Compounds > tacrine

tacrine and piperidines

tacrine has been researched along with piperidines in 145 studies

Research

Studies (145)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.69)18.7374
1990's39 (26.90)18.2507
2000's83 (57.24)29.6817
2010's22 (15.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Henriksson, BG; Järbe, TU; Johansson, JO1
Araki, S; Higurashi, K; Iimura, Y; Karibe, N; Kawakami, Y; Nakamura, T; Sasaki, A; Sugimoto, H; Sugumi, H; Tsuchiya, Y1
Butler, TW; Chapin, DS; Chen, YL; DeMattos, SB; Ives, JL; Jones, SB; Liston, DR; Nagel, AA; Nason, DM; Villalobos, A1
Fujii, T; Fujimoto, K; Kawashima, K; Sato, A; Suzuki, T; Yoshizawa, M1
Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M1
Palacios, JM1
Morisset, S; Schwartz, JC; Traiffort, E1
Schneider, LS2
Cheng, DH; Ren, H; Tang, XC1
Fricker, J1
Nichols, ME1
Ando, I; Kakiuchi, T; Ouchi, Y; Tsukada, H1
Kojima, J; Nakajima, K; Nakayama, K; Ochiai, M1
Geldmacher, DS1
Henry, RG; Wekstein, DR1
Honma, A1
Braida, D; Colibretti, L; Griffini, P; Lamperti, M; Paladini, E; Sala, M1
Nordberg, A; Svensson, AL1
Cheng, DH; Tang, XC1
Tang, XC; Wang, T1
Peskind, ER1
Cummings, JL1
Sunderland, T; Tune, LE1
Brefel-Courbon, C; Freslon, JL; Lazartigues, E; Montastruc, JL; Pelat, M; Rascol, O; Tellioglu, T; Tran, MA1
Lacomblez, L1
Derquesné, C1
Larson, EB; Shadlen, MF1
Hecker, J1
Hu, GY; Lin, JH; Tang, XC1
Cross, AJ; De Souza, RJ; Green, AR; Misra, A; Murray, TK; Snape, MF; Williams, JL1
Pryse-Phillips, W1
Tang, XC; Wang, H1
Dom, R; Lemière, J; Van Gool, D1
Trabucchi, M1
Kosasa, T; Kuriya, Y; Matsui, K; Yamanishi, Y3
Kosasa, T; Kuriya, Y; Yamanishi, Y1
Burns, A; Page, S; Russell, E1
Kaur, J; Zhang, MQ1
Mumenthaler, MS; O'Hara, R; Yesavage, JA1
Kakiuchi, T; Nishiyama, S; Sato, K; Tsukada, H1
Danysz, W; Moebius, HJ; Quack, G; Wenk, GL1
Cummings, J; Fillit, H1
Beyreuther, K; Emilien, G; Maloteaux, JM; Masters, CL1
Braida, D; Ottonello, F; Sala, M; Virag, W1
Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y3
Stahl, SM1
Dronfield, S; Egan, K; Green, AR; Marsden, CA1
Giacobini, E1
Kashiwagi, Y; Kudo, T; Nakamura, Y; Nishikawa, T; Shinosaki, K; Takeda, M; Tanaka, T1
Grutzendler, J; Morris, JC1
Devi, G; Silver, J1
Hake, AM1
Lampley-Dallas, VT1
Gavrilova, SI; Zharikov, GA1
Winblad, B1
Higashi, M; Kawashima, S; Matsuno, T; Yamaguchi, Y1
Hasegawa, H; Ishikawa, M; Isoma, K; Kamei, J; Kohda, T; Ogawa, Y; Ohta, M1
Chen, Z; Li, R; Wei, EQ; Xu, AJ1
Allain, H; Bentue-Ferrer, D; Lecavorzin, P; Polard, E; Reymann, JM; Tribut, O1
Klein, C; Rabey, JM; Werber, AE1
Robert, P1
Blount, PJ; McDeavitt, JT; Nguyen, CD1
Jann, MW; Shirley, KL; Small, GW1
Ott, BR1
Chen, Z; Huang, YW; Wei, EQ; Xu, AJ; Yanai, K1
Castro, A; Martinez, A1
Tang, XC; Zhao, Q1
Kamei, H; Nabeshima, T; Noda, Y1
Bai, DL; Jin, GY; Xia, Y1
Peng, FF; Wu, DC; Zhang, BF; Zhang, JZ1
Hartmann, S; Möbius, HJ1
Albuquerque, EX; Christner, C; Fehrenbacher, A; Höffle, A; Jostock, R; Lübbert, H; Ludwig, J; Maelicke, A; Pereira, EF; Radina, M; Samochocki, M; Ullmer, C; Zerlin, M1
Gandelman-Marton, R; Klein, C; Rabey, JM; Werber, EA1
Butler, R; Prabhakaran, P; Warner, J1
Fuchsberger, T; Hampel, H; Möller, HJ1
Chapin, D; Hubbard, ST; Jones, SB; Liston, DR; Nason, D; Nielsen, JA; Ramirez, A; Shalaby, IA; Villalobos, A; White, WF1
Haen, E; Ibach, B1
Nagura, H1
Li, Y; Luo, C; Shao, D; Tang, X; Zou, C1
Caricati-Neto, A; D'angelo, LC; Garcia, AG; Hyppolito Jurkiewicz, N; Jurkiewicz, A; Reuter, H1
Simard, M; van Reekum, R1
Arya, P; Butler, R; Warner, J2
Carlier, PR; Chan, HH; Chang, DC; Fu, H; Han, Y; Lee, NT; Li, C; Li, M; Li, W; Li, Z; Luo, J; Pang, Y; Pi, R; Pu, Y; Tsang, HW; Tsim, KW; Xiong, K; Xue, H1
Kang, YS; Lee, KE; Lee, NY; Terasaki, T1
Aisen, PS1
Gasper, MC; Lapane, KL; Ott, BR1
Pal, SN; Pillai, KK; Vohora, D1
Alonso, D; Bidon-Chanal, A; Castro, A; Del Monte, M; Dorronsoro, I; García-Palomero, E; Luque, FJ; Martínez, A; Medina, M; Muñoz, P; Orozco, M; Rubio, L1
Campo, VL; Carvalho, I; da Silva, CH; Taft, CA1
Camps, P; Muñoz-Torrero, D1
Butler, R; Warner, J; Wuntakal, B1
Cummings, JL; Ringman, JM1
Chang, DC; Fu, H; Han, Y; Kan, KK; Lao, Y; Lee, NT; Li, M; Li, W; Li, Z; Luo, J; Pang, Y; Tsang, HW; Tsim, KW1
Takatori, Y1
Hwang, MJ; Jin, UH; Kim, CH; Koo, BS; Lee, IS; Suh, SJ1
Gruber, J; Hollenack, K; O'Shea, T; Stefanacci, R; Tangalos, EG; Zarowitz, BJ1
Agrawal, R; Nath, C; Shukla, R; Tyagi, E1
Ballard, CG; Chalmers, KA; Love, S; McKeith, IG; O'Brien, JT; Perry, EK; Todd, C; Wilcock, G1
Fujii, Y; Kamei, C; Mikami, A; Yamamoto, Y1
Semla, TP1
McCain, KR; Sawyer, TS; Spiller, HA1
Bajda, M; Malawska, B; Musiał, A1
Agrawal, R; Nath, C; Saxena, G; Singh, SP1
Adelman, A; Campos-Outcalt, D; Cross, JT; Forciea, MA; Hopkins, R; Mehr, D; Owens, DK; Qaseem, A; Santaguida, P; Schellhase, K; Shekelle, P; Snow, V1
Booker, L; Cowan, D; Ismaila, A; Levine, M; Oremus, M; Patterson, C; Raina, P; Santaguida, P1
Graham, L1
Andrisano, V; Badia, A; Bartolini, M; Bidon-Chanal, A; Camins, A; Camps, P; Clos, MV; Estelrich, J; Formosa, X; Galdeano, C; Gómez, T; Lizondo, M; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Pallàs, M; Scarpellini, M; Viayna, E1
Graham, K; Josif, S1
Cheng, K; Davis, RJ; Drachenberg, C; Nomikos, G; Raufman, JP; Samimi, R; Shant, J; Wade, M; Xie, G1
Akaike, A; Fujii, T; Izumi, Y; Kume, T; Niidome, T; Ohgi, Y; Sugimoto, H; Takada-Takatori, Y1
Ehret, A; Feuerstein, TJ; Förster, S; Jackisch, R; Kammerer, M; Rothmaier, AK; Zentner, J1
Bi, SL; Chen, SY; Huang, J; Wang, CY; Yi, Y1
Dardenne, B; Detrait, ER; Hanon, E; Lamberty, Y1
Boopathy, R; Chitra, L; Layer, PG; Rajesh, RV1
Andrisano, V; Badia, A; Bartolini, M; Bidon-Chanal, A; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Gómez, T; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Viayna, E1
Aw, CC; Browne, ER; Chen, CP; Goh, CW; Lee, JH1
Nath, C; Patro, IK; Saxena, G1
Okochi, M; Takeda, M; Tanaka, T1
Atri, A1
Fujiwara, H; Inada, C; Matsumoto, K; Miyata, T; Thi Le, X; Tsuneyama, K1
Beniashvily, AG; Bondarenko, EV; Burminskiy, DS; Ivachtchenko, AV; Kazey, VI; Lavrovsky, Y; Lepilkina, TA; Morozova, MA; Potanin, SS; Rupchev, GE1
Armentero, MT; Baqi, Y; Bonaventura, J; Canela, EI; Casadó, V; Cortés, A; Costa, G; Farré, D; Franco, R; Lanciego, JL; Lluís, C; Mallol, J; Martínez-Pinilla, E; McCormick, P; Müller, CE; Pinna, A; Sánchez, M; Simola, N1
Andrs, M; Cabelova, P; Dolezal, R; Horova, A; Hruba, E; Korabecny, J; Kuca, K; Musilek, K; Nepovimova, E; Opletalova, V; Ricny, J; Ripova, D; Sedlacek, L; Sepsova, V; Spilovska, K1
Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K1
Ahnaou, A; Drinkenburg, WH; Huysmans, H; Jacobs, T1
Cabelova, P; Janska, K; Jun, D; Karasova, JZ; Korabecny, J; Krusek, J; Kuca, K; Sepsova, V; Skrenkova, K; Soukup, O; Tobin, G1
Cabelova, P; Kassa, J; Korabecny, J; Misik, J; Nepovimova, E1
Draczkowski, P; Halczuk, P; Jozwiak, K; Matosiuk, D; Strzemski, M; Tomaszuk, A1
Kassa, J; Korabecny, J; Kracmarova, A; Misik, J; Nepovimova, E1
Bezerra da Silva, C; Dalarmi, L; Dallarmi Miguel, M; de Fátima Gaspari Dias, J; de Oliveira, M; Elifio-Esposito, S; Fialho do Nascimento, K; Gomes Miguel, O; Moura Burci, L; Pott, A; Warumby Zanin, SM1
Agbaba, D; Benchekroun, M; Brindisi, M; Brogi, S; Butini, S; Campiani, G; Esteban, G; Filipic, S; Gemma, S; Ismaili, L; Marco-Contelles, J; Nikolic, K; Refouvelet, B; Unzeta, M1
Korabecny, J; Kuca, K; Mzik, M; Nepovimova, E; Palička, V; Voříšek, V; Zdarova Karasova, J1
Fernandez, AP; Futch, HS; Herrero-Labrador, R; Marco-Contelles, J; Martínez-Murillo, R; Romero, A; Samadi, A; Serrano, J; Serrano, MP; Unzeta, M1
Alves, G; Falcao, A; Matias, M; Silvestre, S1
Godyń, J; Malawska, B; Panek, D; Pasieka, A; Wichur, T1
Bartolini, M; Fabini, E; Tramarin, A1

Reviews

49 review(s) available for tacrine and piperidines

ArticleYear
New therapeutic approaches to Alzheimer's disease.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 14

    Topics: Alzheimer Disease; Antioxidants; Carbamates; Cholinergic Agents; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon

1996
Dementia in the elderly.
    Journal of the Medical Association of Georgia, 1997, Volume: 86, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Male; Piperidines; Tacrine; United States

1997
Providing dental care for patients diagnosed with Alzheimer's disease.
    Dental clinics of North America, 1997, Volume: 41, Issue:4

    Topics: Aged; Aging; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Caregivers; Cholinesterase Inhibitors; Dental Care for Chronically Ill; Dentist-Patient Relations; Donepezil; Family Relations; Humans; Indans; Middle Aged; Nootropic Agents; Oral Hygiene; Piperidines; Prevalence; Professional-Family Relations; Tacrine

1997
[Therapeutic agents for Alzheimer's disease].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1998, Jan-10, Volume: 87, Issue:1

    Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Monoamine Oxidase Inhibitors; Neuropeptides; Phenylcarbamates; Piperidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Rivastigmine; Spiro Compounds; Tacrine

1998
Pharmacologic approaches to cognitive deficits in Alzheimer's disease.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 9

    Topics: Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Nootropic Agents; Piperidines; Placebos; Tacrine; Treatment Outcome; Trichlorfon

1998
New therapeutic approaches to cognitive impairment.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 11

    Topics: Aged; Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Humans; Indans; Monoamine Oxidase Inhibitors; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon

1998
New cholinergic therapies: treatment tools for the psychiatrist.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 13

    Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Estrogen Replacement Therapy; Estrogens; Female; Humans; Indans; Male; Piperidines; Selective Serotonin Reuptake Inhibitors; Selegiline; Tacrine; Vitamin E

1998
What's new in Alzheimer's disease treatment? Reasons for optimism about future pharmacologic options.
    Postgraduate medicine, 1999, Volume: 105, Issue:1

    Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Piperidines; Tacrine

1999
Alzheimer's disease: the advent of effective therapy.
    Australian and New Zealand journal of medicine, 1998, Volume: 28, Issue:6

    Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Diagnostic Imaging; Donepezil; Female; Humans; Indans; Male; Piperidines; Risk Factors; Tacrine

1998
Do we have drugs for dementia? No.
    Archives of neurology, 1999, Volume: 56, Issue:6

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Ginkgo biloba; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phytotherapy; Piperidines; Plants, Medicinal; Selegiline; Tacrine; Vitamin E

1999
Treatment of Alzheimer's disease: an evaluation of the cholinergic approach.
    Acta neurologica Belgica, 1999, Volume: 99, Issue:2

    Topics: Acetylcholine; Alzheimer Disease; Animals; Carbamates; Chemical and Drug Induced Liver Injury; Cholinergic Agents; Cholinergic Fibers; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Double-Blind Method; Drug Evaluation, Preclinical; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Rivastigmine; Tacrine

1999
An economic perspective on Alzheimer's disease.
    Journal of geriatric psychiatry and neurology, 1999,Spring, Volume: 12, Issue:1

    Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Combined Modality Therapy; Cost of Illness; Costs and Cost Analysis; Donepezil; Humans; Indans; Institutionalization; Italy; Mental Health Services; Neuropsychological Tests; Piperidines; Reality Therapy; Tacrine

1999
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
    Current medicinal chemistry, 2000, Volume: 7, Issue:3

    Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine

2000
Prospects for pharmacological intervention in Alzheimer disease.
    Archives of neurology, 2000, Volume: 57, Issue:4

    Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspartic Acid Endopeptidases; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Endopeptidases; Hippocampus; Humans; Indans; N-Methylaspartate; Nerve Growth Factors; Nicotine; Piperidines; Tacrine

2000
Cholinesterase inhibitors stabilize Alzheimer's disease.
    Annals of the New York Academy of Sciences, 2000, Volume: 920

    Topics: Alzheimer Disease; Brain; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon

2000
Cholinesterase inhibitors for Alzheimer's disease.
    Drugs, 2001, Volume: 61, Issue:1

    Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cost-Benefit Analysis; Donepezil; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2001
Approaches to memory loss in neuropsychiatric disorders.
    Seminars in clinical neuropsychiatry, 2000, Volume: 5, Issue:4

    Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Dementia; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Memory Disorders; Nootropic Agents; Piperidines; Premenopause; Randomized Controlled Trials as Topic; Tacrine

2000
Use of cholinesterase inhibitors for treatment of Alzheimer disease.
    Cleveland Clinic journal of medicine, 2001, Volume: 68, Issue:7

    Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2001
[Current strategies of pathogenetic therapy of Alzheimer's disease].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2001, Issue:7

    Topics: Aged; Alzheimer Disease; Amino Acids; Aminoquinolines; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Estrogens; Ginkgo biloba; Humans; Indans; Memantine; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuronal Plasticity; Neuroprotective Agents; Neurotransmitter Agents; Nicergoline; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Piracetam; Pyrithioxin; Rivastigmine; Selegiline; Tacrine; Time Factors

2001
[Perspectives for drug treatment in Alzheimer's disease].
    Annales de medecine interne, 2001, Volume: 152, Issue:8

    Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2001
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine.
    Current medical research and opinion, 2002, Volume: 18, Issue:3

    Topics: Acetylcholine; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Disease Progression; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome

2002
Clinical use of cholinomimetic agents: a review.
    The Journal of head trauma rehabilitation, 2002, Volume: 17, Issue:4

    Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Brain Injuries; Carbamates; Clinical Trials as Topic; Cytidine Diphosphate Choline; Donepezil; Female; Follow-Up Studies; Humans; Indans; Injections, Intravenous; Injury Severity Score; Male; Middle Aged; Parasympathomimetics; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome

2002
Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors.
    Clinical pharmacokinetics, 2002, Volume: 41, Issue:10

    Topics: Aging; Alzheimer Disease; Biological Availability; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Half-Life; Humans; Indans; Intestinal Absorption; Liver; Phenylcarbamates; Piperidines; Protein Binding; Rivastigmine; Tacrine; Tissue Distribution

2002
Medical treatment of Alzheimer's disease: past, present, and future.
    Medicine and health, Rhode Island, 2002, Volume: 85, Issue:7

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forecasting; Galantamine; Humans; Indans; Male; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome

2002
Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease.
    Mini reviews in medicinal chemistry, 2001, Volume: 1, Issue:3

    Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Binding Sites; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Molecular Conformation; Molecular Structure; Phenylcarbamates; Piperidines; Rivastigmine; Structure-Activity Relationship; Tacrine

2001
[Anti-dementia drugs for Alzheimer disease in present and future].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 120, Issue:1

    Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; tau Proteins

2002
[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:9

    Topics: Alkaloids; Cholinesterase Inhibitors; Donepezil; Indans; Molecular Conformation; Molecular Structure; Piperidines; Sesquiterpenes; Tacrine

2002
Dementia.
    Clinical evidence, 2003, Issue:9

    Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E

2003
[Current therapy of patients with dementia].
    MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2

    Topics: Activities of Daily Living; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Controlled Clinical Trials as Topic; Dementia; Dementia, Vascular; Donepezil; Dopamine Agents; Female; Galantamine; Ginkgo biloba; Humans; Indans; Male; Memantine; Meta-Analysis as Topic; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Placebos; Plant Preparations; Prospective Studies; Rivastigmine; Tacrine; Time Factors

2003
Acetylcholinesterase inhibition in Alzheimer's Disease.
    Current pharmaceutical design, 2004, Volume: 10, Issue:3

    Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2004
[Drugs for the treatment of Alzheimer's disease].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl

    Topics: Acetylcholine; Alzheimer Disease; Antidepressive Agents; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Haloperidol; Humans; Hydroxyzine; Hypnotics and Sedatives; Indans; Injections, Intramuscular; Physostigmine; Piperidines; Selective Serotonin Reuptake Inhibitors; Tacrine

2004
The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies.
    The Journal of neuropsychiatry and clinical neurosciences, 2004,Fall, Volume: 16, Issue:4

    Topics: Aged; Basal Ganglia Diseases; Behavior; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Cognition Disorders; Donepezil; Humans; Indans; Lewy Body Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Tacrine

2004
Dementia.
    Clinical evidence, 2004, Issue:11

    Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamine; Ginkgo biloba; Haloperidol; Humans; Indans; Memantine; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Risperidone; Rivastigmine; Selegiline; Tacrine; Vitamin E

2004
Dementia.
    Clinical evidence, 2004, Issue:12

    Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine

2004
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.
    Journal of the American Academy of Nurse Practitioners, 2005, Volume: Suppl

    Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome

2005
Dimeric and hybrid anti-Alzheimer drug candidates.
    Current medicinal chemistry, 2006, Volume: 13, Issue:4

    Topics: Alzheimer Disease; Aminoquinolines; Animals; Binding Sites; Cholinesterase Inhibitors; Cognition Disorders; Heterocyclic Compounds, 4 or More Rings; Humans; Monoamine Oxidase Inhibitors; Piperidines; Structure-Activity Relationship; Tacrine

2006
Dementia.
    Clinical evidence, 2005, Issue:14

    Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Selegiline; Tacrine

2005
Current and emerging pharmacological treatment options for dementia.
    Behavioural neurology, 2006, Volume: 17, Issue:1

    Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2006
[Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2006, Volume: 126, Issue:8

    Topics: Alzheimer Disease; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Humans; Indans; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine

2006
The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease.
    Journal of the American Medical Directors Association, 2007, Volume: 8, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Evidence-Based Medicine; Geriatric Assessment; Humans; Indans; Mental Disorders; Nootropic Agents; Phenylcarbamates; Piperidines; Positron-Emission Tomography; Rivastigmine; Tacrine

2007
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.
    Current medicinal chemistry, 2007, Volume: 14, Issue:25

    Topics: Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Indole Alkaloids; Isoquinolines; Phenylcarbamates; Physostigmine; Piperidines; Propidium; Rivastigmine; Steroids; Tacrine

2007
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.
    Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5

    Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine

2008
Diagnosis and treatment of dementia with Lewy bodies.
    JAAPA : official journal of the American Academy of Physician Assistants, 2008, Volume: 21, Issue:5

    Topics: Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Nootropic Agents; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Tacrine

2008
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation.
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:3

    Topics: Acetylcholinesterase; Animals; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Indans; Neurons; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine; Up-Regulation

2009
New drugs for Alzheimer's disease in Japan.
    Psychiatry and clinical neurosciences, 2011, Volume: 65, Issue:5

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Japan; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2011
Effective pharmacological management of Alzheimer's disease.
    The American journal of managed care, 2011, Volume: 17 Suppl 13

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Dementia; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome

2011
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease.
    Progress in neurobiology, 2017, Volume: 151

    Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Ligands; Piperidines; Tacrine

2017
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:6

    Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid; Humans; Indans; Opioid Peptides; Pain; Piperidines; Tacrine

2017
Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors.
    Future medicinal chemistry, 2017, Volume: 9, Issue:15

    Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Humans; Indans; Inhibitory Concentration 50; Piperidines; Rivastigmine; Tacrine

2017

Trials

2 trial(s) available for tacrine and piperidines

ArticleYear
The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients.
    Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:6

    Topics: Acetylcholine; Aged; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Electroencephalography; Event-Related Potentials, P300; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Prospective Studies; Reaction Time; Rivastigmine; Tacrine; Treatment Outcome

2003
Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study.
    CNS spectrums, 2014, Volume: 19, Issue:4

    Topics: Adult; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Middle Aged; Pilot Projects; Piperidines; Prepulse Inhibition; Pyrazoles; Pyrimidines; Reaction Time; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Scopolamine; Serotonin Antagonists; Tacrine; Treatment Outcome; Young Adult

2014

Other Studies

94 other study(ies) available for tacrine and piperidines

ArticleYear
Drug discrimination in rats: the effects of phencyclidine and ditran.
    Psychopharmacologia, 1975, Apr-30, Volume: 42, Issue:1

    Topics: Animals; Cues; Cyclohexylamines; Discrimination Learning; Drug Combinations; Fenclonine; Glycolates; Imipramine; Ketamine; Male; Neostigmine; Phencyclidine; Physostigmine; Piperidines; Pyrrolidines; Rats; Tacrine; Tetrabenazine; Yohimbine

1975
Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Acetylcholinesterase; Animals; Benzyl Compounds; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Indicators and Reagents; Kinetics; Male; Molecular Structure; Physostigmine; Piperidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tacrine

1990
5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.
    Journal of medicinal chemistry, 1995, Jul-21, Volume: 38, Issue:15

    Topics: Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Isoxazoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tacrine

1995
Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 350, Issue:5

    Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Male; Movement; Physostigmine; Piperidines; Radioimmunoassay; Rats; Rats, Wistar; Tacrine

1994
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
    European journal of pharmacology, 1996, Apr-29, Volume: 302, Issue:1-3

    Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine

1996
Alzheimer's disease: new pharmacological perspectives.
    Methods and findings in experimental and clinical pharmacology, 1996, Volume: 18 Suppl B

    Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Dihydropyridines; Donepezil; Humans; Indans; Muscarinic Agonists; Oximes; Phenylcarbamates; Piperidines; Pyridines; Rivastigmine; Tacrine; Thiadiazoles

1996
Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity.
    European journal of pharmacology, 1996, Nov-07, Volume: 315, Issue:1

    Topics: Animals; Cerebral Cortex; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Histamine Antagonists; Histamine N-Methyltransferase; Male; Methylhistamines; Mice; Nootropic Agents; Piperidines; Tacrine

1996
Huperzine A, a novel promising acetylcholinesterase inhibitor.
    Neuroreport, 1996, Dec-20, Volume: 8, Issue:1

    Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine

1996
From mechanisms to drugs in Alzheimer's disease.
    Lancet (London, England), 1997, Feb-15, Volume: 349, Issue:9050

    Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dioxoles; Donepezil; Humans; Indans; Memory, Short-Term; Piperidines; Rats; Tacrine

1997
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:3

    Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Physostigmine; Piperidines; Scopolamine; Tacrine; Tomography, Emission-Computed

1997
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
    Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:4

    Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Motor Activity; Piperidines; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine; Tacrine

1997
Donepezil (Aricept) therapy for Alzheimer's disease.
    Comprehensive therapy, 1997, Volume: 23, Issue:7

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Tacrine

1997
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4

    Topics: Amnesia; Animals; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Indans; Male; Maze Learning; Morpholines; Motor Activity; Muscarinic Antagonists; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine

1998
Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells.
    Neuroreport, 1998, May-11, Volume: 9, Issue:7

    Topics: Adrenal Gland Neoplasms; Amyloid beta-Peptides; Animals; Cell Survival; Cholinesterase Inhibitors; Donepezil; Indans; Mecamylamine; Neurons; Neuroprotective Agents; Neurotoxins; Nicotinic Antagonists; PC12 Cells; Peptide Fragments; Pheochromocytoma; Piperidines; Rats; Tacrine; Tubocurarine

1998
Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:2

    Topics: Alkaloids; Animals; Aziridines; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Injections, Intraventricular; Male; Maze Learning; Memory; Memory, Short-Term; Neuromuscular Blocking Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine

1998
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
    European journal of pharmacology, 1998, May-22, Volume: 349, Issue:2-3

    Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine

1998
Advances in diagnosing and treating Alzheimer's disease.
    The Johns Hopkins medical letter health after 50, 1998, Volume: 10, Issue:7

    Topics: Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Tacrine

1998
Alzheimer's disease management.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 13

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Middle Aged; Piperidines; Selegiline; Tacrine; Vitamin E

1998
Pressor and bradycardic effects of tacrine and other acetylcholinesterase inhibitors in the rat.
    European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1

    Topics: Adrenergic Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Atropine Derivatives; Blood Pressure; Carbamates; Cardiovascular Agents; Chlorisondamine; Cholinergic Antagonists; Cholinesterase Inhibitors; Diamines; Diastole; Dose-Response Relationship, Drug; Heart Rate; Male; Phenylcarbamates; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Rivastigmine; Systole; Tacrine

1998
[Drug therapy strategies in Alzheimer's disease].
    La Revue du praticien, 1998, Nov-01, Volume: 48, Issue:17

    Topics: Aggression; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Depression; Donepezil; Humans; Indans; Mental Disorders; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Sleep Wake Disorders; Tacrine

1998
[Alzheimer's disease. Foreword].
    La Revue du praticien, 1998, Nov-01, Volume: 48, Issue:17

    Topics: Age Factors; Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

1998
Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:1

    Topics: Action Potentials; Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; Indans; Male; Membrane Potentials; Mice; Muscle Fibers, Skeletal; Neuromuscular Junction; Phrenic Nerve; Piperidines; Sesquiterpenes; Tacrine

1997
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066.
    Neuropharmacology, 1999, Volume: 38, Issue:1

    Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Carbachol; Cholinesterase Inhibitors; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Indoles; Injections, Intraperitoneal; Isoquinolines; Logistic Models; Male; Physostigmine; Piperidines; Rats; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured

1999
Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:1

    Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine

1998
Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Acetylcholine; Acetylcholinesterase; Administration, Oral; Animals; Brain; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Indans; Male; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine

1999
Effect of donepezil hydrochloride (E2020) on extracellular acetylcholine concentration in the cerebral cortex of rats.
    Japanese journal of pharmacology, 1999, Volume: 81, Issue:2

    Topics: Animals; Benzazepines; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Electrochemistry; Extracellular Space; Indans; Male; Microdialysis; Nootropic Agents; Peripheral Nervous System; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine

1999
Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats.
    European journal of pharmacology, 1999, Dec-10, Volume: 386, Issue:1

    Topics: Aging; Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Erythrocytes; Indans; Male; Peripheral Nervous System; Piperidines; Rats; Rats, Inbred F344; Tacrine

1999
New drugs for Alzheimer's disease.
    The British journal of psychiatry : the journal of mental science, 1999, Volume: 174

    Topics: Alzheimer Disease; Carbamates; Donepezil; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Rivastigmine; Tacrine

1999
Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats.
    European journal of pharmacology, 2000, Feb-18, Volume: 389, Issue:2-3

    Topics: Administration, Oral; Alzheimer Disease; Animals; Benzazepines; Brain; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Male; Memory; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine

2000
Update on Alzheimer's disease: recent findings and treatments.
    The Western journal of medicine, 2000, Volume: 172, Issue:2

    Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Risk Factors; Tacrine

2000
Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain.
    Brain research, 2000, Feb-28, Volume: 857, Issue:1-2

    Topics: Acetylcholine; Age Factors; Animals; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Extracellular Space; Glucose; Indans; Macaca mulatta; Male; Microdialysis; Neurons; Physostigmine; Piperidines; Tacrine; Tomography, Emission-Computed; Wakefulness

2000
No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use.
    Life sciences, 2000, Feb-11, Volume: 66, Issue:12

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Memantine; Piperidines; Rats; Rats, Inbred F344; Tacrine

2000
Practice guidelines for the diagnosis and treatment of Alzheimer's disease in a managed care setting: Part II--Pharmacologic therapy. Alzheimer's Disease (AD) Managed Care Advisory Council.
    Managed care interface, 2000, Volume: 13, Issue:1

    Topics: Algorithms; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Caregivers; Cholinesterase Inhibitors; Clinical Trials as Topic; Cost-Benefit Analysis; Donepezil; Drug Interactions; Estrogens; Female; Ginkgo biloba; Humans; Indans; Male; Managed Care Programs; Nootropic Agents; Patient Selection; Phytotherapy; Piperidines; Plants, Medicinal; Psychotropic Drugs; Quality of Health Care; Selegiline; Tacrine; Time Factors; Vitamin E

2000
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit.
    Pharmacological research, 2000, Volume: 41, Issue:6

    Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine

2000
Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats.
    Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:2

    Topics: Animals; Avoidance Learning; Basal Nucleus of Meynert; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning Disabilities; Male; Maze Learning; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine

2000
The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different.
    The Journal of clinical psychiatry, 2000, Volume: 61, Issue:10

    Topics: Aged; Alzheimer Disease; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Receptors, Nicotinic; Rivastigmine; Tacrine

2000
Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:3

    Topics: Animals; Body Temperature; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Hypothermia; Indans; Lacrimal Apparatus; Male; Phenylcarbamates; Piperidines; Rats; Rivastigmine; Saliva; Tacrine; Tremor; Trichlorfon

2000
[Treatment of the elderly dementia patients].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2000, Volume: 37, Issue:11

    Topics: Aged; Alzheimer Disease; Benzazepines; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Piperidines; Tacrine; Trichlorfon

2000
Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro.
    Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:8

    Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Animals; Benzazepines; Brain; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Inhibitory Concentration 50; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rivastigmine; Tacrine; Time Factors

2000
Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats.
    European journal of pharmacology, 2001, Volume: 415, Issue:2-3

    Topics: Acetylcholinesterase; Animals; Benzazepines; Benzoxazines; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Fasciculation; Indans; Male; Muscarinic Antagonists; Oxazines; Piperidines; Rats; Rats, Wistar; Tacrine; Yawning

2001
Medications for the treatment of Alzheimer's disease.
    The Journal of the Oklahoma State Medical Association, 2001, Volume: 94, Issue:8

    Topics: Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2001
Maintaining functional and behavioral abilities in Alzheimer disease.
    Alzheimer disease and associated disorders, 2001, Volume: 15 Suppl 1

    Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Treatment Outcome

2001
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
    Japanese journal of pharmacology, 2001, Volume: 87, Issue:3

    Topics: Alzheimer Disease; Animals; Avoidance Learning; Choline O-Acetyltransferase; Cognition; Donepezil; Dose-Response Relationship, Drug; Enzyme Induction; Hippocampus; Indans; Male; Maze Learning; Piperidines; Pyridones; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine

2001
Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain.
    Japanese journal of pharmacology, 2002, Volume: 88, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Cholinesterases; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Humans; Indans; Male; Phenothiazines; Piperidines; Quinolines; Rats; Rats, Wistar; Salivation; Tacrine; Temperature

2002
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:4

    Topics: Animals; Benzazepines; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Memory Disorders; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine

2002
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials.
    Neurologia i neurochirurgia polska, 2001, Volume: 35 Suppl 3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Carbamates; Cholinesterase Inhibitors; Cognition; Donepezil; Evaluation Studies as Topic; Event-Related Potentials, P300; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Phenylcarbamates; Piperidines; Reaction Time; Rivastigmine; Sensitivity and Specificity; Severity of Illness Index; Tacrine

2001
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
    Neuroscience letters, 2002, Oct-04, Volume: 331, Issue:1

    Topics: Animals; Benzazepines; Brain; Brain Ischemia; Cholinesterase Inhibitors; Coloring Agents; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Neuroprotective Agents; Organ Culture Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine; Tetrazolium Salts

2002
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
    European journal of pharmacology, 2002, Nov-29, Volume: 455, Issue:2-3

    Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine

2002
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:2

    Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; Indans; Mice; Neuroblastoma; Piperidines; Protective Agents; Rats; Staurosporine; Tacrine

2002
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.
    International clinical psychopharmacology, 2003, Volume: 18, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Carbamates; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Middle Aged; Phenylcarbamates; Piperidines; Product Surveillance, Postmarketing; Rivastigmine; Surveys and Questionnaires; Tacrine; Treatment Outcome

2003
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3

    Topics: Allosteric Regulation; Animals; Carbamates; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Mice; Neurons; Phenylcarbamates; Piperidines; Receptors, Muscarinic; Receptors, Nicotinic; Recombinant Fusion Proteins; Rivastigmine; Tacrine; Trichlorfon

2003
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
    European journal of pharmacology, 2004, Feb-13, Volume: 486, Issue:1

    Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Mice; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine

2004
Anticholinesterases in Alzheimer's disease: a modest effect on moderately severe disease.
    Prescrire international, 2003, Volume: 12, Issue:68

    Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; France; Galantamine; Humans; Indans; Piperidines; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Tacrine; Treatment Outcome

2003
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Ligands; Models, Molecular; Nootropic Agents; Piperidines; Rats; Structure-Activity Relationship; Tacrine

2004
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
    European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Electric Stimulation; Galantamine; In Vitro Techniques; Indans; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Receptors, Purinergic; Rivastigmine; Stimulation, Chemical; Synaptic Transmission; Tacrine; Vas Deferens

2004
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
    The Journal of biological chemistry, 2005, May-06, Volume: 280, Issue:18

    Topics: Animals; Apoptosis; Cells, Cultured; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Glutamic Acid; Indans; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine

2005
Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB).
    Archives of pharmacal research, 2005, Volume: 28, Issue:4

    Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Cell Line, Transformed; Central Nervous System Agents; Choline; Cyclic N-Oxides; Donepezil; Endothelial Cells; Indans; Models, Biological; Nerve Tissue Proteins; Nitrogen Oxides; Organic Cation Transport Proteins; Piperidines; Plasma Membrane Neurotransmitter Transport Proteins; Rats; Symporters; Tacrine

2005
Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
    The American journal of geriatric pharmacotherapy, 2005, Volume: 3, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cohort Studies; Cross-Sectional Studies; Databases, Factual; Dementia; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Nursing Homes; Piperidines; Proportional Hazards Models; Retrospective Studies; Tacrine

2005
Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task.
    Fundamental & clinical pharmacology, 2005, Volume: 19, Issue:5

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Histamine Antagonists; Injections, Intraperitoneal; Male; Maze Learning; Mice; Parasympathomimetics; Piperidines; Psychomotor Performance; Tacrine

2005
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
    Bioorganic & medicinal chemistry, 2005, Dec-15, Volume: 13, Issue:24

    Topics: Acetylcholinesterase; Animals; Binding Sites; Cattle; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Tacrine

2005
Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease.
    Journal of molecular graphics & modelling, 2006, Volume: 25, Issue:2

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Models, Chemical; Models, Molecular; Molecular Structure; Piperidines; Protein Structure, Secondary; Tacrine

2006
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.
    Journal of neurochemistry, 2006, Volume: 98, Issue:5

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Hippocampus; Indans; Isoflurophate; Membrane Potentials; Neurons; Nimodipine; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Tacrine; Time Factors

2006
Pharmacological characterization of orally active cholinesterase inhibitory activity of Prunus persica L. Batsch in rats.
    Journal of molecular neuroscience : MN, 2006, Volume: 29, Issue:2

    Topics: Acetylcholinesterase; Administration, Oral; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Male; Piperidines; Plant Extracts; Prunus; Rats; Rats, Wistar; Tacrine; Tissue Extracts

2006
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice.
    Life sciences, 2007, May-01, Volume: 80, Issue:21

    Topics: Acetylcholinesterase; Analysis of Variance; Animals; Brain; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Indans; Inflammation; Injections, Intraperitoneal; Interleukin-2; Lipopolysaccharides; Mice; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2007
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies.
    Neurology, 2007, May-15, Volume: 68, Issue:20

    Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Autopsy; Cerebral Cortex; Cholinesterase Inhibitors; Clinical Trials as Topic; Cohort Studies; Donepezil; Drug Evaluation; Female; Galantamine; Humans; Indans; Lewy Body Disease; Male; Middle Aged; Neuroprotective Agents; Phenylcarbamates; Piperidines; Prospective Studies; Rivastigmine; Tacrine; tau Proteins; Tauopathies

2007
Effect of histamine on muscimol-induced working memory deficits in radial maze performance.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:3

    Topics: Animals; Brain Chemistry; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Histamine; Histidine; Indans; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Muscimol; Piperidines; Rats; Tacrine

2007
Alzheimer's disease: will advances made in the past turn the tide?
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:9

    Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; History, 20th Century; History, 21st Century; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indans; Memantine; Piperidines; Tacrine

2007
Evaluation of centrally acting cholinesterase inhibitor exposures in adults.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Gastrointestinal Diseases; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Poison Control Centers; Retrospective Studies; Rivastigmine; Tacrine

2007
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
    European journal of pharmacology, 2008, Mar-10, Volume: 581, Issue:3

    Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia; Disease Models, Animal; Donepezil; Glutathione; Indans; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Nootropic Agents; Oxidative Stress; Piperidines; Streptozocin; Tacrine

2008
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations.
    Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5

    Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine

2008
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians.
    Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5

    Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine

2008
AAFP and ACP release guideline on dementia treatment.
    American family physician, 2008, Apr-15, Volume: 77, Issue:8

    Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Guidelines as Topic; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine

2008
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
    Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Models, Molecular; Piperidines; Structure-Activity Relationship; Tacrine

2008
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 295, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Atropine; Autocrine Communication; Caco-2 Cells; Cell Proliferation; Choline; Choline O-Acetyltransferase; Cholinergic Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dose-Response Relationship, Drug; Electrochemistry; Hemicholinium 3; HT29 Cells; Humans; Immunohistochemistry; Membrane Transport Proteins; Muscarinic Antagonists; Physostigmine; Piperidines; Polymerase Chain Reaction; Receptor, Muscarinic M3; RNA, Messenger; Tacrine

2008
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex.
    Journal of Alzheimer's disease : JAD, 2009, Volume: 16, Issue:3

    Topics: Acetylcholine; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Galantamine; Humans; In Vitro Techniques; Indans; Middle Aged; Neocortex; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine; Young Adult

2009
[Protection effects of acetylcholinesterase inhibitors on apoptosis].
    Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2008, Volume: 22, Issue:6

    Topics: Animals; Apoptosis; Cell Count; Cell Proliferation; Cell Survival; Chlorocebus aethiops; Cholinesterase Inhibitors; Donepezil; Drug Antagonism; HeLa Cells; Hepatitis B; Humans; Indans; Lipopolysaccharides; Piperidines; Tacrine; Vero Cells

2008
The inhibitory avoidance test optimized for discovery of cognitive enhancers.
    Behavior research methods, 2009, Volume: 41, Issue:3

    Topics: Animals; Avoidance Learning; Donepezil; Drug Evaluation, Preclinical; Drug Interactions; Indans; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Scopolamine; Tacrine

2009
The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain.
    Biochimie, 2009, Volume: 91, Issue:9

    Topics: Acetylcholinesterase; Amidohydrolases; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Brain; Chick Embryo; Chickens; Cholinesterase Inhibitors; Donepezil; Enzyme Activation; Esterases; In Vitro Techniques; Indans; Isoflurophate; Piperidines; Tacrine

2009
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
    Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3

    Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acid Motifs; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Humans; Indans; Models, Molecular; Piperidines; Protein Multimerization; Protein Structure, Quaternary; Quinolines; Tacrine

2010
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Aging; Animals; Biological Availability; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Galantamine; Half-Life; Hypothermia; Indans; Male; Metabolic Clearance Rate; Piperidines; Random Allocation; Rats; Rats, Inbred Strains; Receptor, Muscarinic M2; Salivation; Tacrine; Tears; Tremor

2011
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
    Behavioural brain research, 2011, Oct-10, Volume: 224, Issue:1

    Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Calcium; Caspase 3; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Glutathione; Indans; Injections, Intraventricular; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mitochondria; Motor Activity; Neurons; Nicotine; Piperidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Nicotinic; Streptozocin; Tacrine

2011
Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures.
    European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3

    Topics: Acetylcholine; Animals; Blotting, Western; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Galantamine; Hippocampus; Indans; Mice; Mice, Inbred ICR; N-Methylaspartate; Organ Culture Techniques; Piperidines; Receptor, Muscarinic M1; Tacrine

2013
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
    Experimental neurology, 2014, Volume: 253

    Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Cannabinoid Receptor Antagonists; Cholinesterase Inhibitors; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Rimonabant; Tacrine; Time Factors; Tremor

2014
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
    European journal of medicinal chemistry, 2014, Jul-23, Volume: 82

    Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines; Quantitative Structure-Activity Relationship; Recombinant Proteins; Tacrine

2014
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 42, Issue:3

    Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Hippocampus; Homocysteine; Hyperhomocysteinemia; Indans; Male; Maze Learning; Memory Disorders; Nerve Tissue Proteins; Nifedipine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Silver Staining; Tacrine

2014
Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential.
    Neuropharmacology, 2014, Volume: 86

    Topics: Animals; Cerebral Cortex; Cognition; Donepezil; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Galantamine; Gamma Rhythm; Indans; Male; Memantine; Motor Activity; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Phenylcarbamates; Piperidines; Principal Component Analysis; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Signal Processing, Computer-Assisted; Tacrine; Theta Rhythm

2014
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.
    General physiology and biophysics, 2015, Volume: 34, Issue:2

    Topics: Animals; Cells, Cultured; Cholinergic Antagonists; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Muscarinic Antagonists; Muscle Fibers, Skeletal; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Tacrine

2015
The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2015, Volume: 159, Issue:4

    Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Quinuclidinyl Benzilate; Rats, Wistar; Tacrine

2015
Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry.
    Biochimica et biophysica acta, 2016, Volume: 1860, Issue:5

    Topics: Acetylcholine; Acetylcholinesterase; Ambenonium Chloride; Animals; Calorimetry; Cholinesterase Inhibitors; Donepezil; Edrophonium; Electrophorus; Fish Proteins; Galantamine; Indans; Kinetics; Piperidines; Tacrine; Thermodynamics

2016
Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats--Is there a potential for Alzheimer's disease treatment?
    Neuroscience letters, 2016, Jan-26, Volume: 612

    Topics: Alzheimer Disease; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Piperidines; Quinuclidinyl Benzilate; Rats, Wistar; Tacrine

2016
Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina.
    Molecules (Basel, Switzerland), 2016, Jan-11, Volume: 21, Issue:1

    Topics: Animals; Cholinesterase Inhibitors; Convulsants; Donepezil; Galantamine; Indans; Locomotion; Models, Biological; Piperidines; Planarians; Rivastigmine; Seizures; Survival Rate; Tacrine

2016
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, May-01, Volume: 1020

    Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Linear Models; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tacrine; Tandem Mass Spectrometry

2016
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
    Journal of psychiatry & neuroscience : JPN, 2017, Volume: 42, Issue:1

    Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Gliosis; Hep G2 Cells; Hippocampus; Humans; Indans; Indoles; Learning; Male; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Plaque, Amyloid; Proof of Concept Study; Recognition, Psychology; Scopolamine; Tacrine

2017
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening.
    Journal of pharmaceutical and biomedical analysis, 2018, Jun-05, Volume: 155

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; Edrophonium; Enzymes, Immobilized; Galantamine; Humans; Indans; Kinetics; Ligands; Piperidines; Recombinant Fusion Proteins; Serum Albumin; Surface Plasmon Resonance; Tacrine

2018