tacrine has been researched along with nimodipine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| de Los Ríos, C; García, AG; Guglietta, A; León, R; López, MG; Marco-Contelles, J; Terencio, J; Villarroya, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barril, X; de los Ríos, C; García, AG; Huertas, O; León, R; López, MG; Luque, FJ; Marco-Contelles, J; Villarroya, M | 1 |
| Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bartolini, M; Bolognesi, ML; Buzzi, E; Chioua, M; Giovannini, C; Iriepa, I; Ismaili, L; Jóźwiak, K; López-Alvarado, P; Maj, M; Marco-Contelles, J; Menéndez, JC; Moraleda, I; Portali, F; Tramarin, A; Wnorowski, A | 1 |
| Darzins, P; Ganesan, R; Molloy, DW; Orange, JB; Standish, T | 1 |
| Dosantos Hernández, JO; Larrabe Medina, J; Ojer Tsakiridu, D; Sánchez Casado, JI; Sologuren Echenagusia, A | 1 |
| Aymard, G; Cayre-Castel, M; Diquet, B; Fernandez, C; Lacomblez, L | 1 |
| Chang, DC; Fu, H; Han, Y; Kan, KK; Lao, Y; Lee, NT; Li, M; Li, W; Li, Z; Luo, J; Pang, Y; Tsang, HW; Tsim, KW | 1 |
| Caricati-Neto, A; de los Rios, C; Garcia, AG; Godinho, RO; Jurkiewicz, A; Jurkiewicz, NH; Léon, R; Marco-Contelles, J; Miranda-Ferreira, R; Pereira, JD; Samadi, A; Smaili, SS; Villaroya, M | 1 |
2 review(s) available for tacrine and nimodipine
| Article | Year |
|---|---|
New treatments for dementia. Myth, magic, and science.
Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Attitude to Death; Attitude to Health; Canada; Cultural Characteristics; Dementia; Drug Approval; Ethics, Medical; Humans; Middle Aged; Nimodipine; Quality of Life; Social Values; Tacrine; Treatment Outcome | 1994 |
[Piracetam, nimodipine and tacrine in the pharmacologic treatment of dementia: bibliographic review].
Topics: Aged; Aged, 80 and over; Dementia; Double-Blind Method; Humans; Nimodipine; Nootropic Agents; Piracetam; Randomized Controlled Trials as Topic; Tacrine | 1996 |
16 other study(ies) available for tacrine and nimodipine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Calcium; Calcium Channels; Cell Proliferation; Cells, Cultured; Dihydropyridines; Eels; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Neuroblastoma; Neuroprotective Agents; Structure-Activity Relationship; Tacrine | 2006 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.
Topics: Acetylcholinesterase; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Dihydropyridines; Humans; Inhibitory Concentration 50; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Neuroprotective Agents; Reactive Oxygen Species; Spectrophotometry, Infrared; Tacrine | 2008 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Hep G2 Cells; Humans; Ligands; Molecular Structure; Pyrimidines; Structure-Activity Relationship | 2018 |
High-performance liquid chromatography with ultraviolet and fluorimetric detection for the simultaneous determination of tacrine, nimodipine, and their respective metabolites in the plasma of patients with Alzheimer disease.
Topics: Alzheimer Disease; Calibration; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Drug Interactions; Drug Stability; Fluorometry; Humans; Linear Models; Nimodipine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tacrine; Vasodilator Agents | 1998 |
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Hippocampus; Indans; Isoflurophate; Membrane Potentials; Neurons; Nimodipine; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Tacrine; Time Factors | 2006 |
Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine Triphosphate; Animals; Butyrylcholinesterase; Calcium; Cerebral Cortex; Cholinesterase Inhibitors; Cytosol; Electric Stimulation; Fura-2; Humans; In Vitro Techniques; Male; Muscle Contraction; Nimodipine; Norepinephrine; Physostigmine; Rats; Rats, Wistar; Tacrine; Vas Deferens | 2011 |