tacrolimus has been researched along with nonactin* in 1 studies
1 other study(ies) available for tacrolimus and nonactin
| Article | Year |
|---|---|
Control of IL-5 production by human helper T cells as a treatment for eosinophilic inflammation: comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors.
Helper T cells are involved in the pathophysiologic condition of asthma, so modulation of cytokine production may be effective therapy.. We aimed to selectively control the synthesis of IL-5 by helper T cells and tested in vivo effects using a murine asthma model.. The effect of dexamethasone, FK506, cyclosporin A, and nonactin (a macrolide compound produced by Streptomyces griseus) on cytokine production by allergen-specific T-cell clones was determined. The effect of these agents and an anti-IL-5 neutralizing antibody on airway eosinophilic inflammation was investigated in a murine asthma model.. Dexamethasone, FK506, and cyclosporin A suppressed the production of IL-2, IL-4, and IL-5 by human helper T cells, which shows a similar concentration-response relationship in each case. Cyclosporin A and dexamethasone inhibited airway eosinophilia in vivo. Nonactin suppressed IL-5 synthesis but not IL-2 or IL-4 synthesis, and it also significantly suppressed airway eosinophilia.. Nonactin only suppressed IL-5 synthesis and was as effective against eosinophilia as cyclosporin A and dexa-methasone, which indicates that IL-5 is a reasonable therapeutic target in allergic disorders that are accompanied by eosinophilic inflammation. Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Asthma; Clone Cells; Cyclosporine; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Humans; Immunosuppressive Agents; Inflammation; Interleukin-2; Interleukin-4; Interleukin-5; Macrolides; Mice; Mice, Inbred BALB C; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Tacrolimus | 2000 |