Compounds > tadalafil
Page last updated: 2024-09-02

tadalafil and fluoxetine

tadalafil has been researched along with fluoxetine in 5 studies

Compound Research Comparison

Studies
(tadalafil)		Trials
(tadalafil)		Recent Studies (post-2010)
(tadalafil)		Studies
(fluoxetine)		Trials
(fluoxetine)		Recent Studies (post-2010) (fluoxetine)
1,7423921,08910,1001,6633,263

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)fluoxetine (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)5.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.119
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.303
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.358
Cytochrome P450 2D6Homo sapiens (human)0.7
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.203
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)5.2
Alpha-2B adrenergic receptorHomo sapiens (human)1.528
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.595
AcetylcholinesteraseHomo sapiens (human)0.13
Prostaglandin G/H synthase 1Homo sapiens (human)6
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.8332
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.452
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.1395
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)5.2
Sodium-dependent serotonin transporterHomo sapiens (human)0.0342
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0538
Cytochrome P450 2C19Homo sapiens (human)0.0525
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)5.2
5-hydroxytryptamine receptor 6Homo sapiens (human)1.661
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)5.2
Sodium-dependent dopamine transporter Homo sapiens (human)5.984
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.3513
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)5.2
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0094
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)5.2
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.6751
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)5.2

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Hackett, G1
Marmo Lucon, A; Mattos, RM; Srougi, M1
Brand, L; Brink, CB; Harvey, BH; Liebenberg, N1

Reviews

1 review(s) available for tadalafil and fluoxetine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for tadalafil and fluoxetine

ArticleYear
Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study.
    Urologia internationalis, 2008, Volume: 80, Issue:2

    Topics: Adult; Carbolines; Double-Blind Method; Ejaculation; Fluoxetine; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Prospective Studies; Selective Serotonin Reuptake Inhibitors; Sexual Dysfunction, Physiological; Tadalafil; Time Factors

2008

Other Studies

3 other study(ies) available for tadalafil and fluoxetine

ArticleYear
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Confusion still reigns in premature ejaculation management.
    International journal of clinical practice, 2007, Volume: 61, Issue:6

    Topics: Carbolines; Drug Therapy, Combination; Ejaculation; Erectile Dysfunction; Fluoxetine; Humans; Male; Phosphodiesterase Inhibitors; Tadalafil; Treatment Outcome

2007
Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression.
    Behavioural pharmacology, 2010, Volume: 21, Issue:5-6

    Topics: Animals; Antidepressive Agents; Atropine; Behavior, Animal; Carbolines; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Swimming; Tadalafil

2010