Compounds > tacrine

tacrine and huprine y

tacrine has been researched along with huprine y in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (50.00)	29.6817
2010's	5 (41.67)	24.3611
2020's	1 (8.33)	2.80

Authors

Authors	Studies
Badia, A; Baños, JE; Barril, X; Camps, P; Luque, FJ; Morral, J; Muñoz-Torrero, D; Orozco, M; Vivas, NM	1
Gago, F; Luque, FJ; Martín-Santamaría, S; Muñoz-Muriedas, J	1
Badia, A; Camps, P; Clos, MV; Formosa, X; Muñoz-Torrero, D; Petrignet, J	1
Badia, A; Camps, P; Clos, MV; Curutchet, C; Gómez, E; Luque, FJ; Muñoz-Muriedas, J; Muñoz-Torrero, D	1
Kumar, A; Mishra, P; Panda, G	1
Alcalá, Mdel M; Badia, A; Camps, P; Hospital, S; Muñoz-Torrero, D; Vivas, NM	1
Camins, A; Camps, P; Canudas, AM; Jiménez, A; Jordá, EG; Muñoz-Torrero, D; Pallàs, M; Rimbau, V; Verdaguer, E	1
Andrisano, V; Badia, A; Bartolini, M; Bidon-Chanal, A; Camps, P; Clos, MV; Formosa, X; Galdeano, C; González-Muñoz, GC; Luque, FJ; Mancini, F; Minguillón, C; Muñoz-Torrero, D; Ratia, M; Relat, J; Rodríguez-Franco, MI; Salmona, M; Sola, I; Viayna, E	1
Badia, A; Camps, P; Clos, MV; Formosa, X; Galdeano, C; Muñoz-Torrero, D; Pera, M; Ratia, M; Relat, J; Sola, I; Viayna, E	1
Dolezal, R; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Korabecny, J; Kuca, K; Kucera, T; Mezeiova, E; Misik, J; Muckova, L; Pham, NL; Pokrievkova, L; Roh, J; Sepsova, V; Soukup, O; Spilovska, K	1
Bartolini, M; Cieslikiewicz-Bouet, M; Clos, MV; Colletier, JP; Coquelle, N; Galdeano, C; Jean, L; Muñoz-Torrero, D; Pérez, B; Renard, PY; Silman, I	1
Albuquerque, HMT; Malafaia, D; Silva, AMS	1

Reviews

2 review(s) available for tacrine and huprine y

Article	Year
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). Bioorganic & medicinal chemistry, 2019, 03-15, Volume: 27, Issue:6 Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Ligands; Neuroprotective Agents	2019
Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review. European journal of medicinal chemistry, 2021, Mar-15, Volume: 214 Topics: Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Curcumin; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Structure-Activity Relationship; Tacrine; tau Proteins	2021

Other Studies

10 other study(ies) available for tacrine and huprine y

Article	Year
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2000, Nov-30, Volume: 43, Issue:24 Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Bridged Bicyclo Compounds; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Humans; In Vitro Techniques; Male; Mice; Models, Molecular; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Neuroprotective Agents; Quinolines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine; Tubocurarine	2000
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis. Journal of medicinal chemistry, 2004, Aug-26, Volume: 47, Issue:18 Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Inhibitory Concentration 50; Protein Binding; Quantitative Structure-Activity Relationship; Structure-Activity Relationship	2004
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors. Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6 Topics: Acetylcholinesterase; Aminoquinolines; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Structure-Activity Relationship; Tacrine	2005
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23 Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Anions; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Erythrocytes; Formamides; Glycine; Heterocyclic Compounds, 4 or More Rings; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tacrine	2006
Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids. Neuropharmacology, 2003, Volume: 44, Issue:6 Topics: Alkaloids; Aminoquinolines; Animals; Brain; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine	2003
(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration. Journal of Alzheimer's disease : JAD, 2004, Volume: 6, Issue:6 Topics: Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Animals, Newborn; Apoptosis; Cerebellum; Cholinesterase Inhibitors; Colchicine; Cytoskeleton; Disease Models, Animal; Flow Cytometry; Glycogen Synthase Kinase 3; Heterocyclic Compounds, 4 or More Rings; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine	2004
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases. Journal of medicinal chemistry, 2012, Jan-26, Volume: 55, Issue:2 Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Membranes, Artificial; Mice; Models, Molecular; Peptide Fragments; Permeability; Prion Diseases; Prions; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Tacrine	2012
Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents. Neuro-degenerative diseases, 2012, Volume: 10, Issue:1-4 Topics: Aminoquinolines; Analysis of Variance; Animals; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Humans; Hydrogen Peroxide; Muscarinic Antagonists; Neuroblastoma; Oxidative Stress; Pirenzepine; Protein Binding; Protein Multimerization; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tacrine; Tritium	2012
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland), 2017, Jul-28, Volume: 22, Issue:8 Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Enzyme Activation; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrolysis; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Molecular Structure; Permeability; Protein Binding; Structure-Activity Relationship; Tacrine	2017
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis. Molecules (Basel, Switzerland), 2018, Mar-11, Volume: 23, Issue:3 Topics: Acetylcholinesterase; Aminoacridines; Aminoquinolines; Butyrylcholinesterase; Cholinesterase Inhibitors; Down-Regulation; GPI-Linked Proteins; Heterocyclic Compounds, 4 or More Rings; Humans; Models, Molecular; Molecular Structure; Myasthenia Gravis; Structure-Activity Relationship; Tacrine	2018