Compounds > tadalafil
Page last updated: 2024-09-02

tadalafil and carvedilol

tadalafil has been researched along with carvedilol in 3 studies

Compound Research Comparison

Studies
(tadalafil)		Trials
(tadalafil)		Recent Studies (post-2010)
(tadalafil)		Studies
(carvedilol)		Trials
(carvedilol)		Recent Studies (post-2010) (carvedilol)
1,7423921,0892,9336801,052

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)carvedilol (IC50)
Solute carrier family 22 member 2Homo sapiens (human)7.5
Solute carrier family 22 member 1 Homo sapiens (human)3.4
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.115
Potassium channel subfamily K member 2Homo sapiens (human)1.6
Beta-2 adrenergic receptorHomo sapiens (human)0.0002
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.538
ATP-dependent translocase ABCB1Homo sapiens (human)5.7333
Beta-1 adrenergic receptorHomo sapiens (human)0.0002
Alpha-2A adrenergic receptorHomo sapiens (human)0.106
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)4.1193
Beta-3 adrenergic receptorHomo sapiens (human)0.0042
D(2) dopamine receptorHomo sapiens (human)0.146
Alpha-2B adrenergic receptorHomo sapiens (human)0.094
Alpha-2C adrenergic receptorHomo sapiens (human)0.09
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0058
D(1A) dopamine receptorHomo sapiens (human)1.498
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.538
Alpha-1D adrenergic receptorHomo sapiens (human)0.0018
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.41
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.115
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.0058
Sodium-dependent serotonin transporterHomo sapiens (human)0.221
D(3) dopamine receptorHomo sapiens (human)0.577
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.023
5-hydroxytryptamine receptor 6Homo sapiens (human)1.519
Potassium channel subfamily K member 10Homo sapiens (human)7.6
Sodium-dependent dopamine transporter Homo sapiens (human)0.845
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.2346
Cytochrome P450 1B1Homo sapiens (human)1.1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)4.1193

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Faller, B; Trunzer, M; Zimmerlin, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for tadalafil and carvedilol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

2 other study(ies) available for tadalafil and carvedilol

ArticleYear
Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.
    Journal of medicinal chemistry, 2009, Jan-22, Volume: 52, Issue:2

    Topics: Chromatography, Liquid; Drug Design; Humans; Likelihood Functions; Microsomes, Liver; Pharmacokinetics; Tandem Mass Spectrometry

2009
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013