Compounds > tacrine

tacrine and pyrimethamine

tacrine has been researched along with pyrimethamine in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (25.00)	18.2507
2000's	2 (25.00)	29.6817
2010's	4 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW	1
Cumming, P; Reiner, PB; Vincent, SR	1
Duoyon, E; Lee, WS; Morrishow, AM; Prell, GD	1
Cheng, X; Horton, JR; Nishibori, M; Sawada, K	1

Other Studies

8 other study(ies) available for tacrine and pyrimethamine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries	2017
Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA). Biochemical pharmacology, 1990, Sep-15, Volume: 40, Issue:6 Topics: 4-Aminopyridine; Aminoacridines; Animals; Antineoplastic Agents; Brain; Histamine; Histamine N-Methyltransferase; Injections, Intraperitoneal; Male; Methyltransferases; Physostigmine; Pyrimethamine; Rats; Tacrine	1990
Inhibitors of histamine methylation in brain promote formation of imidazoleacetic acid, which interacts with GABA receptors. Journal of neurochemistry, 1997, Volume: 68, Issue:1 Topics: Animals; Brain; Gas Chromatography-Mass Spectrometry; Histamine; Imidazoles; Male; Methylation; Physostigmine; Pyrimethamine; Rats; Rats, Sprague-Dawley; Receptors, GABA; Tacrine	1997
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. Journal of molecular biology, 2005, Oct-21, Volume: 353, Issue:2 Topics: Amodiaquine; Animals; Antimalarials; Cholinesterase Inhibitors; Crystallography, X-Ray; Diphenhydramine; Folic Acid Antagonists; Histamine H1 Antagonists; Histamine N-Methyltransferase; Humans; Models, Molecular; Molecular Structure; Protein Conformation; Pyrimethamine; Tacrine	2005