Page last updated: 2024-09-02

tadalafil and doxazosin

tadalafil has been researched along with doxazosin in 5 studies

Compound Research Comparison

Studies
(tadalafil)
Trials
(tadalafil)
Recent Studies (post-2010)
(tadalafil)
Studies
(doxazosin)
Trials
(doxazosin)
Recent Studies (post-2010) (doxazosin)
1,7423921,0891,372439283

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)doxazosin (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.544
Interstitial collagenaseHomo sapiens (human)5.749
Beta-2 adrenergic receptorHomo sapiens (human)2.748
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)2.2155
Alpha-1D adrenergic receptorHomo sapiens (human)0.0034
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.544
Sodium-dependent serotonin transporterHomo sapiens (human)2.688
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.368
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0007
Sodium-dependent dopamine transporter Homo sapiens (human)0.188
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4022
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)2.2155

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bedding, A; Emmick, JT; Jackson, G; Kloner, RA; Mitchell, MI; Pereira, A; Warner, MR1
Darstein, C; Guillaume, M; Jimenez, MC; Lonsdale, F; Mitchell, MI1
Brady, E; Clark, WR; Dgetluck, N; Goldfischer, E; Klise, SR; Kowalczyk, JJ; Shane, MA1
Afsar Yildirim, M; Akdeniz, F; Bozkurt, O; Çelik, S; Demir, O; Gursoy Bulut, M; Hacihasanoglu, ML1

Reviews

1 review(s) available for tadalafil and doxazosin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

3 trial(s) available for tadalafil and doxazosin

ArticleYear
Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men.
    The Journal of urology, 2004, Volume: 172, Issue:5 Pt 1

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenergic alpha-Antagonists; Aged; Carbolines; Cross-Over Studies; Cyclic Nucleotide Phosphodiesterases, Type 5; Double-Blind Method; Doxazosin; Drug Interactions; Hemodynamics; Humans; Male; Middle Aged; Phosphoric Diester Hydrolases; Sulfonamides; Tadalafil; Tamsulosin

2004
Hemodynamic interaction between a daily dosed phosphodiesterase 5 inhibitor, tadalafil, and the alpha-adrenergic blockers, doxazosin and tamsulosin, in middle-aged healthy male subjects.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:10

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Carbolines; Cross-Over Studies; Double-Blind Method; Doxazosin; Drug Interactions; Drug Therapy, Combination; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Sulfonamides; Tadalafil; Tamsulosin

2007
Hemodynamic effects of once-daily tadalafil in men with signs and symptoms of benign prostatic hyperplasia on concomitant α1-adrenergic antagonist therapy: results of a multicenter randomized, double-blind, placebo-controlled trial.
    Urology, 2012, Volume: 79, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Carbolines; Double-Blind Method; Doxazosin; Hemodynamics; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Prostatic Hyperplasia; Tadalafil

2012

Other Studies

1 other study(ies) available for tadalafil and doxazosin

ArticleYear
Tadalafil versus alpha blockers (alfuzosin, doxazosin, tamsulosin and silodosin) as medical expulsive therapy for < 10 mm distal and proximal ureteral stones.
    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 2018, Jun-30, Volume: 90, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Doxazosin; Female; Flank Pain; Humans; Indoles; Male; Middle Aged; Quinazolines; Retrospective Studies; Tadalafil; Tamsulosin; Tomography, X-Ray Computed; Treatment Outcome; Ureteral Calculi; Urological Agents; Young Adult

2018