Compounds > tadalafil
Page last updated: 2024-09-02

tadalafil and midazolam

tadalafil has been researched along with midazolam in 6 studies

Compound Research Comparison

Studies
(tadalafil)		Trials
(tadalafil)		Recent Studies (post-2010)
(tadalafil)		Studies
(midazolam)		Trials
(midazolam)		Recent Studies (post-2010) (midazolam)
1,7423921,0899,8343,1913,301

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)midazolam (IC50)
Cytochrome P450 3A4Homo sapiens (human)2.7427

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Faller, B; Trunzer, M; Zimmerlin, A1
Dalvie, D; Loi, CM; Smith, DA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bedding, AW; Eckstein, J; Forgue, ST; Gillespie, J; Jewell, H; Mitchell, MI; Patterson, BE; Payne, CD; Phillips, DL; Ring, BJ; Vandenbranden, M; Wrighton, SA1
Burhenne, J; Carls, A; Haefeli, WE; Hohmann, N; Mikus, G; Reinhard, R; Schnaidt, S; Witt, L1

Reviews

1 review(s) available for tadalafil and midazolam

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for tadalafil and midazolam

ArticleYear
Effect of tadalafil on cytochrome P450 3A4-mediated clearance: studies in vitro and in vivo.
    Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Anticholesteremic Agents; Area Under Curve; Carbolines; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Lovastatin; Male; Metabolic Clearance Rate; Microsomes, Liver; Midazolam; Middle Aged; Tadalafil

2005
Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.
    The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:8

    Topics: Adolescent; Adult; Anti-HIV Agents; Cytochrome P-450 CYP3A; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Phosphodiesterase 5 Inhibitors; Plasma; Rilpivirine; Tadalafil; Young Adult

2016

Other Studies

3 other study(ies) available for tadalafil and midazolam

ArticleYear
Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.
    Journal of medicinal chemistry, 2009, Jan-22, Volume: 52, Issue:2

    Topics: Chromatography, Liquid; Drug Design; Humans; Likelihood Functions; Microsomes, Liver; Pharmacokinetics; Tandem Mass Spectrometry

2009
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013