tacrine and memantine

tacrine has been researched along with memantine in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	21 (56.76)	29.6817
2010's	15 (40.54)	24.3611
2020's	1 (2.70)	2.80

Authors

Authors	Studies
Andrisano, V; Bartolini, M; Bolognesi, ML; Cavalli, A; Ceccarini, L; McClymont, DW; Melchiorre, C; Mellor, IR; Minarini, A; Pascu, N; Rosini, M; Simoni, E; Tarozzi, A; Tumiatti, V	1
Gaube, F; Heilmann, J; Lehmann, J; Rook, Y; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bazureau, JP; Burgy, G; Carreaux, F; Cochet, C; Delhommel, F; Durieu, E; Elkins, JM; Filippakopoulos, P; Knapp, S; Lo, DC; Meijer, L; Oberholzer, AE; Pearl, LH; Schmid, RS; Soundararajan, M; Tahtouh, T	1
Adolph, O; Appenroth, D; Enzensperger, C; Fleck, C; Föhr, KJ; Gaube, F; Lehmann, J; Otto, R; Penzis, R; Robaa, D; Warncke, P; Winckler, T	1
Bai, R; Gu, J; Guo, J; Jiang, X; Lv, Y; Mi, Z; Shi, Y; Xie, Y; Yao, C; Zhang, C; Zhou, T	1
Danysz, W; Moebius, HJ; Quack, G; Wenk, GL	1
Gavrilova, SI; Zharikov, GA	1
Kamei, H; Nabeshima, T; Noda, Y	1
Hartmann, S; Möbius, HJ	1
Fuchsberger, T; Hampel, H; Möller, HJ	1
Arya, P; Butler, R; Warner, J	2
Aisen, PS	1
Bachurin, SO; Kireeva, EG; Shevtsova, EF	1
Butler, R; Warner, J; Wuntakal, B	1
Chan, HH; Chen, K; Fu, H; Han, Y; Jiang, H; Kan, KK; Lam, CS; Lee, NT; Li, C; Li, M; Li, W; Li, X; Luo, J; Niu, C; Pang, Y; Tsim, KW; Xue, H; Xue, J	1
Semla, TP	1
Niederhofer, H	1
Adelman, A; Campos-Outcalt, D; Cross, JT; Forciea, MA; Hopkins, R; Mehr, D; Owens, DK; Qaseem, A; Santaguida, P; Schellhase, K; Shekelle, P; Snow, V	1
Booker, L; Cowan, D; Ismaila, A; Levine, M; Oremus, M; Patterson, C; Raina, P; Santaguida, P	1
Ai, YX; Chang, DC; Fu, HJ; Han, YF; Lao, YZ; Li, CY; Li, WM; Li, ZW; Liu, LJ; Liu, YW; Luo, JL; Pang, YP; Peoples, RW	1
Graham, L	1
Burbaeva, GSh; Shevtsov, PN; Shevtsova, EF	1
Fang, JH; Jiang, FG; Wang, XH; Xu, ZR	1
Okochi, M; Takeda, M; Tanaka, T	1
Atri, A	1
Bachurin, SO; Burbaeva, GSh; Shevtsov, PN; Shevtsova, EF	1
Ahnaou, A; Drinkenburg, WH; Huysmans, H; Jacobs, T	1
Holubova, K; Horak, M; Kaniakova, M; Kleteckova, L; Korabecny, J; Korinek, M; Krusek, J; Lichnerova, K; Skrenkova, K; Smejkalova, T; Soukup, O; Vales, K	1
Chrienova, Z; Hepnarova, V; Holubova, K; Horak, M; Kaniakova, M; Kleteckova, L; Kobrlova, T; Korabecny, J; Kucera, T; Nepovimova, E; Skrenkova, K; Soukup, O; Vales, K	1
Alcaro, S; Borges, F; Chavarria, D; Gaspar, A; Mesiti, F	1

Reviews

12 review(s) available for tacrine and memantine

Article	Year
[Current strategies of pathogenetic therapy of Alzheimer's disease]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2001, Issue:7 Topics: Aged; Alzheimer Disease; Amino Acids; Aminoquinolines; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Estrogens; Ginkgo biloba; Humans; Indans; Memantine; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuronal Plasticity; Neuroprotective Agents; Neurotransmitter Agents; Nicergoline; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Piracetam; Pyrithioxin; Rivastigmine; Selegiline; Tacrine; Time Factors	2001
[Anti-dementia drugs for Alzheimer disease in present and future]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 120, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; tau Proteins	2002
Alzheimer's disease: emerging noncholinergic treatments. Geriatrics, 2003, Volume: 58 Suppl Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Cost of Illness; Excitatory Amino Acid Antagonists; Ginkgo biloba; Humans; Memantine; Outcome Assessment, Health Care; Phytotherapy; Primary Prevention; Receptors, N-Methyl-D-Aspartate; Tacrine; United States	2003
[Current therapy of patients with dementia]. MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2 Topics: Activities of Daily Living; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Controlled Clinical Trials as Topic; Dementia; Dementia, Vascular; Donepezil; Dopamine Agents; Female; Galantamine; Ginkgo biloba; Humans; Indans; Male; Memantine; Meta-Analysis as Topic; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Placebos; Plant Preparations; Prospective Studies; Rivastigmine; Tacrine; Time Factors	2003
Dementia. Clinical evidence, 2004, Issue:11 Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamine; Ginkgo biloba; Haloperidol; Humans; Indans; Memantine; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Risperidone; Rivastigmine; Selegiline; Tacrine; Vitamin E	2004
Dementia. Clinical evidence, 2004, Issue:12 Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine	2004
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management. Journal of the American Academy of Nurse Practitioners, 2005, Volume: Suppl Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome	2005
Dementia. Clinical evidence, 2005, Issue:14 Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Selegiline; Tacrine	2005
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5 Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine	2008
New drugs for Alzheimer's disease in Japan. Psychiatry and clinical neurosciences, 2011, Volume: 65, Issue:5 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Japan; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2011
Effective pharmacological management of Alzheimer's disease. The American journal of managed care, 2011, Volume: 17 Suppl 13 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Dementia; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome	2011
The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease. European journal of medicinal chemistry, 2019, Nov-01, Volume: 181 Topics: Alzheimer Disease; Animals; Chemistry Techniques, Synthetic; Donepezil; Dopamine Agents; Drug Design; Drug Discovery; Humans; Indans; Memantine; Molecular Targeted Therapy; Neuroprotective Agents; Nootropic Agents; Rivastigmine; Tacrine	2019

Other Studies

25 other study(ies) available for tacrine and memantine

Article	Year
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Ligands; Models, Molecular; Molecular Structure; Protein Binding; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2008
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Alzheimer Disease; Butyrylcholinesterase; Carbolines; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Humans; Inhibitory Concentration 50; Memantine; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. Journal of medicinal chemistry, 2012, Nov-08, Volume: 55, Issue:21 Topics: Alkaloids; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Cell Line; Chromatography, Affinity; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Dioxoles; Dyrk Kinases; Glutamic Acid; Humans; Imidazoles; In Vitro Techniques; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Porifera; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship	2012
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders. Journal of medicinal chemistry, 2015, Aug-27, Volume: 58, Issue:16 Topics: Animals; Carbolines; Cholinesterase Inhibitors; Computational Biology; Excitatory Amino Acid Antagonists; Humans; Indicators and Reagents; Ligands; Monoamine Oxidase Inhibitors; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2015
Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity. Bioorganic & medicinal chemistry, 2020, 06-15, Volume: 28, Issue:12 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Behavior, Animal; Binding Sites; Cell Survival; Coumarins; Disease Models, Animal; Drug Design; Humans; Iron Chelating Agents; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Peptide Fragments; Rats; Structure-Activity Relationship	2020
No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use. Life sciences, 2000, Feb-11, Volume: 66, Issue:12 Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Memantine; Piperidines; Rats; Rats, Inbred F344; Tacrine	2000
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. International clinical psychopharmacology, 2003, Volume: 18, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Carbamates; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Middle Aged; Phenylcarbamates; Piperidines; Product Surveillance, Postmarketing; Rivastigmine; Surveys and Questionnaires; Tacrine; Treatment Outcome	2003
[Mitochondria as the target for neuroprotectors]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2005, Issue:9 Topics: Animals; Antiparkinson Agents; Brain; Cell Death; Cells, Cultured; Dopamine Agents; Ginkgo biloba; Indoles; Intracellular Membranes; Ion Channels; Lipid Peroxidation; Memantine; Mitochondria; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxins; Nootropic Agents; Permeability; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Tacrine	2005
Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Molecular pharmacology, 2007, Volume: 71, Issue:5 Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cells, Cultured; Computer Simulation; Drug Synergism; Glutamic Acid; Isoenzymes; Memantine; Molecular Sequence Data; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine; Time Factors	2007
Alzheimer's disease: will advances made in the past turn the tide? The Annals of pharmacotherapy, 2007, Volume: 41, Issue:9 Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; History, 20th Century; History, 21st Century; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indans; Memantine; Piperidines; Tacrine	2007
Treating autism pharmacologically: also tacrine might improve symptomatology in some cases. Journal of child neurology, 2007, Volume: 22, Issue:8 Topics: Adolescent; Adult; Autistic Disorder; Brain Chemistry; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Humans; Liver; Memantine; Tacrine; Treatment Failure	2007
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations. Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5 Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine	2008
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Annals of internal medicine, 2008, Mar-04, Volume: 148, Issue:5 Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine	2008
Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors. Biochemical and biophysical research communications, 2008, May-16, Volume: 369, Issue:4 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cytoprotection; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Memantine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine	2008
AAFP and ACP release guideline on dementia treatment. American family physician, 2008, Apr-15, Volume: 77, Issue:8 Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Guidelines as Topic; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine	2008
Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases. Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:2 Topics: Alzheimer Disease; Aminoquinolines; Brain; Dopamine Agents; GABA Modulators; Humans; Memantine; Microtubule-Associated Proteins; Microtubules; Nootropic Agents; Phosphorylation; Tacrine; Triazolam	2008
Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage. BMC neuroscience, 2010, Mar-03, Volume: 11 Topics: Animals; Apoptosis; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Inhibitory Concentration 50; Male; Memantine; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Tacrine; Time Factors	2010
Effects of anti-Alzheimer drugs on phosphorylation and assembly of microtubules from brain microtubular proteins. Bulletin of experimental biology and medicine, 2014, Volume: 156, Issue:6 Topics: Alzheimer Disease; Aminoquinolines; Animals; Brain; Memantine; Microtubule-Associated Proteins; Microtubules; Nootropic Agents; Phosphorylation; Rats; Rats, Wistar; Tacrine	2014
Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential. Neuropharmacology, 2014, Volume: 86 Topics: Animals; Cerebral Cortex; Cognition; Donepezil; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Galantamine; Gamma Rhythm; Indans; Male; Memantine; Motor Activity; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Phenylcarbamates; Piperidines; Principal Component Analysis; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Signal Processing, Computer-Assisted; Tacrine; Theta Rhythm	2014
7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo. Neuropharmacology, 2018, 09-15, Volume: 140 Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Humans; Locomotion; Male; Memantine; Mutation; Neurons; Neuroprotective Agents; Prepulse Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Tacrine	2018
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease. Current Alzheimer research, 2019, Volume: 16, Issue:9 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Capillary Permeability; Cell Survival; CHO Cells; Cholinesterase Inhibitors; Cricetulus; Glutamic Acid; HEK293 Cells; Humans; Ligands; Male; Memantine; Molecular Docking Simulation; Neuroprotective Agents; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tacrine; Tissue Culture Techniques	2019