Page last updated: 2024-09-02

tadalafil and simvastatin

tadalafil has been researched along with simvastatin in 5 studies

Compound Research Comparison

Studies
(tadalafil)
Trials
(tadalafil)
Recent Studies (post-2010)
(tadalafil)
Studies
(simvastatin)
Trials
(simvastatin)
Recent Studies (post-2010) (simvastatin)
1,7423921,0898,4421,7303,630

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)simvastatin (IC50)
photoreceptor-specific nuclear receptorHomo sapiens (human)1.164
transactivating tegument protein VP16 [Human herpesvirus 1]Human alphaherpesvirus 1 (Herpes simplex virus type 1)4.426
Bile salt export pumpHomo sapiens (human)10
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHomo sapiens (human)0.7843
ATP-dependent translocase ABCB1Homo sapiens (human)9.5
Insulin receptor Rattus norvegicus (Norway rat)0.0034
Prostaglandin G/H synthase 2Homo sapiens (human)0.0034
3-hydroxy-3-methylglutaryl-coenzyme A reductase Rattus norvegicus (Norway rat)0.0111
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.049
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)6.7

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Ji, YQ; Liu, CP; Lu, WX; Zeng, Q; Zhang, WH; Zhang, YJ1
Mirzaii-Dizgah, I; Salmanyan, B1

Reviews

1 review(s) available for tadalafil and simvastatin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

4 other study(ies) available for tadalafil and simvastatin

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Additive effect of tadalafil and simvastatin on monocrotaline-induced pulmonary hypertension rats.
    Scandinavian cardiovascular journal : SCJ, 2012, Volume: 46, Issue:6

    Topics: Animals; Antihypertensive Agents; Arterial Pressure; Arterioles; Carbolines; Disease Models, Animal; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Inflammation Mediators; Interleukin-6; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Simvastatin; Tadalafil; Time Factors; Vasodilator Agents

2012
Renal function in a rat model of neurogenic bladder, effect of statins and phosphodiesterase-5 inhibitors.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:12

    Topics: Analysis of Variance; Animals; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Male; Organ Size; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Simvastatin; Sulfones; Tadalafil; Urinary Bladder; Urinary Bladder, Neurogenic; Urine

2013