Page last updated: 2024-09-02

tadalafil and finasteride

tadalafil has been researched along with finasteride in 13 studies

Compound Research Comparison

Studies
(tadalafil)
Trials
(tadalafil)
Recent Studies (post-2010)
(tadalafil)
Studies
(finasteride)
Trials
(finasteride)
Recent Studies (post-2010) (finasteride)
1,7423921,0892,514405867

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)finasteride (IC50)
Cytochrome P450 2C9 Homo sapiens (human)2
3-oxo-5-alpha-steroid 4-dehydrogenase 1Homo sapiens (human)0.295
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)0.0109
3-oxo-5-alpha-steroid 4-dehydrogenase 2Homo sapiens (human)0.0131
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)0.3286
Cytochrome P450 2C19Homo sapiens (human)1

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (76.92)24.3611
2020's3 (23.08)2.80

Authors

AuthorsStudies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Casabé, A; Da Pozzo, LF; Henderson, RJ; Henneges, C; Roehrborn, CG; Sorsaburu, S; Viktrup, L; Wong, DG; Zepeda, S1
Büttner, H; Esen, A; Glina, S; Henneges, C; Plekhanov, A; Roehrborn, CG; Sorsaburu, S; Viktrup, L1
Casabé, A; Glina, S; Henneges, C; Roehrborn, CG; Sorsaburu, S; Viktrup, L1
Oh-Oka, H1
Masumori, N1
Kaplan, SA1
Datla, PV; Kodali, B; Pappula, N1
Avcioglu, G; Ersoy, H; Gok, A; Gök, G; Imamoglu, MA; Karabacak, OR; Kartal, IG; Nural, C; Sagnak, AL; Topaloglu, H; Türkmenoglu, TT; Tuygun, C1
Bhojani, N; Nguyen, DD; Trinh, QD1
Abdelaziz, A; Batekh, AE; Emad, N; Galal, M; Hussien, M; Karem, M; Moukhtar, DA; Salem, H1

Reviews

1 review(s) available for tadalafil and finasteride

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

3 trial(s) available for tadalafil and finasteride

ArticleYear
Efficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia.
    The Journal of urology, 2014, Volume: 191, Issue:3

    Topics: Aged; Aged, 80 and over; Carbolines; Double-Blind Method; Drug Therapy, Combination; Finasteride; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Prostatic Hyperplasia; Tadalafil; Treatment Outcome; Urological Agents

2014
Sexual function in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: results of a 6-month, randomized, double-blind, placebo-controlled study of tadalafil coadministered with finasteride.
    The journal of sexual medicine, 2015, Volume: 12, Issue:1

    Topics: Carbolines; Coitus; Comorbidity; Double-Blind Method; Drug Therapy, Combination; Erectile Dysfunction; Finasteride; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Prostatic Hyperplasia; Tadalafil; Treatment Outcome

2015
Treatment satisfaction and clinically meaningful symptom improvement in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: Secondary results from a 6-month, randomized, double-blind study comparing f
    International journal of urology : official journal of the Japanese Urological Association, 2015, Volume: 22, Issue:6

    Topics: 5-alpha Reductase Inhibitors; Aged; Double-Blind Method; Drug Therapy, Combination; Finasteride; Humans; Male; Middle Aged; Organ Size; Patient Satisfaction; Phosphodiesterase 5 Inhibitors; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatism; Severity of Illness Index; Tadalafil

2015

Other Studies

9 other study(ies) available for tadalafil and finasteride

ArticleYear
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Editorial Comment from Dr Oh-oka to Treatment satisfaction and clinically meaningful symptom improvement in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: Secondary results from a 6-month, random
    International journal of urology : official journal of the Japanese Urological Association, 2015, Volume: 22, Issue:6

    Topics: 5-alpha Reductase Inhibitors; Finasteride; Humans; Male; Phosphodiesterase 5 Inhibitors; Prostatic Hyperplasia; Prostatism; Tadalafil

2015
Editorial Comment from Dr Masumori to Treatment satisfaction and clinically meaningful symptom improvement in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: Secondary results from a 6-month, rand
    International journal of urology : official journal of the Japanese Urological Association, 2015, Volume: 22, Issue:6

    Topics: 5-alpha Reductase Inhibitors; Finasteride; Humans; Male; Phosphodiesterase 5 Inhibitors; Prostatic Hyperplasia; Prostatism; Tadalafil

2015
Re: Treatment Satisfaction and Clinically Meaningful Symptom Improvement in Men with Lower Urinary Tract Symptoms and Prostatic Enlargement Secondary to Benign Prostatic Hyperplasia: Secondary Results from a 6-Month, Randomized, Double-Blind Study Compari
    The Journal of urology, 2016, Volume: 196, Issue:4

    Topics: Double-Blind Method; Finasteride; Humans; Lower Urinary Tract Symptoms; Male; Personal Satisfaction; Prostatic Hyperplasia; Tadalafil; Treatment Outcome

2016
Selective and rapid determination of tadalafil and finasteride using solid phase extraction by high performance liquid chromatography and tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2018, Apr-15, Volume: 152

    Topics: Calibration; Chromatography, High Pressure Liquid; Finasteride; Glyburide; Humans; Reproducibility of Results; Solid Phase Extraction; Tadalafil; Tandem Mass Spectrometry

2018
Does Tadalafil Increase The Uptake of Finasteride into Prostate Tissue? A Biochemical and Histological Evaluation in Rats.
    Urology journal, 2018, 11-17, Volume: 15, Issue:6

    Topics: Animals; Dihydrotestosterone; Epithelium; Finasteride; Male; Prostate; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tadalafil; Testosterone; Urological Agents

2018
Combination of Tadalafil and Finasteride for the Treatment of Urinary Tract Symptoms Related to Benign Prostatic Hyperplasia: Commercialization of the Prescribing Cascade.
    European urology, 2022, Volume: 81, Issue:4

    Topics: Drug Therapy, Combination; Finasteride; Humans; Lower Urinary Tract Symptoms; Male; Prostatic Hyperplasia; Tadalafil; Treatment Outcome; Urinary Tract

2022
A fixed-dose combination of finasteride and tadalafil (Entadfi) for BPH.
    The Medical letter on drugs and therapeutics, 2022, 09-05, Volume: 64, Issue:1658

    Topics: Drug Therapy, Combination; Finasteride; Humans; Male; Prostatic Hyperplasia; Tadalafil

2022
Synchronous fluorescence as a green and selective method for the simultaneous determination of finasteride and tadalafil in dosage form and spiked human plasma.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023, Oct-15, Volume: 299

    Topics: Capsules; Finasteride; Fluorescence; Humans; Male; Prostatic Hyperplasia; Spectrometry, Fluorescence; Tadalafil

2023