tacrine and huperzine a

tacrine has been researched along with huperzine a in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (25.64)	18.2507
2000's	20 (51.28)	29.6817
2010's	7 (17.95)	24.3611
2020's	2 (5.13)	2.80

Authors

Authors	Studies
Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X	1
Badia, A; Camps, P; Clos, MV; Formosa, X; Muñoz-Torrero, D; Petrignet, J	1
Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS	1
Belinskaya, T; Borriello, M; Butini, S; Campiani, G; Catalanotti, B; De Angelis, M; Fattorusso, C; Gabellieri, E; Gemma, S; Huleatt, P; Nacci, V; Novellino, E; Saxena, A	1
Al-Rashid, ZF; Beri, V; Cheung, J; Rosenberry, TL; Shiomi, K; Wildman, SA	1
Cheng, DH; Ren, H; Tang, XC	1
Badia, A; Baños, JE; Camps, P; Contreras, J; Görbig, DM; Muñoz-Torrero, D; Simón, M; Vivas, NM	1
Cheng, DH; Tang, XC	1
Tang, XC; Wang, T	1
Ariel, N; Barak, D; Bino, T; Ordentlich, A; Shafferman, A; Velan, B	1
Hu, GY; Lin, JH; Tang, XC	1
Tang, XC; Wang, H	1
Badia, A; Barril, X; Camps, P; El Achab, R; Eladi Baños, J; Görbig, DM; Luque, FJ; Morral, J; Muñoz-Torrero, D; Orozco, M; Vivas, NM	1
Carlier, PR; Du, DM; Han, Y; Liu, J; Pang, YP	1
Barril, X; Luque, FJ; Orozco, M	1
Kaur, J; Zhang, MQ	1
Tang, XC; Wang, R; Xiao, XQ	1
Badia, A; Baños, JE; Barril, X; Camps, P; Luque, FJ; Morral, J; Muñoz-Torrero, D; Orozco, M; Vivas, NM	1
Barril, X; Camps, P; Dvir, H; Harel, M; Luque, FJ; Muñoz-Torrero, D; Orozco, M; Rosenberry, TL; Silman, I; Sussman, JL; Wong, DM	1
Camps, P; Muñoz-Torrero, D	1
Tang, XC; Zhao, Q	1
Bai, DL; Jin, GY; Xia, Y	1
Ma, XC; Tu, ZH; Wang, HX; Xin, J; Zhang, T	1
Alcalá, Mdel M; Badia, A; Camps, P; Hospital, S; Muñoz-Torrero, D; Vivas, NM	1
Bai, D; He, X; Jiang, H; Jin, G; Luo, X; Zhang, H	1
Camins, A; Camps, P; Canudas, AM; Jiménez, A; Jordá, EG; Muñoz-Torrero, D; Pallàs, M; Rimbau, V; Verdaguer, E	1
Dong So, D; Han, Y; Law, SL; Xu, Z; Xue, H; Zheng, H	1
Beck, C; Blank, K; Colenda, CC; Doraiswamy, MP; Kalunian, DA; Lyketsos, CG; Yaffe, K	1
Caballero, J; Fernández, M	1
Badia, A; Camps, P; Clos, MV; Curutchet, C; Gómez, E; Luque, FJ; Muñoz-Muriedas, J; Muñoz-Torrero, D	1
Carlier, PR; Han, YF; Kan, KK; Li, WM; Pang, YP	1
Abib, R; Gonçalves, CA; Guerra, MC; Leite, MC; Lunardi, P; Nardin, P	1
Bautista-Aguilera, OM; Borrell, JI; Brogi, S; Butini, S; Cacabelos, R; Chioua, M; de la Bellacasa, RP; López, MG; Marco-Contelles, J; Pérez, M; Romero, A; Yañez, M	1
Hou, B; Yang, H; Zhang, S; Zuo, Z	1
Andrés, J; Nascimento, ÉCM; Oliva, M	1
Chen, Q; Wang, Y; Xiao, X; Zhu, X	1
Carlier, PR; Cui, W; Fu, H; Han, Y; Hu, S; Li, W; Luo, J; Mak, S; Pang, Y; Pi, R; Tsim, KW	1
Gong, Q; Li, J; Li, X; Liu, W; Mao, F; Qiu, X; Wang, H; Wang, W; Xu, Y; Zhang, H; Zhang, J; Zhu, J	1
Curtis, MA; Lin, SX; Sperry, J	1

Reviews

6 review(s) available for tacrine and huperzine a

Article	Year
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors. Current medicinal chemistry, 2000, Volume: 7, Issue:3 Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine	2000
Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. Mini reviews in medicinal chemistry, 2001, Volume: 1, Issue:2 Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Drug Design; Humans; Models, Molecular; Molecular Conformation; Sesquiterpenes; Structure-Activity Relationship; Tacrine	2001
[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis]. Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:9 Topics: Alkaloids; Cholinesterase Inhibitors; Donepezil; Indans; Molecular Conformation; Molecular Structure; Piperidines; Sesquiterpenes; Tacrine	2002
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. Current Alzheimer research, 2007, Volume: 4, Issue:4 Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Humans; Models, Biological; Sesquiterpenes; Tacrine	2007
Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget. Journal of neurochemistry, 2021, Volume: 158, Issue:6 Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Drug Combinations; Drug Delivery Systems; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Sesquiterpenes; Tacrine	2021
Pyridine alkaloids with activity in the central nervous system. Bioorganic & medicinal chemistry, 2020, 12-15, Volume: 28, Issue:24 Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic	2020

Other Studies

33 other study(ies) available for tacrine and huperzine a

Article	Year
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17 Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship	2002
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors. Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6 Topics: Acetylcholinesterase; Aminoquinolines; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Structure-Activity Relationship; Tacrine	2005
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7 Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo	2006
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11 Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Models, Molecular; Protein Binding; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine	2006
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry, 2013, Oct-22, Volume: 52, Issue:42 Topics: Acetylcholine; Acetylcholinesterase; Aflatoxin B1; Binding Sites; Binding, Competitive; Catalysis; Catalytic Domain; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Humans; Hydrolysis; Kinetics; Models, Chemical; Phenanthrenes; Pyrans; Quinones; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity	2013
Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport, 1996, Dec-20, Volume: 8, Issue:1 Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine	1996
Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:4 Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Cattle; Cholinesterase Inhibitors; Magnetic Resonance Spectroscopy; Male; Neuromuscular Junction; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spectrophotometry, Infrared; Tacrine	1998
Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:2 Topics: Alkaloids; Animals; Aziridines; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Injections, Intraventricular; Male; Maze Learning; Memory; Memory, Short-Term; Neuromuscular Blocking Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine	1998
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. European journal of pharmacology, 1998, May-22, Volume: 349, Issue:2-3 Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine	1998
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors. The Biochemical journal, 1998, Oct-01, Volume: 335 ( Pt 1) Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Chemical; Models, Molecular; Physostigmine; Protein Conformation; Pyridostigmine Bromide; Sesquiterpenes; Structure-Activity Relationship; Tacrine	1998
Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:1 Topics: Action Potentials; Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; Indans; Male; Membrane Potentials; Mice; Muscle Fibers, Skeletal; Neuromuscular Junction; Phrenic Nerve; Piperidines; Sesquiterpenes; Tacrine	1997
Anticholinesterase effects of huperzine A, E2020, and tacrine in rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:1 Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine	1998
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 1999, Aug-26, Volume: 42, Issue:17 Topics: Acetylcholinesterase; Alkaloids; Animals; Binding Sites; Cholinesterase Inhibitors; Diaphragm; In Vitro Techniques; Male; Models, Molecular; Muscle Contraction; Neuromuscular Junction; Neuroprotective Agents; Phrenic Nerve; Quinolines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine; Torpedo	1999
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters, 1999, Aug-16, Volume: 9, Issue:16 Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Sesquiterpenes; Tacrine	1999
Predicting relative binding free energies of tacrine-huperzine A hybrids as inhibitors of acetylcholinesterase. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Acetylcholinesterase; Alkaloids; Amino Acid Substitution; Animals; Cholinesterase Inhibitors; Neuroprotective Agents; Protein Binding; Sesquiterpenes; Tacrine; Thermodynamics; Torpedo	1999
Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury. Journal of neuroscience research, 2000, Sep-01, Volume: 61, Issue:5 Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Catalase; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Glutathione Peroxidase; Lipid Peroxidation; Malondialdehyde; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Rats, Wistar; Sesquiterpenes; Superoxide Dismutase; Tacrine	2000
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2000, Nov-30, Volume: 43, Issue:24 Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Bridged Bicyclo Compounds; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Humans; In Vitro Techniques; Male; Mice; Models, Molecular; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Neuroprotective Agents; Quinolines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine; Tubocurarine	2000
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates. Biochemistry, 2002, Mar-05, Volume: 41, Issue:9 Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Binding Sites; Chlorine; Cholinesterase Inhibitors; Computer Simulation; Crystallization; Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Kinetics; Ligands; Models, Molecular; Protein Conformation; Sesquiterpenes; Species Specificity; Tacrine; Torpedo	2002
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. European journal of pharmacology, 2002, Nov-29, Volume: 455, Issue:2-3 Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine	2002
Acute effects of huperzine A and tacrine on rat liver. Acta pharmacologica Sinica, 2003, Volume: 24, Issue:3 Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Cholinesterase Inhibitors; Female; Hepatocytes; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine	2003
Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids. Neuropharmacology, 2003, Volume: 44, Issue:6 Topics: Alkaloids; Aminoquinolines; Animals; Brain; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine	2003
Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A. Arzneimittel-Forschung, 2003, Volume: 53, Issue:11 Topics: Alkaloids; Alkylation; Binding Sites; Cholinesterase Inhibitors; Indicators and Reagents; Polymers; Protein Conformation; Sesquiterpenes; Tacrine	2003
(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration. Journal of Alzheimer's disease : JAD, 2004, Volume: 6, Issue:6 Topics: Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Animals, Newborn; Apoptosis; Cerebellum; Cholinesterase Inhibitors; Colchicine; Cytoskeleton; Disease Models, Animal; Flow Cytometry; Glycogen Synthase Kinase 3; Heterocyclic Compounds, 4 or More Rings; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine	2004
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine. Journal of peptide science : an official publication of the European Peptide Society, 2006, Volume: 12, Issue:1 Topics: Alkaloids; Animals; Avoidance Learning; Behavior, Animal; Brain Diseases; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Memory; Mice; Peptide Fragments; Scopolamine; Sesquiterpenes; Tacrine	2006
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2006, Volume: 14, Issue:7 Topics: Aged; Alkaloids; Alzheimer Disease; Brain; Caregivers; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Diagnostic and Statistical Manual of Mental Disorders; Galantamine; Geriatric Psychiatry; Health Services for the Aged; Humans; Phenylcarbamates; Professional-Family Relations; Rivastigmine; Sesquiterpenes; Tacrine; United States	2006
Ensembles of Bayesian-regularized genetic neural networks for modeling of acetylcholinesterase inhibition by huprines. Chemical biology & drug design, 2006, Volume: 68, Issue:4 Topics: Acetylcholinesterase; Algorithms; Alkaloids; Animals; Bayes Theorem; Cattle; Cholinesterase Inhibitors; Computer Simulation; Drug Design; Models, Biological; Molecular Structure; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Sesquiterpenes; Tacrine	2006
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23 Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Anions; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Erythrocytes; Formamides; Glycine; Heterocyclic Compounds, 4 or More Rings; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tacrine	2006
Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures. Life sciences, 2013, Apr-09, Volume: 92, Issue:12 Topics: Alkaloids; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dementia; Hippocampus; Male; Nerve Growth Factors; Neuroprotective Agents; Rats; Rats, Wistar; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Sesquiterpenes; Tacrine	2013
Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer's disease. Mini reviews in medicinal chemistry, 2015, Volume: 15, Issue:8 Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Drug Discovery; Hep G2 Cells; Humans; Models, Molecular; Nootropic Agents; Sesquiterpenes; Tacrine	2015
Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives. Archives of pharmacal research, 2016, Volume: 39, Issue:5 Topics: Alkaloids; Aminoquinolines; Cholinesterase Inhibitors; Drug Design; Heterocyclic Compounds, 4 or More Rings; Molecular Docking Simulation; Molecular Structure; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Sesquiterpenes; Tacrine	2016
Binding free energy calculations to rationalize the interactions of huprines with acetylcholinesterase. Journal of computer-aided molecular design, 2018, Volume: 32, Issue:5 Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Cholinesterase Inhibitors; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Sesquiterpenes; Tacrine; Thermodynamics	2018
ABAD/17β-HSD10 reduction contributes to the protective mechanism of huperzine a on the cerebral mitochondrial function in APP/PS1 mice. Neurobiology of aging, 2019, Volume: 81 Topics: 3-Hydroxyacyl CoA Dehydrogenases; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Survival; Cytochromes c; Disease Models, Animal; Male; Mice, Transgenic; Mitochondria; Neuroprotective Agents; Reactive Oxygen Species; Sesquiterpenes; Tacrine	2019
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Depression; Drug Design; Ligands; Mice; Permeability; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Tacrine; Vilazodone Hydrochloride	2018