tacrolimus and tariquidar

tacrolimus has been researched along with tariquidar* in 1 studies

Other Studies

1 other study(ies) available for tacrolimus and tariquidar

Article	Year
Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia. Nature neuroscience, 2006, Volume: 9, Issue:4 The blood-brain barrier possesses active transporters carrying brain-permeable xenobiotics back into the blood against concentration gradients. We demonstrate that multidrug resistance transporter (Mdr)-1 is upregulated on capillary endothelium after focal cerebral ischemia; moreover, Mdr-1 deactivation by pharmacological inhibition or genetic knockout preferably enhances the accumulation and efficacy of two neuroprotectants known as Mdr-1 substrates in the ischemic brain. We predict that Mdr-1 inhibition may greatly facilitate neuroprotective therapies. Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Brain Ischemia; Capillaries; Cerebrovascular Circulation; Endothelium, Vascular; Enzyme Inhibitors; Immunosuppressive Agents; Mice; Mice, Knockout; Neuroprotective Agents; Quinolines; Rifampin; Tacrolimus	2006

Article

Year

Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia.

Nature neuroscience, 2006, Volume: 9, Issue:4

The blood-brain barrier possesses active transporters carrying brain-permeable xenobiotics back into the blood against concentration gradients. We demonstrate that multidrug resistance transporter (Mdr)-1 is upregulated on capillary endothelium after focal cerebral ischemia; moreover, Mdr-1 deactivation by pharmacological inhibition or genetic knockout preferably enhances the accumulation and efficacy of two neuroprotectants known as Mdr-1 substrates in the ischemic brain. We predict that Mdr-1 inhibition may greatly facilitate neuroprotective therapies.

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Brain Ischemia; Capillaries; Cerebrovascular Circulation; Endothelium, Vascular; Enzyme Inhibitors; Immunosuppressive Agents; Mice; Mice, Knockout; Neuroprotective Agents; Quinolines; Rifampin; Tacrolimus

2006