tacrolimus has been researched along with propylene-carbonate* in 1 studies
1 other study(ies) available for tacrolimus and propylene-carbonate
| Article | Year |
|---|---|
In vitro release of Tacrolimus from Tacrolimus ointment and its speculated mechanism.
The in vitro release profiles and the bleeding phenomenon of Tacrolimus and propylene carbonate (PC) as a dispersing solvent for Tacrolimus drug substance in Tacrolimus ointment were investigated when changing concentrations of Tacrolimus and PC in the ointment were used, respectively. The bleeding test result indicated that Tacrolimus was in equilibrium between inside and outside of PC droplets in intact ointment base. A cumulative release amount of Tacrolimus from ointment, plotted against the square root of time, showed a straight line initially with a slope of q1 followed to change a slope to be q2 at a certain time, where the relation of these slopes being q1 Topics: Chemistry, Pharmaceutical; Immunosuppressive Agents; Ointments; Propane; Solvents; Tacrolimus; Thermodynamics | 2004 |