tadalafil has been researched along with ng-nitroarginine methyl ester in 18 studies
| Studies (tadalafil) | Trials (tadalafil) | Recent Studies (post-2010) (tadalafil) | Studies (ng-nitroarginine methyl ester) | Trials (ng-nitroarginine methyl ester) | Recent Studies (post-2010) (ng-nitroarginine methyl ester) |
|---|---|---|---|---|---|
| 1,742 | 392 | 1,089 | 12,640 | 117 | 2,342 |
| Protein | Taxonomy | tadalafil (IC50) | ng-nitroarginine methyl ester (IC50) |
|---|---|---|---|
| Neutrophil elastase | Homo sapiens (human) | 2.7 | |
| Nitric oxide synthase, endothelial | Homo sapiens (human) | 2.1 | |
| Nitric oxide synthase, brain | Homo sapiens (human) | 1.1167 | |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | 2.6 | |
| Nitric oxide synthase, inducible | Homo sapiens (human) | 8 | |
| Collagenase 3 | Homo sapiens (human) | 2.7 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Aufiero, K; Belardi, D; Champion, HC; Dostmann, WR; Isoda, T; Kass, DA; Mergia, E; Mongillo, M; Montrose, DC; Moslehi, J; Smith, CJ; Takimoto, E; Zaccolo, M | 1 |
| Antunes, E; Baracat, JS; Claudino, MA; De Nucci, G; Priviero, FB; Teixeira, CE; Webb, RC | 1 |
| Kukreja, RC | 1 |
| Antunes, E; Priviero, FB; Teixeira, CE; Toque, HA; Webb, RC; Zemse, SM | 1 |
| Antunes, E; Arruda, AM; Barillas, S; Capel, RO; Cogo, JC; De Nucci, G; de Oliveira, MA; Mónica, FZ; Muscará, MN; Nahoum, C; Pissinatti, A; Pissinatti, L; Porto, M; Schenka, AA; Teixeira, SA | 1 |
| Antunes, E; Cogo, JC; De Nucci, G; Mónica, FZ; Porto, M; Rojas-Moscoso, J; Schenka, AA | 1 |
| Erdem, SR; Keskin, U; Peskircioglu, CL; Toksoz, S | 1 |
| Gulati, P; Singh, N | 2 |
| Otari, KV; Upasani, CD | 1 |
| Hosoda, H; Ikeda, T; Ikemura, K; Kamimoto, Y; Katayama, K; Kondo, E; Kubo, M; Ma, N; Maki, S; Miyoshi, T; Nii, M; Okuda, M; Osato, K; Tanaka, H; Tanaka, K; Umekawa, T; Yoshida, T; Yoshikawa, K | 1 |
| Fonteles, MC; Gonzaga-Silva, LF; Linhares, BL; Marinho, LB; Moraes, MO; Nascimento, NRF; Reges, R; Santos, CF; Silva, APG | 1 |
| Barreira, MA; Carvalho, MF; Fechine, FVJ; Gonzaga-Silva, LF; Oliveira, RRM; Pamplona, TL | 1 |
| Cai, W; Chen, S; Li, Y; Niu, X; Wang, B; Yang, N | 1 |
| Ikeda, T; Katsuragi, S; Kawamura, T; Maki, S; Tachibana, R; Takeuchi, H; Tanaka, H; Tanaka, K; Toriyabe, K; Yoshikawa, K | 1 |
| Banjac, NM; Jakovljević, VL; Prodanović, DV; Stilinović, NP; Tomas Petrović, AD; Vasović, LV; Vasović, VM | 1 |
| Ikeda, T; Kawamura, T; Tachibana, R; Takakura, S; Takeuchi, H; Tanaka, H; Tanaka, K; Yoshikawa, K | 1 |
| Otari, KV; Patil, RJ; Upasani, CD | 1 |
18 other study(ies) available for tadalafil and ng-nitroarginine methyl ester
| Article | Year |
|---|---|
cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenoviridae; Adrenergic beta-Agonists; Animals; Carbolines; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Fluorescence Resonance Energy Transfer; Genetic Vectors; Guanylate Cyclase; Isoproterenol; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Second Messenger Systems; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Tadalafil | 2005 |
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tadalafil; Tetrodotoxin | 2006 |
Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antihypertensive Agents; Carbolines; Cardiomyopathies; Cardiovascular Agents; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Doxorubicin; Endothelium, Vascular; Enzyme Inhibitors; Erectile Dysfunction; Heart Failure; Humans; Hypertension; Hypertension, Pulmonary; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents; Ventricular Remodeling | 2007 |
Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects.
Topics: Animals; Carbolines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanylate Cyclase; Imidazoles; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitroglycerin; Oxadiazoles; Penile Erection; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2009 |
Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus.
Topics: Acetylcholine; Animals; Callithrix; Carbolines; Crotalus; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Microscopy, Electron, Scanning; NG-Nitroarginine Methyl Ester; Nitrergic Neurons; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Penis; Pyrazoles; Pyridines; Quinoxalines; Sodium Channel Blockers; Sodium Channels; Tadalafil; Tetrodotoxin; Vasodilator Agents | 2011 |
Immunohistochemical and functional characterization of nitric oxide signaling pathway in isolated aorta from Crotalus durissus terrificus.
Topics: Acetylcholine; Animals; Aorta; Carbolines; Crotalus; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium, Vascular; Gene Expression Profiling; Guanylate Cyclase; Immunohistochemistry; In Vitro Techniques; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Pyrazoles; Pyridines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Tadalafil; Vasodilation | 2012 |
The effect of long-term oral tadalafil treatment on corpus cavernosum function in an experimental spinal cord transection rat model.
Topics: Acetylcholine; Animals; Arginine; Carbolines; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Erectile Dysfunction; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penis; Phosphodiesterase 5 Inhibitors; Rats; Rats, Wistar; Spinal Cord Injuries; Tadalafil; Vasodilator Agents | 2013 |
Neuroprotective effect of tadalafil, a PDE-5 inhibitor, and its modulation by L-NAME in mouse model of ischemia-reperfusion injury.
Topics: Animals; Carbolines; Cerebral Infarction; Male; Memory; Mice; Motor Activity; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Phosphodiesterase 5 Inhibitors; Reperfusion Injury; Tadalafil | 2014 |
Tadalafil enhances the neuroprotective effects of ischemic postconditioning in mice, probably in a nitric oxide associated manner.
Topics: Animals; Ataxia; Brain; Brain Ischemia; Carbolines; Cerebral Infarction; Cyclic Nucleotide Phosphodiesterases, Type 5; Ischemic Postconditioning; Male; Memory Disorders; Mice; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Reperfusion Injury; Tadalafil | 2014 |
Involvement of NO-cGMP pathway in anti-hyperalgesic effect of PDE5 inhibitor tadalafil in experimental hyperalgesia.
Topics: Animals; Carrageenan; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Rats; Rats, Wistar; Tadalafil | 2015 |
Tadalafil Improves L-NG-Nitroarginine Methyl Ester-Induced Preeclampsia With Fetal Growth Restriction-Like Symptoms in Pregnant Mice.
Topics: Animals; Blood Pressure; Cyclic GMP; Enzyme Inhibitors; Female; Fetal Development; Fetal Growth Retardation; Kidney; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phosphodiesterase 5 Inhibitors; Placenta; Pre-Eclampsia; Pregnancy; Proteinuria; Tadalafil | 2017 |
Effect of co-administration of two different phosphodiesterase inhibitors and a β
Topics: Adrenergic beta-3 Receptor Agonists; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Ethanolamines; Humans; Male; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Rolipram; Tadalafil; Treatment Outcome; Urinary Bladder; Urinary Bladder, Overactive | 2018 |
Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice1.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Ethanolamines; Male; Mice; NG-Nitroarginine Methyl Ester; Random Allocation; Tadalafil; Urinary Bladder, Overactive; Urination; Urological Agents | 2019 |
Effect and mechanism of prophylactic use of tadalafil during pregnancy on l-NAME-induced preeclampsia-like rats.
Topics: Animals; Blood Pressure; Cytokines; Female; Femoral Artery; Kidney; NG-Nitroarginine Methyl Ester; Phosphodiesterase 5 Inhibitors; Placenta; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Tadalafil; Ultrasonography | 2020 |
Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring.
Topics: Adipocytes; Animals; Diet, High-Fat; Female; Fetal Development; Fetal Growth Retardation; Glucose Tolerance Test; Hypertension; Hypertrophy; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Non-alcoholic Fatty Liver Disease; Pregnancy; Prenatal Exposure Delayed Effects; Tadalafil | 2021 |
Tadalafil in Increasing Doses: The Influence on Coronary Blood Flow and Oxidative Stress in Isolated Rat Hearts.
Topics: Animals; Coronary Circulation; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Tadalafil | 2022 |
Tadalafil Treatment of Mice with Fetal Growth Restriction and Preeclampsia Improves Placental mTOR Signaling.
Topics: Animals; Female; Fetal Growth Retardation; Mice; NG-Nitroarginine Methyl Ester; Placenta; Pre-Eclampsia; Pregnancy; Signal Transduction; Tadalafil; TOR Serine-Threonine Kinases | 2022 |
Improvement of cognitive dysfunction by a novel phosphodiesterase type 5 inhibitor, Tadalafil.
Topics: Cognitive Dysfunction; Cyclic GMP; Humans; Memory Disorders; NG-Nitroarginine Methyl Ester; Phosphodiesterase 5 Inhibitors; Scopolamine; Tadalafil | 2023 |