tadalafil has been researched along with roflumilast in 8 studies
| Studies (tadalafil) | Trials (tadalafil) | Recent Studies (post-2010) (tadalafil) | Studies (roflumilast) | Trials (roflumilast) | Recent Studies (post-2010) (roflumilast) |
|---|---|---|---|---|---|
| 1,742 | 392 | 1,089 | 566 | 90 | 425 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY | 1 |
| Hughes, RA; Manallack, DT; Thompson, PE | 1 |
| Huang, YY; Li, Z; Luo, HB; Wu, D; Wu, Y | 1 |
| Chai, S; Chen, S; Deng, L; Du, K; Shen, R; Sun, H; Sun, T; Xi, M; Xie, M | 1 |
| Kertys, M; Kosutova, P; Medvedova, I; Mikolka, P; Mokra, D; Mokry, J; Urbanova, A | 1 |
| Kertys, M; Mokry, J; Urbanova, A | 1 |
| Akhtar, M; Hasan, N; Najmi, AK; Parvez, S; Yar, MS; Zameer, S | 1 |
| Agis-Torres, Á; Barahona, MV; Benedito, S; Climent, B; Fernandes, VS; Hernández, M; López-Oliva, ME; Martínez, MP; Navarro-Dorado, J; Prieto, D; Recio, P | 1 |
3 review(s) available for tadalafil and roflumilast
| Article | Year |
|---|---|
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines | 2005 |
Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Cognition; Humans; Phosphodiesterase Inhibitors | 2018 |
Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alzheimer Disease; Animals; Cognition; Cyclic GMP; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases | 2022 |
5 other study(ies) available for tadalafil and roflumilast
| Article | Year |
|---|---|
Structural basis for the activity of drugs that inhibit phosphodiesterases.
Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary | 2004 |
Effects of tadalafil (PDE5 inhibitor) and roflumilast (PDE4 inhibitor) on airway reactivity and markers of inflammation in ovalbumin-induced airway hyperresponsiveness in guinea pigs.
Topics: Aminopyridines; Animals; Benzamides; Biomarkers; Cyclopropanes; Guinea Pigs; Inflammation Mediators; Lung; Male; Organ Culture Techniques; Ovalbumin; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Random Allocation; Respiratory Hypersensitivity; Tadalafil; Treatment Outcome | 2017 |
Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig Plasma.
Topics: Aminopyridines; Animals; Benzamides; Chromatography, High Pressure Liquid; Cyclopropanes; Guinea Pigs; Linear Models; Male; Phosphodiesterase Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Tadalafil; Tandem Mass Spectrometry | 2018 |
Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cyclic AMP; Cyclic GMP; Cyclopropanes; Cytokines; Gene Expression Regulation; Hippocampus; Male; Memory Disorders; Morris Water Maze Test; Oxidative Stress; Peptide Fragments; Random Allocation; Rats; Rats, Wistar; Tadalafil; Vasodilator Agents | 2021 |
In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dose-Response Relationship, Drug; Gasotransmitters; Hydrogen Sulfide; Male; Muscle Relaxation; Nitroarginine; Penis; Peripheral Nerves; Rats, Wistar; Tadalafil | 2022 |