Page last updated: 2024-09-02

tadalafil and metoprolol

tadalafil has been researched along with metoprolol in 4 studies

Compound Research Comparison

Studies (tadalafil)	Trials (tadalafil)	Recent Studies (post-2010) (tadalafil)	Studies (metoprolol)	Trials (metoprolol)	Recent Studies (post-2010) (metoprolol)
1,742	392	1,089	5,821	1,743	1,304

Protein Interaction Comparison

Protein	Taxonomy	metoprolol (IC50)
Beta-2 adrenergic receptor	Homo sapiens (human)	2.573
Beta-1 adrenergic receptor	Homo sapiens (human)	0.176
Cytochrome P450 2C9	Homo sapiens (human)	4.87
Cytochrome P450 2J2	Homo sapiens (human)	4.87

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dalvie, D; Loi, CM; Smith, DA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Cocco, G	1

Reviews

1 review(s) available for tadalafil and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for tadalafil and metoprolol

Article	Year
Erectile dysfunction after therapy with metoprolol: the Hawthorne effect. Cardiology, 2009, Volume: 112, Issue:3 Topics: Adrenergic beta-Antagonists; Carbolines; Cross-Over Studies; Drug Interactions; Effect Modifier, Epidemiologic; Erectile Dysfunction; Humans; Hypertension; Male; Metoprolol; Middle Aged; Patient Education as Topic; Phosphodiesterase Inhibitors; Placebo Effect; Tadalafil	2009

Other Studies

2 other study(ies) available for tadalafil and metoprolol

Article	Year
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013

Article

Year

Which metabolites circulate?

Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013