Compounds > tadalafil
Page last updated: 2024-09-02

tadalafil and amitriptyline

tadalafil has been researched along with amitriptyline in 2 studies

Compound Research Comparison

Studies
(tadalafil)		Trials
(tadalafil)		Recent Studies (post-2010)
(tadalafil)		Studies
(amitriptyline)		Trials
(amitriptyline)		Recent Studies (post-2010) (amitriptyline)
1,7423921,0896,9351,3811,060

Protein Interaction Comparison

ProteinTaxonomytadalafil (IC50)amitriptyline (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.006
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.023
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.081
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.0053
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.3
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.044
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.008
Alpha-2A adrenergic receptorHomo sapiens (human)0.1755
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.011
D(2) dopamine receptorHomo sapiens (human)1.009
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.044
Alpha-2B adrenergic receptorHomo sapiens (human)0.004
Alpha-2C adrenergic receptorHomo sapiens (human)0.0295
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.02
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.026
D(1A) dopamine receptorHomo sapiens (human)0.355
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.0324
Histamine H2 receptorHomo sapiens (human)0.73
Alpha-1D adrenergic receptorHomo sapiens (human)0.105
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.015
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.006
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.02
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)0.044
Sodium-dependent serotonin transporterHomo sapiens (human)0.2756
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)0.044
Histamine H1 receptorHomo sapiens (human)0.0048
D(3) dopamine receptorHomo sapiens (human)0.182
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.07
Histamine H2 receptorCavia porcellus (domestic guinea pig)0.66
5-hydroxytryptamine receptor 6Homo sapiens (human)0.14
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)7.2446
Sodium channel protein type 5 subunit alphaHomo sapiens (human)1.6
Sodium channel protein type 9 subunit alphaHomo sapiens (human)4
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)0.044
Sodium channel protein type 2 subunit alphaHomo sapiens (human)3.1
Sigma non-opioid intracellular receptor 1Homo sapiens (human)1.031
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.044

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for tadalafil and amitriptyline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

1 other study(ies) available for tadalafil and amitriptyline

ArticleYear
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013