Page last updated: 2024-09-02

tadalafil and imipramine

tadalafil has been researched along with imipramine in 4 studies

Compound Research Comparison

Studies
(tadalafil)
Trials
(tadalafil)
Recent Studies (post-2010)
(tadalafil)
Studies
(imipramine)
Trials
(imipramine)
Recent Studies (post-2010) (imipramine)
1,7423921,08910,3201,359801

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)imipramine (IC50)
Solute carrier family 22 member 2Homo sapiens (human)0.6
Solute carrier family 22 member 1 Homo sapiens (human)7.95
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)8.3
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)8.3
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.044
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.3
Cytochrome P450 2D6Homo sapiens (human)0.0051
D(2) dopamine receptorHomo sapiens (human)0.41
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.044
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.16
Sphingomyelin phosphodiesteraseHomo sapiens (human)5
DRattus norvegicus (Norway rat)2.0992
D(3) dopamine receptorRattus norvegicus (Norway rat)0.81
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.044
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)3.3884
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)3.3884
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)3.3884
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.16
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.074
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)3.3884
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.81
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.22
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.044
D(4) dopamine receptorRattus norvegicus (Norway rat)0.81
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)0.044
Histamine H1 receptorRattus norvegicus (Norway rat)0.0001
Sodium-dependent serotonin transporterHomo sapiens (human)0.0074
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.81
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)0.044
Histamine H1 receptorHomo sapiens (human)0.027
Sodium channel protein type 1 subunit alphaHomo sapiens (human)3.6
Sodium channel protein type 4 subunit alphaHomo sapiens (human)3.6
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.044
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.16
Histamine H2 receptorCavia porcellus (domestic guinea pig)1.9
D(2) dopamine receptorRattus norvegicus (Norway rat)0.81
Sodium channel protein type 7 subunit alphaHomo sapiens (human)3.6
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)8.3
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.3913
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)8.3
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)8.3
Sodium channel protein type 5 subunit alphaHomo sapiens (human)3.6
Sodium channel protein type 9 subunit alphaHomo sapiens (human)3.6
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)0.044
Multidrug and toxin extrusion protein 1Homo sapiens (human)10
Sodium channel protein type 2 subunit alphaHomo sapiens (human)3.6
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.044
Sodium channel protein type 3 subunit alphaHomo sapiens (human)3.6
Solute carrier family 22 member 2Rattus norvegicus (Norway rat)9.9
Sodium channel protein type 11 subunit alphaHomo sapiens (human)3.6
Sodium channel protein type 8 subunit alphaHomo sapiens (human)3.6
TransporterRattus norvegicus (Norway rat)0.81
Sodium channel protein type 10 subunit alphaHomo sapiens (human)3.6

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Dalvie, D; Loi, CM; Smith, DA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Abadi, AH; Abdel-Halim, M; Engel, M; Fathalla, RK; Hammam, MA; Hartmann, RW; Hefnawy, A; Keeton, AB; Maher, A; Maxuitenko, Y; Piazza, GA; Racheed, NAS; Sigler, S1

Reviews

1 review(s) available for tadalafil and imipramine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

3 other study(ies) available for tadalafil and imipramine

ArticleYear
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
    Journal of medicinal chemistry, 2021, 04-22, Volume: 64, Issue:8

    Topics: Animals; Blood Proteins; Celecoxib; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Female; Half-Life; Humans; Isoenzymes; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phosphodiesterase 5 Inhibitors; Protein Binding; Pyrazoles; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship

2021