Page last updated: 2024-09-02

tadalafil and papaverine

tadalafil has been researched along with papaverine in 5 studies

Compound Research Comparison

Studies (tadalafil)	Trials (tadalafil)	Recent Studies (post-2010) (tadalafil)	Studies (papaverine)	Trials (papaverine)	Recent Studies (post-2010) (papaverine)
1,742	392	1,089	6,027	305	355

Protein Interaction Comparison

Protein	Taxonomy	papaverine (IC50)
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Rattus norvegicus (Norway rat)	0.076
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	2.3
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	8.8
3',5'-cyclic-AMP phosphodiesterase	Sus scrofa (pig)	1.7
Bile salt export pump	Homo sapiens (human)	10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (human)	1.6
Cytochrome P450 2C19	Homo sapiens (human)	0.762
Serine hydroxymethyltransferase, mitochondrial	Homo sapiens (human)	2.6915
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	Homo sapiens (human)	9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Homo sapiens (human)	9
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	1.4
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	7.2444
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	1.03
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	Homo sapiens (human)	9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Homo sapiens (human)	0.697
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Rattus norvegicus (Norway rat)	0.036
Phosphodiesterase	Sus scrofa (pig)	0.62
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens (human)	0.07

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Cestari, A; Deho', F; Guazzoni, G; Montorsi, F; Rigatti, P; Salonia, A; Stief, C	1
Hatzichristou, DG; Hatzimouratidis, K	1
Chen, B; Chen, Z; Hu, JL; Huang, YR; Ma, Y; Wang, HX; Wang, YX; Xia, JG; Yang, Y	1

Reviews

3 review(s) available for tadalafil and papaverine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacological management of erectile dysfunction. BJU international, 2003, Volume: 91, Issue:5 Topics: Administration, Oral; Adrenergic alpha-Antagonists; Alprostadil; Apomorphine; Carbolines; Drug Combinations; Erectile Dysfunction; Humans; Imidazoles; Injections; Male; Papaverine; Phentolamine; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents	2003
A comparative review of the options for treatment of erectile dysfunction: which treatment for which patient? Drugs, 2005, Volume: 65, Issue:12 Topics: Administration, Oral; Alprostadil; Apomorphine; Carbolines; Constriction; Contraindications; Dopamine Agonists; Drug Combinations; Enzyme Inhibitors; Erectile Dysfunction; Humans; Imidazoles; Male; Papaverine; Patient Satisfaction; Penile Prosthesis; Penis; Phentolamine; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Sulfones; Tadalafil; Treatment Failure; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents	2005

Trials

1 trial(s) available for tadalafil and papaverine

Article	Year
Pharmaco-induced erections for penile color-duplex ultrasound: oral PDE5 inhibitors or intracavernosal injection? International journal of impotence research, 2012, Volume: 24, Issue:5 Topics: Administration, Oral; Adult; Arteries; Carbolines; Humans; Impotence, Vasculogenic; Injections; Male; Middle Aged; Papaverine; Penile Erection; Penis; Phosphodiesterase 5 Inhibitors; Piperazines; Prospective Studies; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Ultrasonography, Doppler, Color; Vasodilator Agents	2012

Article

Year

Pharmaco-induced erections for penile color-duplex ultrasound: oral PDE5 inhibitors or intracavernosal injection?

International journal of impotence research, 2012, Volume: 24, Issue:5

Topics: Administration, Oral; Adult; Arteries; Carbolines; Humans; Impotence, Vasculogenic; Injections; Male; Middle Aged; Papaverine; Penile Erection; Penis; Phosphodiesterase 5 Inhibitors; Piperazines; Prospective Studies; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Ultrasonography, Doppler, Color; Vasodilator Agents

2012

Other Studies

1 other study(ies) available for tadalafil and papaverine

Article	Year
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013

Article

Year

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013