tadalafil has been researched along with vardenafil dihydrochloride in 254 studies
| Studies (tadalafil) | Trials (tadalafil) | Recent Studies (post-2010) (tadalafil) | Studies (vardenafil dihydrochloride) | Trials (vardenafil dihydrochloride) | Recent Studies (post-2010) (vardenafil dihydrochloride) |
|---|---|---|---|---|---|
| 1,742 | 392 | 1,089 | 780 | 151 | 289 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 135 (53.15) | 29.6817 |
| 2010's | 93 (36.61) | 24.3611 |
| 2020's | 26 (10.24) | 2.80 |
| Authors | Studies |
|---|---|
| Brock, G | 1 |
| Cartledge, J; Eardley, I | 1 |
| Kumon, H; Nagai, A | 1 |
| Rotella, DP | 1 |
| Gleiter, CH; Gresser, U | 1 |
| Satyanarayana, R; Vickers, MA | 1 |
| Cestari, A; Deho', F; Guazzoni, G; Montorsi, F; Rigatti, P; Salonia, A; Stief, C | 1 |
| Wyllie, MG | 1 |
| Jünemann, KP | 1 |
| McKenna, KE; Rosen, RC | 1 |
| Mason, RG | 1 |
| Kuthe, A | 1 |
| Josefson, D | 1 |
| Cho, JM; Eum, SJ; Heo, YS; Hwang, KY; Hyun, YL; Jeon, YH; Kim, E; Kim, JH; Lee, JI; Lee, JO; Lee, TG; Moon, J; Park, SY; Ro, S; Sung, BJ; Yoon, JM | 1 |
| Kostis, JB; Rosen, RC | 1 |
| Naughton, K | 1 |
| Gaines, KK | 1 |
| Dinsmore, W | 1 |
| Romics, I | 1 |
| Kirkpatrick, P; Neumeyer, K | 1 |
| Briganti, A; Gallina, A; Montorsi, F; Rigatti, P; Salonia, A; Suardi, N | 1 |
| Burnett, AL | 1 |
| Beasley, A; Bessay, EP; Blount, MA; Corbin, JD; Francis, SH; Sekhar, KR; Zoraghi, R | 1 |
| Bischoff, E | 1 |
| Bakker, F; Blok-Tip, L; De Kaste, D; Hamzink, M; Hartog, KD; Ten Hove, J; Vredenbregt, M; Zomer, B | 1 |
| Ghofrani, HA; Grimminger, F; Haredza, P; Karadaş, B; Olschewski, H; Reichenberger, F; Schermuly, RT; Seeger, W; Voswinckel, R; Weissmann, N | 1 |
| Beasley, CM; Crumb, WJ; Dustan Sarazan, R; Emmick, JT; Ferguson, KM; Sausen, PJ; Strnat, CA | 1 |
| Anderson, PC; Arya, M; Gommersall, L; Hayne, D; Patel, HR | 1 |
| Berzas Nevado, JJ; Castañeda Peñalvo, G; Mora Diez, N; Rodríguez Flores, J | 1 |
| Kloner, RA | 2 |
| Keil, TU | 1 |
| McCullough, A | 1 |
| Wooten, JM | 1 |
| Goldstein, I; Lewis, JH; Rosen, R | 1 |
| Perimenis, P | 1 |
| Doggrell, SA | 1 |
| Campbell, HE | 1 |
| Chen, B; Han, H; Wan, Z; Xiao, S; Yang, D; Yao, S; Zhang, F; Zhu, X | 1 |
| Whitehill, D | 1 |
| Egan, RA; Fraunfelder, FW | 1 |
| Takahashi, Y | 1 |
| Adomat, H; Eberding, A; Fleshner, N; Guns, E; Harvey, M; Hersey, K; Wood, C | 1 |
| Beasley, A; Blount, MA; Corbin, JD; Francis, SH | 1 |
| Hatzichristou, DG; Hatzimouratidis, K | 1 |
| Gupta, M; Kovar, A; Meibohm, B | 1 |
| Hackett, GI | 1 |
| Priviero, FB; Teixeira, CE; Webb, RC | 1 |
| Huang, YR; Jin, W | 1 |
| Agrawal, A; Castell, DO; Hila, A; Tutuian, R | 1 |
| Barbieri, L; Briganti, A; Deho', F; Montorsi, F; Rigatti, P; Salonia, A; Zanni, G | 1 |
| Brown, M; Lambert, SM; Masson, P; Shabsigh, R | 1 |
| Hayreh, SS | 1 |
| Brown, JW; Fiore, AC; Meldrum, DR; Sheridan, BC; Tsai, BM; Turrentine, MW; Wang, M | 1 |
| Seftel, AD | 1 |
| Carson, CC | 1 |
| Ficorelli, CT; Weeks, B | 1 |
| Burhani, S; Harnett, JP; McLaughlin, TP; Mulhall, JP; Russell, D; Scott, B | 1 |
| Corbin, J; Montorsi, F; Phillips, S | 1 |
| Pomeranz, HD | 1 |
| Briganti, A; Gallina, A; Montorsi, F; Montorsi, P; Rigatti, P; Saccà, A; Salonia, A | 1 |
| Oguz, H; Verit, A | 1 |
| Agarwal, A; Nandipati, KC; Raina, R; Zippe, CD | 1 |
| Hedelin, H; Ljunggren, C; Ströberg, P | 1 |
| Bekos, A; Hatzichristou, D; Hatzimouratidis, K; Ioannidis, E; Moysidis, K; Tsimtsiou, Z | 1 |
| Minhas, S; Ralph, DJ; Wang, WF | 1 |
| Wolfe, SM | 1 |
| Adaikan, PG; Lau, LC | 1 |
| Chartier-Kastler, E; Denys, P; Previnaire, JG; Soler, JM | 1 |
| Flurer, RA; Gamble, BM; Gratz, SR | 1 |
| Wooltorton, E | 1 |
| Prisant, LM | 1 |
| van Driel, MF | 1 |
| Bessay, EP; Blount, MA; Corbin, JD; Francis, SH; Ke, H; Zoraghi, R | 1 |
| Campaña, JMC; Ciutat, LF; Miranda, EF; Tolrà, JR | 1 |
| Hatzichristou, D; Hatzimouratidis, K | 1 |
| Hütter, J; Sandner, P; Stelte-Ludwig, B; Tinel, H | 1 |
| Gopalakrishanan, G; Tharyan, P | 1 |
| Ahuja, S; Deeley, MC; Garcia, CS; Giuliano, F; Porst, H; Rosen, RC; Seftel, AD; Shabsigh, R | 1 |
| Beardsworth, A; Bertsch, J; Haro, JM; Kontodimas, S; Martin-Morales, A | 1 |
| Becker, AJ; Gratzke, C; Kedia, G; Reich, O; Schlenker, B; Seitz, M; Stief, CG; Uckert, S | 1 |
| Beasley, A; Bessay, EP; Blount, MA; Corbin, JD; Francis, SH; Grimes, KA; Zoraghi, R | 1 |
| Ghofrani, HA; Grimminger, F | 1 |
| Gustafsson, LE; Hallén, K; Wiklund, NP | 1 |
| Kukreja, RC | 1 |
| Nini, A; Vardi, M | 1 |
| Grimsley, SJ; Jones, GE; Khan, MH | 1 |
| Bridge, S; Harnett, JP; Hvidsten, K; Kell, PD; Morant, SV | 1 |
| Abdel Aziz, AT; Abdel Aziz, MT; Atta, H; El-Shehaby, AM; Hassouna, AA; Marzouk, SA; Mostafa, T; Obaia, EM; Rashed, L; Sabry, D | 1 |
| Gratzke, C; Reich, O; Schlenker, B; Seitz, M; Stief, CG; Tilki, D; Uckert, S | 1 |
| Bischoff, E; Huetter, J; Neuser, D; Sandner, P; Stelte-Ludwig, B; Tinel, H; Ulbrich, E | 1 |
| Beasley, A; Bessay, EP; Blount, MA; Corbin, JD; Francis, SH; Zoraghi, R | 1 |
| Corbin, JD; Francis, SH; Weeks, JL; Zoraghi, R | 1 |
| Chodorowski, Z; Korolkiewicz, RP; Kozłowska-Boszko, B; Roszkowska-Kranc, K; Sein Anand, J; Tajanko, E | 1 |
| Barbieri, L; Briganti, A; Dehò, F; Gallina, A; Guazzoni, G; Montorsi, F; Rigatti, P; Saccà, A; Salonia, A; Suardi, N; Zanni, G | 1 |
| Beardsworth, A; Belger, M; Bertsch, J; Haro, JM; Hatzichristou, D; Martin-Morales, A; Riley, A; von Keitz, A; Wolka, AM | 1 |
| Chan, AY; Lai, CK; Lam, YH; Mak, TW; Poon, WT | 1 |
| Corbin, JD; Francis, SH; Zoraghi, R | 1 |
| Hedelin, H; Ljunggren, C; Salomonsson, K; Ströberg, P | 1 |
| Atta, H; Aziz, AT; Aziz, MT; El-Shehaby, AM; Hassouna, AA; Marzouk, SA; Mostafa, T; Obaia, EM; Rashed, L; Sabry, D | 1 |
| Jonas, U; Kedia, G; Knapp, WH; Scheller, F; Sormes, M; Stief, CG; Uckert, S | 1 |
| Ghiadoni, L; Taddei, S; Versari, D | 1 |
| Antunes, E; De Nucci, G; Morganti, RP; Priviero, FB; Teixeira, CE; Toque, HA | 1 |
| Antunes, JE; da Cunha, EF; Freitas, MP; Ramalho, TC; Rittner, R | 1 |
| Antonialli, MM; Freitas, VM; Menezes, FG; Nascimento, JW | 1 |
| Antunes, E; Priviero, FB; Teixeira, CE; Toque, HA; Webb, RC; Zemse, SM | 1 |
| Sakuma, M; Shirato, K | 1 |
| De Berardis, G; Franciosi, M; Morelli, P; Nicolucci, A; Pamparana, F; Pellegrini, F; Tognoni, G | 1 |
| Buhse, LF; Gryniewicz, CM; Kauffman, JF; Reepmeyer, JC | 1 |
| Fusco, F; Mirone, V; Montorsi, F; Rossi, A; Sicuteri, R | 1 |
| Baldo, OB; Cartledge, J; Eardley, I; Storey, A; Taylor, J | 1 |
| Cecconi, F; Del Popolo, G; Lombardi, G; Macchiarella, A | 1 |
| Hauzeur, C; Roumeguère, T; Schulman, C; Vanhaeverbeek, M; Wespes, E; Zouaoui Boudjeltia, K | 1 |
| Antunes, E; Baracat, JS; Claudino, MA; De Nucci, G; Fregonesi, A; Priviero, FB; Teixeira, CE; Toque, HA | 1 |
| De Orsi, D; Gagliardi, L; Gallinella, B; Marchei, E; Martufi, A; Nebuloni, P; Pellegrini, M; Pichini, S; Scaravelli, G | 1 |
| Prasad, B; Savaliya, AA; Shah, RP; Singh, S | 1 |
| Aversa, A; Balercia, G; Bocchio, M; Boscaro, M; Carani, C; Corona, G; Fabbri, A; Foresta, C; Forti, G; Francavilla, S; Granata, AR; Gravina, GL; Isidori, AM; Jannini, EA; Lenzi, A; Maggi, M; Mansani, R; Palego, P; Spera, G; Vetri, M | 1 |
| Argiolas, A; Boi, A; Melis, MR; Sanna, F; Succu, S | 1 |
| Fusco, F; Haro, JM; Imbimbo, C; Kontodimas, S; Mirone, V; Rossi, A; Sicuteri, R | 1 |
| Shindel, AW | 1 |
| Chaumais, MC; Humbert, M; Jaïs, X; Montani, D; Natali, D; Price, LC; Savale, L; Simonneau, G; Sitbon, O | 1 |
| Egawa, T; Ikeda, M; Kameyama, N; Kataoka, Y; Sejima, H; Shibuya, K; Shuto, H; Tominaga, K; Yamauchi, A | 1 |
| Harn, GL; Lajis, R; Man, CN; Nor, NM | 1 |
| Chivers, ML; Rosen, RC | 1 |
| Borrull, F; Knepper, TP; Marcé, RM; Nieto, A; Peschka, M; Pocurull, E | 1 |
| French, DD; Margo, CE | 1 |
| Gonenc, F; Ozgur, BC; Yazicioglu, AH | 1 |
| Heidelbaugh, JJ | 1 |
| Katz, A | 1 |
| Kopa, Z; Romics, I | 1 |
| Martinac, AI; Milcić, N; Sokolić, M; Tomić, S | 1 |
| Harte, CB; Meston, CM | 1 |
| Bajramovic, S; Dzelaludin, J | 1 |
| Allmen, Hv; Chang, LL; Harper, K; Henderson, SC; Hornbuckle, K; Ma, M | 1 |
| Demirtas, A; Ekmekcioglu, O; Gökçe, A; Halis, F | 2 |
| Anzillotti, L; Botrè, F; de la Torre, X; Strano-Rossi, S | 1 |
| Chung, E | 1 |
| Ding, L; Huang, Z; Wang, M; Yan, H; Zhang, Y; Zhu, S | 1 |
| Yuang, RQ | 1 |
| Kiliçkesmez, K; Küçükoğlu, MS | 1 |
| Jang, YM; Kim, CS; Kwon, SW; Lee, BJ; Lee, HM | 1 |
| Kamenov, ZA | 1 |
| Akgül, T; Ayyıldız, A; Germiyanoğlu, C; Huri, E; Ustün, H; Yagmurdur, H | 1 |
| Hwang, EC; Kim, SO; Park, K | 1 |
| Ambudkar, SV; An, X; Chen, ZS; Dai, CL; Ding, PR; Lee, JW; Lu, QS; Ohnuma, S; Singh, S; Talele, TT; Tiwari, AK; Yang, DH | 1 |
| Corbin, JD; Francis, SH | 1 |
| Costabile, R; Lowe, G | 1 |
| Eisenreich, W; Schramek, N; Wollein, U | 1 |
| Banasiak, W; Inorowicz, E; Jankowska, EA; Josiak, K; Kremis, E; Ponikowski, P | 1 |
| Corona, G; Fusco, F; Mondaini, N; Razzoli, E; Rossi, A; Ungar, A | 1 |
| Costabile, RA; Lowe, G | 1 |
| Helfand, BT; Mazur, DJ; McVary, KT | 1 |
| Aliferis, K; Farpour, B; Matter, MA; Petropoulos, IK; Safran, AB | 1 |
| Brock, GB; Chung, E; DeRogatis, LR; Jannini, EA | 1 |
| Celso, M; Del Popolo, G; Lombardi, G; Mencarini, M; Nelli, F | 1 |
| Carini, M; Corona, G; Gacci, M; Kaplan, SA; Maggi, M; McVary, KT; Mirone, V; Roehrborn, CG; Salvi, M; Serni, S; Vignozzi, L | 1 |
| de Kaste, D; Venhuis, BJ | 1 |
| Agostino, PV; de la Iglesia, HO; Golombek, DA; Plano, SA | 1 |
| Andersen, ML; Cavalheiro, EA; Matos, G; Scorza, FA; Tufik, S | 1 |
| Barrio, RJ; Echeazarra, L; Goicolea, MA; Gómez-Caballero, A; Montaña, M; Sallés, J; Unceta, N | 1 |
| El-Demerdash, A; Lee, SJ; Song, F | 1 |
| Fujishige, K; Inoue, H; Kikkawa, K; Kobayashi, T; Kojima, K; Kotera, J; Mochida, H; Noto, T; Omori, K; Sasaki, T; Yamada, Y; Yee, S | 1 |
| Burnett, AL; Day, WW; DiDonato, K; Heller, WH; Kikkawa, K; Kotera, J; Omori, K; Peterson, CA; Wang, R; Yee, S | 1 |
| Cahill, KB; Carleton, KL; Cote, RH; Quade, JH | 1 |
| Shaeer, O | 1 |
| Bregel, D; Kaiser, R; Kraemer, T; Rust, KY; Wilkens, H; Wilske, J | 1 |
| Goldstein, I; Scranton, RE; Stecher, VJ | 1 |
| Callahan, RJ; Dunn, JD; Gryniewicz-Ruzicka, CM; Mans, DJ | 1 |
| Brock, G; Burnett, A; Ghanem, H; Giuliano, F; Glina, S; Hellstrom, W; Martin-Morales, A; Porst, H; Salonia, A; Sharlip, I | 1 |
| Miller, MS | 1 |
| Chen, Q; Ding, H; Lee, J; Liu, Y; Mao, C; Qin, X; Ren, Z; Tang, J; Tian, J; Yang, Z; Yuan, J; Zhang, R | 1 |
| Andersson, KE; Gratzke, C; Herlemann, A; Sievert, KD | 1 |
| Allanore, Y; Blaise, S; Caglayan, E; Carpentier, PH; Cracowski, JL; Roustit, M | 1 |
| Deyo, RA; Dobscha, SK; Donovan, M; Johnson, ES; Morasco, BJ; Petrik, A; Smith, DH; Tillotson, CJ; Yang, X | 1 |
| Borregales, L; Cairoli, C; Reyes, LA; Rubio-Aurioles, E; Sorsaburu, S | 1 |
| Al-Mitwalli, K; El-Meliegy, A; Gurbuz, S; Hussein, T; Istarabadi, M; Lei, Y; Mostafa, T; Rabah, D | 1 |
| Chadwell, K; Fenkl, EA; Jones, SG; Patsdaughter, CA | 1 |
| Ge, X; Kee, CL; Koh, HL; Li, L; Low, MY; Patel, DN | 1 |
| Carini, M; Cellai, I; Comeglio, P; Filippi, S; Gacci, M; Maggi, M; Maneschi, E; Morelli, A; Nesi, G; Santi, R; Sebastianelli, A; Serni, S; Vignozzi, L | 1 |
| Burns, PR; Goldfischer, ER; Kim, ED; Ni, X; Seftel, AD | 1 |
| Corte-Real, F; Franco, JM; Marcos, M; Mustra, C; Proença, P; Vieira, DN | 1 |
| Cho, S; Han, KM; Kim, NS; Kim, SH; Kim, WS; Lee, JH | 1 |
| Cai, YH; Feng, LJ; Huang, YY; Li, X; Li, Z; Luo, HB; Wu, Y | 1 |
| Bretsztajn, L; Eardley, I; Mohee, A; Storey, A | 1 |
| Kamata, Y; Minota, S | 1 |
| Alkan, F; Erturkuner, P; Ozbek, E; Simsek, A; Tasci, AI; Tugcu, V | 1 |
| Angulo, J; Cardoso, J; Cuevas, P; Fernández, A; La Fuente, JM; Martínez-Salamanca, JI; Wright, HM | 1 |
| Hsu, JC; Lu, CY; Tang, DH | 1 |
| Athyros, V; Doumas, M; Katsiki, N; Lazaridis, A | 1 |
| Aronsen, L; Lysaa, R; Orvoll, E; Ravna, AW; Sager, G | 1 |
| Baygani, S; Burns, P; Goldfischer, E; Kim, E; Seftel, A | 1 |
| Cui, Y; Gao, Z; Liu, X; Shi, L | 1 |
| Abu El-Enin, MA; Al-Ghaffar Hammouda, Mel-S; El-Ashry, SM; El-Sherbiny, DT; El-Wasseef, DR | 1 |
| Can, B; Çerkez, C; Ergün, H; Göktürk, H; Işılgan, SE; Kaya, B; Serel, S; Yığman, Z | 1 |
| ElAgouri, G; ElAmrawy, F; ElYazbi, A; Eshra, A; Nounou, MI | 1 |
| Hu, T; Kang, M; Qu, X; Song, Q; Yang, L; Zhang, D; Zhao, Y | 1 |
| Echeverría-García, F; García-Perdomo, HA; Tobías, A | 1 |
| Hassan, M; Sheweita, SA; Wally, M | 1 |
| Li, AS; Pomeranz, HD | 1 |
| Mostafa, T | 1 |
| Al Busaidi, I; Al Lawati, HA; Kadavilpparampu, AM; Suliman, FO | 1 |
| Liu, L; Tan, P; Tang, Z; Wei, Q; Wei, S; Yang, L | 1 |
| Gamidov, SI; Izhbaev, SK; Ovchinnikov, RI; Popova, AY | 1 |
| Alp, HH; Başbugan, Y; Ediz, L; Huyut, Z; Şekeroğlu, MR; Yildirim, S | 1 |
| Großer, C; Hoenicka, M; Hofmann, HS; Lang, G; Lehle, K; Neu, R; Ried, M; Szöke, T | 1 |
| Mostafa, RE; Omara, EA; Salama, A | 1 |
| Deibert, P; Kreisel, W; Lazaro, A; Rössle, M; Schaffner, D; Stankovic, Z | 1 |
| Hassan, TA; Mulhall, JP; Rienow, J | 1 |
| Bala Divya, M; Dash, P; Guruprasad, K; Guruprasad, L | 1 |
| Bakırdere, S; Özbek, B; Öztürk Er, E | 1 |
| Arnold, DG; Oakley, JL | 1 |
| Kang, H; Lee, JH; Lee, YM; Park, HN; Park, S | 1 |
| Cari, L; Costantini, E; Illiano, E; Kopa, Z; Nocentini, G; Petrillo, MG; Scroppo, FI; Silvani, M; Zucchi, A | 1 |
| Ding, S; Huang, X; Liu, L; Song, G; Wang, D; Xu, H | 1 |
| Kimura, K; Matsushita, R; Tsuboi, H; Yoshida, N; Zhu, S | 1 |
| Akalın, EE; Anğın, AD; Basak, K; Cikman, MS; Kaptanagasi, AO; Sakin, O | 1 |
| Cai, Z; Li, H; Ma, C; Zhang, J | 1 |
| Chopra, I; Hassan, TA; Mulhall, JP; Patel, D; Tang, WY | 1 |
| Li, C; Moezzi, B; Xu, D | 1 |
| Hong, J; Kim, BH; Kim, HJ; Lee, JH; Lee, ME; Lee, W; Lee, YM; Oh, HB; Park, S | 1 |
| Ahmad, N; Blair, HC; Gera, S; Gumerova, A; Hadelia, E; Haider, S; Ievleva, K; Iqbal, J; Kim, SM; Korkmaz, F; Kuo, TC; Li, W; Liu, L; Liu, P; Lizneva, D; Mathew, M; Miyashita, H; New, MI; Perez-Pena, H; Ryu, V; Sant, D; Stanley, S; Sun, L; Tamler, R; Taneja, C; Tourkova, I; Yuen, T; Zaidi, M; Zhu, LL | 1 |
| Cho, HD; Eom, HY; Ha, N; Han, SB; Kang, MH; Kim, G; Kim, J; Kim, U; Koo, HR; Seo, S; Song, UT; Suh, JH | 1 |
| De Nunzio, C; Lombardo, R; Tema, G | 1 |
| Balbaa, ME; Meftah, AA; Sheweita, MS; Sheweita, SA | 1 |
| Chiba, F; Iwase, H; Nagasawa, S; Saka, K; Torimitsu, S; Yajima, D; Yamagishi, Y; Yamaguchi, R | 1 |
| Baek, SY; Han, JH; Kim, H; Lee, JH; Min, AY; Park, OR; Yang, YJ | 1 |
| Kimura, K; Sanada, T; Tsuboi, H; Yoshida, N | 1 |
| Allazov, SA; Gafarov, RR; Giyasov, SI; Shodmonova, ZR | 1 |
| Barbagallo, F; Casarini, L; D'Alessandro, S; Di Rocco, G; Guerrini, R; Lazzaretti, C; Limoncella, S; Pacifico, S; Paradiso, E; Santi, D; Simoni, M; Sola, M; Tagliavini, S; Trenti, T | 1 |
| Alghobary, MF; Mostafa, T | 1 |
| Abdine, HH; Aboras, SI; Korany, MA; Ragab, MAA | 1 |
| Al-Majed, AA; Alshehri, YM; Attwa, MW; Bakheit, AH | 1 |
| Chhonker, SK; Koiri, RK; Rawat, D | 1 |
| Das, A; Koka, S; Kukreja, RC; Samidurai, A; Wang, R; Xi, L | 1 |
| Forootanfar, H; Hamzehnejadi, M; Homayouni, F; Jahani, Z; Langarizadeh, MA; Rezaei, M; Tavakoli, MR | 1 |
| Al-Hemyari, SS; Ibrahim, B; Jairoun, AA; Shahwan, M; Zyoud, SH | 1 |
| Abbasi, B; Breyer, BN; Hakam, N; Lui, JL; Shaw, NM | 1 |
| Afsharrezaei, F; Bahri, RA; Gholami, M; Shafiee, A; Teymouri Athar, MM | 1 |
| Caglayan, MO; Üstündağ, İ | 1 |
| Cellek, S; Ilg, MM; Megson, M; Ralph, DJ | 1 |
| Argenziano, G; Brancaccio, G; Briatico, G; Capone, F; Cilio, S; Crocetto, F; Ferro, M; Imbimbo, C; Salonia, A | 1 |
82 review(s) available for tadalafil and vardenafil dihydrochloride
| Article | Year |
|---|---|
[New medications for treatment of erectile dysfunction].
Topics: alpha-MSH; Arginine; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Penile Erection; Peptides, Cyclic; Phosphodiesterase Inhibitors; Pinacidil; Piperazines; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2002 |
Phosphodiesterase 5 inhibitors: current status and potential applications.
Topics: Carbolines; Chemistry, Pharmaceutical; Clinical Trials as Topic; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Structure-Activity Relationship; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2002 |
Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Contraindications; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Prevalence; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2002 |
Pharmacological management of erectile dysfunction.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Alprostadil; Apomorphine; Carbolines; Drug Combinations; Erectile Dysfunction; Humans; Imidazoles; Injections; Male; Papaverine; Phentolamine; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2003 |
The phosphodiesterase inhibitor 'war'.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Patient Compliance; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2003 |
[How effective are PDE-5 inhibitors?].
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Clinical Trials as Topic; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Imidazoles; Male; Multicenter Studies as Topic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2003 |
PDE-5 inhibition and sexual response: pharmacological mechanisms and clinical outcomes.
Topics: Carbolines; Clinical Trials as Topic; Cyclic GMP; Erectile Dysfunction; Female; Humans; Imidazoles; Male; Muscle, Smooth; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2002 |
Phosphodiesterase 5 inhibitors in male sexual dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2003 |
Overview of phosphodiesterase 5 inhibition in erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2003 |
Oral drug treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Apomorphine; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2003 |
Treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Molecular Structure; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vacuum; Vardenafil Dihydrochloride; Vasodilator Agents | 2004 |
[Treatment of erectile dysfunction].
Topics: Adrenergic alpha-Antagonists; Androgens; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phytotherapy; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents; Yohimbine | 2004 |
Emerging oral drugs for erectile dysfunction.
Topics: Administration, Oral; Administration, Sublingual; Adult; Aged; Apomorphine; Carbolines; Comorbidity; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dopamine Agonists; Double-Blind Method; Drug Interactions; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Multicenter Studies as Topic; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Second Messenger Systems; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2004 |
Potency, selectivity, and consequences of nonselectivity of PDE inhibition.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Heart Rate; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Substrate Specificity; Sulfones; Tachycardia; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilation; Vision, Ocular | 2004 |
New oral drugs for erectile dysfunction.
Topics: Apomorphine; Carbolines; Dopamine Agonists; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Randomized Controlled Trials as Topic; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
New phosphodiesterase inhibitors in the treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Diabetes Complications; Drug Interactions; Humans; Imidazoles; Impotence, Vasculogenic; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenergic alpha-Antagonists; Arteriosclerosis; Blood Pressure; Carbolines; Contraindications; Coronary Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Interactions; Endothelium, Vascular; Erectile Dysfunction; Heart Rate; Humans; Hypotension; Imidazoles; Isosorbide Dinitrate; Male; Molecular Structure; Myocardial Infarction; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilation; Vasodilator Agents | 2004 |
Phosphodiesterase-5 inhibitors: clinical market and basic science comparative studies.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
Erectile dysfunction.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Patient Selection; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction.
Topics: Carbolines; Controlled Clinical Trials as Topic; Cross-Over Studies; Erectile Dysfunction; Humans; Imidazoles; Male; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Clinical monograph for drug formulary review: erectile dysfunction agents.
Topics: Carbolines; Drug Information Services; Erectile Dysfunction; Formularies as Topic; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
[Erectile dysfunction (ED) and diabetes mellitus].
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Diabetes Complications; Diabetic Neuropathies; Diagnosis, Differential; Erectile Dysfunction; Humans; Imidazoles; Male; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2005 |
A comparative review of the options for treatment of erectile dysfunction: which treatment for which patient?
Topics: Administration, Oral; Alprostadil; Apomorphine; Carbolines; Constriction; Contraindications; Dopamine Agonists; Drug Combinations; Enzyme Inhibitors; Erectile Dysfunction; Humans; Imidazoles; Male; Papaverine; Patient Satisfaction; Penile Prosthesis; Penis; Phentolamine; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Failure; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2005 |
The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Biological Availability; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Cytochrome P-450 CYP3A; Drug Interactions; Erectile Dysfunction; Humans; Imidazoles; Male; Metabolic Clearance Rate; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Patient preferences in treatment of erectile dysfunction: the continuing importance of patient education.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Patient Education as Topic; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Purines; Safety; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2005 |
[Treatment of erectile dysfunction after radical retropubic prostatectomy with PDE5 inhibitor].
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Prostatectomy; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Clinical update on phosphodiesterase type-5 inhibitors for erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
PDE-5 inhibitors: current status and future trends.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Forecasting; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Erectile dysfunction drugs and non-arteritic anterior ischemic optic neuropathy: is there a cause and effect relationship?
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Optic Disk; Optic Neuropathy, Ischemic; Phosphodiesterase Inhibitors; Piperazines; Purines; Risk Factors; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Interactions; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Cardiac safety in clinical trials of phosphodiesterase 5 inhibitors.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Blood Pressure; Carbolines; Clinical Trials as Topic; Coronary Artery Disease; Cyclic Nucleotide Phosphodiesterases, Type 5; Electrophysiology; Erectile Dysfunction; Heart Rate; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenergic alpha-Antagonists; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Interactions; Erectile Dysfunction; Humans; Imidazoles; Male; Nitroglycerin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2005 |
Review of phosphodiesterases in the urogenital system: new directions for therapeutic intervention.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Ejaculation; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; RNA, Messenger; Sildenafil Citrate; Sulfones; Tadalafil; Time Factors; Triazines; Urogenital System; Vardenafil Dihydrochloride | 2004 |
Drug Insight: oral phosphodiesterase type 5 inhibitors for erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Erectile dysfunction following radical retropubic prostatectomy: epidemiology, pathophysiology and pharmacological management.
Topics: Administration, Oral; Aged; Algorithms; Alprostadil; Carbolines; Combined Modality Therapy; Drug Therapy, Combination; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Penile Prosthesis; Phosphodiesterase Inhibitors; Piperazines; Practice Guidelines as Topic; Prostatectomy; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2006 |
Phosphodiesterase 5 inhibitors in the treatment of premature ejaculation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Ejaculation; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sexual Dysfunction, Physiological; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2006 |
Phosphodiesterase-5 inhibitors and their hemodynamic effects.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Antihypertensive Agents; Blood Pressure; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Therapy, Combination; Erectile Dysfunction; Humans; Hypertension; Hypotension; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vascular Resistance | 2006 |
[Phosphodiesterase inhibitors: effectiveness and new applications].
Topics: Carbolines; Coronary Disease; Erectile Dysfunction; Humans; Hypertension; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Prostatic Hyperplasia; Pulmonary Disease, Chronic Obstructive; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2006 |
Phosphodiesterase type 5 inhibitors: the day after.
Topics: Animals; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
Erectile dysfunction.
Topics: Adult; Alprostadil; Apomorphine; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Penile Erection; Penile Prosthesis; Piperazines; Purines; Sex Counseling; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Yohimbine | 2006 |
Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Time Factors; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2006 |
[Treatment of pulmonary arterial hypertension: phosphodiesterase-5 inhibitors].
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Hypertension, Pulmonary; Imidazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2006 |
Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Diabetic Angiopathies; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
Phosphodiesterase 5 inhibition in essential hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Carbolines; Endothelium; Humans; Hypertension; Imidazoles; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2008 |
[Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension].
Topics: Carbolines; Humans; Hypertension, Pulmonary; Imidazoles; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2008 |
Tadalafil and vardenafil vs sildenafil: a review of patient-preference studies.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Patient Satisfaction; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Quality of Life; Self Concept; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2009 |
Ten years of phosphodiesterase type 5 inhibitors in spinal cord injured patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Reproduction; Sildenafil Citrate; Spinal Cord Injuries; Sulfones; Surveys and Questionnaires; Tadalafil; Triazines; Vardenafil Dihydrochloride; Young Adult | 2009 |
Is there a rationale for the chronic use of phosphodiesterase-5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia?
Topics: Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Prostatic Hyperplasia; Prostatism; Purines; Quality of Life; Quinazolines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2009 |
Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension.
Topics: Algorithms; Carbolines; Humans; Hypertension, Pulmonary; Imidazoles; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Veno-Occlusive Disease; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2009 |
Phosphodiesterase type 5 inhibitors and female sexual response: faulty protocols or paradigms?
Topics: Animals; Carbolines; Clitoris; Female; Humans; Imidazoles; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sex Factors; Sexual Dysfunction, Physiological; Sexual Dysfunctions, Psychological; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vagina; Vardenafil Dihydrochloride; Women's Health | 2010 |
Management of erectile dysfunction.
Topics: Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Risk Factors; Risk Reduction Behavior; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2010 |
[Phosphodiesterase type 5 inhibitors in the treatment of pulmonary arterial hypertension].
Topics: Carbolines; Drug Therapy, Combination; Hemodynamics; Humans; Hypertension, Pulmonary; Imidazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2010 |
Prevalence and medical management of erectile dysfunction in Asia.
Topics: Adult; Aged; Asia; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug-Related Side Effects and Adverse Reactions; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Prevalence; Purines; Pyrimidines; Pyrimidinones; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2011 |
Phosphodiesterase type 5 inhibitor abuse: a critical review.
Topics: Carbolines; Drug Contamination; Humans; Imidazoles; Internet; Marketing; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Substance-Related Disorders; Sulfones; Tadalafil; Triazines; United States; United States Food and Drug Administration; Vardenafil Dihydrochloride | 2011 |
[Is there a place for treatment with type 5 phosphodiesterase inhibitors in heart failure patients?].
Topics: Carbolines; Heart Failure; Humans; Imidazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2011 |
Phosphodiesterase type 5 (PDE5) inhibitors in erectile dysfunction: the proper drug for the proper patient.
Topics: Algorithms; Carbolines; Cardiovascular Diseases; Diabetes Mellitus; Humans; Hypertension; Imidazoles; Impotence, Vasculogenic; Male; Men's Health; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrimidines; Risk Factors; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2011 |
Influences of neuroregulatory factors on the development of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction in aging men.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Carbolines; Disease Progression; Erectile Dysfunction; Humans; Imidazoles; Lower Urinary Tract Symptoms; Male; Men's Health; Middle Aged; Neurotransmitter Agents; Piperazines; Prognosis; Prostatic Hyperplasia; Purines; Receptors, Neurotransmitter; Risk Assessment; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2012 |
Treating erectile dysfunction and central neurological diseases with oral phosphodiesterase type 5 inhibitors. Review of the literature.
Topics: Carbolines; Central Nervous System Diseases; Clinical Trials as Topic; Humans; Imidazoles; Impotence, Vasculogenic; Male; Multiple Sclerosis; Parkinson Disease; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Spinal Dysraphism; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2012 |
A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Carbolines; Drug Therapy, Combination; Erectile Dysfunction; Humans; Imidazoles; Lower Urinary Tract Symptoms; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Prostatic Hyperplasia; Purines; Pyrimidines; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2012 |
Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks.
Topics: Carbolines; Chemistry Techniques, Analytical; Cyclic Nucleotide Phosphodiesterases, Type 5; Dietary Supplements; Drug Contamination; Erectile Dysfunction; Humans; Imidazoles; Ions; Male; Models, Chemical; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2012 |
Erectile dysfunction diagnosis and treatment as a means to improve medication adherence and optimize comorbidity management.
Topics: 5-alpha Reductase Inhibitors; Affect; Antidepressive Agents; Antihypertensive Agents; Carbolines; Comorbidity; Drug Therapy, Combination; Erectile Dysfunction; Humans; Imidazoles; Long-Term Care; Male; Medication Adherence; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Self Concept; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2013 |
SOP conservative (medical and mechanical) treatment of erectile dysfunction.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alprostadil; Carbolines; Drug Therapy, Combination; Erectile Dysfunction; Humans; Hypogonadism; Imidazoles; Male; Middle Aged; Penile Erection; Phosphodiesterase 5 Inhibitors; Piperazines; Pyrimidines; Risk Factors; Sulfonamides; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Yohimbine | 2013 |
Role of phosphodiesterase type 5 inhibitors for lower urinary tract symptoms.
Topics: Adrenergic alpha-Antagonists; Carbolines; Drug Resistance; Drug Therapy, Combination; Erectile Dysfunction; Humans; Imidazoles; Lower Urinary Tract Symptoms; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Prostate; Prostatic Hyperplasia; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2013 |
Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction: a systematic review and network meta-analysis.
Topics: Administration, Oral; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Odds Ratio; Penile Erection; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Risk Assessment; Risk Factors; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2013 |
[Medicinal therapy of benign prostate syndrome with phosphodiesterase-5 inhibitors].
Topics: Carbolines; Controlled Clinical Trials as Topic; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Lower Urinary Tract Symptoms; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Prostatic Hyperplasia; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Urodynamics; Vardenafil Dihydrochloride | 2013 |
Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud's phenomenon: systematic review and meta-analysis of randomised trials.
Topics: Carbolines; Humans; Imidazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Raynaud Disease; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2013 |
Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges.
Topics: Carbolines; Chemistry Techniques, Analytical; Drug Contamination; Humans; Imidazoles; Pharmaceutical Preparations; Phosphodiesterase 5 Inhibitors; Piperazines; Plant Preparations; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2014 |
PDE-5 inhibitors: clinical points.
Topics: Cardiovascular Diseases; Drug Incompatibility; Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride; Vasodilator Agents | 2015 |
Efficacy and safety of phosphodiesterase type 5 (PDE5) inhibitors in treating erectile dysfunction after bilateral nerve-sparing radical prostatectomy.
Topics: Erectile Dysfunction; Humans; Male; Organ Sparing Treatments; Peripheral Nerves; Phosphodiesterase 5 Inhibitors; Postoperative Complications; Prostatectomy; Pyrimidines; Sildenafil Citrate; Tadalafil; Treatment Outcome; Vardenafil Dihydrochloride | 2016 |
Effectiveness of Phosphodiesterase 5 Inhibitors in the Treatment of Erectile Dysfunction in Patients with Spinal Cord Trauma: Systematic Review and Meta-Analysis.
Topics: Adult; Aged; Carbolines; Erectile Dysfunction; Humans; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Randomized Controlled Trials as Topic; Sildenafil Citrate; Spinal Cord Injuries; Tadalafil; Treatment Outcome; Vardenafil Dihydrochloride; Young Adult | 2017 |
Useful Implications of Low-dose Long-term Use of PDE-5 Inhibitors.
Topics: Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Treatment Outcome; Vardenafil Dihydrochloride | 2016 |
The Effect of Oral Phosphodiesterase-5 Inhibitors on Sperm Parameters: A Meta-analysis and Systematic Review.
Topics: Administration, Oral; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Sperm Count; Sperm Motility; Spermatozoa; Tadalafil; Vardenafil Dihydrochloride | 2017 |
[Phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction: past, present and future].
Topics: Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2017 |
The first-generation phosphodiesterase 5 inhibitors and their pharmacokinetic issue.
Topics: Administration, Mucosal; Adult; Aged; Aged, 80 and over; Erectile Dysfunction; Humans; Male; Middle Aged; Mouth Mucosa; Patient Compliance; Patient Satisfaction; Phosphodiesterase 5 Inhibitors; Quality of Life; Sexual Behavior; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2019 |
Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognition; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Flavonoids; Humans; Neurons; Neuroprotective Agents; Phosphodiesterase 5 Inhibitors; Purinones; Pyrimidines; Signal Transduction; Sildenafil Citrate; Sulfonamides; Tadalafil; Vardenafil Dihydrochloride | 2019 |
Phosphodiesterases 5 Inhibitors and Erectile Dysfunction Recovery after Pelvic Surgery: Future Perspectives for New Drugs and New Formulations.
Topics: Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Prostatectomy; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2021 |
Recreational Use of Oral PDE5 Inhibitors: The Other Side of Midnight.
Topics: Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2022 |
Lodenafil.
Topics: Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2022 |
Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-a possible prevention strategy for COVID-19?
Topics: Animals; COVID-19; COVID-19 Drug Treatment; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hydroxychloroquine; Hyperglycemia; Insulin Resistance; Male; Mice; Myocardial Infarction; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2023 |
Prostaglandins as a Topical Therapy for Erectile Dysfunction: A Comprehensive Review.
Topics: Alprostadil; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Male; Prostaglandins; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2022 |
Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on esophageal motility: a systematic review.
Topics: Cyclic Nucleotide Phosphodiesterases, Type 5; Esophageal Achalasia; Humans; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2023 |
The relationship between the history of PDE5-inhibitors assumption and melanoma: a systematic review.
Topics: Humans; Male; Melanoma; Melanoma, Cutaneous Malignant; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Skin Neoplasms; Tadalafil; Vardenafil Dihydrochloride | 2023 |
12 trial(s) available for tadalafil and vardenafil dihydrochloride
| Article | Year |
|---|---|
Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Adult; Aged; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Hypertension, Pulmonary; Imidazoles; Male; Middle Aged; Oxygen; Phosphoric Diester Hydrolases; Piperazines; Prospective Studies; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride; Vascular Resistance; Vasodilator Agents | 2004 |
Phosphodiesterase inhibitors in the treatment of erectile dysfunction in spinal cord-injured men.
Topics: Adult; Analysis of Variance; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Reaction Time; Retrospective Studies; Sildenafil Citrate; Spinal Cord Injuries; Sulfones; Surveys and Questionnaires; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
Prospective, randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors.
Topics: Aged; Carbolines; Coitus; Cross-Over Studies; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Prospective Studies; Purines; Quality of Life; Severity of Illness Index; Sexual Behavior; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2006 |
Therapeutic effectiveness and patient satisfaction after 6 months of treatment with tadalafil, sildenafil, and vardenafil: results from the erectile dysfunction observational study (EDOS).
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Prospective Studies; Purines; Remission Induction; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Time Factors; Triazines; Vardenafil Dihydrochloride | 2007 |
[PDE5 inhibitors in treatment of benign prostatic syndrome].
Topics: Animals; Carbolines; Cell Division; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Imidazoles; Isometric Contraction; Male; Middle Aged; Muscle, Smooth; Organ Culture Techniques; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prospective Studies; Prostate; Prostatic Hyperplasia; Purines; Rats; Sildenafil Citrate; Stromal Cells; Sulfones; Syndrome; Tadalafil; Triazines; Urethra; Urinary Bladder; Vardenafil Dihydrochloride | 2007 |
The ENDOTRIAL study: a spontaneous, open-label, randomized, multicenter, crossover study on the efficacy of sildenafil, tadalafil, and vardenafil in the treatment of erectile dysfunction.
Topics: Analysis of Variance; Carbolines; Confidence Intervals; Cross-Over Studies; Health Surveys; Humans; Imidazoles; Impotence, Vasculogenic; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Risk; Sildenafil Citrate; Statistics as Topic; Sulfones; Tadalafil; Time Factors; Triazines; Vardenafil Dihydrochloride | 2009 |
The effects of phosphodiesterase type 5 inhibitors on penile rigidity variables during a period with no sexual stimulation: a laboratory setting double-blind study.
Topics: Adolescent; Adult; Carbolines; Double-Blind Method; Ejaculation; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Penile Erection; Phosphodiesterase 5 Inhibitors; Photic Stimulation; Piperazines; Purines; Quality of Life; Sexual Behavior; Sildenafil Citrate; Sulfones; Tadalafil; Time Factors; Triazines; Vardenafil Dihydrochloride; Young Adult | 2011 |
Comparison of the first intake of vardenafil and tadalafil in patients with diabetic neuropathy and diabetic erectile dysfunction.
Topics: Age Factors; Carbolines; Diabetic Neuropathies; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Risk Factors; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2011 |
The effects of three phosphodiesterase type 5 inhibitors on ejaculation latency time in lifelong premature ejaculators: a double-blind laboratory setting study.
Topics: Administration, Oral; Adult; Carbolines; Dose-Response Relationship, Drug; Ejaculation; Follow-Up Studies; Humans; Imidazoles; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sexual Dysfunction, Physiological; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride; Young Adult | 2011 |
PDE5 inhibitors blunt inflammation in human BPH: a potential mechanism of action for PDE5 inhibitors in LUTS.
Topics: Aged; Aged, 80 and over; Carbolines; Cyclic GMP; Double-Blind Method; Humans; Imidazoles; Inflammation; Interleukin-8; Lower Urinary Tract Symptoms; Male; Middle Aged; Myofibroblasts; Phosphodiesterase 5 Inhibitors; Pilot Projects; Piperazines; Prostate; Prostatic Hyperplasia; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2013 |
A return to normal erectile function with tadalafil once daily after an incomplete response to as-needed PDE5 inhibitor therapy.
Topics: Carbolines; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Penile Erection; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2014 |
Comparative efficacy of tadalafil once daily in men with erectile dysfunction who demonstrated previous partial responses to as-needed sildenafil, tadalafil, or vardenafil.
Topics: Adult; Carbolines; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Preference; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2015 |
160 other study(ies) available for tadalafil and vardenafil dihydrochloride
| Article | Year |
|---|---|
Towards optimal ED management: educational forum - II.
Topics: Canada; Carbolines; Diabetes Complications; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2001 |
Tadalafil (Cialis) for men with erectile dysfunction.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2002 |
Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Clinical Trials, Phase III as Topic; Cyclic Nucleotide Phosphodiesterases, Type 5; Diabetes Complications; Erectile Dysfunction; Humans; Imidazoles; Male; Multicenter Studies as Topic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2002 |
New phosphodiesterase type 5 inhibitors in the management of erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United Kingdom; Vardenafil Dihydrochloride | 2003 |
US advertising campaign begins for alternative to sildenafil.
Topics: Advertising; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2003 |
Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Binding Sites; Carbolines; Catalytic Domain; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Hydrogen Bonding; Imidazoles; Models, Molecular; Phosphoric Diester Hydrolases; Piperazines; Protein Conformation; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2003 |
Are they better than Viagra? Two new drugs for erectile dysfunction work like Viagra and carry similar risks and benefits. Their subtle differences, however, may make a difference for some men.
Topics: Carbolines; Drug Interactions; Erectile Dysfunction; Humans; Imidazoles; Male; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2004 |
Cialis is here. The soft sell.
Topics: Carbolines; Commerce; Drug Industry; Erectile Dysfunction; Humans; Imidazoles; Male; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United States; Vardenafil Dihydrochloride | 2004 |
Tadalafil (Cialis) and vardenafil (Levitra) recently approved drugs for erectile dysfunction.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
Pills for erectile dysfunction: now there are three.
Topics: Carbolines; Drug Interactions; Erectile Dysfunction; Food-Drug Interactions; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
Tadalafil and vardenafil.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Approval; Erectile Dysfunction; Forecasting; Humans; Imidazoles; Legislation, Drug; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
Atazanavir (Reyataz): new recommendations if combined with tenofovir (Viread) -- and warning on Viagra, Cialis, and Levitra.
Topics: Adenine; Atazanavir Sulfate; Carbolines; Drug Information Services; Drug Interactions; Drug Therapy, Combination; HIV Infections; Humans; Imidazoles; Oligopeptides; Organophosphonates; Organophosphorus Compounds; Piperazines; Purines; Pyridines; Reverse Transcriptase Inhibitors; Sildenafil Citrate; Sulfones; Tadalafil; Tenofovir; Triazines; Vardenafil Dihydrochloride | 2004 |
A consumer's guide to impotence drugs.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Enzyme Inhibitors; Erectile Dysfunction; Humans; Imidazoles; Male; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2004 |
Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Binding Sites; Carbolines; Catalytic Domain; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; Kinetics; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Protein Structure, Tertiary; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Tritium; Vardenafil Dihydrochloride | 2004 |
Structure elucidation of sildenafil analogues in herbal products.
Topics: Carbolines; Chromatography, Liquid; Imidazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Phosphodiesterase Inhibitors; Piperazines; Plant Preparations; Purines; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2004 |
Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5--sildenafil, tadalafil, and vardenafil.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cation Transport Proteins; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Heart Rate; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Potassium Channels, Voltage-Gated; Purines; Sildenafil Citrate; Sulfones; Tachycardia, Ventricular; Tadalafil; Triazines; Vardenafil Dihydrochloride; Ventricular Fibrillation | 2004 |
Development of a Micellar electrokinetic capillary chromatography method for the determination of three drugs employed in the erectile dysfunction therapy.
Topics: Carbolines; Chromatography, Micellar Electrokinetic Capillary; Erectile Dysfunction; Humans; Imidazoles; Male; Piperazines; Purines; Reproducibility of Results; Sensitivity and Specificity; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2004 |
[Birthday of a "potency pill". Helmut Newton celebrates posthumously likewise].
Topics: Carbolines; Contraceptives, Oral; Erectile Dysfunction; Erotica; Female; Germany; History, 20th Century; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Photography; Piperazines; Purines; Sexual Behavior; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2004 |
Patient education series. Erectile dysfunction.
Topics: Carbolines; Contraindications; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Editorial comment on the manuscript entitled 'Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction'.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphoric Diester Hydrolases; Piperazines; Purines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Simultaneous determination of sildenafil, vardenafil and tadalafil as forbidden components in natural dietary supplements for male sexual potency by high-performance liquid chromatography-electrospray ionization mass spectrometry.
Topics: Carbolines; Chromatography, High Pressure Liquid; Dietary Supplements; Drug Contamination; Imidazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
ED drugs covered, but managed care unmoved.
Topics: Carbolines; Erectile Dysfunction; Formularies as Topic; Humans; Imidazoles; Insurance Coverage; Insurance, Pharmaceutical Services; Male; Managed Care Programs; Medicare; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United States; Vardenafil Dihydrochloride | 2005 |
Viagra, Levitra, and Cialis: what's the difference?
Topics: Adult; Age Factors; Aged; Carbolines; Contraindications; Drug Interactions; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Risk Factors; Sildenafil Citrate; Sulfones; Tadalafil; Time Factors; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2005 |
Viagra and anterior ischemic optic neuropathy.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Humans; Imidazoles; Male; Optic Neuropathy, Ischemic; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2005 |
Evidence for contamination of herbal erectile dysfunction products with phosphodiesterase type 5 inhibitors.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Chromatography, High Pressure Liquid; Drug Contamination; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Phytotherapy; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Chromatography, Gel; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Humans; Hypertension, Pulmonary; Imidazoles; Lung; Myocardium; Piperazines; Rats; Sulfones; Tadalafil; Triazines; Tritium; Vardenafil Dihydrochloride | 2005 |
Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilation | 2006 |
Successful use of phosphodiesterase type 5 inhibitors to control symptomatic esophageal hypercontractility: a case report.
Topics: Adult; Carbolines; Esophageal Motility Disorders; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Evaluation, Preclinical; Gene Expression Regulation; Hypertension, Pulmonary; Hypoxia; Imidazoles; Interleukin-1; Isometric Contraction; Male; Phenylephrine; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Tumor Necrosis Factor-alpha; Vardenafil Dihydrochloride; Vasoconstriction | 2006 |
How new drugs help treat erectile dysfunction.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Nursing Assessment; Patient Education as Topic; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2006 |
Medication utilization behavior in patients receiving phosphodiesterase type 5 inhibitors for erectile dysfunction.
Topics: Adult; Carbolines; Drug Prescriptions; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Acceptance of Health Care; Phosphodiesterase Inhibitors; Piperazines; Purines; Self Administration; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2005 |
Can erectile dysfunction drug use lead to ischaemic optic neuropathy?
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Optic Neuropathy, Ischemic; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2006 |
Beyond Viagra. What are your options?
Topics: Carbolines; Contraindications; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Testosterone; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2006 |
Ophthalmic aspects of erectile dysfunction drugs.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adverse Drug Reaction Reporting Systems; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Optic Neuropathy, Ischemic; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vision Disorders | 2006 |
Prescribing all phosphodiesterase 5 inhibitors to a patient with erectile dysfunction--a realistic and feasible option in everyday clinical practice--outcomes of a simple treatment regime.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Adult; Aged; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Prescriptions; Drug Therapy, Combination; Erectile Dysfunction; Feasibility Studies; Follow-Up Studies; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Retrospective Studies; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2006 |
Treatment strategy for "non-responders" to tadalafil and vardenafil: a real-life study.
Topics: Adult; Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2006 |
There have been inadequate warnings that erectile dysfunction drugs can cause blindness.
Topics: Blindness; Carbolines; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Erectile Dysfunction; Humans; Imidazoles; Incidence; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Risk Assessment; Risk Factors; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United States; Vardenafil Dihydrochloride; Vasodilator Agents; Video Recording | 2005 |
Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Carbolines; Dose-Response Relationship, Drug; Imidazoles; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Oxadiazoles; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Verapamil | 2006 |
Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices.
Topics: Benzodioxoles; Carbolines; Cyclotrons; Designer Drugs; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Imidazoles; Molecular Weight; Piperazines; Purines; Pyrimidinones; Reproducibility of Results; Sensitivity and Specificity; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Sulfones; Tadalafil; Technology, Pharmaceutical; Triazines; Vardenafil Dihydrochloride | 2006 |
Visual loss with erectile dysfunction medications.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Atherosclerosis; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Optic Neuropathy, Ischemic; Phosphodiesterase Inhibitors; Piperazines; Purines; Risk Factors; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vision Disorders | 2006 |
A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Amino Acid Sequence; Binding Sites; Carbolines; Centrifugation, Density Gradient; Cyclic Nucleotide Phosphodiesterases, Type 5; Dimerization; Holoenzymes; Humans; Imidazoles; Inhibitory Concentration 50; Kinetics; Molecular Weight; Mutant Proteins; Phosphodiesterase Inhibitors; Piperazines; Protein Structure, Tertiary; Purines; Sildenafil Citrate; Structure-Activity Relationship; Sulfones; Tadalafil; Triazines; Tritium; Vardenafil Dihydrochloride | 2006 |
Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Prostatic Hyperplasia; Prostatism; Purines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2006 |
In vitro effects of PDE5 inhibitors sildenafil, vardenafil and tadalafil on isolated human ureteral smooth muscle: a basic research approach.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Butylscopolammonium Bromide; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Male; Middle Aged; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Piperazines; Potassium Chloride; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Ureter; Vardenafil Dihydrochloride | 2007 |
Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Catalytic Domain; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Electrophoresis, Polyacrylamide Gel; Humans; Imidazoles; Ligands; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Conformation; Protein Phosphatase 1; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Trypsin; Vardenafil Dihydrochloride | 2007 |
Erectile dysfunction.
Topics: Carbolines; Contraindications; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2006 |
[Viagra -- patients stand by their treatment].
Topics: Adult; Aged; Carbolines; Clinical Trials as Topic; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2006 |
Inhibitors of phosphodiesterase 5 (PDE 5) inhibit the nerve-induced release of nitric oxide from the rabbit corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Imidazoles; In Vitro Techniques; Male; Muscle, Smooth; Nitrergic Neurons; Nitric Oxide; Penis; Phosphodiesterase Inhibitors; Piperazines; Priapism; Purines; Rabbits; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antihypertensive Agents; Carbolines; Cardiomyopathies; Cardiovascular Agents; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Doxorubicin; Endothelium, Vascular; Enzyme Inhibitors; Erectile Dysfunction; Heart Failure; Humans; Hypertension; Hypertension, Pulmonary; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents; Ventricular Remodeling | 2007 |
Mechanism of Phosphodiesterase 5 inhibitor relief of prostatitis symptoms.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; Immunity, Innate; Male; Models, Immunological; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Prostate; Prostatitis; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
Factors that predict changing the type of phosphodiesterase type 5 inhibitor medication among men in the UK.
Topics: Adolescent; Adult; Aged; Carbolines; Cohort Studies; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Purines; Retrospective Studies; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2007 |
Oral phosphodiesterase-5 inhibitors: effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Heme Oxygenase (Decyclizing); Imidazoles; Male; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
[PDE5 inhibitors. A new option in the treatment of ureteral colic?].
Topics: Aged; Carbolines; Colic; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Isometric Contraction; Male; Middle Aged; Muscle, Smooth; Organ Culture Techniques; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Radioimmunoassay; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Ureter; Ureteral Calculi; Ureteral Diseases; Vardenafil Dihydrochloride | 2007 |
Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors.
Topics: Animals; Carbolines; Catalytic Domain; Cattle; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Imidazoles; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Sulfones; Tadalafil; Triazines; Tritium; Vardenafil Dihydrochloride | 2007 |
N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Catalytic Domain; Centrifugation, Density Gradient; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Imidazoles; Isoenzymes; Phosphoric Diester Hydrolases; Piperazines; Protein Structure, Quaternary; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
[Drug counterfeiting--the risk to the public health].
Topics: Carbolines; Drug Compounding; Drug Contamination; Drug Industry; Drug Labeling; Drug Packaging; Erectile Dysfunction; Fraud; Humans; Imidazoles; Legislation, Drug; Male; Phosphodiesterase Inhibitors; Piperazines; Poland; Public Health; Purines; Quality Control; Risk Assessment; Sildenafil Citrate; Spectrum Analysis, Raman; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
Acceptance of and discontinuation rate from erectile dysfunction oral treatment in patients following bilateral nerve-sparing radical prostatectomy.
Topics: Carbolines; Erectile Dysfunction; Follow-Up Studies; Humans; Imidazoles; Male; Middle Aged; Patient Compliance; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Postoperative Complications; Prostate; Prostatectomy; Prostatic Neoplasms; Purines; Quality of Life; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Time Factors; Treatment Outcome; Treatment Refusal; Triazines; Vardenafil Dihydrochloride | 2008 |
Patterns of switching phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction: results from the Erectile Dysfunction Observational Study.
Topics: Adolescent; Adult; Aged; Carbolines; Cohort Studies; Erectile Dysfunction; Follow-Up Studies; Humans; Imidazoles; Male; Middle Aged; Patient Compliance; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Prospective Studies; Purines; Regression Analysis; Severity of Illness Index; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Time Factors; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2007 |
Analogues of erectile dysfunction drugs: an under-recognised threat.
Topics: Adult; Ataxia; Carbolines; Data Collection; Drug Contamination; Erectile Dysfunction; Hong Kong; Humans; Imidazoles; Male; Nonprescription Drugs; Phosphodiesterase Inhibitors; Piperazines; Plant Preparations; Purines; Pyrimidinones; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2007 |
Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Binding Sites; Carbolines; Catalytic Domain; Crystallography, X-Ray; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Histidine; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Kinetics; Molecular Sequence Data; Mutation; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sequence Alignment; Sildenafil Citrate; Sulfones; Tadalafil; Thermodynamics; Triazines; Tyrosine; Vardenafil Dihydrochloride | 2007 |
Giving patients with erectile dysfunction the opportunity to try all three available phosphodiesterase type 5 inhibitors contributes to better long-term treatment compliance.
Topics: Adult; Aged; Carbolines; Erectile Dysfunction; Follow-Up Studies; Humans; Imidazoles; Longitudinal Studies; Male; Middle Aged; Patient Compliance; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2008 |
The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbolines; Cyclic GMP; Heme Oxygenase (Decyclizing); Imidazoles; Male; Penis; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2008 |
Erectile dysfunction: the Viagra revolution.
Topics: Carbolines; Ejaculation; Erectile Dysfunction; Humans; Imidazoles; Male; Nitric Oxide; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2005 |
Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides in isolated human prostatic tissue.
Topics: Aged; Benzamides; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Male; Middle Aged; Norepinephrine; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostate; Purines; Pyridines; Rolipram; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2008 |
Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets.
Topics: Animals; Blood Platelets; Calcium; Calcium Channel Blockers; Calcium Channels; Carbolines; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Imidazoles; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Rabbits; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilation | 2008 |
In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil.
Topics: Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Imidazoles; Mice; Models, Molecular; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Quantitative Structure-Activity Relationship; Rats; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2008 |
Can Viagra really cause hearing and vision loss? If so, is this a reason to avoid using it?
Topics: Carbolines; Hearing Loss; Humans; Imidazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Time Factors; Triazines; Vardenafil Dihydrochloride; Vision Disorders | 2008 |
Use of phosphodiesterase-5 inhibitors by college students.
Topics: Adolescent; Adult; Brazil; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Self Medication; Sildenafil Citrate; Students; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents; Young Adult | 2008 |
Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects.
Topics: Animals; Carbolines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanylate Cyclase; Imidazoles; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitroglycerin; Oxadiazoles; Penile Erection; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2009 |
Management of erectile dysfunction in general practice.
Topics: Attitude of Health Personnel; Carbolines; Cardiovascular Diseases; Drug Prescriptions; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Physician-Patient Relations; Piperazines; Practice Patterns, Physicians'; Primary Health Care; Purines; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2009 |
Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry.
Topics: Adult; Amines; Carbolines; Dietary Supplements; Drug Contamination; Erectile Dysfunction; Humans; Imidazoles; Ions; Male; Piperazines; Plant Preparations; Purines; Reference Standards; Sildenafil Citrate; Spectrum Analysis; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2009 |
Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Prospective Studies; Purines; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Time Factors; Triazines; Vardenafil Dihydrochloride | 2009 |
Comparative relaxing effects of sildenafil, vardenafil, and tadalafil in human corpus cavernosum: contribution of endogenous nitric oxide release.
Topics: Adolescent; Adult; Aged; Carbolines; Humans; Imidazoles; Male; Middle Aged; Muscle Relaxation; Nitric Oxide; Penis; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Young Adult | 2009 |
High performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of vardenafil, sildenafil, tadalafil, testosterone and local anesthetics in cosmetic creams sold on the Internet web sites.
Topics: Anesthetics, Local; Carbolines; Chromatography, High Pressure Liquid; Cosmetics; Female; Humans; Imidazoles; Internet; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Reproducibility of Results; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Sulfones; Tadalafil; Testosterone; Triazines; Vardenafil Dihydrochloride | 2009 |
Screening of Indian aphrodisiac ayurvedic/herbal healthcare products for adulteration with sildenafil, tadalafil and/or vardenafil using LC/PDA and extracted ion LC-MS/TOF.
Topics: Aphrodisiacs; Carbolines; Chromatography, Liquid; Drug Contamination; Humans; Imidazoles; India; Male; Mass Spectrometry; Medicine, Ayurvedic; Phosphodiesterase Inhibitors; Piperazines; Plant Preparations; Purines; Reference Standards; Reproducibility of Results; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2010 |
Phosphodiesterase type 5 inhibitors facilitate noncontact erections in male rats: site of action in the brain and mechanism of action.
Topics: Analysis of Variance; Animals; Area Under Curve; Arousal; Brain; Carbolines; Cyclic GMP; Dopamine; Female; Imidazoles; Male; Microdialysis; Muscle, Smooth; Nitric Oxide; Nucleus Accumbens; Penile Erection; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Ventral Tegmental Area | 2009 |
Patterns of treatment with PDE5 inhibitors in the clinical practice in Italy: longitudinal data from the Erectile Dysfunction Observational Study.
Topics: Adult; Aged; Aged, 80 and over; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Practice Patterns, Physicians'; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2009 |
2009 update on phosphodiesterase type 5 inhibitor therapy part 2: updates on optimal utilization for sexual concerns and rare toxicities in this class.
Topics: Carbolines; Clitoris; Education, Medical, Continuing; Female; Hearing Disorders; Humans; Imidazoles; Impotence, Vasculogenic; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sexual Dysfunctions, Psychological; Sexuality; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2009 |
Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model.
Topics: Animals; Carbolines; Climacteric; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Flushing; Gene Expression Regulation; Imidazoles; Male; Mice; Mice, Inbred ICR; Models, Animal; Nitrates; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; RNA, Messenger; Sex Characteristics; Sildenafil Citrate; Skin; Sulfones; Tadalafil; Tail; Triazines; Vardenafil Dihydrochloride | 2009 |
Identification of sildenafil, tadalafil and vardenafil by gas chromatography-mass spectrometry on short capillary column.
Topics: Carbolines; Food Analysis; Gas Chromatography-Mass Spectrometry; Imidazoles; Piperazines; Plant Preparations; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2009 |
Phosphodiesterase type V inhibitors: Occurrence and fate in wastewater and sewage sludge.
Topics: Carbolines; Chromatography, Liquid; Germany; Imidazoles; Mass Spectrometry; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Reproducibility of Results; Sewage; Sildenafil Citrate; Spain; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Purification | 2010 |
Central serous chorioretinopathy and phosphodiesterase-5 inhibitors: a case-control postmarketing surveillance study.
Topics: Adolescent; Adult; Carbolines; Case-Control Studies; Central Serous Chorioretinopathy; Databases, Factual; Drug Prescriptions; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Product Surveillance, Postmarketing; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United States; United States Department of Veterans Affairs; Vardenafil Dihydrochloride; Young Adult | 2010 |
Sildenafil or vardenafil nonresponders' erectile response to tadalafil.
Topics: Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Satisfaction; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Failure; Triazines; Vardenafil Dihydrochloride | 2009 |
Erectile dysfunction.
Topics: Blood Glucose; Carbolines; Cardiovascular Diseases; Cholesterol; Erectile Dysfunction; Humans; Imidazoles; Impotence, Vasculogenic; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Severity of Illness Index; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2010 |
[Therapy of erectile dysfunction].
Topics: Adrenergic alpha-Antagonists; Androgens; Carbolines; Diagnosis, Differential; Erectile Dysfunction; Humans; Imidazoles; Injections; Male; Penile Implantation; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vacuum; Vardenafil Dihydrochloride; Vasodilator Agents | 2010 |
Identification of counterfeit medicines for erectile dysfunction from an illegal supply chain.
Topics: Carbolines; Chromatography, High Pressure Liquid; Croatia; Erectile Dysfunction; Fraud; Humans; Imidazoles; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2010 |
Recreational use of erectile dysfunction medications in undergraduate men in the United States: characteristics and associated risk factors.
Topics: Adolescent; Adult; Carbolines; Chi-Square Distribution; Cross-Sectional Studies; Humans; Imidazoles; Male; Piperazines; Purines; Risk Factors; Risk-Taking; Sexual Behavior; Sexuality; Sildenafil Citrate; Students; Sulfones; Surveys and Questionnaires; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2011 |
Evaluation of therapeutic response of patients with erectile dysfunction.
Topics: Adolescent; Adult; Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Patient Preference; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Young Adult | 2009 |
Co-possession of phosphodiesterase type-5 inhibitors (PDE5-I) with nitrates.
Topics: Adolescent; Adult; Aged; Carbolines; Databases, Factual; Drug Therapy, Combination; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Nitrates; Pharmaceutical Services; Phosphodiesterase Inhibitors; Piperazines; Practice Patterns, Physicians'; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Young Adult | 2010 |
A gas chromatography/mass spectrometry method for the determination of sildenafil, vardenafil and tadalafil and their metabolites in human urine.
Topics: Carbolines; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2010 |
Failure of PDE5 inhibitor use: a case of nonresponder? (CME).
Topics: Carbolines; Diagnosis, Differential; Humans; Imidazoles; Impotence, Vasculogenic; Male; Middle Aged; Patient Care Team; Penile Erection; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Referral and Consultation; Risk Factors; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Failure; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2010 |
Simultaneous determination of yohimbine, sildenafil, vardenafil and tadalafil in dietary supplements using high-performance liquid chromatography-tandem mass spectrometry.
Topics: Adrenergic alpha-Antagonists; Carbolines; Chromatography, High Pressure Liquid; Dietary Supplements; Erectile Dysfunction; Humans; Imidazoles; Male; Molecular Structure; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Tandem Mass Spectrometry; Triazines; Vardenafil Dihydrochloride; Yohimbine | 2010 |
[Benefits of tadalafil in sexual activity-related time concerns].
Topics: Carbolines; Erectile Dysfunction; Female; Humans; Imidazoles; Interpersonal Relations; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Time Factors; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2010 |
Separation and structural elucidation of a novel analogue of vardenafil included as an adulterant in a dietary supplement by liquid chromatography-electrospray ionization mass spectrometry, infrared spectroscopy and nuclear magnetic resonance spectroscopy
Topics: Carbolines; Chromatography, Liquid; Dietary Supplements; Drug Contamination; Erectile Dysfunction; Humans; Imidazoles; Magnetic Resonance Spectroscopy; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Saccharomyces cerevisiae; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2011 |
Phosphodiesterase 5 inhibitors attenuate renal tubular apoptosis after partial unilateral ureteral obstruction: an experimental study.
Topics: Animals; Apoptosis; Carbolines; Ceftriaxone; Imidazoles; Kidney Tubules; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Ureteral Obstruction; Vardenafil Dihydrochloride | 2011 |
The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; KB Cells; Models, Molecular; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Conformation; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2011 |
Conformational conversion of PDE5 by incubation with sildenafil or metal ion is accompanied by stimulation of allosteric cGMP binding.
Topics: Allosteric Regulation; Allosteric Site; Animals; Carbolines; Carrier Proteins; Catalytic Domain; Cattle; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Phosphodiesterase 5 Inhibitors; Phosphorylation; Piperazines; Protein Binding; Protein Conformation; Purines; Sildenafil Citrate; Substrate Specificity; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2011 |
Identification of novel sildenafil-analogues in an adulterated herbal food supplement.
Topics: Carbolines; Dietary Supplements; Drug Contamination; Food Contamination; Humans; Imidazoles; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Plant Preparations; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2011 |
10-Year analysis of adverse event reports to the Food and Drug Administration for phosphodiesterase type-5 inhibitors.
Topics: Carbolines; Cardiovascular Diseases; Erectile Dysfunction; Humans; Imidazoles; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Product Surveillance, Postmarketing; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United States; United States Food and Drug Administration; Vardenafil Dihydrochloride | 2012 |
Should central serous chorioretinopathy be added to the list of ocular side effects of phosphodiesterase 5 inhibitors?
Topics: Aged; Carbolines; Central Serous Chorioretinopathy; Erectile Dysfunction; Fluorescein Angiography; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Sulfones; Tadalafil; Tomography, Optical Coherence; Triazines; Vardenafil Dihydrochloride; Vision Disorders | 2012 |
How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Penile Erection; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2012 |
cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.
Topics: Animals; Carbolines; Circadian Rhythm; Cricetinae; Female; Guanylate Cyclase; Humans; Imidazoles; Male; Mesocricetus; Mice; Period Circadian Proteins; Phosphodiesterase 5 Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Species Specificity; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2012 |
PDEI-5 for erectile dysfunction: a potential role in seizure susceptibility.
Topics: Aged; Animals; Carbolines; Disease Susceptibility; Erectile Dysfunction; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Prevalence; Purines; Rats; Seizures; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2012 |
Validation of an LC-ESI-MS/MS method for the quantitation of phosphodiesterase-5 inhibitors and their main metabolites in rat serum and brain tissue samples.
Topics: Acetonitriles; Animals; Biotransformation; Brain; Calibration; Carbolines; Chromatography, Liquid; Dealkylation; Formates; Imidazoles; Injections, Intraperitoneal; Limit of Detection; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Sulfones; Tadalafil; Tandem Mass Spectrometry; Triazines; Vardenafil Dihydrochloride | 2012 |
Screening for multiple phosphodiesterase type 5 inhibitor drugs in dietary supplement materials by flow injection mass spectrometry and their quantification by liquid chromatography tandem mass spectrometry.
Topics: Carbolines; Chromatography, Liquid; Dietary Supplements; Drug Contamination; Flow Injection Analysis; Imidazoles; Mass Spectrometry; Phosphodiesterase 5 Inhibitors; Piperazines; Plant Preparations; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Tandem Mass Spectrometry; Triazines; Vardenafil Dihydrochloride | 2012 |
Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction.
Topics: Animals; Carbolines; Dogs; Dose-Response Relationship, Drug; Erectile Dysfunction; Humans; Imidazoles; Infusions, Intravenous; Male; Penile Erection; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrimidines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2012 |
Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability.
Topics: Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Penile Erection; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrimidines; Randomized Controlled Trials as Topic; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2012 |
Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.
Topics: Amino Acid Sequence; Amino Acids; Carbolines; Catalytic Domain; Cloning, Molecular; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide Phosphodiesterases, Type 6; Drug Design; Enzyme Inhibitors; Evolution, Molecular; Eye Proteins; Humans; Imidazoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Binding; Retina; Sequence Homology, Amino Acid; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2012 |
The Global Online Sexuality Survey (GOSS): the United States of America in 2011 chapter II: phosphodiesterase inhibitors utilization among English speakers.
Topics: Adult; Aged; Carbolines; Comorbidity; Coronary Artery Disease; Cross-Sectional Studies; Drug Administration Schedule; Drug Utilization; Erectile Dysfunction; Health Surveys; Humans; Illicit Drugs; Imidazoles; Internet; Male; Middle Aged; Nonprescription Drugs; Phosphodiesterase Inhibitors; Piperazines; Prescription Drugs; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United States; Vardenafil Dihydrochloride | 2013 |
Detection and validated quantification of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, tadalafil, and 2 of their metabolites in human blood plasma by LC-MS/MS--application to forensic and therapeutic drug monitoring cases.
Topics: Adult; Aged; Antihypertensive Agents; Biotransformation; Carbolines; Chromatography, High Pressure Liquid; Drug Monitoring; Familial Primary Pulmonary Hypertension; Forensic Toxicology; Humans; Hypertension, Pulmonary; Imidazoles; Limit of Detection; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Reproducibility of Results; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Sulfones; Tadalafil; Tandem Mass Spectrometry; Triazines; Vardenafil Dihydrochloride | 2012 |
Rapid-screening detection of acetildenafils, sildenafils and avanafil by ion mobility spectrometry.
Topics: Carbolines; Chemistry Techniques, Analytical; Dietary Supplements; Food Contamination; Food Inspection; Imidazoles; Isomerism; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrimidines; Sildenafil Citrate; Sulfones; Tadalafil; Tandem Mass Spectrometry; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2013 |
Prescription opioids for back pain and use of medications for erectile dysfunction.
Topics: Adult; Age Factors; Aged; Analgesics, Opioid; Androgens; Back Pain; Carbolines; Comorbidity; Cross-Sectional Studies; Depression; Drug Prescriptions; Erectile Dysfunction; Hormone Replacement Therapy; Humans; Imidazoles; Insurance, Health; Logistic Models; Male; Middle Aged; Piperazines; Prevalence; Purines; Sildenafil Citrate; Smoking; Sulfones; Tadalafil; Testosterone; Triazines; United States; Urological Agents; Vardenafil Dihydrochloride | 2013 |
A 6 month, prospective, observational study of PDE5 inhibitor treatment persistence and adherence in Latin American men with erectile dysfunction.
Topics: Carbolines; Carbonates; Erectile Dysfunction; Humans; Imidazoles; Latin America; Male; Medication Adherence; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Prospective Studies; Purines; Pyrimidines; Self Concept; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Treatment Outcome; Triazines; Vardenafil Dihydrochloride | 2013 |
A 6-month, prospective, observational study of PDE5 inhibitor treatment persistence and adherence in Middle Eastern and North African men with erectile dysfunction.
Topics: Carbolines; Egypt; Erectile Dysfunction; Humans; Imidazoles; Male; Medication Adherence; Middle Aged; Phosphodiesterase 5 Inhibitors; Piperazines; Prospective Studies; Purines; Saudi Arabia; Self Concept; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tadalafil; Treatment Outcome; Triazines; United Arab Emirates; Vardenafil Dihydrochloride | 2013 |
Condom attitudes of heterosexual men ages 50 and older using prescribed drugs (Viagra, Cialis, Levitra) to treat erectile dysfunction.
Topics: Carbolines; Condoms; Erectile Dysfunction; Female; Health Behavior; Health Promotion; Heterosexuality; Humans; Imidazoles; Male; Middle Aged; Piperazines; Purines; Safe Sex; Sexual Partners; Sexually Transmitted Diseases; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2013 |
Validated UPLC-MS/MS assay for the determination of synthetic phosphodiesterase type-5 inhibitors in postmortem blood samples.
Topics: Carbolines; Chromatography, Liquid; Forensic Toxicology; Humans; Imidazoles; Limit of Detection; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Spectrometry, Mass, Electrospray Ionization; Sulfones; Tadalafil; Tandem Mass Spectrometry; Triazines; Vardenafil Dihydrochloride | 2013 |
Monitoring by LC-MS/MS of 48 compounds of sildenafil, tadalafil, vardenafil and their analogues in illicit health food products in the Korean market advertised as enhancing male sexual performance.
Topics: Advertising; Carbolines; Chromatography, Liquid; Food Contamination; Food, Organic; Humans; Imidazoles; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Reproductive Health; Republic of Korea; Sildenafil Citrate; Substance Abuse Detection; Sulfones; Tadalafil; Tandem Mass Spectrometry; Triazines; Vardenafil Dihydrochloride | 2013 |
The molecular basis for the selectivity of tadalafil toward phosphodiesterase 5 and 6: a modeling study.
Topics: Binding Sites; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide Phosphodiesterases, Type 6; Erectile Dysfunction; Humans; Imidazoles; Ligands; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Purines; Sildenafil Citrate; Structural Homology, Protein; Sulfones; Tadalafil; Thermodynamics; Triazines; Urological Agents; Vardenafil Dihydrochloride | 2013 |
Management of ED under the "severe distress" criteria in the NHS: a real-life study.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Carbolines; Drug Costs; Erectile Dysfunction; Humans; Imidazoles; Longitudinal Studies; Male; Middle Aged; Patient Compliance; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; State Medicine; Sulfones; Tadalafil; Triazines; United Kingdom; Vardenafil Dihydrochloride; Young Adult | 2014 |
Effects of phosphodiesterase type 5 inhibitors on Raynaud's phenomenon.
Topics: Administration, Oral; Adult; Aged; Carbolines; Female; Fingers; Humans; Imidazoles; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Pilot Projects; Piperazines; Prospective Studies; Purines; Raynaud Disease; Regional Blood Flow; Sildenafil Citrate; Skin Temperature; Sulfonamides; Sulfones; Tadalafil; Thermography; Time Factors; Treatment Outcome; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2014 |
Effects of the recreational use of PDE5 inhibitors on the corpus cavernosum of young, healthy rats.
Topics: Animals; Carbolines; Collagen; Fibroblasts; Imidazoles; Male; Microscopy, Electron; Penile Erection; Penis; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfonamides; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2014 |
Nebivolol potentiates the efficacy of PDE5 inhibitors to relax corpus cavernosum and penile arteries from diabetic patients by enhancing the NO/cGMP pathway.
Topics: Arteries; Benzopyrans; Carbolines; Cyclic GMP; Diabetes Mellitus, Type 2; Drug Synergism; Erectile Dysfunction; Ethanolamines; Humans; Imidazoles; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Nebivolol; Nitric Oxide; Penile Erection; Penis; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2014 |
Erectile dysfunction and the drugs to treat it. In many cases, medications are all a man needs to stay sexually active.
Topics: Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Life Style; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrimidines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2014 |
Risk-benefit assessment of oral phosphodiesterase type 5 inhibitors for treatment of erectile dysfunction: a multiple criteria decision analysis.
Topics: Adult; Aged; Erectile Dysfunction; Humans; Male; Middle Aged; Penile Erection; Phosphodiesterase 5 Inhibitors; Risk Assessment; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2015 |
Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors.
Topics: ATP-Binding Cassette Transporters; Caffeine; Carbolines; Cyclic AMP; Cyclic GMP; Dipyridamole; Humans; Imidazoles; Kinetics; Multidrug Resistance-Associated Proteins; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purinones; Sulfones; Tadalafil; Theophylline; Triazines; Vardenafil Dihydrochloride | 2014 |
Validated spectrofluorimetric method for determination of two phosphodiesterase inhibitors tadalafil and vardenafil in pharmaceutical preparations and spiked human plasma.
Topics: Humans; Hydrogen-Ion Concentration; Molecular Structure; Pharmaceutical Preparations; Phosphodiesterase Inhibitors; Spectrometry, Fluorescence; Surface-Active Agents; Tadalafil; Vardenafil Dihydrochloride | 2016 |
Comparison of the effects of systemic sildenafil, tadalafil, and vardenafil treatments on skin flap survival in rats.
Topics: Animals; Biopsy, Needle; Blood Flow Velocity; Disease Models, Animal; Female; Graft Rejection; Immunohistochemistry; Infusions, Intravenous; Laser-Doppler Flowmetry; Microcirculation; Random Allocation; Rats; Rats, Wistar; Reference Values; Sildenafil Citrate; Skin Transplantation; Surgical Flaps; Tadalafil; Vardenafil Dihydrochloride; Wound Healing | 2015 |
Male enhancement Nutraceuticals in the Middle East market: Claim, pharmaceutical quality and safety assessments.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Creatinine; Dietary Supplements; Drug Contamination; gamma-Glutamyltransferase; Male; Middle East; Phosphodiesterase 5 Inhibitors; Rats, Wistar; Sildenafil Citrate; Tadalafil; Urea; Vardenafil Dihydrochloride | 2015 |
[Rapid screening and confirmation of illegally added anti- impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry].
Topics: Benzylamines; Chromatography, High Pressure Liquid; Drug Contamination; Erectile Dysfunction; Humans; Indole Alkaloids; Male; Mass Spectrometry; Naphthalenes; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride; Vasodilator Agents | 2015 |
Erectile Dysfunction Drugs Changed the Protein Expressions and Activities of Drug-Metabolising Enzymes in the Liver of Male Rats.
Topics: Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Erectile Dysfunction; Isoenzymes; Liver; Male; Metabolic Detoxication, Phase I; Phosphodiesterase 5 Inhibitors; Rats; Risk Assessment; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2016 |
Food and Drug Administration Adverse Event Reports of Retinal Vascular Occlusions Associated With Phosphodiesterase Type 5 Inhibitor Use.
Topics: Adverse Drug Reaction Reporting Systems; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Phosphodiesterase 5 Inhibitors; Product Surveillance, Postmarketing; Pyrimidines; Retinal Artery Occlusion; Retinal Vein Occlusion; Sildenafil Citrate; Tadalafil; United States; United States Food and Drug Administration; Vardenafil Dihydrochloride | 2016 |
Determination of Common Adulterants in Herbal Medicine and Food Samples using Core-shell Column Coupled to Tandem Mass Spectrometry.
Topics: Chromatography, Liquid; Drug Contamination; Food Analysis; Food Contamination; Household Products; Oman; Plant Preparations; Sildenafil Citrate; Tadalafil; Tandem Mass Spectrometry; Vardenafil Dihydrochloride | 2017 |
The effect of PDE5 inhibitors on bone and oxidative damage in ovariectomy-induced osteoporosis.
Topics: Animals; Biomarkers; Bone and Bones; Bone Density; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Osteoporosis; Ovariectomy; Phosphodiesterase 5 Inhibitors; Pyrimidines; Rats, Wistar; Sulfonamides; Tadalafil; Treatment Outcome; Vardenafil Dihydrochloride | 2017 |
Superior vasodilation of human pulmonary vessels by vardenafil compared with tadalafil and sildenafil: additive effects of bosentan.
Topics: Antihypertensive Agents; Bosentan; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Pulmonary Veins; Sildenafil Citrate; Sulfonamides; Tadalafil; Vardenafil Dihydrochloride; Vasodilation; Vasodilator Agents | 2017 |
Effects of phosphodiestrase type 5 inhibitors in epinephrine-induced arrhythmia in rats: Involvement of lactate dehydrogenase and creatine kinase downregulation and adiponectin expression.
Topics: Adiponectin; Animals; Anti-Arrhythmia Agents; Apoptosis; Arrhythmias, Cardiac; Caspase 3; Creatine Kinase; Disease Models, Animal; Electrocardiography; Epinephrine; Glutathione; Heart Rate; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocardium; Necrosis; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Rats, Wistar; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2018 |
Beneficial long term effect of a phosphodiesterase-5-inhibitor in cirrhotic portal hypertension: A case report with 8 years follow-up.
Topics: Administration, Oral; Cholangitis, Sclerosing; Computed Tomography Angiography; Endoscopy, Digestive System; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hemodynamics; Hepatitis, Autoimmune; Humans; Hypertension, Portal; Liver Cirrhosis; Middle Aged; Phosphodiesterase 5 Inhibitors; Syndrome; Tadalafil; Time Factors; Treatment Outcome; Vardenafil Dihydrochloride | 2018 |
Sexual habits of men with ED who take phosphodiesterase 5 inhibitors: a survey conducted in 7 countries.
Topics: Adult; Aged; Brazil; China; Coitus; Drug Administration Schedule; Erectile Dysfunction; Habits; Humans; Italy; Japan; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Russia; Sildenafil Citrate; Surveys and Questionnaires; Tadalafil; Taiwan; Time Factors; Turkey; Vardenafil Dihydrochloride | 2018 |
Three-dimensional models of Mycobacterium tuberculosis proteins Rv1555, Rv1554 and their docking analyses with sildenafil, tadalafil, vardenafil drugs, suggest interference with quinol binding likely to affect protein's function.
Topics: Bacterial Proteins; Binding Sites; Drug Repositioning; Escherichia coli; Hydroquinones; Microbial Sensitivity Tests; Models, Molecular; Molecular Docking Simulation; Mycobacterium tuberculosis; Protein Binding; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2018 |
Accurate and sensitive determination of sildenafil, tadalafil, vardenafil, and avanafil in illicit erectile dysfunction medications and human urine by LC with quadrupole-TOF-MS/MS and their behaviors in simulated gastric conditions.
Topics: Chromatography, Liquid; Erectile Dysfunction; Humans; Illicit Drugs; Male; Pyrimidines; Sildenafil Citrate; Stomach; Tadalafil; Tandem Mass Spectrometry; Vardenafil Dihydrochloride | 2019 |
Self-Regulation in the Pharmaceutical Industry: The Exposure of Children and Adolescents to Erectile Dysfunction Commercials.
Topics: Adolescent; Child; Direct-to-Consumer Advertising; Drug Industry; Erectile Dysfunction; Guideline Adherence; Guidelines as Topic; Humans; Male; Prescription Drugs; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride; Vasodilator Agents | 2019 |
Development of a specific fragment pattern-based quadrupole-Orbitrap mass spectrometry method to screen adulterated products of phosphodiesterase-5 inhibitors and their analogues.
Topics: Chromatography, High Pressure Liquid; Counterfeit Drugs; Dietary Supplements; Drug Contamination; Food Contamination; Mass Spectrometry; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride; Vasodilator Agents | 2019 |
Falsified vardenafil tablets available online.
Topics: Counterfeit Drugs; Humans; Japan; Pharmaceutical Services, Online; Principal Component Analysis; Quality Control; Sildenafil Citrate; Spectrum Analysis, Raman; Tablets; Tadalafil; Urological Agents; Vardenafil Dihydrochloride | 2020 |
Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary.
Topics: Animals; Female; Ovarian Diseases; Ovary; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Sildenafil Citrate; Tadalafil; Torsion Abnormality; Vardenafil Dihydrochloride | 2019 |
To evaluate the efficacy and safety of different kinds of PDE5-Is with tamsulosin as a medical therapy for LUTS secondary to benign prostatic hyperplasia: A protocol for systematic review and meta analysis.
Topics: Adrenergic alpha-1 Receptor Antagonists; Bayes Theorem; Drug Therapy, Combination; Humans; Male; Meta-Analysis as Topic; Network Meta-Analysis; Phosphodiesterase 5 Inhibitors; Prostatic Hyperplasia; Randomized Controlled Trials as Topic; Research Design; Sildenafil Citrate; Systematic Review as Topic; Tadalafil; Tamsulosin; Vardenafil Dihydrochloride | 2020 |
Phosphodiesterase Type-5 Inhibitor Prescription Patterns in the United States Among Men With Erectile Dysfunction: An Update.
Topics: Adult; Aged; Carbolines; Erectile Dysfunction; Humans; Imidazoles; Male; Medicare; Middle Aged; Phosphodiesterase 5 Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Prescriptions; Purines; Retrospective Studies; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; United States; Vardenafil Dihydrochloride | 2020 |
Identification of Erectile Dysfunction Drugs in Dietary Supplements by Liquid Chromatography Ion Trap Mass Spectrometry.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Dietary Supplements; Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Tandem Mass Spectrometry; Vardenafil Dihydrochloride | 2021 |
Reliable screening and classification of phosphodiesterase type 5 inhibitors in dietary supplements using gas chromatography / mass spectrometry combined with specific common ions.
Topics: Dietary Supplements; Discriminant Analysis; Drug Evaluation, Preclinical; Gas Chromatography-Mass Spectrometry; Ions; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Time Factors; Vardenafil Dihydrochloride | 2020 |
Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
Topics: Aging; Animals; Bone and Bones; Bone Density; Brain; Cell Differentiation; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Repositioning; Erectile Dysfunction; Humans; Male; Mice; Middle Aged; Models, Animal; Models, Molecular; Neurons; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporotic Fractures; Phosphodiesterase 5 Inhibitors; Primary Cell Culture; Tadalafil; Vardenafil Dihydrochloride | 2020 |
Screening of Phosphodiesterase-5 Inhibitors and Their Analogs in Dietary Supplements by Liquid Chromatography-Hybrid Ion Trap-Time of Flight Mass Spectrometry.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyclic Nucleotide Phosphodiesterases, Type 5; Dietary Supplements; Drug Contamination; Mass Spectrometry; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Tandem Mass Spectrometry; Vardenafil Dihydrochloride | 2020 |
Erectile dysfunction drugs altered the activities of antioxidant enzymes, oxidative stress and the protein expressions of some cytochrome P450 isozymes involved in the steroidogenesis of steroid hormones.
Topics: Animals; Antioxidants; Cytochrome P-450 Enzyme System; Erectile Dysfunction; Glutathione; Isoenzymes; Liver; Male; Oxidative Stress; Rabbits; Sildenafil Citrate; Steroids; Tadalafil; Testis; Thiobarbituric Acid Reactive Substances; Vardenafil Dihydrochloride | 2020 |
Association between sexual activity-related death and non-prescription use of phosphodiesterase type 5 inhibitors.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Contraindications, Drug; Death, Sudden, Cardiac; Erectile Dysfunction; Forensic Medicine; Humans; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Risk; Sexual Behavior; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2021 |
Detection of 94 compounds related to sexual enhancement including sildenafil, tadalafil, vardenafil and their analogues in various formulations of dietary supplements and food samples using HPLC and LC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Dietary Supplements; Drug Contamination; Food Analysis; Food Contamination; Humans; Sildenafil Citrate; Tadalafil; Tandem Mass Spectrometry; Vardenafil Dihydrochloride | 2021 |
Detection Method of Falsified Medicines by Using a Low-Cost Raman Scattering Spectrometer Combined with Soft Independent Modeling of Class Analogy and Partial Least Squares Discriminant Analysis.
Topics: Counterfeit Drugs; Fluconazole; Least-Squares Analysis; Models, Chemical; Sildenafil Citrate; Spectrum Analysis, Raman; Tablets; Tadalafil; Vardenafil Dihydrochloride | 2021 |
[Phosphodesterase type 5 inhibitors clinical efficiency and role in therapy for erectile dysfunction].
Topics: Erectile Dysfunction; Humans; Male; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride | 2021 |
Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.
Topics: Animals; Cell Line, Tumor; HEK293 Cells; Humans; Male; Mice; Phosphodiesterase 5 Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Protein Isoforms; Purines; Second Messenger Systems; Sildenafil Citrate; Steroids; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2022 |
HPLC/Fluorescence-Diode Array Detection for Rapid and Reliable Determination of Illegal Synthetic Drugs in Male Sexual Herbal and Honey Remedies: Comparative Study with UFLC-MS.
Topics: Aphrodisiacs; Chromatography, High Pressure Liquid; Chromatography, Liquid; Honey; Humans; Illicit Drugs; Male; Mass Spectrometry; Synthetic Drugs; Tadalafil; Vardenafil Dihydrochloride; Yohimbine | 2022 |
Repurposing PDE5 inhibitor tadalafil and sildenafil as anticancer agent against hepatocellular carcinoma via targeting key events of glucose metabolism and multidrug resistance.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carbolines; Carcinoma, Hepatocellular; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Repositioning; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucose; Imidazoles; Liver Neoplasms; Neoplasm Proteins; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2022 |
Screening and Determination of Synthetic PDE-5 Inhibitors in Adulterated Sexual Enhancement Supplements.
Topics: Dietary Supplements; Drug Contamination; Humans; Pharmaceutical Preparations; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Tandem Mass Spectrometry; Vardenafil Dihydrochloride | 2022 |
Adverse reactions of PDE5 inhibitors: An analysis of the World Health Organization pharmacovigilance database.
Topics: Adolescent; Adult; Erectile Dysfunction; Humans; Male; Melanoma; Melanoma, Cutaneous Malignant; Pharmacovigilance; Phosphodiesterase 5 Inhibitors; Priapism; Sildenafil Citrate; Tadalafil; Vardenafil Dihydrochloride; World Health Organization | 2023 |
Spectroscopic determination of hydrophobic adulterant tadalafil by aptasensor based ellipsometry.
Topics: Carbolines; Humans; Imidazoles; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Vardenafil Dihydrochloride | 2024 |
A combination of phosphodiesterase type 5 inhibitor and tamoxifen for acute Peyronie's disease: the first clinical signals.
Topics: Humans; Male; Penile Induration; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tadalafil; Tamoxifen; Triazines; Vardenafil Dihydrochloride | 2023 |