tacrine has been researched along with glutamic acid in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Bowen, DM; Lowe, SL; Palmer, AM; Steele, JE | 1 |
| Choi, DW; Davenport, CJ; Monyer, H | 1 |
| Gean, PW; Huang, CC; Wang, SJ | 1 |
| Benz, A; Mennerick, S; Zorumski, CF | 1 |
| Carlier, PR; Chan, HH; Chang, DC; Fu, H; Han, Y; Lee, NT; Li, C; Li, M; Li, W; Li, Z; Luo, J; Pang, Y; Pi, R; Pu, Y; Tsang, HW; Tsim, KW; Xiong, K; Xue, H | 1 |
| Aisen, PS | 1 |
| Ennis, M; Hayar, A; Heinbockel, T; Zhu, M | 1 |
| Fu, H; Han, Y; Kan, KK; Lee, NT; Li, M; Li, W; Li, X; Pang, Y; Tsim, KW | 1 |
| Akaike, A; Fujii, T; Katsuki, H; Kume, T; Niidome, T; Okabe, S; Sugimoto, H; Sugimoto, M; Takada-Takatori, Y | 1 |
| Chan, HH; Chen, K; Fu, H; Han, Y; Jiang, H; Kan, KK; Lam, CS; Lee, NT; Li, C; Li, M; Li, W; Li, X; Luo, J; Niu, C; Pang, Y; Tsim, KW; Xue, H; Xue, J | 1 |
| Chang, DC; Chen, C; Fu, H; Han, Y; Lao, Y; Lee, NT; Li, M; Li, P; Li, W; Liu, W; Liu, Y; Pang, Y; Tsim, KW; Yu, H | 1 |
| Ai, YX; Chang, DC; Fu, HJ; Han, YF; Lao, YZ; Li, CY; Li, WM; Li, ZW; Liu, LJ; Liu, YW; Luo, JL; Pang, YP; Peoples, RW | 1 |
| Nakazawa, K; Ohwada, T; Oka, J; Saito, Y; Sato, K | 1 |
| Chen, K; Han, Y; Jiang, H; Li, W; Mak, M; Pang, Y; Wang, Q | 1 |
| Connor, JR; Lee, SY; Mitchell, RM; Simmons, Z | 1 |
| Fang, JH; Jiang, FG; Wang, XH; Xu, ZR | 1 |
| Chen, X; Decker, M; Fleck, C; Heilmann, J; Kling, B; Kraus, B; Lupp, A; Zenger, K | 1 |
| Choi, C; Cui, W; Han, Y; Hu, S; Mak, S; Pang, Y; Tang, J | 1 |
| Chao, XJ; Chen, ZW; Cui, W; Han, YF; He, XX; Kong, AN; Liu, AM; Liu, PQ; Mak, SH; Pi, RB; Ramassamy, C; Wang, SG; Wang, YT; Yu, ZL | 1 |
| Choi, C; Cui, W; Han, Y; Hu, S; Hu, Y; Lee, M; Mak, S; Pang, Y; Tang, J; Xu, D | 1 |
| Chrienova, Z; Hepnarova, V; Holubova, K; Horak, M; Kaniakova, M; Kleteckova, L; Kobrlova, T; Korabecny, J; Kucera, T; Nepovimova, E; Skrenkova, K; Soukup, O; Vales, K | 1 |
| Mannoury-la-Cour, C; Mantas, I; Millan, MJ; Svenningsson, P; Yang, Y; Zhang, X | 1 |
3 review(s) available for tacrine and glutamic acid
| Article | Year |
|---|---|
Tacrine in relation to amino acid transmitters in Alzheimer's disease.
Topics: Alzheimer Disease; Aminoacridines; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Tacrine | 1990 |
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2005 |
Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Calcium Channels, L-Type; Cholinesterase Inhibitors; Drug Design; Glutamic Acid; Hippocampus; Humans; Long-Term Potentiation; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Tacrine | 2009 |
19 other study(ies) available for tacrine and glutamic acid
| Article | Year |
|---|---|
Tetrahydroaminoacridine selectively attenuates NMDA receptor-mediated neurotoxicity.
Topics: Aminoacridines; Animals; Aspartic Acid; Cells, Cultured; Cholinesterase Inhibitors; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tacrine | 1988 |
Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Atropine; Electric Stimulation; Evoked Potentials; Glutamic Acid; In Vitro Techniques; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Synaptic Transmission; Tacrine | 1995 |
Components of glial responses to exogenous and synaptic glutamate in rat hippocampal microcultures.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Microglia; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Tacrine | 1996 |
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
Topics: Animals; Apoptosis; Cells, Cultured; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Glutamic Acid; Indans; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine | 2005 |
Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells.
Topics: Amino Acids; Animals; Aspartic Acid; Benzoates; Dopamine D2 Receptor Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA-B Receptor Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Neuronal Plasticity; Neurons, Afferent; Odorants; Olfactory Bulb; Olfactory Nerve; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Synapses; Tacrine; Xanthenes | 2006 |
Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine.
Topics: Animals; Benzimidazoles; Cell Death; Cells, Cultured; Cerebral Cortex; Fluoresceins; Fluorescent Dyes; Glutamic Acid; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Tacrine | 2006 |
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Cysteine; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Fetus; Galantamine; Glutamic Acid; Ionomycin; Ionophores; Mecamylamine; Neuroprotective Agents; Nicotinic Antagonists; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitrosothiols; Tacrine | 2006 |
Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cells, Cultured; Computer Simulation; Drug Synergism; Glutamic Acid; Isoenzymes; Memantine; Molecular Sequence Data; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine; Time Factors | 2007 |
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Cerebellum; Energy Metabolism; Glutamic Acid; Mitochondria; Mitochondrial Proteins; N-Methylaspartate; Neurons; Oxidative Stress; Proteome; Proteomics; Rats; Tacrine | 2007 |
Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cytoprotection; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Memantine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine | 2008 |
Effects of tamoxifen on L-glutamate transporters of astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Estrogen Antagonists; Glutamic Acid; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Estrogen; Tacrine; Tamoxifen | 2008 |
HFE polymorphisms affect cellular glutamate regulation.
Topics: Analysis of Variance; Calcium; Cell Line, Tumor; Deferoxamine; Enzyme Inhibitors; Ferric Compounds; Gene Expression Regulation, Neoplastic; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutaminase; Hemochromatosis Protein; Histocompatibility Antigens Class I; Humans; Intracellular Fluid; Iron; Membrane Proteins; Minocycline; Neuroblastoma; Polymorphism, Genetic; Quaternary Ammonium Compounds; Siderophores; Sodium; Tacrine; Transfection; Tritium; Vesicular Glutamate Transport Protein 1 | 2011 |
Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage.
Topics: Animals; Apoptosis; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Inhibitory Concentration 50; Male; Memantine; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Tacrine; Time Factors | 2010 |
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
Topics: Acetylcholinesterase; Allosteric Regulation; Animals; Butyrylcholinesterase; Cell Count; Cell Line; Cell Survival; Cholinesterase Inhibitors; Cognition; Eels; Female; Glutamic Acid; Hepatic Stellate Cells; Horses; Lipid Peroxidation; Liver; Maze Learning; Mice; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Silybin; Silymarin; Tacrine | 2012 |
Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways.
Topics: Animals; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; MAP Kinase Signaling System; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tacrine | 2013 |
Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-induced cell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Caffeic Acids; Cell Death; Cell Line, Transformed; Cytoskeletal Proteins; Glutamic Acid; Heme Oxygenase-1; Humans; Kelch-Like ECH-Associated Protein 1; Membrane Potential, Mitochondrial; Mice; Neurons; NF-E2-Related Factor 2; Nootropic Agents; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Tacrine; Transfection | 2014 |
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Glutamic Acid; MAP Kinase Signaling System; Neurites; Neurogenesis; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Rats, Sprague-Dawley; Tacrine | 2015 |
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Capillary Permeability; Cell Survival; CHO Cells; Cholinesterase Inhibitors; Cricetulus; Glutamic Acid; HEK293 Cells; Humans; Ligands; Male; Memantine; Molecular Docking Simulation; Neuroprotective Agents; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tacrine; Tissue Culture Techniques | 2019 |
Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; GABAergic Neurons; Glutamic Acid; Levodopa; Locomotion; Male; Medial Forebrain Bundle; Mice; Mice, Knockout; Movement; Neuronal Plasticity; Oxidopamine; Parkinsonian Disorders; Receptors, G-Protein-Coupled; RNA, Messenger; Serotonin; Tacrine; Tremor | 2020 |