tacrine has been researched along with scopolamine hydrobromide in 93 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.30) | 18.7374 |
| 1990's | 44 (47.31) | 18.2507 |
| 2000's | 28 (30.11) | 29.6817 |
| 2010's | 17 (18.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blitzer, RD; Cornfeldt, M; Davis, L; Effland, RC; Haroutunian, V; Huger, FP; Klein, JT; Landau, E; Martin, LL; Olsen, GE; Petko, WW; Smith, CP; Wilker, JC; Wong, GS | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Bard, B; Carrupt, PA; Martel, S | 1 |
| Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Cai, P; Kong, LY; Liu, QH; Wang, XB; Wang, ZM; Wu, JJ; Xu, DQ; Yang, XL | 1 |
| Airaksinen, MM; Koivisto, E; Lammintausta, R; Lukkarinen, K; Miettinen, R; Riekkinen, P; Valjakka, A | 1 |
| Briley, M; Chopin, P | 1 |
| Cross, AJ; Green, AR; Murray, TK | 1 |
| Jertz, G; Murphy, M; Pinker, S; Siegfried, K; Simpson, PM; Wesnes, KA; White, L | 1 |
| Abe, E | 1 |
| Jäkälä, P; Koivisto, E; Miettinen, R; Riekkinen, P; Sirviö, J | 1 |
| Burov, IuV; Kadysheva, LV; Robakidze, TN; Sukhanova, SA | 1 |
| Burov, IuV; Kadysheva, LV; Robakidze, TN; Shaposhnikova, GI; Voronin, AE | 1 |
| Miyoshi, K; Ueki, A | 1 |
| Dokla, CP; Rydelek-Fitzgerald, L | 1 |
| Peters, SC; Shannon, HE | 1 |
| Bemis, KG; Hendrix, JC; Shannon, HE; Ward, JS | 1 |
| Itoh, J; Kameyama, T; Nabeshima, T | 1 |
| Hayashi, S; Sakurai, M; Tanaka, Y | 1 |
| Bores, GM; Cornfeldt, ML; Davis, KL; Haroutunian, V; Huger, FP; Kapples, KJ; Pierrat, FA; Shutske, GM; Szewczak, MR | 1 |
| Pearce, BD; Potter, LT | 1 |
| Brinkman, SD; Gershon, S | 1 |
| Barnes, JC; Higgins, GA; Jones, DN; Kirkby, DL | 1 |
| Baĭmanov, TD; Burov, IuV; Robakidze, TN | 1 |
| Barzaghi, F; M'Harzi, M; Oberlander, C; Palou, AM | 1 |
| Herremans, AH; Hijzen, TH; Olivier, B; Slangen, JL | 1 |
| Fitten, LJ; Halgren, E; O'Neill, J; Perryman, KM | 1 |
| Adem, A; Henriksson, BE; Mohammed, AH; Winblad, B | 1 |
| Egawa, M; Eguchi, J; Tobe, A; Yuasa, T | 1 |
| Ano, M; Hirata, K; Kitamura, K; Maekawa, M; Narita, H; Ono, S; Ukai, W; Yamafuji, T | 1 |
| Suzuki, N; Yoshida, S | 1 |
| Siegfried, KR | 1 |
| Ekonsalo, T; Fisher, A; Riekkinen, M; Riekkinen, P; Sirviö, J | 1 |
| Kitajima, I; Ohno, M; Ueki, S; Yamamoto, T; Yatsugi, S | 1 |
| Atterwill, C; Dewhurst, BB; Starr, B; Walker, TM | 1 |
| Camacho, F; Winslow, JT | 1 |
| Jackson, JJ; Soliman, MR | 1 |
| Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M | 1 |
| Kobayashi, T; Matsuno, K; Mita, S; Nakata, K; Okamoto, K; Senda, T | 1 |
| Carriero, DL; Cousins, MS; Gianutsos, G; Mayorga, AJ; Salamone, JD | 1 |
| Cheng, DH; Ren, H; Tang, XC | 1 |
| Harder, JA; Kelly, ME | 1 |
| Barzaghi, F; Gieules, C; M'Harzi, M; Oberlander, C; Palou, AM; Willig, F | 1 |
| Ando, I; Kakiuchi, T; Ouchi, Y; Tsukada, H | 1 |
| Kojima, J; Nakajima, K; Nakayama, K; Ochiai, M | 1 |
| Braida, D; Colibretti, L; Griffini, P; Lamperti, M; Paladini, E; Sala, M | 1 |
| Tang, XC; Wang, T | 1 |
| Borisova, AO; Burov, IuV; Goncharenko, SB; Robakidze, TN | 1 |
| Cassel, JC; Kelche, C; Stemmelin, J; Will, B | 1 |
| Callahan, MJ | 1 |
| Carlier, PR; Han, YF; Ho, WL; Lee, NT; Pang, YP; Wang, H | 1 |
| Bejar, C; Wang, RH; Weinstock, M | 1 |
| Huston, JP; Schildein, S; Schwarting, RK | 1 |
| Braida, D; Ottonello, F; Sala, M; Virag, W | 1 |
| Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y | 1 |
| Diavolitsis, P; Dringenberg, HC; Laporte, PP | 1 |
| Han, YF; Pan, SY | 1 |
| Diavolitsis, P; Dringenberg, HC | 1 |
| Carvalho, RC; Costa, KL; Frussa-Filho, R; Kameda, SR; Rigo, GS; Silva, RH; Taricano, ID | 1 |
| Higashi, M; Kawashima, S; Matsuno, T; Yamaguchi, Y | 1 |
| Chopin, P; Colpaert, FC; Marien, M | 1 |
| Chen, Z; Li, R; Wei, EQ; Xu, AJ | 1 |
| Bruce, A; Dringenberg, HC; Rubenstein, ML; Solty, H; Tomaszek, S | 1 |
| Bruins Slot, LA; Chopin, P; Colpaert, FC | 1 |
| Del Río, J; Diez-Ariza, M; García-Alloza, M; Lasheras, B; Ramírez, MJ; Redondo, C | 1 |
| Carelli, V; Di Stefano, A; Giorgioni, G; Liberatore, F; Marra, R; Rispoli, V; Rotiroti, D; Scipione, L | 1 |
| Bermudez, I; Groot-Kormelink, PJ; Smulders, CJ; van Kleef, RG; Vijverberg, HP; Zwart, R | 1 |
| Das, A; Dikshit, M; Nath, C | 1 |
| Dong So, D; Han, Y; Law, SL; Xu, Z; Xue, H; Zheng, H | 1 |
| Foley, AG; Murphy, KJ; O'connell, AW; Regan, CM | 1 |
| Carelli, V; Costa, N; De Vita, D; Liberatore, F; Marra, R; Rispoli, V; Rotiroti, D; Scipione, L | 1 |
| Choi, JS; Jung, JW; Kim, DH; Kim, HJ; Kim, SY; Kim, YW; Lee, KT; Lee, S; Lee, YS; Ryu, JH; Shin, BY; Yoon, BH | 1 |
| Appenroth, D; Decker, M; Fang, L; Fleck, C; Kiehntopf, M; Lehmann, J; Lupp, A; Peng, S; Zhang, Y | 1 |
| Dong, H; Fang, HY; Ko, KM; Pan, SY; Xiang, CJ; Yu, ZL | 1 |
| Assini, FL; Duzzioni, M; Takahashi, RN | 1 |
| Dardenne, B; Detrait, ER; Hanon, E; Lamberty, Y | 1 |
| Appenroth, D; Decker, M; Fang, L; Fleck, C; Lehmann, J; Schott, Y | 1 |
| Joh, EH; Kim, DH; Lee, IA | 1 |
| Chen, XN; Cheng, LL; Du, JR; Kuang, X; Wang, LL; Wang, Y; Yang, W; Yu, L | 1 |
| Chang, M; Choi, CL; Han, RW; Han, YF; Hu, SQ; Peng, YL; Wang, P; Wang, R; Yin, M; Zhang, RS | 1 |
| Adeyemi, OO; Agbaje, EO; Ishola, IO; Shukla, R; Tota, S | 1 |
| Adeyemi, OO; Agbaje, EO; Ishola, IO; Narender, T; Shukla, R; Tota, S | 1 |
| Beniashvily, AG; Bondarenko, EV; Burminskiy, DS; Ivachtchenko, AV; Kazey, VI; Lavrovsky, Y; Lepilkina, TA; Morozova, MA; Potanin, SS; Rupchev, GE | 1 |
| Ahnaou, A; Drinkenburg, WH; Huysmans, H; Jacobs, T | 1 |
| Han, JM; Kim, DW; Kim, HG; Lee, HW; Lee, JS; Lee, SK; Saravanakumar, A; Son, CG | 1 |
| Arunrungvichian, K; Boonyarat, C; Fokin, VV; Taylor, P; Vajragupta, O | 1 |
| Fernandez, AP; Futch, HS; Herrero-Labrador, R; Marco-Contelles, J; Martínez-Murillo, R; Romero, A; Samadi, A; Serrano, J; Serrano, MP; Unzeta, M | 1 |
| Bian, Y; Chen, Y; Li, Q; Lin, H; Mo, J; Pei, Y; Sun, H; Yang, H; Zhu, J | 1 |
| Chen, H; Cui, W; Han, Y; Hu, S; Huang, L; Lin, J; Mak, SH; Wang, C; Wang, Q; Xiang, S | 1 |
| Ahmadi, A; Nahri-Niknafs, B; Noori, S; Roghani, M | 1 |
2 review(s) available for tacrine and scopolamine hydrobromide
| Article | Year |
|---|---|
Measurement of cholinergic drug effects on memory in Alzheimer's disease.
Topics: Alzheimer Disease; Arecoline; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Memory; Memory Disorders; Parasympatholytics; Parasympathomimetics; Physostigmine; Scopolamine; Tacrine | 1983 |
Pharmacodynamic and early clinical studies with velnacrine.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Placebos; Scopolamine; Tacrine; Tomography, Emission-Computed, Single-Photon | 1993 |
3 trial(s) available for tacrine and scopolamine hydrobromide
| Article | Year |
|---|---|
Measurement of cholinergic drug effects on memory in Alzheimer's disease.
Topics: Alzheimer Disease; Arecoline; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Memory; Memory Disorders; Parasympatholytics; Parasympathomimetics; Physostigmine; Scopolamine; Tacrine | 1983 |
Pharmacodynamic and early clinical studies with velnacrine.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Placebos; Scopolamine; Tacrine; Tomography, Emission-Computed, Single-Photon | 1993 |
Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study.
Topics: Adult; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Middle Aged; Pilot Projects; Piperidines; Prepulse Inhibition; Pyrazoles; Pyrimidines; Reaction Time; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Scopolamine; Serotonin Antagonists; Tacrine; Treatment Outcome; Young Adult | 2014 |
90 other study(ies) available for tacrine and scopolamine hydrobromide
| Article | Year |
|---|---|
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biogenic Amines; Brain; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Parasympatholytics; Pyridines; Rats; Structure-Activity Relationship | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations | 2002 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical | 2009 |
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Copper; Donepezil; Drug Design; Humans; Indans; Kinetics; Liver; Mice; Models, Molecular; Peptide Fragments; Piperidines; Protein Aggregates; Protein Conformation | 2016 |
Modulation of EEG rhythmicity and spike activity in the rat hippocampus by systemically administered tetrahydroaminoacridine, scopolamine and atipamezole.
Topics: Adrenergic alpha-Antagonists; Animals; Electrodes, Implanted; Electroencephalography; Hippocampus; Imidazoles; Injections; Male; Rats; Rats, Inbred Strains; Scopolamine; Tacrine; Theta Rhythm | 1991 |
Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats.
Topics: Amnesia; Animals; Avoidance Learning; Cognition; Dihydroergotoxine; Dose-Response Relationship, Drug; Galantamine; Ginkgo biloba; Male; Nicergoline; Piracetam; Plant Extracts; Rats; Rats, Inbred Strains; Scopolamine; Secologanin Tryptamine Alkaloids; Tacrine; Yohimbine | 1992 |
Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats.
Topics: Animals; Conditioning, Operant; Male; Memory; Physostigmine; Psychomotor Performance; Rats; Scopolamine; Tacrine | 1991 |
Cholinesterase inhibition in the scopolamine model of dementia.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Humans; Memory; Scopolamine; Tacrine | 1991 |
Reversal effect of DM-9384 on scopolamine-induced acetylcholine depletion in certain regions of the mouse brain.
Topics: Acetylcholine; Amnesia; Animals; Brain Chemistry; Central Nervous System Agents; Male; Mice; Mice, Inbred Strains; Parasympathetic Nervous System; Physostigmine; Pyrrolidines; Pyrrolidinones; Scopolamine; Tacrine | 1991 |
The effects of THA on scopolamine and nucleus basalis lesion-induced EEG slowing.
Topics: Acetylcholinesterase; Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; Electroencephalography; Male; Organ Specificity; Pilocarpine; Rats; Rats, Inbred Strains; Scopolamine; Tacrine | 1991 |
[Experimental study of the effects of amiridin and tacrine on learning and memory].
Topics: Acetylcholinesterase; Aminoquinolines; Amnesia; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Dementia; In Vitro Techniques; Learning; Male; Memory; Mice; Psychotropic Drugs; Rats; Scopolamine; Tacrine | 1991 |
[Study of anti-amnesic activity of amiridin in a model of amnesic syndrome].
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Cerebral Cortex; Cholinesterase Inhibitors; In Vitro Techniques; Lipids; Male; Physostigmine; Piracetam; Psychotropic Drugs; Rats; Scopolamine; Synaptosomes; Syndrome; Tacrine | 1991 |
[Cholinesterase inhibitor].
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Humans; Learning Disabilities; Memory; Neurons; Physostigmine; Scopolamine; Tacrine | 1991 |
Comparison of tetrahydroaminoacridine and physostigmine on scopolamine-induced free swim behavior in the rat.
Topics: Animals; Behavior, Animal; Male; Physostigmine; Rats; Scopolamine; Swimming; Tacrine | 1991 |
A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Ergolines; Male; Mice; Motor Activity; Oxotremorine; Quinpirole; Receptors, Cholinergic; Receptors, Dopamine; Scopolamine; Tacrine | 1990 |
Interactions between scopolamine and muscarinic cholinergic agonists or cholinesterase inhibitors on spatial alternation performance in rats.
Topics: Animals; Arecoline; Behavior, Animal; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory; Oxotremorine; Parasympathomimetics; Physostigmine; Pilocarpine; Rats; Rats, Inbred F344; Scopolamine; Spatial Behavior; Succinimides; Tacrine | 1990 |
Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock.
Topics: Amnesia; Animals; Electroshock; Injections, Intraventricular; Male; Memory; Mice; Mice, Inbred Strains; Physostigmine; Psychotropic Drugs; Pyrrolidinones; Scopolamine; Tacrine | 1990 |
Effect of scopolamine and HP 029, a cholinesterase inhibitor, on long-term potentiation in hippocampal slices of the guinea pig.
Topics: Action Potentials; Aminoacridines; Animals; Cholinergic Fibers; Cholinesterase Inhibitors; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Scopolamine; Tacrine; Time Factors | 1989 |
9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.
Topics: Alzheimer Disease; Aminoacridines; Animals; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Male; Memory; Mice; Rats; Rats, Inbred Strains; Scopolamine; Structure-Activity Relationship; Tacrine | 1989 |
Effects of tetrahydroaminoacridine on M1 and M2 muscarine receptors.
Topics: Acetylcholinesterase; Aminoacridines; Animals; Binding, Competitive; Brain Stem; Butyrylcholinesterase; Hippocampus; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine; Tacrine | 1988 |
Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems.
Topics: Aging; Animals; Attention; Behavior, Animal; Cholinergic Agents; Exploratory Behavior; Male; Mecamylamine; Motor Activity; Parasympathetic Nervous System; Rats; Rats, Inbred Strains; Reaction Time; Scopolamine; Tacrine | 1995 |
[The effect of amiridine and tacrine on reversible capture of neuromediators in experimental memory disorders].
Topics: Aminoquinolines; Animals; Biogenic Monoamines; Cholinesterase Inhibitors; Disease Models, Animal; Male; Memory Disorders; Neurotransmitter Agents; Nootropic Agents; Rats; Scopolamine; Tacrine | 1995 |
Antagonism of scopolamine-induced memory impairments in rats by the muscarinic agonist RU 35,926 (CI-979).
Topics: Animals; Dihydropyridines; Male; Maze Learning; Memory; Memory, Short-Term; Muscarinic Agonists; Oximes; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine; Synaptic Transmission; Tacrine | 1995 |
Cholinergic drug effects on a delayed conditional discrimination task in the rat.
Topics: Animals; Appetitive Behavior; Arecoline; Brain; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mental Recall; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Physostigmine; Rats; Rats, Wistar; Receptors, Cholinergic; Retention, Psychology; Scopolamine; Scopolamine Derivatives; Synaptic Transmission; Tacrine | 1995 |
Influence of cholinesterase inhibitors on cortical slow-wave activity in aging nonhuman primate.
Topics: Aging; Amodiaquine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Electrodes; Electroencephalography; Female; Macaca radiata; Physostigmine; Scopolamine; Tacrine | 1994 |
A novel anticholinesterase THB013: biochemical and behavioural studies.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Cholinesterase Inhibitors; Male; Maze Learning; Models, Biological; Rats; Receptors, Muscarinic; Scopolamine; Tacrine | 1994 |
Effects of a novel compound MCI-225 on impaired learning and memory in rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Carbon Dioxide; Cholinesterase Inhibitors; Learning Disabilities; Male; Memory Disorders; Motor Activity; Orientation; Piperazines; Psychotropic Drugs; Pyrimidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1994 |
Protective effect of R(-)-1-(benzo[b]thiophen-5-yl)- 2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride (T-588), a novel cerebral activator, against experimental cerebral anoxia.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Diethylamines; Energy Metabolism; Glycolysis; Hypoxia, Brain; Imipramine; Male; Mice; Mice, Inbred Strains; Pentobarbital; Potassium Cyanide; Scopolamine; Sleep; Tacrine; Thiophenes | 1993 |
Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats.
Topics: Administration, Oral; Aminoquinolines; Amnesia; Animals; Avoidance Learning; Body Temperature; Cholinesterase Inhibitors; Injections, Intraperitoneal; Miosis; Physostigmine; Psychotropic Drugs; Rats; Salivation; Scopolamine; Tacrine; Tremor | 1993 |
Effects of muscarinic receptor agonists and anticholinesterase drugs on high voltage spindles and slow waves.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Electroencephalography; Male; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Tacrine | 1993 |
Ameliorative effects of the centrally active cholinesterase inhibitor, NIK-247, on impairment of working memory in rats.
Topics: Acetylcholinesterase; Aminoquinolines; Animals; Appetitive Behavior; Brain; Cholinesterase Inhibitors; Hippocampus; Male; Mental Recall; Orientation; Physostigmine; Psychotropic Drugs; Rats; Rats, Wistar; Receptors, Cholinergic; Regional Blood Flow; Retention, Psychology; Scopolamine; Tacrine | 1993 |
Potential neurotoxicity of a novel aminoacridine analogue.
Topics: Aminoacridines; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Exploratory Behavior; Memory; Metallothionein; Mice; Neuroblastoma; Neurotoxins; Neutral Red; Oxidation-Reduction; Scopolamine; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured | 1995 |
Cholinergic modulation of a decrement in social investigation following repeated contacts between mice.
Topics: Aggression; Animals; Behavior, Animal; Female; Interpersonal Relations; Male; Memory; Mice; Mice, Inbred Strains; Ovariectomy; Scopolamine; Smell; Tacrine | 1995 |
Effects of tacrine (THA) on spatial reference memory and cholinergic enzymes in specific rat brain regions.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Male; Memory; Parasympatholytics; Rats; Rats, Sprague-Dawley; Scopolamine; Spatial Behavior; Tacrine | 1996 |
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1996 |
Ameliorating effect of SA4503, a novel sigma 1 receptor agonist, on memory impairments induced by cholinergic dysfunction in rats.
Topics: Animals; Avoidance Learning; Guinea Pigs; Ibotenic Acid; Male; Memory; Memory Disorders; Nootropic Agents; Pain Measurement; Pentazocine; Piperazines; Prosencephalon; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, sigma; Scopolamine; Tacrine | 1996 |
Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Jaw; Male; Muscarinic Antagonists; Parasympathomimetics; Parkinson Disease; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine; Tremor | 1997 |
Huperzine A, a novel promising acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1996 |
The effect of several putative cognition enhancers on a water maze acquisition deficit produced by pCPA + scopolamine combination treatment.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cholinesterase Inhibitors; Cognition; Drug Interactions; Fenclonine; Male; Maze Learning; Muscarinic Agonists; Muscarinic Antagonists; Ondansetron; Oxotremorine; Rats; Scopolamine; Serotonin Agents; Serotonin Antagonists; Tacrine | 1997 |
Ameliorating effects of RU 47213, a novel oral and long-lasting cholinomimetic agent, on working memory impairments in rats.
Topics: Animals; Cholinergic Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Antagonism; Male; Maze Learning; Memory; Muscarinic Antagonists; Pyridines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1997 |
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys.
Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Physostigmine; Piperidines; Scopolamine; Tacrine; Tomography, Emission-Computed | 1997 |
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Motor Activity; Piperidines; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine; Tacrine | 1997 |
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
Topics: Amnesia; Animals; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Indans; Male; Maze Learning; Morpholines; Motor Activity; Muscarinic Antagonists; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1998 |
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1998 |
[Effect of the new 9-aminoacridine derivative on the working and long-term memory in rats].
Topics: Acridines; Aminoquinolines; Amnesia; Animals; Cholinesterase Inhibitors; Learning; Male; Memory; Nootropic Agents; Rats; Scopolamine; Tacrine | 1999 |
Sensitivity to cholinergic drug treatments of aged rats with variable degrees of spatial memory impairment.
Topics: Aging; Animals; Brain; Cholinergic Agents; Escape Reaction; Female; Maze Learning; Mental Recall; Motor Activity; Orientation; Physostigmine; Postural Balance; Psychomotor Performance; Rats; Rats, Long-Evans; Retention, Psychology; Scopolamine; Space Perception; Tacrine | 1999 |
Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys.
Topics: Animals; Cholinesterase Inhibitors; Dihydropyridines; Drug Interactions; Female; Macaca mulatta; Male; Muscarinic Agonists; Oximes; Psychomotor Performance; Scopolamine; Tacrine | 1999 |
Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor.
Topics: Animals; Cholinesterase Inhibitors; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 1999 |
Effect of rivastigmine on scopolamine-induced memory impairment in rats.
Topics: Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Drug Therapy, Combination; Hippocampus; Male; Maze Learning; Memory; Muscarinic Antagonists; Muscle, Skeletal; Phenylcarbamates; Rats; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Tacrine | 1999 |
Injections of tacrine and scopolamine into the nucleus accumbens: opposing effects of immediate vs delayed posttrial treatment on memory of an open field.
Topics: Animals; Arousal; Brain Mapping; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Injections; Male; Mental Recall; Muscarinic Antagonists; Neurons; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Scopolamine; Social Environment; Tacrine | 2000 |
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit.
Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine | 2000 |
Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats.
Topics: Animals; Avoidance Learning; Basal Nucleus of Meynert; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning Disabilities; Male; Maze Learning; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 2000 |
Increased effectiveness of tacrine by deprenyl co-treatment in rats: EEG and behavioral evidence.
Topics: Animals; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electroencephalography; Male; Maze Learning; Monoamine Oxidase Inhibitors; Rats; Rats, Long-Evans; Reserpine; Scopolamine; Selegiline; Tacrine | 2000 |
Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine.
Topics: Animals; Atropine; Avoidance Learning; Cholinesterase Inhibitors; Learning Disabilities; Male; Mice; Motor Activity; Muscarinic Antagonists; Retention, Psychology; Scopolamine; Scopolamine Derivatives; Solanaceous Alkaloids; Tacrine | 2000 |
Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment.
Topics: Alpha Rhythm; Animals; Antipsychotic Agents; Cholinesterase Inhibitors; Data Collection; Electroencephalography; Fluoxetine; Male; Muscarinic Antagonists; Piperazines; Pyridines; Rats; Rats, Long-Evans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reserpine; Scopolamine; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Tacrine | 2002 |
Effects of amphetamine on the plus-maze discriminative avoidance task in mice.
Topics: Amphetamine; Animals; Avoidance Learning; Cholinesterase Inhibitors; Discrimination, Psychological; Dopamine Uptake Inhibitors; Emotions; Male; Maze Learning; Memory; Mice; Motor Activity; Muscarinic Antagonists; Scopolamine; Tacrine | 2002 |
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Choline O-Acetyltransferase; Cognition; Donepezil; Dose-Response Relationship, Drug; Enzyme Induction; Hippocampus; Indans; Male; Maze Learning; Piperidines; Pyridones; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2001 |
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Anti-Anxiety Agents; Avoidance Learning; Basal Nucleus of Meynert; Benzopyrans; Brimonidine Tartrate; Cholinesterase Inhibitors; Cognition; Diazepam; Excitatory Amino Acid Agonists; Ibotenic Acid; Imidazoles; Male; Maze Learning; Memory; Mice; Muscarinic Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2002 |
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
Topics: Animals; Benzazepines; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Memory Disorders; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2002 |
Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Electroencephalography; Monoamine Oxidase Inhibitors; Muscarinic Antagonists; Prosencephalon; Quipazine; Rats; Rats, Long-Evans; Reserpine; Scopolamine; Selegiline; Serotonin Antagonists; Tacrine | 2002 |
Tacrine-scopolamine interactions on state-dependent retrieval.
Topics: Analysis of Variance; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory; Muscarinic Antagonists; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2003 |
Flumazenil and tacrine increase the effectiveness of ondansetron on scopolamine-induced impairment of spatial learning in rats.
Topics: Animals; Cholinesterase Inhibitors; Drug Therapy, Combination; Flumazenil; Learning; Male; Maze Learning; Memory; Muscarinic Antagonists; Ondansetron; Rats; Rats, Wistar; Receptors, GABA-A; Scopolamine; Serotonin Antagonists; Tacrine | 2003 |
Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Basal Nucleus of Meynert; Cell Count; Choline; Cholinesterase Inhibitors; Cognition Disorders; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Esters; Immunohistochemistry; Male; Maze Learning; Memory Disorders; Propiophenones; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Scopolamine; Spatial Behavior; Tacrine; Time Factors | 2004 |
Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Azocines; Binding, Competitive; Cholinergic Agents; Cholinesterase Inhibitors; Dichlorvos; Dose-Response Relationship, Drug; Female; Galantamine; Humans; Membrane Potentials; Models, Biological; Nicotine; Oocytes; Phenylcarbamates; Physostigmine; Plasmids; Quinolizines; Receptors, Nicotinic; Rivastigmine; Scopolamine; Tacrine; Xenopus laevis | 2005 |
Role of molecular isoforms of acetylcholinesterase in learning and memory functions.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Isoenzymes; Learning; Male; Memory; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2005 |
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Topics: Alkaloids; Animals; Avoidance Learning; Behavior, Animal; Brain Diseases; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Memory; Mice; Peptide Fragments; Scopolamine; Sesquiterpenes; Tacrine | 2006 |
Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing.
Topics: Acetylcholine; Amnesia; Animals; Avoidance Learning; Cognition; Dentate Gyrus; Dose-Response Relationship, Drug; Environment; GABA Antagonists; Maze Learning; Memory; Muscarinic Antagonists; Neural Cell Adhesion Molecules; Neuronal Plasticity; Neurons; Neuroprotective Agents; Nipecotic Acids; Nootropic Agents; Oximes; Pyrrolidinones; Rats; Scopolamine; Selegiline; Sialic Acids; Tacrine | 2006 |
Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats.
Topics: Animals; Behavior, Animal; Choline; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Enzyme Inhibitors; Galantamine; Male; Rats; Rats, Wistar; Scopolamine; Tacrine | 2006 |
The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.
Topics: Administration, Oral; Animals; Avoidance Learning; Behavior, Animal; Cassia; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Escape Reaction; Injections, Intraperitoneal; Ischemic Attack, Transient; Learning Disabilities; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Plant Extracts; Scopolamine; Seeds; Tacrine; Time Factors | 2007 |
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Chemistry, Pharmaceutical; Cognition; Cognition Disorders; Drug Design; Female; Humans; Inhibitory Concentration 50; Liver; Muscarinic Antagonists; Nitric Oxide; Nitric Oxide Donors; Rats; Scopolamine; Tacrine | 2008 |
Comparison studies of tacrine and bis7-tacrine on the suppression of scopolamine-induced behavioral changes and inhibition of acetylcholinesterase in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Scopolamine; Tacrine | 2009 |
Object location memory in mice: pharmacological validation and further evidence of hippocampal CA1 participation.
Topics: Animals; Central Nervous System Agents; Cholinesterase Inhibitors; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraperitoneal; Lidocaine; Locomotion; Male; Memory; Mice; Muscarinic Antagonists; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Scopolamine; Space Perception; Tacrine; Time Factors | 2009 |
The inhibitory avoidance test optimized for discovery of cognitive enhancers.
Topics: Animals; Avoidance Learning; Donepezil; Drug Evaluation, Preclinical; Drug Interactions; Indans; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Scopolamine; Tacrine | 2009 |
Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm.
Topics: Animals; Carbolines; Cognition; Cognition Disorders; Coumaric Acids; Female; Maze Learning; Rats; Rats, Wistar; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine; Tacrine | 2010 |
Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice.
Topics: Acetylcholinesterase; Animals; Arctium; Avoidance Learning; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Functional Food; Furans; Glucosides; Lignans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Scopolamine; Seeds; Tacrine | 2011 |
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
Topics: 4-Butyrolactone; Acetylcholinesterase; Angelica; Animals; Choline O-Acetyltransferase; Cholinergic Agents; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plant Roots; Scopolamine; Tacrine | 2011 |
Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins.
Topics: Analysis of Variance; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Learning Disabilities; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred Strains; Reaction Time; Recognition, Psychology; Retention, Psychology; Scopolamine; Tacrine | 2012 |
Combretum mucronatum and Capparis thonningii prevent scopolamine-induced memory deficit in mice.
Topics: Administration, Oral; Animals; Antioxidants; Avoidance Learning; Brain; Capparis; Cholinesterase Inhibitors; Combretum; Dementia; Disease Models, Animal; Dose-Response Relationship, Drug; Maze Learning; Medicine, African Traditional; Memory Disorders; Mice; Nigeria; Oxidative Stress; Plant Extracts; Plant Roots; Scopolamine; Tacrine | 2013 |
Protective effect of Cnestis ferruginea and its active constituent on scopolamine-induced memory impairment in mice: a behavioral and biochemical study.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Antioxidants; Avoidance Learning; Biflavonoids; Cholinesterase Inhibitors; Connaraceae; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Medicine, African Traditional; Memory Disorders; Mice; Oxidative Stress; Plant Extracts; Scopolamine; Tacrine | 2013 |
Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential.
Topics: Animals; Cerebral Cortex; Cognition; Donepezil; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Galantamine; Gamma Rhythm; Indans; Male; Memantine; Motor Activity; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Phenylcarbamates; Piperidines; Principal Component Analysis; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Signal Processing, Computer-Assisted; Tacrine; Theta Rhythm | 2014 |
Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Doublecortin Protein; Hippocampus; Lipid Peroxidation; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurogenesis; Nitric Oxide; Oxidative Stress; Pinus; Plant Extracts; Random Allocation; Scopolamine; Tacrine | 2015 |
Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Injections, Intraperitoneal; Male; Maze Learning; Memory Disorders; Mice, Inbred ICR; Models, Chemical; Motor Activity; Nicotinic Agonists; Nootropic Agents; Recognition, Psychology; Scopolamine; Tacrine | 2015 |
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Gliosis; Hep G2 Cells; Hippocampus; Humans; Indans; Indoles; Learning; Male; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Plaque, Amyloid; Proof of Concept Study; Recognition, Psychology; Scopolamine; Tacrine | 2017 |
Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Ligands; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Peptide Fragments; Protein Aggregates; Scopolamine; Structure-Activity Relationship; Tacrine | 2018 |
Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Models, Animal; Male; Maze Learning; Mice; Motor Activity; Scopolamine; Tacrine | 2018 |
Substituted Aminobenzothiazole Derivatives of Tacrine: Synthesis and Study on Learning and Memory Impairment in Scopolamine-Induced Model of Amnesia in Rat.
Topics: Alzheimer Disease; Amination; Amnesia; Animals; Benzothiazoles; Learning; Male; Maze Learning; Nootropic Agents; Rats; Rats, Wistar; Scopolamine; Tacrine | 2019 |