tacrine has been researched along with pargyline in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (75.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Du, Z; Huang, L; Li, X; Lu, C; Yan, J; Zhou, Q | 1 |
| Chen, J; Chen, X; Huang, L; Li, X; Sun, Y | 1 |
| Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W | 1 |
| Jiang, N; Kong, LY; Lan, JS; Li, F; Wang, J; Wang, X; Wang, ZM; Wu, JJ; Xie, SS | 1 |
| Brazzolotto, X; Brus, B; Colletier, JP; Coquelle, N; Gobec, S; Knez, D; Kos, J; Košak, U; Nachon, F; Pišlar, A | 1 |
| Annie Rilda, PR; Baek, SC; Grace Thomas Parambi, D; Inasu, ST; Joy, M; Kim, H; Kumar Krishnan, G; Lohidakshan, KK; Mathew, B; Mathew, GE; Nithyamol, P; Pil Lee, J; Randev, RV; Vijayan, V | 1 |
| Baek, SC; Cho, ML; Kang, MG; Kim, H; Lee, H; Lee, JP; Oh, SR; Park, CM; Park, D; Park, JE; Ryu, HW | 1 |
| Christen, P; Cretton, S; Gasper, AL; Henriques, AT; Klein-Júnior, LC; Nejad-Ebrahimi, S; Vander Heyden, Y | 1 |
| Bai, R; Gu, J; Guo, J; Jiang, X; Lv, Y; Mi, Z; Shi, Y; Xie, Y; Yao, C; Zhang, C; Zhou, T | 1 |
| Andrys, R; Capek, J; Handl, J; Hrabinova, M; Janockova, J; Kobrlova, T; Korabecny, J; Marco-Contelles, JL; Mezeiova, E; Micankova, P; Muckova, L; Nepovimova, E; Pejchal, J; Rousar, T; Simunkova, M; Soukup, O; Valko, M | 1 |
| Cross, AJ; De Souza, RJ; Green, AR; Robinson, TN | 1 |
| Huang, L; Li, J; Li, X; Mao, F; Wei, H | 1 |
16 other study(ies) available for tacrine and pargyline
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Recombinant Proteins; Selegiline; Structure-Activity Relationship; Tacrine | 2013 |
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine | 2013 |
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine | 2015 |
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Donepezil; Dose-Response Relationship, Drug; Drug Design; Eels; Humans; Indans; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Structure-Activity Relationship | 2016 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Death; Cell Line; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Naphthalenes; Peptide Fragments; Piperidines; Structure-Activity Relationship; Sulfonamides | 2017 |
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors.
Topics: | 2018 |
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.
Topics: Acetylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Coumarins; Enzyme Assays; Humans; Kinetics; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Structure-Activity Relationship | 2019 |
Bioactive Azepine-Indole Alkaloids from
Topics: Azepines; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Circular Dichroism; Indole Alkaloids; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Monoamine Oxidase Inhibitors; Plant Components, Aerial; Plant Extracts; Plant Leaves; Psychotria; Spectrometry, Mass, Electrospray Ionization | 2020 |
Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Behavior, Animal; Binding Sites; Cell Survival; Coumarins; Disease Models, Animal; Drug Design; Humans; Iron Chelating Agents; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Peptide Fragments; Rats; Structure-Activity Relationship | 2020 |
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Drug Design; Humans; Naphthoquinones; Structure-Activity Relationship | 2021 |
The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat brain tissue prisms.
Topics: Aminoacridines; Animals; Biogenic Monoamines; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine; Fenfluramine; In Vitro Techniques; Male; Parasympathomimetics; Pargyline; Potassium Channels; Rats; Serotonin; Tacrine | 1989 |
Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Humans; Molecular Structure; Pargyline; Propylamines; Structure-Activity Relationship; Tacrine | 2015 |