tadalafil has been researched along with hydantoins in 3 studies
| Studies (tadalafil) | Trials (tadalafil) | Recent Studies (post-2010) (tadalafil) | Studies (hydantoins) | Trials (hydantoins) | Recent Studies (post-2010) (hydantoins) |
|---|---|---|---|---|---|
| 1,742 | 392 | 1,089 | 3,404 | 80 | 435 |
| Protein | Taxonomy | tadalafil (IC50) | hydantoins (IC50) |
|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coste, H; Daugan, A; Grondin, P; Hyafil, F; Kirilovsky, J; Labaudinière, R; Le Monnier de Gouville, AC; Ruault, C | 1 |
| Coste, H; Daugan, A; Grondin, P; Hyafil, F; Kirilovsky, J; Labaudinière, R; Le Monnier de Gouville, AC; Linget, JM; Ruault, C | 1 |
| Abadi, AH; Ahmed, NS; Ali, AH; El-Nashar, SM; Fajardo, AM; Gary, BD; Negri, M; Piazza, GA; Tinsley, HN | 1 |
3 other study(ies) available for tadalafil and hydantoins
| Article | Year |
|---|---|
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Carbolines; Cattle; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Hydantoins; Indicators and Reagents; Isomerism; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Tadalafil | 2003 |
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Carbolines; Cattle; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Hydantoins; Indicators and Reagents; Isomerism; Models, Molecular; Molecular Conformation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Tadalafil | 2003 |
Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Carbolines; Cell Proliferation; Cyclic Nucleotide Phosphodiesterases, Type 5; Diketopiperazines; Drug Design; Enzyme Assays; Humans; Hydantoins; Hydrogen Bonding; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Phosphodiesterase 5 Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Secondary; Recombinant Proteins; Structure-Activity Relationship; Tadalafil; Thermodynamics | 2012 |