tacrine has been researched along with warfarin in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Garnett, WR; Rajagopalan, R; Reece, PA; Rock, WL; Sedman, AJ; Taylor, JR; Underwood, B | 1 |
| Walsh, AC | 1 |
| Chai, KY; Chung, HT; Jeong, OS; Jun, JY; Kim, T; Kim, YC; Kwon, TO; Lee, HS; Oh, H; Yun, YG | 1 |
| Kang, TH; Kim, YC; Oh, H; Park, EJ; Sohn, DH | 1 |
| Gainullina, ET; Kondratyev, KV; Ryzhikov, SB; Taranchenko, VF | 1 |
| Cardoso, CL; Cass, QB; Corrêa, AG; Vanzolini, KL; Vieira, LC | 1 |
| Kong, LY; Li, JY; Wang, XB; Xie, SS; Yang, L | 1 |
| Alipour, M; Foroumadi, A; Ghandi, M; Khoobi, M; Moradi, A; Nadri, H; Razavi, SF; Sakhteman, A; Shafiee, A | 1 |
| Peng, DY; Sun, Q; Yang, GF; Yang, SG; Yang, WC; Zhu, XL | 1 |
| Hamulakova, S; Hrabinova, M; Imrich, J; Janovec, L; Korabecny, J; Kristian, P; Kuca, K; Spilovska, K | 1 |
| Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W | 1 |
| Bednarikova, Z; Brezova, V; Drostinova, L; Gazova, Z; Hamulakova, S; Hrabinova, M; Jomova, K; Jun, D; Kristian, P; Kuca, K; Lauro, P; Poprac, P; Sepsova, V; Soukup, O; Valko, M | 1 |
| Abbasi, MSA; Afridi, S; Bajorath, J; Furtmann, N; Iqbal, J; Langer, P; Zaib, S | 1 |
| Bednarikova, Z; Gazova, Z; Hamulakova, S; Holztragerova, M; Hsu, WT; Ulicna, K; Wang, SS; Wu, JW | 1 |
| Hamulakova, S; Hrabinova, M; Janockova, J; Janovec, L; Jun, D; Kuca, K; Sepsova, V; Soukup, O | 1 |
| Correa, AG; Ferreira, AG; Gul, S; Mehmood, M; Monteiro, JL; Tanoli, NU; Tanoli, SAK; Ul-Haq, Z; Venâncio, T; Vieira, LCC | 1 |
| Akbarzadeh, T; Edraki, N; Karimpour-Razkenari, E; Khanavi, M; Mahdavi, M; Najafi, Z; Saeedi, M; Sharifzadeh, M | 1 |
| Fedoročko, P; Hamuľaková, S; Hudáčová, M; Jendželovský, R; Konkoľová, E; Kožurková, M; Ševc, J; Vargová, J | 1 |
| Banerjee, A; Bhatia, R; Chakrabarti, SS; Kaur, U; Parashar, G; Rawal, RK | 1 |
1 review(s) available for tacrine and warfarin
| Article | Year |
|---|---|
Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Coumarins; Humans; Ligands; Structure-Activity Relationship; Tacrine | 2021 |
28 other study(ies) available for tacrine and warfarin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Lack of effect of tacrine administration on the anticoagulant activity of warfarin.
Topics: Aged; Aged, 80 and over; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Prothrombin Time; Tacrine; Time Factors; Warfarin | 1995 |
Anticoagulant therapy and Alzheimer's disease.
Topics: Alzheimer Disease; Anticoagulants; Clinical Trials as Topic; Dementia, Vascular; Humans; Tacrine; Warfarin | 1993 |
Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.
Topics: Angelica; Carcinoma, Hepatocellular; Coumarins; Furans; Furocoumarins; Humans; Medicine, East Asian Traditional; Molecular Structure; Plant Extracts; Plant Roots; Tacrine; Tumor Cells, Cultured | 2002 |
An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa.
Topics: Agrimonia; Animals; Cell Line, Tumor; Coumarins; Hepatocytes; Humans; Male; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Tacrine; tert-Butylhydroperoxide | 2004 |
Fluorescent method for evaluation of cholinesterase inhibitors.
Topics: Animals; Buffers; Butyrylcholinesterase; Butyrylthiocholine; Cholinesterase Inhibitors; Coumarins; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Fluorescent Dyes; Horses; Hydrogen-Ion Concentration; Kinetics; Phosphates; Sensitivity and Specificity; Spectrometry, Fluorescence; Tacrine | 2006 |
Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Chromatography, Liquid; Coumarins; Enzymes, Immobilized; Galantamine; High-Throughput Screening Assays; Inhibitory Concentration 50; Kinetics; Ligands; Tacrine; Tandem Mass Spectrometry | 2013 |
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tacrine | 2013 |
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.
Topics: Acetylcholinesterase; Benzopyrans; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumarins; Drug Design; Enzyme Activation; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Tacrine | 2013 |
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Tacrine | 2014 |
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Coumarins; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Structure-Activity Relationship; Tacrine | 2014 |
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine | 2015 |
Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Copper; Coumarins; GPI-Linked Proteins; Humans; Oxidative Stress; Peptide Fragments; Tacrine | 2016 |
Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Coumarins; Humans; Molecular Docking Simulation; Protein Binding; Tacrine | 2018 |
Lysozyme amyloid fibrillization in presence of tacrine/acridone-coumarin heterodimers.
Topics: Amyloid; Coumarins; Humans; Microscopy, Atomic Force; Muramidase; Tacrine | 2018 |
Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.
Topics: Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Coumarins; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Permeability; Structure-Activity Relationship; Tacrine; Thiourea | 2018 |
Characterization of the interactions between coumarin-derivatives and acetylcholinesterase: Examination by NMR and docking simulations.
Topics: Acetylcholinesterase; Animals; Binding Sites; Cholinesterase Inhibitors; Coumarins; Crystallography, X-Ray; Electrophorus; GPI-Linked Proteins; Humans; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Nootropic Agents; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Tacrine; Thermodynamics | 2018 |
Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer's compounds: In vitro and in vivo biological evaluation and docking study.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Cholinesterase Inhibitors; Coumarins; Humans; Male; Maze Learning; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Nootropic Agents; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Tacrine; Torpedo; Triazoles | 2019 |
Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines.
Topics: A549 Cells; Antineoplastic Agents; Cell Proliferation; Coumarins; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Poly-ADP-Ribose Binding Proteins; Tacrine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 2021 |