tacrine has been researched along with physostigmine in 170 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (10.59) | 18.7374 |
| 1990's | 101 (59.41) | 18.2507 |
| 2000's | 32 (18.82) | 29.6817 |
| 2010's | 16 (9.41) | 24.3611 |
| 2020's | 3 (1.76) | 2.80 |
| Authors | Studies |
|---|---|
| Araki, S; Higurashi, K; Iimura, Y; Karibe, N; Sasaki, A; Sugimoto, H; Sugumi, H; Tsuchiya, Y; Yamanishi, Y; Yamatsu, K | 1 |
| Chapman, JM; Kosh, JW; Sowell, JW; Tang, Y; Valli, MJ | 1 |
| Chapman, JM; Kosh, JW; Sowell, JW; Tang, Y; Usher, LA; Valli, MJ; Vaughan, CM | 1 |
| Chen, YL; Dunaiskis, A; Hedberg, K; Ives, J; Johnson, J; Jones, S; Liston, D; Nielsen, J; Russo, L | 1 |
| Cardozo, MG; Hopfinger, AJ; Iimura, Y; Sugimoto, H; Yamanishi, Y | 1 |
| Iimura, Y; Sugimoto, H; Yamanishi, Y; Yamatsu, K | 1 |
| Butler, TW; Chapin, DS; Chen, YL; DeMattos, SB; Ives, JL; Jones, SB; Liston, DR; Nagel, AA; Nason, DM; Villalobos, A | 1 |
| Bigg, DC; Briley, M; Calmel, F; Carilla, E; Vidaluc, JL | 1 |
| Chapin, D; Chen, YL; Hubbard, S; Ives, JL; Jones, SB; Jung, S; Liston, DR; Mahar, M; Nagel, AA; Vincent, LA | 1 |
| Biggers, CK; Blake, JF; Butler, TW; Chapin, DS; Chen, YL; Ives, JL; Jones, SB; Liston, DR; Nagel, AA; Villalobos, A | 1 |
| Bigg, D; Briley, M; Calmel, F; Carilla, E; Chopin, P; Stenger, A; Vidaluc, JL | 1 |
| Chen, Y; Collantes, ER; Tong, W; Welsh, WJ | 1 |
| Bier, J; Cho, SJ; Garsia, ML; Tropsha, A | 1 |
| Karplus, M; So, SS | 1 |
| Andrisano, V; Bolognesi, ML; Budriesi, R; Cavalli, A; Cavrini, V; Melchiorre, C; Recanatini, M; Rosini, M; Tumiatti, V | 1 |
| Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X | 1 |
| Andrisano, V; Angeli, P; Banzi, R; Bartolini, M; Cavalli, A; Marucci, G; Melchiorre, C; Minarini, A; Recanatini, M; Rosini, M; Tumiatti, V | 1 |
| Andrisano, V; Banzi, R; Bartolini, M; Melchiorre, C; Minarini, A; Rosini, M; Tumiatti, V | 1 |
| Alley, GM; Brossi, A; Deschamps, JR; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, D; Yu, QS; Zhan, M | 1 |
| Bianchi, DA; Bracca, AB; Hirschmann, GS; Kaufman, TS; Theoduloz, C | 1 |
| Andrisano, V; Bartolini, M; Bidon-Chanal, A; de Austria, C; del Monte-Millán, M; Dorronsoro, I; García-Palomero, E; Luque, FJ; Martínez, A; Medina, M; Muñoz-Ruiz, P; Orozco, M; Rubio, L; Usán, P; Valenzuela, R | 1 |
| Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS | 1 |
| Arnold, N; Brandt, W; Geissler, T; Kehlen, A; Porzel, A; Schlenzig, D; Wessjohann, L | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Castro, MJ; Estévez-Braun, A; Faraoni, MB; Maier, MS; Murray, AP; Ravelo, AG; Richmond, V; Romero, C | 1 |
| Ji, J; Peng, Y; Rakesh, KP; Wang, S; Xu, M; Zhu, L | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Andricopulo, AD; Cenci, AR; de Oliveira, AS; Ferreira, LLG; Machado, V; Nunes, RJ; Sandjo, LP; Sens, L; Teixeira, KF; Tizziani, T; Yunes, RA | 1 |
| Henriksson, BG; Järbe, TU; Johansson, JO | 1 |
| Bajgar, J; Fusek, J; Hrdina, V; Patocka, J | 1 |
| Mendelson, G | 2 |
| Baĭmanov, TD; Burov, IuV; Maĭsov, NI | 1 |
| Curran, SM; Dougal, NJ; Ebmeier, KP; Goodwin, GM; Hanson, MT; Hunter, R; Murray, CL; Patterson, J; Siegfried, K; Wyper, DJ | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| Badia, A; Baños, JE; Bosch, F; Morales, M | 2 |
| Galli, A; Gori, I; Lucherini, M; Mori, F | 1 |
| Feuerstein, TJ; Jackisch, R; Lehmann, J; Sauermann, W; van Velthoven, V | 1 |
| Stern, GM | 1 |
| Miyamoto, MD; Provan, SD | 1 |
| Shillcutt, S; Soininen, H; Unni, L | 1 |
| Cross, AJ; Green, AR; Murray, TK | 1 |
| Abe, E | 1 |
| Musílková, J; Tucek, S | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Burov, IuV; Kadysheva, LV; Robakidze, TN; Shaposhnikova, GI; Voronin, AE | 1 |
| Asai, S; Ishii, Y; Ishikawa, K; Kogure, M; Kubo, T; Shibanoki, S | 1 |
| Galli, A; Mori, F | 1 |
| Barz, H; Bickel, U; Cervos-Navarro, J; Fischer, JP; Gusztony, G; Kaden, B; Kewitz, H; Thomsen, T | 1 |
| Miyoshi, K; Ueki, A | 2 |
| Fischer, JP; Kewitz, H; Thomsen, T; Zendeh, B | 1 |
| Dokla, CP; Rydelek-Fitzgerald, L | 1 |
| Volger, BW | 1 |
| Archer, T; Mohammed, AK; Nordberg, A; Wahlström, G | 1 |
| Menini, C; Rektor, I; Silva-Barrat, C; Svejdová, M | 1 |
| Cook, L; DeNoble, KF; DeNoble, VJ; Johnson, LC; Myers, MJ; Scribner, RM; Spencer, KR | 1 |
| Bemis, KG; Hendrix, JC; Shannon, HE; Ward, JS | 1 |
| Lai, Z; Nilsson-Håkansson, L; Nordberg, A | 1 |
| Harvey, AL; Rowan, EG | 1 |
| Archer, T; Gillberg, PG; Gordh, T; Hartvig, P; Jansson, I; Post, C; Sottile, A | 1 |
| Chow, D; Feldman, S; Lau, SW | 1 |
| Itoh, J; Kameyama, T; Nabeshima, T | 1 |
| Araki, S; Higurashi, K; Iimura, Y; Karibe, N; Kawakami, Y; Nakamura, T; Sasaki, A; Sugimoto, H; Sugumi, H; Tsuchiya, Y | 1 |
| Irie, T; Katsube, J; Natori, K; Okazaki, Y | 2 |
| Cumming, P; Reiner, PB; Vincent, SR | 1 |
| Geula, C; Mesulam, MM | 1 |
| Drukarch, B; Kits, KS; Lodder, JC; Stoof, JC; Van der Meer, EG | 1 |
| Herink, J; Hrdina, V; Koupilová, M | 1 |
| Giacobini, E; Hallak, M | 1 |
| Cross, AJ; Green, AR; Hunter, AJ; Jones, JA; Murray, TK | 1 |
| Kewitz, H; Pleul, O; Thomsen, T | 1 |
| Jarema, M | 1 |
| Atack, JR; Bonham, JR; Court, JA; Perry, EK; Rodway, M; Smith, CJ | 1 |
| Read, SL | 1 |
| Geula, C; Mesulam, MM; Morán, MA | 1 |
| Adem, A; Hardy, J; Nilsson, L; Nordberg, A; Winblad, B | 1 |
| Branconnier, RJ; Miller, LL | 1 |
| Curley, WH; Dretchen, KL; Standaert, FG | 1 |
| Brinkman, SD; Gershon, S | 1 |
| Bassant, MH; Jazat-Poindessous, F; Lamour, Y | 1 |
| Herremans, AH; Hijzen, TH; Olivier, B; Slangen, JL | 1 |
| Bragadin, M; Dell'Antone, P; Zatta, P | 1 |
| Bahro, M; Berger, M; Gann, H; Hohagen, F; Lis, S; Riemann, D; Stadmüller, G | 1 |
| Fitten, LJ; Halgren, E; O'Neill, J; Perryman, KM | 1 |
| Fujii, T; Fujimoto, K; Kawashima, K; Sato, A; Suzuki, T; Yoshizawa, M | 1 |
| Håkansson, L | 1 |
| Kojima, J; Yamana, K | 1 |
| Fujimoto, K; Kawashima, K; Nonaka, H; Suzuki, T | 1 |
| Clarke, PB; el-Bizri, H; Reuben, M | 1 |
| Cantí, C; Marsal, J; Martí, E; Solsona, C | 1 |
| Suzuki, N; Yoshida, S | 1 |
| Glasky, A; Melchior, CL; Ritzmann, RF; Steinberg, A | 1 |
| Mohammed, AH | 1 |
| Johansson, M; Nordberg, A | 1 |
| Coull, JT; Sahakian, BJ | 1 |
| Gustafson, L | 1 |
| Whitehouse, PJ | 1 |
| Glasky, AJ; Heydari, N; Melchior, CL; Pirzadeh, B; Ritzmann, RF | 1 |
| Riekkinen, M; Riekkinen, P | 1 |
| Bassant, MH; Jazat, F; Lamour, Y | 1 |
| Badia, A; Dierssen, M; Màrmol, F; Vivas, NM | 1 |
| Giacobini, E; Messamore, E; Ogane, N; Warpman, U | 1 |
| Olin, JT; Pawluczyk, S; Schneider, LS | 1 |
| Kitajima, I; Ohno, M; Ueki, S; Yamamoto, T; Yatsugi, S | 1 |
| Glasky, AJ; Kling, A; Melchior, CL; Ritzmann, RF | 1 |
| Nordberg, A; Xiao, WB; Zhang, X | 1 |
| Cutler, NR; Sramek, JJ | 2 |
| Camacho, F; Smith, CP; Vargas, HM; Winslow, JT | 1 |
| Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M | 1 |
| Emmerling, MR; Garvin, J; Monteith, DK; Theiss, JC | 1 |
| Farlow, MR; Lahiri, DK | 1 |
| Duoyon, E; Lee, WS; Morrishow, AM; Prell, GD | 1 |
| Mielke, R | 1 |
| Asano, T; Ito, S; Nakazato, Y; Ohta, T; Sugawara, T | 1 |
| Jäkälä, P; Riekkinen, P | 1 |
| Grewig, S; Hinz, VC; Schmidt, BH | 1 |
| Ando, I; Kakiuchi, T; Ouchi, Y; Tsukada, H | 1 |
| Farlow, MR; Greig, NH; Lahiri, DK; Nurnberger, JI | 1 |
| Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Mitch, CH; Peters, SC; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Ward, JS; Whitesitt, CA; Zhang, W | 1 |
| Ito, S; Kitamura, N; Nakazato, Y; Ohta, T; Sugawara, T | 1 |
| Kojima, J; Onodera, K | 1 |
| Ariel, N; Barak, D; Bino, T; Ordentlich, A; Shafferman, A; Velan, B | 1 |
| Brefel-Courbon, C; Freslon, JL; Lazartigues, E; Montastruc, JL; Pelat, M; Rascol, O; Tellioglu, T; Tran, MA | 1 |
| Bodas, E; Cantí, C; Marsal, J; Solsona, C | 1 |
| Cross, AJ; De Souza, RJ; Green, AR; Misra, A; Murray, TK; Snape, MF; Williams, JL | 1 |
| Carlier, PR; Han, YF; Hui, KM; Li, CY; Li, ZW; Pang, YP; Wang, H; Xue, H | 1 |
| Cassel, JC; Kelche, C; Stemmelin, J; Will, B | 1 |
| Kaur, J; Zhang, MQ | 1 |
| Kakiuchi, T; Nishiyama, S; Sato, K; Tsukada, H | 1 |
| Kása, P; Rakonczay, Z; Török, L | 1 |
| Braida, D; Ottonello, F; Sala, M; Virag, W | 1 |
| Lacombe, P; Peruzzi, P; von Euw, D | 1 |
| Gotti, C; Smulders, CJ; van Kleef, RG; Vijverberg, HP; Zwart, R | 1 |
| Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y | 1 |
| Brossi, A; De Micheli, E; Deutsch, J; Greig, NH; Holloway, HW; Ingram, DK; Lahiri, DK; Perry, TA; Soncrant, TT; Utsuki, T; Yu, QS | 1 |
| Bernard, V; Bloch, B; Liste, I | 1 |
| Robert, P | 1 |
| Blount, PJ; McDeavitt, JT; Nguyen, CD | 1 |
| Tang, XC; Zhao, Q | 1 |
| Egashira, N; Fujiwara, M; Iwasaki, K; Matsumoto, Y; Mishima, K | 1 |
| Butler, R; Prabhakaran, P; Warner, J | 1 |
| Rakonczay, Z | 1 |
| Chapin, D; Hubbard, ST; Jones, SB; Liston, DR; Nason, D; Nielsen, JA; Ramirez, A; Shalaby, IA; Villalobos, A; White, WF | 1 |
| Nagura, H | 1 |
| Hallam, KT; Horgan, JE; McGrath, C; Norman, TR | 1 |
| Caricati-Neto, A; D'angelo, LC; Garcia, AG; Hyppolito Jurkiewicz, N; Jurkiewicz, A; Reuter, H | 1 |
| Arya, P; Butler, R; Warner, J | 2 |
| Bermudez, I; Groot-Kormelink, PJ; Smulders, CJ; van Kleef, RG; Vijverberg, HP; Zwart, R | 1 |
| Butler, R; Warner, J; Wuntakal, B | 1 |
| Bajda, M; Malawska, B; Musiał, A | 1 |
| Cheng, K; Davis, RJ; Drachenberg, C; Nomikos, G; Raufman, JP; Samimi, R; Shant, J; Wade, M; Xie, G | 1 |
| Ehret, A; Feuerstein, TJ; Förster, S; Jackisch, R; Kammerer, M; Rothmaier, AK; Zentner, J | 1 |
| Fallarero, A; Hatakka, A; Järvinen, P; Vuorela, P | 1 |
| Hasan, MY; Kuča, K; Lorke, DE; Nurulain, SM; Petroianu, GA; Shafiullah, M | 2 |
| Auber, A; Chiamulera, C; Giarola, A | 1 |
| Caricati-Neto, A; de los Rios, C; Garcia, AG; Godinho, RO; Jurkiewicz, A; Jurkiewicz, NH; Léon, R; Marco-Contelles, J; Miranda-Ferreira, R; Pereira, JD; Samadi, A; Smaili, SS; Villaroya, M | 1 |
| Houghton, PJ; Kim, H; Kim, J; Kim, S; Oh, M; Whang, W; Zhang, X | 1 |
| Hasan, MY; Kuča, K; Lorke, DE; Nurulain, SM; Petroianu, GA | 2 |
21 review(s) available for tacrine and physostigmine
| Article | Year |
|---|---|
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Triazoles | 2019 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
New drug interventions in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Arginine Vasopressin; Cholinesterase Inhibitors; G(M1) Ganglioside; Humans; Mental Recall; Neuropsychological Tests; Physostigmine; Pilot Projects; Receptors, Cholinergic; Tacrine | 1992 |
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Physostigmine; Tacrine | 1991 |
Shifting patterns of cortical cholinesterases in Alzheimer's disease: implications for treatment, diagnosis, and pathogenesis.
Topics: Acetylcholinesterase; Alzheimer Disease; Cerebral Cortex; Humans; Physostigmine; Tacrine | 1990 |
[Progress in the studies of the etiology and treatment of Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Brain; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Dopamine; gamma-Aminobutyric Acid; Humans; Physostigmine; Tacrine | 1988 |
Update on cholinergic enhancement therapy for Alzheimer disease.
Topics: Alzheimer Disease; Aminoacridines; Cholinergic Fibers; Cholinesterase Inhibitors; Humans; Physostigmine; Tacrine | 1987 |
Cannabis: effects on memory and the cholinergic limbic system.
Topics: Acetylcholine; Acetylcholinesterase; Cannabinoids; Cannabis; Choline; Dronabinol; Habituation, Psychophysiologic; Hippocampus; Humans; Limbic System; Memory; Mental Recall; Models, Biological; Parasympatholytics; Physostigmine; Tacrine; Transfer, Psychology | 1983 |
Measurement of cholinergic drug effects on memory in Alzheimer's disease.
Topics: Alzheimer Disease; Arecoline; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Memory; Memory Disorders; Parasympatholytics; Parasympathomimetics; Physostigmine; Scopolamine; Tacrine | 1983 |
Mechanism of action of cholinesterase inhibitors in Alzheimer's disease.
Topics: Acetylcholine; Aged; Alzheimer Disease; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Female; Humans; Male; Neurotransmitter Agents; Physostigmine; Receptors, Cholinergic; Tacrine | 1993 |
Pharmacokinetic studies of cholinesterase inhibitors.
Topics: Adult; Aged; Alzheimer Disease; Female; Galantamine; Humans; Male; Middle Aged; Physostigmine; Tacrine | 1993 |
Cholinergic therapy in dementia.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Female; Humans; Male; Physostigmine; Receptors, Muscarinic; Receptors, Nicotinic; Tacrine | 1993 |
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine | 2000 |
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine.
Topics: Acetylcholine; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Disease Progression; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome | 2002 |
Clinical use of cholinomimetic agents: a review.
Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Brain Injuries; Carbamates; Clinical Trials as Topic; Cytidine Diphosphate Choline; Donepezil; Female; Follow-Up Studies; Humans; Indans; Injections, Intravenous; Injury Severity Score; Male; Middle Aged; Parasympathomimetics; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2002 |
Dementia.
Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E | 2003 |
[Drugs for the treatment of Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Antidepressive Agents; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Haloperidol; Humans; Hydroxyzine; Hypnotics and Sedatives; Indans; Injections, Intramuscular; Physostigmine; Piperidines; Selective Serotonin Reuptake Inhibitors; Tacrine | 2004 |
Dementia.
Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamine; Ginkgo biloba; Haloperidol; Humans; Indans; Memantine; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Risperidone; Rivastigmine; Selegiline; Tacrine; Vitamin E | 2004 |
Dementia.
Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine | 2004 |
Dementia.
Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Selegiline; Tacrine | 2005 |
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.
Topics: Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Indole Alkaloids; Isoquinolines; Phenylcarbamates; Physostigmine; Piperidines; Propidium; Rivastigmine; Steroids; Tacrine | 2007 |
8 trial(s) available for tacrine and physostigmine
| Article | Year |
|---|---|
Effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Physostigmine; Tacrine; Tomography, Emission-Computed, Single-Photon | 1992 |
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Physostigmine; Tacrine | 1991 |
Measurement of cholinergic drug effects on memory in Alzheimer's disease.
Topics: Alzheimer Disease; Arecoline; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Memory; Memory Disorders; Parasympatholytics; Parasympathomimetics; Physostigmine; Scopolamine; Tacrine | 1983 |
Cholinergic neurotransmission, REM sleep and depression.
Topics: Adolescent; Adult; Aged; Alzheimer Disease; Brain Stem; Cholinergic Agonists; Cholinergic Fibers; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Galantamine; Humans; Male; Mental Disorders; Middle Aged; Parasympathomimetics; Physostigmine; Polysomnography; Reaction Time; Receptors, Muscarinic; Sleep Stages; Sleep Wake Disorders; Sleep, REM; Succinimides; Synaptic Transmission; Tacrine | 1994 |
Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB.
Topics: Activities of Daily Living; Alzheimer Disease; Attention; Cross-Sectional Studies; Double-Blind Method; Drug Therapy, Computer-Assisted; Female; Humans; Male; Memory; Neuropsychological Tests; Nicotine; Physostigmine; Placebos; Reaction Time; Tacrine; Treatment Outcome | 1993 |
Physostigmine and tetrahydroaminoacridine treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cerebrovascular Circulation; Cross-Sectional Studies; Double-Blind Method; Electroencephalography; Female; Humans; Male; Neuropsychological Tests; Physostigmine; Tacrine; Treatment Outcome | 1993 |
A double-blind crossover pilot study of l-deprenyl (selegiline) combined with cholinesterase inhibitor in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Delayed-Action Preparations; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Physostigmine; Pilot Projects; Psychiatric Status Rating Scales; Selegiline; Tacrine | 1993 |
The target population in phase I clinical trials of cholinergic compounds in Alzheimer disease: the role of the "bridging study".
Topics: Alzheimer Disease; Cholinergic Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Physostigmine; Safety; Tacrine | 1995 |
143 other study(ies) available for tacrine and physostigmine
| Article | Year |
|---|---|
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.
Topics: Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Male; Molecular Structure; Phthalimides; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship | 1992 |
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
Topics: Acetylcholine; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Synergism; Erythrocytes; Humans; Ileum; Male; Mice; Muscle Contraction; Ranitidine; Rats; Receptors, Muscarinic | 1992 |
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Topics: Animals; Cholinesterase Inhibitors; Furans; Humans; Male; Mice; Parasympathomimetics; Ranitidine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Structure-Activity Relationship | 1992 |
Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues.
Topics: Animals; Brain; Cholinesterase Inhibitors; Lethal Dose 50; Male; Mice; Physostigmine; Structure-Activity Relationship | 1992 |
QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.
Topics: Cholinesterase Inhibitors; Indans; Models, Molecular; Piperidines; Structure-Activity Relationship | 1992 |
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Topics: Animals; Binding Sites; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Male; Mice; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship | 1995 |
5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.
Topics: Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Isoxazoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tacrine | 1995 |
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.
Topics: Animals; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Molecular Conformation; Rats; Structure-Activity Relationship; Thiourea | 1995 |
Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.
Topics: Animals; Benzothiazoles; Butyrylcholinesterase; Cholinesterase Inhibitors; Corpus Striatum; Drug Design; Male; Mice; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles | 1995 |
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Avoidance Learning; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computer Graphics; Isoxazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Morpholines; Piperidines; Prosencephalon; Structure-Activity Relationship | 1994 |
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.
Topics: Acetylcholinesterase; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Dementia; Dose-Response Relationship, Drug; Hydrogen Bonding; Mice; Molecular Conformation; Molecular Structure; Piperidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea | 1994 |
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Models, Molecular; Piperidines | 1996 |
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Binding Sites; Cholinesterase Inhibitors; Molecular Structure | 1996 |
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
Topics: Cholinesterase Inhibitors; Dopamine beta-Hydroxylase; Drug Design; Enzyme Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Molecular Conformation; Molecular Structure; Neural Networks, Computer; Phosphorylases; Receptors, Aryl Hydrocarbon; Static Electricity; Structure-Activity Relationship | 1997 |
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Kinetics; Ligands; Models, Molecular; Polyamines; Receptor, Muscarinic M2; Receptors, Muscarinic; Structure-Activity Relationship | 1998 |
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.
Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship | 2002 |
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Topics: Acetylcholinesterase; Amides; Animals; Anisoles; Atrial Function; Butyrylcholinesterase; Cholinesterase Inhibitors; Diaphragm; Guinea Pigs; Heart Atria; Humans; In Vitro Techniques; Models, Molecular; Muscarinic Antagonists; Myocardial Contraction; Neuromuscular Blockade; Neuromuscular Junction; Polyamines; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic; Stereoisomerism; Structure-Activity Relationship | 2003 |
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Piperidines; Polyamines; Structure-Activity Relationship | 2004 |
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.
Topics: Acetylcholinesterase; Amyloid beta-Protein Precursor; Benzofurans; Butyrylcholinesterase; Carbamates; Cell Line; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Neurons; Oxepins; Structure-Activity Relationship | 2005 |
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Isoquinolines | 2005 |
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cell Line, Tumor; Cholinesterase Inhibitors; Dimerization; Drug Design; Erythrocytes; Fluorometry; Humans; Models, Molecular; Nootropic Agents; Protein Binding; Structure-Activity Relationship; Tacrine | 2005 |
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo | 2006 |
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Topics: Acetylcholinesterase; Agaricales; Animals; Cattle; Cholinesterase Inhibitors; Erythrocytes; Fruiting Bodies, Fungal; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Eels; Horses; Kinetics; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Triterpenes | 2014 |
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies.
Topics: | 2022 |
Drug discrimination in rats: the effects of phencyclidine and ditran.
Topics: Animals; Cues; Cyclohexylamines; Discrimination Learning; Drug Combinations; Fenclonine; Glycolates; Imipramine; Ketamine; Male; Neostigmine; Phencyclidine; Physostigmine; Piperidines; Pyrrolidines; Rats; Tacrine; Tetrabenazine; Yohimbine | 1975 |
In vivo kinetics of blood cholinesterase inhibition by 9-amino-1, 2, 3, 4-tetrahydroacridine, its 7-methoxy derivative and physostigmine in rats.
Topics: Acetylcholinesterase; Acridines; Animals; Kinetics; Male; Physostigmine; Rats; Tacrine | 1979 |
Letter: Treatment of hallucinogenic-plant toxicity.
Topics: Acridines; Antidotes; Autonomic Nervous System; Datura stramonium; Hallucinogens; Humans; Physostigmine; Plant Poisoning; Plants, Medicinal; Plants, Toxic; Tacrine | 1976 |
Letter: Antidotes for drug overdose.
Topics: Acridines; Humans; Orphenadrine; Physostigmine; Tacrine | 1975 |
[Effects of amiridin and tacrine, drugs effective in Alzheimer's disease, on synaptosomal uptake of neuromediators].
Topics: Alzheimer Disease; Aminoquinolines; Animals; Cholinesterase Inhibitors; Dopamine; Epinephrine; gamma-Aminobutyric Acid; Neurotransmitter Agents; Norepinephrine; Physostigmine; Piracetam; Psychotropic Drugs; Rats; Serotonin; Synaptosomes; Tacrine | 1992 |
Involvement of cholinergic mechanisms in impairment of working memory in rats following basolateral amygdaloid lesions.
Topics: Amygdala; Animals; Learning; Male; Memory; Memory, Short-Term; Oxotremorine; Parasympathetic Nervous System; Physostigmine; Rats; Rats, Wistar; Tacrine | 1992 |
Effects of velnacrine, tacrine and physostigmine on tetanic twitch responses at the rat neuromuscular junction.
Topics: Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Neuromuscular Junction; Phrenic Nerve; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine | 1992 |
In vitro protection of acetylcholinesterase and butyrylcholinesterase by tetrahydroaminoacridine. Comparison with physostigmine.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Isoflurophate; Neostigmine; Organophosphorus Compounds; Physostigmine; Tacrine | 1992 |
The autoinhibitory feedback control of acetylcholine release in human neocortex tissue.
Topics: Acetylcholine; Aging; Atropine; Cerebral Cortex; Electric Stimulation; Feedback; Humans; In Vitro Techniques; Muscarinic Antagonists; Oxotremorine; Physostigmine; Receptors, Cholinergic; Tacrine | 1992 |
Tetrahydroaminoacridine and physostigmine have opposing effects on probability of transmitter release at the frog neuromuscular junction.
Topics: Animals; Evoked Potentials; In Vitro Techniques; Kinetics; Motor Endplate; Neostigmine; Neurotransmitter Agents; Physostigmine; Potassium; Rana pipiens; Skin; Tacrine | 1991 |
Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain; Cholinesterase Inhibitors; Cholinesterases; Dichlorvos; Dopamine; Drug Administration Schedule; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Norepinephrine; Physostigmine; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Tacrine; Trichlorfon | 1990 |
Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats.
Topics: Animals; Conditioning, Operant; Male; Memory; Physostigmine; Psychomotor Performance; Rats; Scopolamine; Tacrine | 1991 |
Reversal effect of DM-9384 on scopolamine-induced acetylcholine depletion in certain regions of the mouse brain.
Topics: Acetylcholine; Amnesia; Animals; Brain Chemistry; Central Nervous System Agents; Male; Mice; Mice, Inbred Strains; Parasympathetic Nervous System; Physostigmine; Pyrrolidines; Pyrrolidinones; Scopolamine; Tacrine | 1991 |
The binding of cholinesterase inhibitors tacrine (tetrahydroaminoacridine) and 7-methoxytacrine to muscarinic acetylcholine receptors in rat brain in the presence of eserine.
Topics: Animals; Binding, Competitive; Cerebellum; Cerebral Cortex; Cholinesterase Inhibitors; Female; Kinetics; Physostigmine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tacrine | 1991 |
9-Amino-1,2,3,4-tetrahydroacridine is a potent inhibitor of histamine N-methyltransferase.
Topics: Animals; Brain; Cattle; Histamine; Histamine N-Methyltransferase; In Vitro Techniques; Male; Methylhistamines; Mice; Mice, Inbred Strains; Neostigmine; Physostigmine; Tacrine | 1991 |
[Study of anti-amnesic activity of amiridin in a model of amnesic syndrome].
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Cerebral Cortex; Cholinesterase Inhibitors; In Vitro Techniques; Lipids; Male; Physostigmine; Piracetam; Psychotropic Drugs; Rats; Scopolamine; Synaptosomes; Syndrome; Tacrine | 1991 |
Effect of 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta-(b)-quinoline monohydrate hydrochloride (NIK-247) on cholinergic enzyme activity in rats.
Topics: Acetylcholine; Aminoquinolines; Animals; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Corpus Striatum; Parasympathetic Nervous System; Physostigmine; Psychotropic Drugs; Rats; Rats, Inbred Strains; Tacrine | 1991 |
Effectiveness of 1,2,3,4-tetrahydro-9-aminoacridine (THA) as a pretreatment drug for protection of mice from acute diisopropylfluorophosphate (DFP) intoxication.
Topics: Animals; Brain; Cholinesterase Inhibitors; Diaphragm; Dose-Response Relationship, Drug; Isoflurophate; Male; Mice; Physostigmine; Poisoning; Pyridostigmine Bromide; Tacrine; Time Factors | 1991 |
Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Erythrocytes; Female; Galantamine; Hippocampus; Humans; Male; Mice; Middle Aged; Physostigmine; Tacrine | 1991 |
[Cholinesterase inhibitor].
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Humans; Learning Disabilities; Memory; Neurons; Physostigmine; Scopolamine; Tacrine | 1991 |
In vitro effects of various cholinesterase inhibitors on acetyl- and butyrylcholinesterase of healthy volunteers.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Erythrocytes; Humans; Physostigmine; Pyridostigmine Bromide; Tacrine; Tetraisopropylpyrophosphamide | 1991 |
Comparison of tetrahydroaminoacridine and physostigmine on scopolamine-induced free swim behavior in the rat.
Topics: Animals; Behavior, Animal; Male; Physostigmine; Rats; Scopolamine; Swimming; Tacrine | 1991 |
Learning deficits in aged rats pretreated chronically with barbital and tested late in abstinence: alleviation by tetrahydroaminoacridine.
Topics: Age Factors; Animals; Barbital; Brain; Learning; Learning Disabilities; Male; Organ Size; Physostigmine; Rats; Rats, Inbred Strains; Swimming; Tacrine | 1990 |
Unexpected potentializing effect of a tacrine derivative (9-amino-7-methoxy-1,2,3,4 tetrahydroacridine) upon the non-epileptic myoclonus in baboons Papio papio.
Topics: Animals; Atropine; Drug Synergism; Epilepsies, Myoclonic; Myoclonus; Papio; Physostigmine; Tacrine | 1990 |
Comparison of DuP 996, with physostigmine, THA and 3,4-DAP on hypoxia-induced amnesia in rats.
Topics: 4-Aminopyridine; Amnesia; Animals; Avoidance Learning; Hypoxia; Indoles; Male; Oxygen Consumption; Parasympathetic Nervous System; Physostigmine; Pyridines; Rats; Rats, Inbred Strains; Tacrine | 1990 |
Interactions between scopolamine and muscarinic cholinergic agonists or cholinesterase inhibitors on spatial alternation performance in rats.
Topics: Animals; Arecoline; Behavior, Animal; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory; Oxotremorine; Parasympathomimetics; Physostigmine; Pilocarpine; Rats; Rats, Inbred F344; Scopolamine; Spatial Behavior; Succinimides; Tacrine | 1990 |
Tetrahydroaminoacridine induces opposite changes in muscarinic and nicotinic receptors in rat brain.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Mesencephalon; Physostigmine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Nicotinic; Tacrine | 1990 |
Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents.
Topics: Acetylcholine; Acetylcholinesterase; Aminoacridines; Aminopyridines; Animals; In Vitro Techniques; Membrane Potentials; Mice; Neuromuscular Junction; Physostigmine; Potassium; Tacrine | 1990 |
Behavioral effects after intrathecal administration of cholinergic receptor agonists in the rat.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mecamylamine; Motor Activity; Nicotine; Nociceptors; Parasympathomimetics; Physostigmine; Quinolizines; Rats; Rats, Inbred Strains; Reaction Time; Tacrine | 1990 |
Simultaneous determination of physostigmine and tetrahydroaminoacridine in a transdermal permeation study by high-performance liquid chromatography.
Topics: Aged; Aminoacridines; Cadaver; Chromatography, High Pressure Liquid; Humans; Male; Permeability; Physostigmine; Skin; Tacrine | 1990 |
Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock.
Topics: Amnesia; Animals; Electroshock; Injections, Intraventricular; Male; Memory; Mice; Mice, Inbred Strains; Physostigmine; Psychotropic Drugs; Pyrrolidinones; Scopolamine; Tacrine | 1990 |
Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives.
Topics: Acetylcholinesterase; Animals; Benzyl Compounds; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Indicators and Reagents; Kinetics; Male; Molecular Structure; Physostigmine; Piperidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tacrine | 1990 |
Pharmacological and biochemical assessment of SM-10888, a novel cholinesterase inhibitor.
Topics: Aminacrine; Aminoacridines; Aminoquinolines; Animals; Body Temperature; Cerebral Cortex; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Nucleic Acids; Physostigmine; Rats; Salivation; Tacrine | 1990 |
Effect of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice.
Topics: Aminacrine; Aminoacridines; Aminoquinolines; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cycloheximide; Electroshock; Exploratory Behavior; Habituation, Psychophysiologic; Male; Mice; Physostigmine; Tacrine | 1990 |
Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA).
Topics: 4-Aminopyridine; Aminoacridines; Animals; Antineoplastic Agents; Brain; Histamine; Histamine N-Methyltransferase; Injections, Intraperitoneal; Male; Methyltransferases; Physostigmine; Pyrimethamine; Rats; Tacrine | 1990 |
9-Amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetylcholinesterase activity and slow outward K+ current.
Topics: Alzheimer Disease; Aminoacridines; Animals; Atropine; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Electrophysiology; In Vitro Techniques; Ion Channels; Lymnaea; Male; Oxotremorine; Physostigmine; Rats; Rats, Inbred Strains; Tacrine | 1987 |
Effects of tetrahydroaminoacridine (tacrine) derivatives and physostigmine in convulsions induced by pentylenetetrazol.
Topics: Aminoacridines; Animals; Cholinesterase Inhibitors; Male; Pentylenetetrazole; Physostigmine; Rats; Rats, Inbred Strains; Seizures; Tacrine | 1989 |
Effects of cholinergic drugs on learning impairment in ventral globus pallidus-lesioned rats.
Topics: Aminoacridines; Aminoquinolines; Animals; Avoidance Learning; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electroshock; Globus Pallidus; Kainic Acid; Memory; Motor Activity; Parasympathomimetics; Physostigmine; Rats; Rats, Inbred Strains; Retention, Psychology; Tacrine | 1989 |
Physostigmine, tacrine and metrifonate: the effect of multiple doses on acetylcholine metabolism in rat brain.
Topics: Acetylcholine; Aminoacridines; Animals; Brain; Brain Chemistry; Caudate Nucleus; Choline; Choline O-Acetyltransferase; Cholinesterases; Male; Physostigmine; Rats; Rats, Inbred Strains; Tacrine; Time Factors; Trichlorfon | 1989 |
The cholinergic pharmacology of tetrahydroaminoacridine in vivo and in vitro.
Topics: Aminoacridines; Animals; Behavior, Animal; Brain Chemistry; Cholinesterase Inhibitors; Gallamine Triethiodide; In Vitro Techniques; Male; Mice; Myocardium; N-Methylscopolamine; Nicotine; Oxotremorine; Parasympathetic Nervous System; Physostigmine; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Tacrine | 1989 |
Estimation of cholinesterase activity (EC 3.1.1.7; 3.1.1.8) in undiluted plasma and erythrocytes as a tool for measuring in vivo effects of reversible inhibitors.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Carbon Radioisotopes; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Female; Humans; Kinetics; Male; Physostigmine; Pyridostigmine Bromide; Radioisotope Dilution Technique; Reference Values; Sex Factors; Tacrine | 1988 |
Interaction of 9-amino-1,2,3,4-tetrahydroaminoacridine (THA) with human cortical nicotinic and muscarinic receptor binding in vitro.
Topics: Acetylcholinesterase; Aged; Aminoacridines; Binding, Competitive; Cerebral Cortex; Humans; Middle Aged; Physostigmine; Receptors, Muscarinic; Receptors, Nicotinic; Tacrine | 1988 |
Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles.
Topics: Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Cholinesterase Inhibitors; Female; Histocytochemistry; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Neurofibrils; Physostigmine; Tacrine | 1987 |
Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brains via nicotinic receptors?
Topics: Acetylcholine; Aged; Alzheimer Disease; Aminoacridines; Dementia; Female; Frontal Lobe; Humans; In Vitro Techniques; Male; Physostigmine; Receptors, Nicotinic; Tacrine | 1987 |
Physostigmine inhibition of 3',5'-cyclic AMP phosphodiesterase from cat sciatic nerve.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cats; Etazolate; Hydrogen-Ion Concentration; In Vitro Techniques; Neuromuscular Junction; Physostigmine; Sciatic Nerve; Tacrine; Theophylline | 1984 |
Metabolic response to tacrine (THA) and physostigmine in the aged rat brain.
Topics: Aging; Animals; Autoradiography; Brain; Carbon Radioisotopes; Cholinesterase Inhibitors; Deoxyglucose; Glucose; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine | 1995 |
Cholinergic drug effects on a delayed conditional discrimination task in the rat.
Topics: Animals; Appetitive Behavior; Arecoline; Brain; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mental Recall; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Physostigmine; Rats; Rats, Wistar; Receptors, Cholinergic; Retention, Psychology; Scopolamine; Scopolamine Derivatives; Synaptic Transmission; Tacrine | 1995 |
Anticholinesterasic drugs: tacrine but not physostigmine, accumulates in acidic compartments of the cells.
Topics: Acridine Orange; Alzheimer Disease; Animals; Biological Transport, Active; Cell Line; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Lysosomes; Male; Mice; Organelles; Physostigmine; Rats; Rats, Wistar; T-Lymphocytes; Tacrine | 1995 |
Influence of cholinesterase inhibitors on cortical slow-wave activity in aging nonhuman primate.
Topics: Aging; Amodiaquine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Electrodes; Electroencephalography; Female; Macaca radiata; Physostigmine; Scopolamine; Tacrine | 1994 |
Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Male; Movement; Physostigmine; Piperidines; Radioimmunoassay; Rats; Rats, Wistar; Tacrine | 1994 |
[Effects of NIK-247 on the spontaneous EEG of normal and nucleus basalis magnocellularis lesioned rats].
Topics: Administration, Oral; Aminoquinolines; Animals; Cholinesterase Inhibitors; Electroencephalography; Male; Physostigmine; Psychotropic Drugs; Rats; Rats, Wistar; Substantia Innominata; Tacrine | 1994 |
Tacrine increases stimulation-evoked acetylcholine release from rat hippocampal slices.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Physostigmine; Rats; Tacrine | 1994 |
Blockade of nicotinic responses by physostigmine, tacrine and other cholinesterase inhibitors in rat striatum.
Topics: Animals; Choline; Cholinesterase Inhibitors; Corpus Striatum; Dopamine; Drug Interactions; In Vitro Techniques; Male; Nicotine; Nicotinic Antagonists; Physostigmine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Synaptosomes; Tacrine; Tritium | 1994 |
Tacrine-induced increase in the release of spontaneous high quantal content events in Torpedo electric organ.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Electric Organ; Electrophysiology; In Vitro Techniques; Kinetics; Membrane Potentials; Microelectrodes; Motor Endplate; Nerve Endings; Physostigmine; Synaptosomes; Tacrine; Torpedo | 1994 |
Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats.
Topics: Administration, Oral; Aminoquinolines; Amnesia; Animals; Avoidance Learning; Body Temperature; Cholinesterase Inhibitors; Injections, Intraperitoneal; Miosis; Physostigmine; Psychotropic Drugs; Rats; Salivation; Scopolamine; Tacrine; Tremor | 1993 |
The interaction of ethanol with the cognitive enhancers tacrine, physostigmine, and AIT-082.
Topics: Aminobenzoates; Animals; Behavior, Animal; Body Temperature; Cognition; Conscious Sedation; Drug Interactions; Ethanol; Hypoxanthines; Male; Mice; Mice, Inbred C57BL; Physostigmine; Purines; Tacrine | 1994 |
Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Learning; Memory; Physostigmine; Rats; Tacrine | 1993 |
Effect of AIT-082, a purine analog, on working memory in normal and aged mice.
Topics: Aging; Aminobenzoates; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hypoxanthines; Male; Memory, Short-Term; Mice; Physostigmine; Psychotropic Drugs; Purines; Tacrine | 1994 |
Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation.
Topics: Animals; Cholinesterase Inhibitors; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Neuromuscular Blocking Agents; Neuromuscular Junction; Phrenic Nerve; Physostigmine; Rats; Rats, Sprague-Dawley; Respiratory Muscles; Tacrine | 1993 |
Effects of THA and physostigmine on spatial navigation and avoidance performance in mecamylamine and PCPA-treated rats.
Topics: Animals; Avoidance Learning; Cholinesterase Inhibitors; Fenclonine; Male; Mecamylamine; Motor Activity; Physostigmine; Rats; Rats, Wistar; Reaction Time; Retention, Psychology; Space Perception; Tacrine | 1994 |
Tetrahydroaminoacridine and physostigmine increase cerebral glucose utilization in specific cortical and subcortical regions in the rat.
Topics: Animals; Brain; Deoxyglucose; Glucose; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine; Time Factors; Tissue Distribution | 1993 |
Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the beta-adrenoceptor transduction system.
Topics: Animals; Cerebral Cortex; Hippocampus; In Vitro Techniques; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction; Tacrine | 1993 |
Cholinesterase inhibitor effects on extracellular acetylcholine in rat cortex.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dialysis; Electrochemistry; Extracellular Space; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine | 1993 |
Ameliorative effects of the centrally active cholinesterase inhibitor, NIK-247, on impairment of working memory in rats.
Topics: Acetylcholinesterase; Aminoquinolines; Animals; Appetitive Behavior; Brain; Cholinesterase Inhibitors; Hippocampus; Male; Mental Recall; Orientation; Physostigmine; Psychotropic Drugs; Rats; Rats, Wistar; Receptors, Cholinergic; Regional Blood Flow; Retention, Psychology; Scopolamine; Tacrine | 1993 |
Effect of age and strain on working memory in mice as measured by win-shift paradigm.
Topics: Aging; Animals; Male; Memory, Short-Term; Mice; Mice, Inbred C57BL; Models, Psychological; Physostigmine; Species Specificity; Tacrine | 1993 |
Effect of in vivo microdialysis of 1,2,3,4-tetrahydro-9-aminoacridine (THA) on the extracellular concentration of acetylcholine in the striatum of anesthetized rats.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Cholinesterase Inhibitors; Corpus Striatum; Dialysis; Male; Physostigmine; Potassium; Rats; Rats, Sprague-Dawley; Tacrine | 1993 |
Scientific and ethical concerns in clinical trials in Alzheimer's patients: the bridging study.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Dihydropyridines; Ethics, Medical; Humans; Nootropic Agents; Oximes; Physostigmine; Psychotropic Drugs; Pyridines; Tacrine; Thiadiazoles | 1995 |
Alpha 2-adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Benzazepines; Cholinesterase Inhibitors; Drug Synergism; Galantamine; Idazoxan; Male; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine; Yohimbine | 1996 |
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1996 |
Cytotoxicity study of tacrine, structurally and pharmacologically related compounds using rat hepatocytes.
Topics: Acetylcholinesterase; Aminacrine; Animals; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Liver; Male; Nootropic Agents; Physostigmine; Proflavine; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine | 1996 |
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines.
Topics: Amyloid beta-Protein Precursor; Animals; Arecoline; Astrocytes; Atropine; Calcimycin; Carbachol; Cholinesterase Inhibitors; Enzyme Inhibitors; HeLa Cells; Humans; Ionophores; Muscarinic Agonists; Muscarinic Antagonists; Neuroblastoma; PC12 Cells; Physostigmine; Rats; Staurosporine; Tacrine | 1996 |
Inhibitors of histamine methylation in brain promote formation of imidazoleacetic acid, which interacts with GABA receptors.
Topics: Animals; Brain; Gas Chromatography-Mass Spectrometry; Histamine; Imidazoles; Male; Methylation; Physostigmine; Pyrimethamine; Rats; Rats, Sprague-Dawley; Receptors, GABA; Tacrine | 1997 |
[Neuroprotective therapy of Alzheimer's disease?].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Galantamine; Humans; Neuroprotective Agents; Physostigmine; Piracetam; Tacrine | 1996 |
Tacrine inhibits nicotinic secretory and current responses in adrenal chromaffin cells.
Topics: Acetylcholine; Animals; Catecholamines; Cholinesterase Inhibitors; Chromaffin Cells; Female; Guinea Pigs; Male; Membrane Potentials; Nicotine; Nicotinic Antagonists; Perfusion; Physostigmine; Tacrine | 1997 |
Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats.
Topics: Aging; Amphetamines; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electroencephalography; Ketanserin; Male; Physostigmine; Rats; Rats, Wistar; Reaction Time; Receptors, Cholinergic; Receptors, Serotonin; Tacrine; Thalamus | 1997 |
Metrifonate induces cholinesterase inhibition exclusively via slow release of dichlorvos.
Topics: Animals; Biodegradation, Environmental; Brain; Cholinesterase Inhibitors; Cholinesterases; Dichlorvos; Hydrogen-Ion Concentration; Kinetics; Male; Physostigmine; Rats; Rats, Wistar; Tacrine; Trichlorfon | 1996 |
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys.
Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Physostigmine; Piperidines; Scopolamine; Tacrine; Tomography, Emission-Computed | 1997 |
Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures.
Topics: 4-Aminopyridine; Amifampridine; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; HeLa Cells; Humans; PC12 Cells; Physostigmine; Rats; Tacrine; Trichlorfon; Tumor Cells, Cultured | 1997 |
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Cholinesterase Inhibitors; Dihydropyridines; Dose-Response Relationship, Drug; Hydrolysis; Hypothermia; Imines; Lithium; Male; Mice; Mice, Inbred Strains; Muscarinic Agonists; Oximes; Parasympathomimetics; Phosphatidylinositols; Physostigmine; Pilocarpine; Pyridines; Quinuclidines; Radioligand Assay; Salivation; Tacrine; Tetrazoles; Thiadiazoles; Tremor | 1998 |
Inhibitory effects of tacrine and physostigmine on catecholamine secretion and membrane currents in guinea-pig adrenal chromaffin cells.
Topics: Adrenal Glands; Animals; Calcium; Catecholamines; Cholinesterase Inhibitors; Chromaffin Cells; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Physostigmine; Potassium; Sodium; Tacrine; Veratridine | 1998 |
NIK-247 induces long-term potentiation of synaptic transmission in the CA1 region of rat hippocampal slices through M2 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Aminoquinolines; Animals; Carbachol; Cholinesterase Inhibitors; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Physostigmine; Rats; Rats, Wistar; Receptors, Muscarinic; Synaptic Transmission; Tacrine | 1998 |
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Chemical; Models, Molecular; Physostigmine; Protein Conformation; Pyridostigmine Bromide; Sesquiterpenes; Structure-Activity Relationship; Tacrine | 1998 |
Pressor and bradycardic effects of tacrine and other acetylcholinesterase inhibitors in the rat.
Topics: Adrenergic Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Atropine Derivatives; Blood Pressure; Carbamates; Cardiovascular Agents; Chlorisondamine; Cholinergic Antagonists; Cholinesterase Inhibitors; Diamines; Diastole; Dose-Response Relationship, Drug; Heart Rate; Male; Phenylcarbamates; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Rivastigmine; Systole; Tacrine | 1998 |
Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes.
Topics: Animals; Cell Membrane; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Nicotinic Antagonists; Oocytes; Physostigmine; Receptors, Nicotinic; Tacrine; Torpedo; Xenopus | 1998 |
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Carbachol; Cholinesterase Inhibitors; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Indoles; Injections, Intraperitoneal; Isoquinolines; Logistic Models; Male; Physostigmine; Piperidines; Rats; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured | 1999 |
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Electric Stimulation; Electrophysiology; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Physostigmine; Radioligand Assay; Rats; Receptors, Muscarinic; Tacrine | 1999 |
Sensitivity to cholinergic drug treatments of aged rats with variable degrees of spatial memory impairment.
Topics: Aging; Animals; Brain; Cholinergic Agents; Escape Reaction; Female; Maze Learning; Mental Recall; Motor Activity; Orientation; Physostigmine; Postural Balance; Psychomotor Performance; Rats; Rats, Long-Evans; Retention, Psychology; Scopolamine; Space Perception; Tacrine | 1999 |
Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain.
Topics: Acetylcholine; Age Factors; Animals; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Extracellular Space; Glucose; Indans; Macaca mulatta; Male; Microdialysis; Neurons; Physostigmine; Piperidines; Tacrine; Tomography, Emission-Computed; Wakefulness | 2000 |
Preferential inhibition of acetylcholinesterase molecular forms in normal human brain.
Topics: Acetylcholinesterase; Benzazepines; Brain; Cholinesterase Inhibitors; Humans; Physostigmine; Tacrine | 1999 |
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit.
Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine | 2000 |
Differentiated cerebrovascular effects of physostigmine and tacrine in cortical areas deafferented from the nucleus basalis magnocellularis suggest involvement of basalocortical projections to microvessels.
Topics: Animals; Basal Nucleus of Meynert; Cerebral Cortex; Cerebrovascular Circulation; Denervation; Ibotenic Acid; Male; Microcirculation; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine | 2000 |
Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholinesterase-inhibiting drugs.
Topics: Acetylcholine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Ion Transport; Ligands; Models, Neurological; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Physostigmine; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Tacrine; Xenopus laevis | 2000 |
Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Animals; Benzazepines; Brain; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Inhibitory Concentration 50; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rivastigmine; Tacrine; Time Factors | 2000 |
The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Half-Life; Infusions, Intravenous; Male; Physostigmine; Rats; Rats, Inbred F344; Tacrine | 2000 |
Acute and chronic acetylcholinesterase inhibition regulates in vivo the localization and abundance of muscarinic receptors m2 and m4 at the cell surface and in the cytoplasm of striatal neurons.
Topics: Acetylcholinesterase; Animals; Atropine; Cell Membrane; Cholinesterase Inhibitors; Cytoplasm; Dendrites; Drug Administration Schedule; Immunohistochemistry; Male; Microscopy, Electron; Muscarinic Antagonists; Neostriatum; Neurons; Organelles; Physostigmine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; RNA, Messenger; Tacrine; Trichlorfon; Up-Regulation | 2002 |
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine | 2002 |
Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; Dronabinol; Hallucinogens; Hippocampus; Male; Maze Learning; Memory; Memory Disorders; Microdialysis; Physostigmine; Rats; Rats, Wistar; Space Perception; Tacrine | 2002 |
Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzazepines; Brain; Butyrylcholinesterase; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Edrophonium; Humans; In Vitro Techniques; Phenylcarbamates; Physostigmine; Rivastigmine; Tacrine; Trichlorfon | 2003 |
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Mice; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine | 2004 |
An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat.
Topics: Alzheimer Disease; Animals; Arousal; Basal Nucleus of Meynert; Cholinergic Fibers; Cholinesterase Inhibitors; Defecation; Escape Reaction; Injections, Intraperitoneal; Maze Learning; Memory, Short-Term; Motor Activity; Olfactory Bulb; Orientation; Physostigmine; Rats; Rats, Sprague-Dawley; Social Environment; Tacrine | 2004 |
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Electric Stimulation; Galantamine; In Vitro Techniques; Indans; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Receptors, Purinergic; Rivastigmine; Stimulation, Chemical; Synaptic Transmission; Tacrine; Vas Deferens | 2004 |
Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Azocines; Binding, Competitive; Cholinergic Agents; Cholinesterase Inhibitors; Dichlorvos; Dose-Response Relationship, Drug; Female; Galantamine; Humans; Membrane Potentials; Models, Biological; Nicotine; Oocytes; Phenylcarbamates; Physostigmine; Plasmids; Quinolizines; Receptors, Nicotinic; Rivastigmine; Scopolamine; Tacrine; Xenopus laevis | 2005 |
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation.
Topics: Acetylcholine; Acetylcholinesterase; Atropine; Autocrine Communication; Caco-2 Cells; Cell Proliferation; Choline; Choline O-Acetyltransferase; Cholinergic Agents; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Colonic Neoplasms; Dose-Response Relationship, Drug; Electrochemistry; Hemicholinium 3; HT29 Cells; Humans; Immunohistochemistry; Membrane Transport Proteins; Muscarinic Antagonists; Physostigmine; Piperidines; Polymerase Chain Reaction; Receptor, Muscarinic M3; RNA, Messenger; Tacrine | 2008 |
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex.
Topics: Acetylcholine; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Galantamine; Humans; In Vitro Techniques; Indans; Middle Aged; Neocortex; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine; Young Adult | 2009 |
Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Dithionitrobenzoic Acid; Physostigmine; Pyrrolidinones; Tacrine | 2011 |
Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors.
Topics: Amiloride; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Inhibitory Concentration 50; Isoflurophate; Male; Methylene Blue; Metoclopramide; Oximes; Physostigmine; Proportional Hazards Models; Pyridinium Compounds; Pyridostigmine Bromide; Ranitidine; Rats; Tacrine; Tiapride Hydrochloride | 2011 |
Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats.
Topics: Animals; Cholinesterase Inhibitors; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Galantamine; Generalization, Stimulus; Male; Nicotine; Nicotinic Agonists; Physostigmine; Rats; Rats, Sprague-Dawley; Tacrine | 2011 |
Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine Triphosphate; Animals; Butyrylcholinesterase; Calcium; Cerebral Cortex; Cholinesterase Inhibitors; Cytosol; Electric Stimulation; Fura-2; Humans; In Vitro Techniques; Male; Muscle Contraction; Nimodipine; Norepinephrine; Physostigmine; Rats; Rats, Wistar; Tacrine; Vas Deferens | 2011 |
Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon.
Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Organophosphate Poisoning; Oximes; Paraoxon; Physostigmine; Pyridostigmine Bromide; Ranitidine; Rats; Rats, Wistar; Tacrine; Tiapride Hydrochloride | 2013 |
Epimediphine, a novel alkaloid from Epimedium koreanum inhibits acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Aporphines; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Epimedium; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Physostigmine; Tacrine | 2013 |
Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl.
Topics: Animals; Azinphosmethyl; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Oximes; Physostigmine; Proportional Hazards Models; Pyridinium Compounds; Pyridostigmine Bromide; Ranitidine; Rats; Rats, Wistar; Tacrine | 2015 |
Combined Pre- and Posttreatment of Paraoxon Exposure.
Topics: Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Organophosphates; Oximes; Paraoxon; Physostigmine; Post-Exposure Prophylaxis; Pre-Exposure Prophylaxis; Proportional Hazards Models; Pyridostigmine Bromide; Ranitidine; Rats; Rats, Wistar; Survival Analysis; Tacrine | 2020 |