Page last updated: 2024-09-02

tadalafil and zaprinast

tadalafil has been researched along with zaprinast in 9 studies

Compound Research Comparison

Studies
(tadalafil)
Trials
(tadalafil)
Recent Studies (post-2010)
(tadalafil)
Studies
(zaprinast)
Trials
(zaprinast)
Recent Studies (post-2010) (zaprinast)
1,7423921,089576287

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)zaprinast (IC50)
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.9442
cGMP-specific 3',5'-cyclic phosphodiesteraseCanis lupus familiaris (dog)0.76
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)2.6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)3.55
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)2.6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)3.55
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)3.55
cGMP-specific 3',5'-cyclic phosphodiesteraseBos taurus (cattle)0.4
G-protein coupled receptor 35Homo sapiens (human)0.8294

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's6 (66.67)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Hughes, RA; Manallack, DT; Thompson, PE1
Antunes, JE; da Cunha, EF; Freitas, MP; Ramalho, TC; Rittner, R1
Beghyn, TB; Bourin, A; Charton, J; Cos, P; Deprez, B; Laconde, G; Leroux, F; Maes, L1
Leeson, PD; Young, RJ1
Chai, S; Chen, S; Deng, L; Du, K; Shen, R; Sun, H; Sun, T; Xi, M; Xie, M1
Bowles, EA; Ellsworth, ML; Elrick, MM; Knebel, SM; Sprague, RS; Stephenson, AH; Zdanovec, AK1
Bowles, EA; Ellsworth, ML; Moody, GN; Sprague, RS; Stephenson, AH; Yeragunta, Y1
Aronsen, L; Lysaa, R; Orvoll, E; Ravna, AW; Sager, G1
Ding, S; Huang, X; Liu, L; Song, G; Wang, D; Xu, H1

Reviews

4 review(s) available for tadalafil and zaprinast

ArticleYear
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
    Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines

2005
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations.
    Journal of medicinal chemistry, 2018, 08-09, Volume: 61, Issue:15

    Topics: Animals; Chemical Phenomena; Drug Discovery; Humans; Hydrophobic and Hydrophilic Interactions

2018
Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.
    European journal of medicinal chemistry, 2022, Mar-15, Volume: 232

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alzheimer Disease; Animals; Cognition; Cyclic GMP; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases

2022
Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer's disease.
    Brain research bulletin, 2019, Volume: 153

    Topics: Alzheimer Disease; Animals; Cognition; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Flavonoids; Humans; Neurons; Neuroprotective Agents; Phosphodiesterase 5 Inhibitors; Purinones; Pyrimidines; Signal Transduction; Sildenafil Citrate; Sulfonamides; Tadalafil; Vardenafil Dihydrochloride

2019

Other Studies

5 other study(ies) available for tadalafil and zaprinast

ArticleYear
In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil.
    Bioorganic & medicinal chemistry, 2008, Aug-15, Volume: 16, Issue:16

    Topics: Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Imidazoles; Mice; Models, Molecular; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Quantitative Structure-Activity Relationship; Rats; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride

2008
Drug to genome to drug: discovery of new antiplasmodial compounds.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: Amino Acid Sequence; Antimalarials; Carbolines; Catalytic Domain; Cyclic AMP; Cyclic GMP; Diketopiperazines; Drug Design; Drug Discovery; Genome, Human; Genome, Protozoan; Humans; Hydrolysis; Models, Molecular; Molecular Sequence Data; Parasitic Sensitivity Tests; Phosphodiesterase 5 Inhibitors; Phosphoric Diester Hydrolases; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Tadalafil

2011
Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3',5' monophosphate accumulation and adenosine 3'5' triphosphate release from human erythrocytes.
    Experimental biology and medicine (Maywood, N.J.), 2013, Volume: 238, Issue:9

    Topics: Adenosine Triphosphate; Adult; Carbolines; Cyclic AMP; Epoprostenol; Erythrocytes; Female; Humans; Iloprost; Male; Middle Aged; Phosphodiesterase Inhibitors; Purinones; Signal Transduction; Tadalafil; Vasodilator Agents

2013
Phosphodiesterase 5 inhibitors augment UT-15C-stimulated ATP release from erythrocytes of humans with pulmonary arterial hypertension.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:1

    Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Antihypertensive Agents; Carbolines; Cyclic AMP; Drug Synergism; Epoprostenol; Erythrocytes; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Purinones; Tadalafil; Young Adult

2015
Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: ATP-Binding Cassette Transporters; Caffeine; Carbolines; Cyclic AMP; Cyclic GMP; Dipyridamole; Humans; Imidazoles; Kinetics; Multidrug Resistance-Associated Proteins; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purinones; Sulfones; Tadalafil; Theophylline; Triazines; Vardenafil Dihydrochloride

2014