Page last updated: 2024-09-02

tadalafil and rp 73401

tadalafil has been researched along with rp 73401 in 3 studies

Compound Research Comparison

Studies
(tadalafil)
Trials
(tadalafil)
Recent Studies (post-2010)
(tadalafil)
Studies
(rp 73401)
Trials
(rp 73401)
Recent Studies (post-2010) (rp 73401)
1,7423921,08992023

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)rp 73401 (IC50)
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.78
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)2.78
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.78
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)0.001
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)0.0027
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)2.78
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.5166
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)0.0035
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.5363
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)2.78
Endothelin-1 receptorSus scrofa (pig)0.001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)2.78
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)2.78
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)2.78

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY1
Jonas, U; Kedia, G; Knapp, WH; Scheller, F; Sormes, M; Stief, CG; Uckert, S1
Bednorz, M; Ghofrani, HA; Grimminger, F; Parajuli, N; Pichl, A; Schermuly, RT; Seeger, W; Seimetz, M; Weissmann, N1

Other Studies

3 other study(ies) available for tadalafil and rp 73401

ArticleYear
Structural basis for the activity of drugs that inhibit phosphodiesterases.
    Structure (London, England : 1993), 2004, Volume: 12, Issue:12

    Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary

2004
Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides in isolated human prostatic tissue.
    Urology, 2008, Volume: 71, Issue:3

    Topics: Aged; Benzamides; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Male; Middle Aged; Norepinephrine; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostate; Purines; Pyridines; Rolipram; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride

2008
Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Benzamides; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Hypertension, Pulmonary; Lung; Lung Compliance; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pyridines; Smoke; Smoking; Tadalafil

2015