Page last updated: 2024-09-03

tafenoquine and primaquine

tafenoquine has been researched along with primaquine in 71 studies

Compound Research Comparison

Studies (tafenoquine)	Trials (tafenoquine)	Recent Studies (post-2010) (tafenoquine)	Studies (primaquine)	Trials (primaquine)	Recent Studies (post-2010) (primaquine)
186	37	113	2,196	196	711

Protein Interaction Comparison

Protein	Taxonomy	primaquine (IC50)
Cytochrome P450 1A2	Homo sapiens (human)	0.1824
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	7.5
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.016
Serine hydroxymethyltransferase, mitochondrial	Homo sapiens (human)	0.4365
Thiosulfate sulfurtransferase	Homo sapiens (human)	2.9
60 kDa chaperonin	Escherichia coli	6.2
10 kDa chaperonin	Escherichia coli	6.2

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.41)	18.7374
1990's	13 (18.31)	18.2507
2000's	11 (15.49)	29.6817
2010's	35 (49.30)	24.3611
2020's	11 (15.49)	2.80

Authors

Authors	Studies
Blumbergs, P; LaMontagne, MP; Smith, DC	1
Queener, SF	1
Ager, A; Ellis, W; Guan, J; Kyle, D; Lin, AJ; Milhous, W; Sacci, J; Zhang, Q	1
Fitos, I; Mády, G; Visy, J; Zsila, F	1
Ager, AL; Bartlett, MS; Croft, SL; Khan, IA; McChesney, JD; Nanayakkara, NP; Walker, LA; Yardley, V	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Hudson, TH; Kozar, MP; Lin, AJ; Magill, AJ; Melendez, V; Ohrt, C; Shiraki, H	1
Carvalho, L; Castanys, S; Gamarro, F; Manzano, JI; Pérez-Victoria, JM	1
Kozar, MP; Lin, AJ; Luong, T; Melendez, V; Sathunuru, R; Zhang, L	1
Kozar, MP; Li, Q; Lin, AJ; Liu, X; Melendez, V; O'Neil, MT; Wang, X	1
Caridha, D; Kozar, MP; Lin, AJ; O'Neil, MT; Pybus, B; Sathunuru, R; Zhang, L	1
Benoit-Vical, F; Dechy-Cabaret, O	1
Fidock, DA; Flannery, EL; Winzeler, EA	1
Avery, VM; Sykes, ML	1
Iyer, PS; Kannan, M; Khan, FR; Raichurkar, AV	1
Ittarat, I; Webster, HK; Yuthavong, Y	1
Bartlett, MS; Berman, JD; Dean, RA; Ellis, WY; Milhous, WK; Queener, SF; Smith, JW	1
Clavin, AM; Coleman, RE; Milhous, WK	1
Bartlett, MS; Durkin, MM; Queener, SF; Shaw, MA; Smith, JW	1
Baskin, SI; Fricke, RF; Scharf, BA	1
Trigg, PI	1
Appiah, A; Hollingdale, MR; Li, J; Long, GW; McCutchan, TF; Milhous, WK; Zhu, JD	1
Baskin, SI; Clark, JH; Kirby, SD; Steinhaus, RK	1
Brewer, TG; Idowu, OR; Kelley, C; Peggins, JO	1
Bartlett, MS; Goheen, MP; Queener, SF; Shaw, MM; Smith, JW	1
Peters, W	1
Kain, KC; Keystone, JS; Shanks, GD	1
Eamsila, C; Edstein, MD; Kitchener, S; Nasveld, PE; Rieckmann, KH; Sasiprapha, T; Walsh, DS	1
Dutta, GP; Puri, SK	1
Peters, W; Robinson, BL; Stewart, LB	1
Coleman, RE; Eikarat, N; Kittayapong, P; Ponsa, N; Sattabongkot, J	1
Chambers, JA	1
Brewer, TG; Heppner, DG; Krudsood, S; Looareesuwan, S; Phumratanaprapin, W; Silachamroon, U; Siriyanonda, D; Tang, DB; Walsh, DS; Wilairatana, P	1
Edstein, MD; Elmes, NJ; Kitchener, SJ; Kocisko, DA; Nasveld, PE	1
Croft, SL; Gamarro, F; Yardley, V	1
Imre, T; Iványi, R; Jicsinszky, L; Mizsei, R; Németh, K; Simonyi, M; Szemán, J; Szente, L; Tárkányi, G; Varga, E; Visy, J	1
Fernando, D; Rajapakse, S; Rodrigo, C	2
Shanks, GD	1
Baresel, PC; Campo, B; Magill, AJ; Ohrt, C; Rochford, R; Sampath, A; Tekwani, BL; Walker, LA	1
Arthur, P; Carter, N; Chuenchom, N; Duparc, S; Green, JA; Gupta, SK; Kellam, L; Kleim, JP; Kochar, SK; Krudsood, S; Lacerda, MV; Llanos-Cuentas, A; Möhrle, JJ; Rueangweerayut, R; Ugwuegbulam, C	1
Caridha, D; Hickman, M; Li, Q; Melendez, V; O'Neil, M; Pybus, B; Xie, L; Zeng, Q; Zhang, J	1
Berman, J; DiTusa, C; Gettayacamin, M; Im-erbsin, R; Kozar, MP; Ohrt, C; Pybus, B; Sousa, J; Tungtaeng, A	1
Duan, D; Li, Q; Marcsisin, SR; Nanayakkara, NP; Nolan, CK; Paris, RM; Potter, BM; Pybus, BS; Read, LT; Reichard, GA; Sciotti, RJ; Smith, B; Smith, PL; Sousa, JC; Tekwani, BL; Vuong, C; Walker, LA; Xie, LH; Zhang, J; Zhang, P; Zottig, VE	1
Fernando, SD; Rajapakse, S; Rodrigo, C	1
Beck, HP; Carter, N; Duparc, S; Green, JA; Koh, G; Krudsood, S; Lacerda, MV; Llanos-Cuentas, A; Osorio, L; Rubio, JP; Rueangweerayut, R; Wampfler, R	1
Beaumont, C; Carter, N; Duparc, S; Green, JA; Koh, GC; Krudsood, S; Llanos-Cuentas, A; Rubio, JP; Rueangweerayut, R; St Jean, PL; Taylor, M; Xue, Z	1
Kaewpruk, N; Mungthin, M; Sitthichot, N; Suwandittakul, N; Tan-ariya, P; Ward, SA	1
Berman, J; Caridha, D; Dickson, SP; Hickman, M; Lee, PJ; Li, Q; Marcsisin, SR; Milner, EE; Read, LT; Roncal, N; Vesely, BA; Xie, LH; Zhang, J; Zhang, P	1
Bancone, G; Chu, CS; Jittamala, P; Taylor, WRJ; Watson, J; White, NJ	1
Bancone, G; Bansil, P; Chu, CS; Domingo, GJ; Gornsawun, G; Nosten, F; Pal, S; Porn, P	1
Euswas, A; Fukuda, MM; Ittiverakul, M; Krudsood, S; Miller, RS; Ohrt, C; Warrasak, S	1
Berman, J; Brown, T; Dow, G; Toovey, S	1
Kain, KC	1
White, NJ	1
Abdissa, A; Abebe, C; Angus, B; Batista Pereira, D; Beck, HP; Brand, F; Breton, JJ; Brito, MAM; Buathong, N; Casapía, M; Chuquiyauri, R; Clover, DD; Costa, MRF; Diro, E; Duparc, S; Espino, FEJ; Fletcher, K; Getie, S; Green, JA; Hardaker, E; Jones, SW; Kellam, LM; Kleim, JP; Koh, GCKW; Krudsood, S; Lacerda, MVG; Llanos-Cuentas, A; Lon, C; Mia, RZ; Mohamed, K; Mohammed, R; Monteiro, WM; Noedl, H; Rousell, VM; Saunders, DL; Tada, MS; Ugwuegbulam, CO; Val, F; Wubie, KM; Yilma, D; Zeynudin, A	1
Angus, B; Aruachan, S; Bancone, G; Breton, JJ; Brito, MAM; Casapía, M; Chu, CS; Chuquiyauri, R; Clover, DD; Costa, MRF; Craig, G; Duparc, S; Green, JA; Hardaker, E; Hien, TT; Jones, SW; Kendall, L; Koh, GCKW; Lacerda, MVG; Llanos-Cuentas, A; Mohamed, K; Monteiro, WM; Namaik-Larp, C; Nguyen, CH; Nosten, FH; Papwijitsil, R; Rousell, VM; Val, F; Vélez, ID; Villegas, MF; Wilches, VM	1
McCarthy, S; Quinn, JC	1
Taylor, AR; Watson, JA	1
Duparc, S; Green, JA; Koh, GCKW	1
Markus, MB	1
Janković, SM; Kostić, M; Milosavljević, MN; Ranković, G; Stefanović, S	1
Commons, RJ; McCarthy, JS; Price, RN	1
Devine, A; Dittrich, S; Howes, RE; Ley, B; Moore, KA; Price, DJ; Price, RN; Simpson, JA	1
Contreras-Mancilla, J; Delgado-Ratto, C; Fernandez-Miñope, C; Ferrucci, HR; Gamboa, D; Llanos-Cuentas, A; Van Geertruyden, JP	1
Dolensky, J; Hochegger, P; Kaiser, M; Mäser, P; Saf, R; Seebacher, W; Weis, R	1
Herrera, S; Hsiang, MS; Llanos-Cuentas, A; Manrrique, P; Rosas-Aguirre, A	1
Nekkab, N; Watson, JA; White, M	1
Gautam, CS; Sharma, J; Singh, H; Singh, J	1
Choi, JY; Kim, C; Kim, JD; Kim, JH; Lee, J; Suh, J; Yeom, JS	1
Baird, JK; Berni, A; Budiman, W; Cedar, E; Chand, K; Crenna-Darusallam, C; Duparc, S; Ekawati, LL; Elyazar, I; Fernando, D; Fletcher, K; Goyal, N; Green, JA; Instiaty, I; Jones, S; Kleim, JP; Lardo, S; Martin, A; Noviyanti, R; Prasetya, CB; Rolfe, K; Santy, YW; Satyagraha, AW; Sharma, H; Soebandrio, A; Subekti, D; Sutanto, I; Tan, LK; Taylor, M	1

Reviews

13 review(s) available for tafenoquine and primaquine

Article	Year
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. Journal of medicinal chemistry, 1995, Nov-24, Volume: 38, Issue:24 Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infections; Pneumonia, Pneumocystis; Structure-Activity Relationship	1995
Using genetic methods to define the targets of compounds with antimalarial activity. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum	2013
Approaches to protozoan drug discovery: phenotypic screening. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2013
The evolution of tafenoquine--antimalarial for a new millennium? Journal of the Royal Society of Medicine, 1999, Volume: 92, Issue:7 Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Primaquine	1999
Malaria chemoprophylaxis in the age of drug resistance. II. Drugs that may be available in the future. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001, Aug-01, Volume: 33, Issue:3 Topics: Aminoquinolines; Animals; Antimalarials; Drug Resistance; Humans; Malaria; Plasmodium; Primaquine; Travel	2001
Malaria prophylaxis/radical cure: recent experiences of the Australian Defence Force. Medecine tropicale : revue du Corps de sante colonial, 2001, Volume: 61, Issue:1 Topics: Aminoquinolines; Antimalarials; Australia; Controlled Clinical Trials as Topic; Endemic Diseases; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Military Personnel; Primaquine	2001
Military aviators, special operations forces, and causal malaria prophylaxis. Military medicine, 2003, Volume: 168, Issue:12 Topics: Aminoquinolines; Antimalarials; Atovaquone; Aviation; Chloroquine; Doxycycline; Drug Combinations; Humans; Malaria; Mefloquine; Military Personnel; Naphthoquinones; Primaquine; Proguanil; United States	2003
Primaquine in vivax malaria: an update and review on management issues. Malaria journal, 2011, Dec-12, Volume: 10 Topics: Aminoquinolines; Antimalarials; Artemisinins; Chloroquine; Clinical Trials as Topic; Drug Resistance; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Vivax; Plasmodium vivax; Primaquine	2011
Tafenoquine for preventing relapse in people with Plasmodium vivax malaria. The Cochrane database of systematic reviews, 2015, Apr-29, Issue:4 Topics: Adult; Aminoquinolines; Antimalarials; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria, Vivax; Primaquine; Primary Prevention; Randomized Controlled Trials as Topic; Recurrence	2015
Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines. Malaria journal, 2018, Nov-06, Volume: 17, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Humans; Macaca mulatta; Malaria, Vivax; Primaquine	2018
Tafenoquine for preventing relapse in people with Plasmodium vivax malaria. The Cochrane database of systematic reviews, 2020, 09-06, Volume: 9 Topics: Adult; Aminoquinolines; Antimalarials; Chloroquine; Drug Administration Schedule; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria, Vivax; Parasitemia; Placebos; Primaquine; Randomized Controlled Trials as Topic; Recurrence; Secondary Prevention	2020
Tafenoquine for the treatment of Expert opinion on pharmacotherapy, 2022, Volume: 23, Issue:7 Topics: Aminoquinolines; Antimalarials; Humans; Malaria, Vivax; Plasmodium vivax; Primaquine; Recurrence	2022
Tafenoquine for The Indian journal of medical research, 2021, Volume: 154, Issue:6 Topics: Aminoquinolines; Antimalarials; Female; Humans; Malaria, Vivax; Plasmodium vivax; Pregnancy; Primaquine; Recurrence	2021

Trials

10 trial(s) available for tafenoquine and primaquine

Article	Year
Malaria prophylaxis/radical cure: recent experiences of the Australian Defence Force. Medecine tropicale : revue du Corps de sante colonial, 2001, Volume: 61, Issue:1 Topics: Aminoquinolines; Antimalarials; Australia; Controlled Clinical Trials as Topic; Endemic Diseases; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Military Personnel; Primaquine	2001
Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Oct-15, Volume: 39, Issue:8 Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Female; Humans; Malaria, Vivax; Male; Methemoglobin; Middle Aged; Primaquine; Risk; Secondary Prevention; Time Factors	2004
The efficacy and tolerability of three different regimens of tafenoquine versus primaquine for post-exposure prophylaxis of Plasmodium vivax malaria in the Southwest Pacific. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008, Volume: 102, Issue:11 Topics: Adult; Aminoquinolines; Animals; Antimalarials; Australia; Dose-Response Relationship, Drug; Female; Humans; Malaria, Vivax; Male; Military Personnel; Plasmodium vivax; Primaquine; Statistics as Topic; Young Adult	2008
Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study. Lancet (London, England), 2014, Mar-22, Volume: 383, Issue:9922 Topics: Adolescent; Adult; Aged; Aminoquinolines; Antimalarials; Brazil; Chloroquine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; India; Malaria, Vivax; Male; Middle Aged; Peru; Primaquine; Secondary Prevention; Thailand; Treatment Outcome; Young Adult	2014
Estimation of the Antirelapse Efficacy of Tafenoquine, Using Plasmodium vivax Genotyping. The Journal of infectious diseases, 2016, Mar-01, Volume: 213, Issue:5 Topics: Aminoquinolines; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Double-Blind Method; Genotype; Humans; Malaria, Vivax; Plasmodium vivax; Primaquine; Secondary Prevention	2016
Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial. Malaria journal, 2016, Feb-18, Volume: 15 Topics: Aminoquinolines; Antimalarials; Chloroquine; Cytochrome P-450 CYP2D6; Female; Humans; Malaria, Vivax; Primaquine; Treatment Outcome	2016
Comparative ophthalmic assessment of patients receiving tafenoquine or chloroquine/primaquine in a randomized clinical trial for Plasmodium vivax malaria radical cure. International ophthalmology, 2019, Volume: 39, Issue:8 Topics: Adult; Aminoquinolines; Antimalarials; Cornea; Dose-Response Relationship, Drug; Double-Blind Method; Eye Infections, Parasitic; Female; Humans; Malaria, Vivax; Male; Middle Aged; Plasmodium vivax; Primaquine; Retina; Retrospective Studies; Slit Lamp Microscopy; Time Factors; Treatment Outcome; Young Adult	2019
Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria. The New England journal of medicine, 2019, 01-17, Volume: 380, Issue:3 Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Chloroquine; Cytochrome P-450 CYP2D6; Disease-Free Survival; Double-Blind Method; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase; Hemoglobins; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Logistic Models; Malaria, Vivax; Male; Parasitemia; Plasmodium vivax; Primaquine; Secondary Prevention	2019
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria. The New England journal of medicine, 2019, 01-17, Volume: 380, Issue:3 Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Chloroquine; Disease-Free Survival; Double-Blind Method; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Kaplan-Meier Estimate; Malaria, Vivax; Male; Parasitemia; Plasmodium vivax; Primaquine; Prospective Studies; Secondary Prevention	2019
Tafenoquine co-administered with dihydroartemisinin-piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study. The Lancet. Infectious diseases, 2023, Volume: 23, Issue:10 Topics: Antimalarials; Artemisinins; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Malaria, Vivax; Plasmodium vivax; Primaquine; Quinolines	2023

Other Studies

49 other study(ies) available for tafenoquine and primaquine

Article	Year
Antimalarials. 16. Synthesis of 2-substituted analogues of 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl)phenoxy]quinoline as candidate antimalarials. Journal of medicinal chemistry, 1989, Volume: 32, Issue:8 Topics: Aminoquinolines; Animals; Antimalarials; Chemical Phenomena; Chemistry; Malaria; Mice; Plasmodium berghei; Structure-Activity Relationship	1989
Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives. Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20 Topics: Administration, Oral; Animals; Antimalarials; Carbamates; Guanidines; Imidazoles; Imidazolidines; Malaria; Male; Mice; Plasmodium falciparum; Plasmodium yoelii; Structure-Activity Relationship	2005
Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Antimalarials; Binding Sites; Chromatography, Affinity; Circular Dichroism; Humans; Molecular Structure; Orosomucoid; Protein Binding; Serum Albumin; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship	2008
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6 Topics: Aminoquinolines; Animals; Antifungal Agents; Antiprotozoal Agents; Dogs; Female; Hemolysis; Humans; Leishmania donovani; Leishmaniasis, Visceral; Malaria; Male; Methemoglobinemia; Mice; Mice, Inbred BALB C; Plasmodium berghei; Pneumocystis carinii; Pneumonia, Pneumocystis; Stereoisomerism; Structure-Activity Relationship	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives. Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Malaria; Mice; Microsomes, Liver; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2011
Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3 Topics: Adenosine Triphosphate; Aminoquinolines; Antiprotozoal Agents; Drug Resistance; Glycolysis; Leishmania major; Pyruvate Kinase	2011
New imidazolidinedione derivatives as antimalarial agents. Bioorganic & medicinal chemistry, 2011, Feb-15, Volume: 19, Issue:4 Topics: Animals; Antimalarials; Humans; Imidazolidines; Macaca mulatta; Mice; Molecular Structure; Plasmodium berghei; Plasmodium cynomolgi; Plasmodium falciparum; Structure-Activity Relationship	2011
Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Administration, Oral; Animals; Antimalarials; Guanidines; Imidazolidines; Imidazolines; Macaca mulatta; Malaria; Mice; Plasmodium berghei; Plasmodium cynomolgi; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship	2011
Antimalarial activities of new guanidylimidazole and guanidylimidazoline derivatives. Journal of medicinal chemistry, 2011, Oct-13, Volume: 54, Issue:19 Topics: Animals; Antimalarials; Crystallography, X-Ray; Guanidines; Humans; Imidazoles; Imidazolines; In Vitro Techniques; Macaca mulatta; Malaria; Mice; Microsomes, Liver; Plasmodium berghei; Plasmodium falciparum; Recurrence; Structure-Activity Relationship	2011
Effects of antimalarial molecules on the gametocyte stage of Plasmodium falciparum: the debate. Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23 Topics: Animals; Antimalarials; Germ Cells; Plasmodium falciparum	2012
Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents. Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5 Topics: Aminoquinolines; Antimalarials; Humans; Malaria, Falciparum; Molecular Docking Simulation; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrazoles; Pyrimidines; Structure-Activity Relationship	2015
High-performance liquid chromatographic determination of dihydroorotate dehydrogenase of Plasmodium falciparum and effects of antimalarials on enzyme activity. Journal of chromatography, 1992, Nov-06, Volume: 582, Issue:1-2 Topics: Aminoquinolines; Animals; Antimalarials; Chromatography, High Pressure Liquid; Dihydroorotate Dehydrogenase; Enzyme Activation; Naphthoquinones; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Primaquine	1992
Efficacy of intermittent dosage of 8-aminoquinolines for therapy or prophylaxis of Pneumocystis pneumonia in rats. The Journal of infectious diseases, 1992, Volume: 165, Issue:4 Topics: Aminoquinolines; Animals; Clindamycin; Disease Models, Animal; Drug Administration Schedule; Female; Pneumonia, Pneumocystis; Primaquine; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms; Trimethoprim, Sulfamethoxazole Drug Combination	1992
Gametocytocidal and sporontocidal activity of antimalarials against Plasmodium berghei ANKA in ICR Mice and Anopheles stephensi mosquitoes. The American journal of tropical medicine and hygiene, 1992, Volume: 46, Issue:2 Topics: Acridines; Aminoquinolines; Analysis of Variance; Animals; Anopheles; Antimalarials; Female; Germ Cells; Guanidines; Imidazoles; Mice; Mice, Inbred ICR; Naphthoquinones; Phenanthrenes; Plasmodium berghei; Primaquine	1992
Inoculated mouse model of Pneumocystis carinii infection. Diagnostic microbiology and infectious disease, 1992, Volume: 15, Issue:2 Topics: Aminoquinolines; Animals; Antimalarials; Clindamycin; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Immunosuppression Therapy; Mice; Mice, Inbred BALB C; Pneumocystis Infections; Primaquine; Trimethoprim, Sulfamethoxazole Drug Combination	1992
Comparison of methemoglobin formers in protection against the toxic effects of cyanide. General pharmacology, 1992, Volume: 23, Issue:1 Topics: Aminoquinolines; Aniline Compounds; Animals; Dose-Response Relationship, Drug; Hemoglobins; Ketones; Lethal Dose 50; Male; Methemoglobin; Mice; Mice, Inbred ICR; Motor Activity; Oxidation-Reduction; Primaquine; Propiophenones; Sodium Cyanide	1992
Drug use and design in the nineties. Acta Leidensia, 1991, Volume: 60, Issue:1 Topics: Aminoquinolines; Amodiaquine; Antimalarials; Artemisinins; Calcium Channel Blockers; Chloroquine; Humans; Malaria; Mefloquine; Naphthoquinones; Phenanthrenes; Primaquine; Quinine; Sesquiterpenes; Sulfadoxine	1991
Plasmodium berghei: quantitation of in vitro effects of antimalarial drugs on exoerythrocytic development by a ribosomal RNA probe. Experimental parasitology, 1991, Volume: 72, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Base Sequence; Cells, Cultured; Liver; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Nucleic Acid Hybridization; Plasmodium berghei; Primaquine; Pyrimethamine; RNA Probes; RNA, Protozoan; RNA, Ribosomal	1991
Formation of methemoglobin and metmyoglobin using 8-aminoquinoline derivatives or sodium nitrite and subsequent reaction with cyanide. Journal of applied toxicology : JAT, 1990, Volume: 10, Issue:5 Topics: Aminoquinolines; Chemical Phenomena; Chemistry, Physical; Cyanides; Humans; Indicators and Reagents; Kinetics; Methemoglobin; Metmyoglobin; Oxidation-Reduction; Primaquine; Protein Binding; Sodium Nitrite	1990
Metabolism of a candidate 8-aminoquinoline antimalarial agent, WR 238605, by rat liver microsomes. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chromatography, Gas; Chromatography, High Pressure Liquid; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Primaquine; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet	1995
Effects of 8-aminoquinolines on the ultrastructural morphology of Pneumocystis carinii. International journal of experimental pathology, 1993, Volume: 74, Issue:4 Topics: Aminoquinolines; Humans; Microscopy, Electron; Pneumocystis; Primaquine	1993
Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys. Acta tropica, 2003, Volume: 86, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Female; Macaca mulatta; Malaria; Male; Monkey Diseases; Parasitemia; Plasmodium cynomolgi; Primaquine	2003
The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines. Annals of tropical medicine and parasitology, 2003, Volume: 97, Issue:3 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Resistance; Drug Therapy, Combination; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Mice; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Primaquine; Time Factors	2003
Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand. The American journal of tropical medicine and hygiene, 2003, Volume: 69, Issue:5 Topics: Aminoquinolines; Animals; Anopheles; Antimalarials; Artemisinins; Dose-Response Relationship, Drug; Humans; Insect Vectors; Malaria, Vivax; Mice; Parasitic Sensitivity Tests; Plasmodium vivax; Primaquine; Sesquiterpenes	2003
Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Aminoquinolines; Animals; Antiprotozoal Agents; Female; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Primaquine; Trypanosoma cruzi	2010
Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins. Journal of pharmaceutical and biomedical analysis, 2011, Feb-20, Volume: 54, Issue:3 Topics: Aminoquinolines; Anions; Antimalarials; beta-Cyclodextrins; Chloroquine; Cyclodextrins; Electrophoresis, Capillary; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mefloquine; Primaquine; Stereoisomerism	2011
Possible options for malaria chemoprophylaxis on the horizon. Journal of travel medicine, 1999, Volume: 6 Suppl 1 Topics: Aminoquinolines; Antimalarials; Azithromycin; Chemoprevention; Doxycycline; Drug Therapy, Combination; Humans; Malaria; Medication Adherence; Primaquine	1999
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity. Proceedings of the National Academy of Sciences of the United States of America, 2013, Oct-22, Volume: 110, Issue:43 Topics: Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Combined Modality Therapy; Dapsone; Dose-Response Relationship, Drug; Doxycycline; Drug Evaluation, Preclinical; Erythrocyte Count; Erythrocyte Transfusion; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Mefloquine; Mice; Mice, Inbred NOD; Mice, SCID; Primaquine; Pyrimethamine; Reproducibility of Results; Sensitivity and Specificity; Transplantation, Heterologous	2013
Assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. Malaria journal, 2014, Apr-14, Volume: 13 Topics: Aminoquinolines; Animals; Antimalarials; Area Under Curve; Flow Cytometry; Half-Life; Liver; Malaria; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Plasmodium berghei; Primaquine; Sporozoites	2014
Causal prophylactic efficacy of primaquine, tafenoquine, and atovaquone-proguanil against Plasmodium cynomolgi in a rhesus monkey model. The Journal of parasitology, 2014, Volume: 100, Issue:5 Topics: Aminoquinolines; Animals; Antimalarials; Atovaquone; Disease Models, Animal; Drug Combinations; Macaca mulatta; Malaria; Parasitemia; Plasmodium cynomolgi; Primaquine; Proguanil	2014
Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:7 Topics: Aminoquinolines; Animals; Antimalarials; Area Under Curve; Biotransformation; Cytochrome P-450 CYP2D6; Half-Life; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Primaquine	2015
PFMDR1 POLYMORPHISMS INFLUENCE ON IN VITRO SENSITIVITY OF THAI PLASMODIUM FALCIPARUM ISOLATES TO PRIMAQUINE, SITAMAQUINE AND TAFENOQUINE. The Southeast Asian journal of tropical medicine and public health, 2016, Volume: 47, Issue:3 Topics: Aminoquinolines; Antimalarials; Humans; Malaria, Falciparum; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Primaquine; Thailand	2016
Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei. Malaria journal, 2016, Dec-07, Volume: 15, Issue:1 Topics: Aminoquinolines; Animals; Antimalarials; Chemoprevention; Cytochrome P-450 CYP2D6; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy; Female; Malaria; Male; Mice, Inbred C57BL; Mice, Knockout; Plasmodium berghei; Primaquine; Treatment Outcome	2016
Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria. PLoS neglected tropical diseases, 2018, Volume: 12, Issue:4 Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency; Heterozygote; Humans; Lactation; Malaria, Vivax; Male; Plasmodium vivax; Pregnancy; Primaquine; Young Adult	2018
Validation of the quantitative point-of-care CareStart biosensor for assessment of G6PD activity in venous blood. PloS one, 2018, Volume: 13, Issue:5 Topics: Adult; Aminoquinolines; Antimalarials; Area Under Curve; Biosensing Techniques; Clinical Enzyme Tests; Endemic Diseases; Ethnicity; Female; Genotype; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Hemoglobinometry; Humans; Malaria, Vivax; Male; Methemoglobinemia; Myanmar; Point-of-Care Systems; Pregnancy; Pregnancy Complications, Hematologic; Primaquine; ROC Curve; Spectrophotometry, Ultraviolet	2018
Single-dose radical cure for Plasmodium vivax. Journal of travel medicine, 2019, 06-01, Volume: 26, Issue:4 Topics: Aminoquinolines; Humans; Malaria; Plasmodium vivax; Primaquine; Travel	2019
Tafenoquine - A Radical Improvement? The New England journal of medicine, 2019, 01-17, Volume: 380, Issue:3 Topics: Aminoquinolines; Humans; Malaria, Vivax; Primaquine; Recurrence	2019
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria. The New England journal of medicine, 2019, 05-09, Volume: 380, Issue:19 Topics: Aminoquinolines; Humans; Malaria, Vivax; Plasmodium vivax; Primaquine; Recurrence	2019
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria. The New England journal of medicine, 2019, 05-09, Volume: 380, Issue:19 Topics: Aminoquinolines; Humans; Malaria, Vivax; Plasmodium vivax; Primaquine; Recurrence	2019
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria. Reply. The New England journal of medicine, 2019, 05-09, Volume: 380, Issue:19 Topics: Aminoquinolines; Humans; Malaria, Vivax; Plasmodium vivax; Primaquine; Recurrence	2019
Killing of Plasmodium vivax by Primaquine and Tafenoquine. Trends in parasitology, 2019, Volume: 35, Issue:11 Topics: Aminoquinolines; Antimalarials; Humans; Hydrogen Peroxide; Malaria, Vivax; Plasmodium vivax; Primaquine; Recurrence	2019
Cost-utility of tafenoquine vs. primaquine for the radical cure (prevention of relapse) of Journal of chemotherapy (Florence, Italy), 2020, Volume: 32, Issue:1 Topics: Aminoquinolines; Antimalarials; Cost-Benefit Analysis; Humans; Malaria, Vivax; Markov Chains; Monte Carlo Method; Primaquine; Recurrence; Serbia	2020
Tafenoquine for the radical cure and prevention of malaria: the importance of testing for G6PD deficiency. The Medical journal of Australia, 2020, Volume: 212, Issue:4 Topics: Aminoquinolines; Antimalarials; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria; Male; Practice Guidelines as Topic; Primaquine	2020
Cost-Effectiveness Analysis of Sex-Stratified The American journal of tropical medicine and hygiene, 2020, Volume: 103, Issue:1 Topics: Adult; Afghanistan; Aminoquinolines; Anemia, Hemolytic; Antimalarials; Chloroquine; Cost-Benefit Analysis; Ethiopia; Female; Glucosephosphate Dehydrogenase Deficiency; Hemizygote; Heterozygote; Homozygote; Humans; Indonesia; Malaria, Vivax; Male; Mass Screening; Medication Adherence; Plasmodium vivax; Primaquine; Quality-Adjusted Life Years; Recurrence; Sex Factors; Vietnam	2020
Towards one standard treatment for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria: Perspectives from and for the Peruvian Amazon. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021, Volume: 105 Topics: Adult; Aminoquinolines; Artemisinins; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Peru; Plasmodium falciparum; Plasmodium vivax; Prevalence; Primaquine; Reference Standards	2021
8-Amino-6-Methoxyquinoline-Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity. Molecules (Basel, Switzerland), 2021, Sep-12, Volume: 26, Issue:18 Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; Cell Survival; Inhibitory Concentration 50; Plasmodium falciparum; Primaquine; Quinolines; Rats; Tetrazoles	2021
Tafenoquine for the prevention of Plasmodium vivax malaria relapse. The Lancet. Microbe, 2021, Volume: 2, Issue:5 Topics: Aminoquinolines; Humans; Malaria, Vivax; Primaquine; Recurrence	2021
Cost-Benefit Analysis of Tafenoquine for Radical Cure of Journal of Korean medical science, 2022, Jul-11, Volume: 37, Issue:27 Topics: Aminoquinolines; Antimalarials; Cost-Benefit Analysis; Humans; Malaria, Vivax; Primaquine; Recurrence	2022