shimizu, Y | 1 |
| Dioszegi, M; Ji, C; Kondru, R; Mirzadegan, T; Rotstein, D; Sankuratri, S; Zhang, J | 1 |
| Frimurer, TM; Jensen, PC; Mokrosinski, J; Rosenkilde, MM; Steen, A; Thiele, S | 1 |
| Chan, LW; Pei, XM; Sin, TK; Siu, PM; Wong, CS; Yip, SP; Yu, AP; Yung, BY | 1 |
10 other study(ies) available for tak 779 and piperidines
| Article | Year |
|---|---|
Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket.
Topics: Alanine; Amides; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Butanes; Cattle; CCR5 Receptor Antagonists; CHO Cells; Cricetinae; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Protein Structure, Secondary; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, CCR5; Rhodopsin; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2003 |
Development of a novel high-throughput surrogate assay to measure HIV envelope/CCR5/CD4-mediated viral/cell fusion using BacMam baculovirus technology.
Topics: Amides; Baculoviridae; Butyric Acid; CCR5 Receptor Antagonists; CD4 Antigens; Cell Fusion; Cell Line; Cell Line, Tumor; Cyclic N-Oxides; Dimethyl Sulfoxide; Gene Products, env; Gene Products, rev; Gene Products, tat; HIV; HIV Envelope Protein gp120; HIV Long Terminal Repeat; Humans; Oximes; Piperidines; Plasmids; Pyridines; Quaternary Ammonium Compounds; Receptors, CCR5; rev Gene Products, Human Immunodeficiency Virus; tat Gene Products, Human Immunodeficiency Virus; Transduction, Genetic; Transfection | 2003 |
Analysis of binding sites for the new small-molecule CCR5 antagonist TAK-220 on human CCR5.
Topics: Amides; Amino Acid Sequence; Anti-HIV Agents; Binding Sites; CCR5 Receptor Antagonists; HIV-1; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Piperidines; Quaternary Ammonium Compounds; Receptors, CCR5 | 2005 |
Interaction of small molecule inhibitors of HIV-1 entry with CCR5.
Topics: Amides; Binding Sites; Cell Line; Cyclic N-Oxides; HIV Fusion Inhibitors; HIV-1; Humans; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Oximes; Piperidines; Protein Structure, Secondary; Pyridines; Quaternary Ammonium Compounds; Receptors, CCR5 | 2006 |
An anti-CCR5 monoclonal antibody and small molecule CCR5 antagonists synergize by inhibiting different stages of human immunodeficiency virus type 1 entry.
Topics: Amides; Anti-HIV Agents; Antibodies, Monoclonal; CCR5 Receptor Antagonists; Cyclic N-Oxides; Drug Synergism; HeLa Cells; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; In Vitro Techniques; Oximes; Peptide Fragments; Piperidines; Pyridines; Quaternary Ammonium Compounds; Receptors, CCR5; Recombinant Proteins | 2006 |
Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model.
Topics: Amides; Animals; Bone Marrow; Bone Resorption; CCR5 Receptor Antagonists; Cell Division; Cell Line, Tumor; Cell Movement; Chemokine CCL3; Chemokine CCL4; Chemokines, CC; Chemotaxis; Female; Macrophage Inflammatory Proteins; Mice; Mice, Inbred C57BL; Multiple Myeloma; Neoplasm Proteins; Neovascularization, Pathologic; Osteoclasts; Osteolysis; Phenylurea Compounds; Piperidines; Quaternary Ammonium Compounds; Receptors, CCR1; Receptors, CCR5; Receptors, Chemokine; Recombinant Fusion Proteins; Stromal Cells; Tumor Burden | 2006 |
Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor.
Topics: Amides; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Calcium; CCR5 Receptor Antagonists; Cell Line; Cell Membrane; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Cyclic N-Oxides; Cyclohexanes; HIV Fusion Inhibitors; Humans; Macaca mulatta; Maraviroc; Mice; Molecular Sequence Data; Oximes; Piperidines; Precursor Cells, B-Lymphoid; Pyridines; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, CCR5; Sequence Homology, Amino Acid; Species Specificity; Transfection; Triazoles | 2007 |
Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.
Topics: Amides; Amino Acid Sequence; Animals; Anti-HIV Agents; Benzoates; Binding Sites; CCR5 Receptor Antagonists; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Diketopiperazines; HIV Fusion Inhibitors; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Maraviroc; Membrane Fusion; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Piperazines; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrimidines; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, CCR5; Sequence Homology, Amino Acid; Spiro Compounds; Static Electricity; Transfection; Triazoles | 2008 |
Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.
Topics: Allosteric Regulation; Amides; Animals; Benzoates; Chemokines; Chlorocebus aethiops; COS Cells; Cyclic N-Oxides; Diketopiperazines; Humans; Oximes; Piperazines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Receptors, CCR2; Receptors, CCR5; Recombinant Fusion Proteins; Spiro Compounds | 2011 |
[D-Lys3]-GHRP-6 exhibits pro-autophagic effects on skeletal muscle.
Topics: Amides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzylamines; Cyclams; Doxorubicin; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Muscle Cells; Muscle, Skeletal; Oligopeptides; Piperidines; Quaternary Ammonium Compounds; Quinazolinones; Receptors, CXCR4; Signal Transduction | 2015 |