Page last updated: 2024-09-02

tadalafil and isoproterenol

tadalafil has been researched along with isoproterenol in 3 studies

Compound Research Comparison

Studies (tadalafil)	Trials (tadalafil)	Recent Studies (post-2010) (tadalafil)	Studies (isoproterenol)	Trials (isoproterenol)	Recent Studies (post-2010) (isoproterenol)
1,742	392	1,089	30,780	803	2,640

Protein Interaction Comparison

Protein	Taxonomy	isoproterenol (IC50)
Beta-2 adrenergic receptor	Homo sapiens (human)	0.246
Beta-1 adrenergic receptor	Homo sapiens (human)	0.333
Beta-2 adrenergic receptor	Rattus norvegicus (Norway rat)	0.2125
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	1.77
Beta-1 adrenergic receptor	Rattus norvegicus (Norway rat)	0.2125
Beta-3 adrenergic receptor	Rattus norvegicus (Norway rat)	0.2125
Beta-2 adrenergic receptor	Canis lupus familiaris (dog)	0.6667

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Aufiero, K; Belardi, D; Champion, HC; Dostmann, WR; Isoda, T; Kass, DA; Mergia, E; Mongillo, M; Montrose, DC; Moslehi, J; Smith, CJ; Takimoto, E; Zaccolo, M	1

Reviews

1 review(s) available for tadalafil and isoproterenol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

2 other study(ies) available for tadalafil and isoproterenol

Article	Year
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. Circulation research, 2005, Jan-07, Volume: 96, Issue:1 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenoviridae; Adrenergic beta-Agonists; Animals; Carbolines; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Fluorescence Resonance Energy Transfer; Genetic Vectors; Guanylate Cyclase; Isoproterenol; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Second Messenger Systems; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Tadalafil	2005

Article

Year

Identifying off-target effects and hidden phenotypes of drugs in human cells.

Nature chemical biology, 2006, Volume: 2, Issue:6

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.

Circulation research, 2005, Jan-07, Volume: 96, Issue:1

Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenoviridae; Adrenergic beta-Agonists; Animals; Carbolines; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Fluorescence Resonance Energy Transfer; Genetic Vectors; Guanylate Cyclase; Isoproterenol; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Second Messenger Systems; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Tadalafil

2005